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206 articles for “ACE 2”
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Studies of Environmental Effect of Aluminium-2014 Alloy in 1m Acetic Acid using Extratcted Inhibitor
Abstract: AbstractThis examination considers distinctive natural elements influencing consumption under marine inundation conditions and proposes a scientific model consolidating their impacts on erosion corruption through the boat life. The examination receives a nonlinear capacity of time as the reference erosion model aligned with operational consumption information at long haul normal conditions to speak to the erosion conduct under standard natural conditions.Based on recently acquired field information, an erosion disintegration model is …
Published in Journal of Energy, Environment & Carbon Credits · Vol. 10, Issue 2, 2020 · pp. 19–26 Read article
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Dissolution Enhancement in Nano/Micro-Sized Dispersions of Piroxicam with the Novel Polymer Soluplus® and Polyvinyl Pyrrolidone
Abstract: Piroxicam, a Non-Steroidal Anti-Inflammatory Drug (NSAID), belongs to the class II of the biopharmaceutical classification system (BCS) and thus exhibits poor bioavailability. In an effort to tackle this issue, we report here the comparative properties of the solid dispersions of piroxicam made from a novel graft copolymer of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol (Soluplus) and the linear polymer polyvinyl pyrrolidone (K 25), both the dispersions synthesized identically using solvent evaporation method. …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 3, Issue 1, 2012 · pp. 10–19 Read article
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Identification of Specificity Determining Positions through Phylogenetic Studies and Molecular Modeling of ICP27 as a Drug Target of Herpes Simplex Virus-1
Abstract: An ever-growing effort to apply computational power to the combined chemical and biological space in order to streamline drug discovery, design, development and optimization can be achieved through computational approaches. Herpes simplex is an infection that is caused by a herpes simplex virus (HSV), and is one of the most common human infections transmissible to a body site. Infection with HSV can result in several diseases ranging from apparent infections …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 2, Issue 1, 2015 · pp. 32–43 Read article
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Topical Application of Acetone Solution of Cucurbitacin-A at 48 Hours After the Fourth Moult on the Parameters of Cocoon Spinned by Mature fifth instar larvae of Silkworm, Bombyx mori (L) [Race: Double Hybrid - (CSR6 x CSR26) x CSR2 x CSR27)].
Abstract: The topical application of acetone solution of Cucurbitacin-A at 48 hours after the fourth moult to the fifth instared larvae of silkworm, Bombyx mori (L) [Race: Double Hybrid - (CSR6 x CSR26) x CSR2 x CSR27)] was found significant influence on the parameteres of the silk cocoon and silk fibre. The weight of whole cocoon (deflossed), silk shell weight, weight of pupa and silk shell percentage or ratio in the …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 11, Issue 1, 2020 · pp. 16–25 Read article
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A New Extractive Spectrophotometric Method for the Determination of Oxydemeton methyl in Relation to its Environmental and Toxicological Analysis
Abstract: In view of the wide agricultural use of oxydemeton methyl insecticide and its associated toxic effects, it has been determined in the soil, water and foodstuffs to assess its environmental relevance. A new, simple and sensitive extractive spectrophotometric method has been developed for the purpose. It is based on microwave-assisted alkaline hydrolysis of insecticide to form 2-ethylsulfinyl-ethyl mercaptan and transformation of the latter through reaction with carbon disulphide and nickel(II) …
Published in Research and Reviews: A Journal of Toxicology · Vol. 2, Issue 2, 2012 · pp. 1–11 Read article
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Extraction of Natural Dye from Red Rose Flowers
Abstract: In this research work, locally available red flowers of the red rose are selected for the extraction of anthocyanin. Ethanol solvent was used to extract anthocyanin from flowers. Different methods are used to obtain natural dyes from flowers. FTIR, pH, and UV tests were performed to characterize the extracted anthocyanin. The pH differential method was used to measure the total anthocyanin content in red rose flowers. The color of the …
Published in Research & Reviews : Journal of Herbal Science · Vol. 14, Issue 3, 2025 · pp. 14–23 Read article
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Formulation and Evaluation of Microencapsulated Levofloxacin Gel
Abstract: To treat various buccal infectious diseases, a sustained release microencapsulated levofloxacin gel was formulated. Levofloxacin microspheres were being prepared following o/w emulsion solvent evaporation technique by varying concentrations of ethyl acetate, ethyl cellulose and tween 80. Depending on their flow properties almost all the microspheres were found to be excellent. The drug-excipient compatibility study carried out using Fourier transform infrared spectroscopy (FTIR), and differential scanning calorimetry (DSC) resulted that the …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 3, Issue 1, 2016 · pp. 39–47 Read article
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Cyclooxygenase 3 Inhibition: A Probable Mechanism of Acetaminophen in Human: A Review
Abstract: The key rate-limiting step in prostanoid and thromboxane biosynthesis is catalyzed by Cyclooxygenases (COXs) and is the target of nonsteroidal anti-inflammatory drugs (NSAIDs). Until recently, the existence of only two isoforms: COX-1 and COX-2; remained under debate as the anti-pyretic and analgesic property of acetaminophen (paracetamol) could not be explained by mere COX-1 or COX-2 blockades. A novel COX-1 splice variant termed COX-3, sensitive to acetaminophen, was recently discovered in …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 6, Issue 3, 2015 · pp. 23–29 Read article
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Wound Healing Potential of Medicinal Plants: A Review
Abstract: Wound healing is an integrated cellular and biochemical process of restoring normal structure functions of damaged tissue. Healing is a natural phenomenon by which body itself overcome the damaged to the tissue, but the rate of healing is very slow and chance of microbial infection is high. Improvement in healing process can be accomplished either by shortening the time required for healing or to minimize the undesired consequences. India has …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 4, Issue 2, 2017 · pp. 17–40 Read article
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Starter Culture Development for Spontaneously Fermented Buttermilk
Abstract: Fourteen fermented milks were made from ultra-high temperature (UHT) treated milk using mixtures of three strains of lactic acid bacteria (LAB) and two yeast strains isolated from spontaneously fermented buttermilk (SFB). The isolates used for this experiment were Lactococcus (Lc.) lactis ssp lactis strain NGLC1, Lc. lactis ssp lactis strain NGLC2, Lactobacillus plantarum strain NGLB1, Saccharomyces cerevisiae strain NGY1 and Kluyveromyces marxianus strain NGY2. Inoculated milk was fermented for 48 …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 6, Issue 1, 2016 · pp. 11–25 Read article
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Drugs for Alzheimer’s Disease from Salix Alba Discovered Computationally Utilizing Virtual Screening and Docking against 1b41 Protein
Abstract: Objective : The of this research is to evaluate the feasibility of using molecular docking techniques to identify novel acetylcholinesterase, a key enzyme implicated in the pathogenesis of Alzheimer’s disease, a neurodegenerative disorder with a gradual but steady progression to death, due to the gradual accumulation of beta-plaques and neurofibrillary tangles, as well as a decline in acetylcholine levels. Due to its function in converting acetylcholine into acyl and choline …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 2, 2023 · pp. 07–19 Read article
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Evaluation of Anthelmintic, Analgesic and Neuropharmacological Activity of Merremia hederacea
Abstract: The aim of the present study was to evaluate the phytochemical screening, anthelmintic activity, analgesic properties and neuropharmacological activity of the leaf extract of Merremia hederacea (Family: Convovulaceae). After preliminary phytochemical screening, the leaf extract of Merremia hederacea contain flavonoids, tannins, alkaloids and reducing sugars. Anthelmintic activity test was done by comparing the time of paralysis and the time of death of earthworms Pheretima posthuma compared with the standard drug, …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 10, Issue 1, 2020 · pp. 28–33 Read article
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Protein-Tyrosine Phosphatase-1B (PTP-1B) Inhibitory Perspectives of Hydroxylated Chalcones: Exploration through Docking Studies
Abstract: The current research emphasized on exploring the Protein-Tyrosine Phosphatase-1 B (PTP-1B) inhibitory potentials of hydroxylated chalcone derivatives against PDB ID: 4I8N (PTP-1B in complex with an inhibitor [(4-{(2s)-2-(1,3-benzoxazol-2-yl)-2-[(4-fluorophenyl)sulfamoyl]ethyl}phenyl)amino](oxo)acetic acid) by molecular docking approach using the iGEMDOCK (Genetic Evolutionary Method for Molecular Docking) software. The current molecular docking analysis of some hydroxylated chalcone derivatives have presented a profound inhibition of the antidiabetic target PTP-1B by interacting with the amino acid residues …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 6, Issue 1, 2019 · pp. 4–8 Read article
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Development and validation of a method for simulataneous determination of tenovifir disoproxil fumarate emtriculabine and isonized in bulk and pharmaceutical dosage form using RP-HPLC with relevance to toxicological aspects
Abstract: Hence, proposed analytical methods are simple, novel, economical, rapid, sensitive, reproducible and accurate for the Simultaneous estimation of Tenofovir Disoproxil Fumarate, Emtricitabine and Isoniazid in Bulk and Phamaceutical dosage form by using RP- HPLC. This Method gives reliable assay results with short analysis time using mobile phase of Acetonitrile : 0.02M Potassium Dihydrogen Orthophosphate: water (pH 5.3) in the ratio of 60: 25: 15 respectively. Retention time was found to …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 1, 2024 · pp. 17–25 Read article
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Polymer Encapsulants for Photovoltaic Modules: Electrical Insulation Performance and Long-Term Durability under Accelerated UV Exposure
Abstract: Influence on the reliability and service life of PV modules is a major issue, which is influenced by the encapsulant degradation in long-term exposure to the sun's ultraviolet (UV) radiation. A systematic accelerated UV aging study of Ethylene Vinyl Acetate (EVA), Polyolefin Elastomer (POE), and Polyvinyl Butyral (PVB) films under IEC 61215-2:2021 specified test chamber conditions of Q-UV is conducted. The material properties were tested at various exposure intervals including …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 384–408 Read article
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Determination of RP-HPLC Method for Safinamide: Its Bulk and Tablet Dosage Form
Abstract: A new method was established for estimation of Safinamide by RP-HPLC method. The chromatographic conditions were successfully developed for the separation of Safinamide by using Agilent C18 column (4.6×150 mm, 5 µ); flow rate was 1 ml/min, mobile phase ratio was Methnol, Acetonitril (60:40), pH 3 (pH was adjusted with orthophosphoric acid), detection wavelength was 235 nm. The instrument used was WATERS HPLC Auto Sampler, Separation module 2695, photo diode …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 5, Issue 3, 2018 · pp. 1–6 Read article
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RP-HPLC method for simultaneous determination of Drospirenone and Ethinylestradiol in Bulk and their Pharmaceutical dosage form
Abstract: Oral contraceptive is used to prevent the pregnancy which is contain hormones to block the release of eggs from the ovaries. Most of them contain estrogen and progesterone. Nowadays, usage of hormonal contraceptive is sharply enhancing; around 100 million of women worldwide are taking these drugs. With this drug fertility rate can be supressed as long as they want or plan their activity along with these drugs provide efficacy, reliability, …
Published in Trends in Drug Delivery · Vol. 11, Issue 3, 2024 · pp. 46–67 Read article
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Development and Validation of RP-HPLC Method for Determination of Thermal Degradation Impurity in Macrolide Immunosuppressant Substance and Drug Product
Abstract: The present study describes a simple and stability-indicating reverse phase high-performance liquid chromatography (RP-HPLC) method for the quantification of the thermal degradation impurities of Tacrolimus (FK506) namely Ally ester rearrangement impurity (Impurity R) in Tacrolimus capsules and drug substances. Successful separation of impurity R from Tacrolimus, its other related substances and its tautomers were achieved on a Zorbax XDB C8 (150×4.6 mm, 5 μm) and detector of UV at 210 …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 3, Issue 1, 2016 · pp. 14–19 Read article
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Study of the Hammett equation for oxidation of 2 – Hydroxy – 1 - Naphthalidene Anil and para substituted chloroanils by potassium bromate in acid medium
Abstract: The kinetics of oxidation of the Schiff base and its substituted anils by potassium bromate in aquo-acetic acid medium has been studied in this work. The study of thermodynamic parameters is done, and the rate constants for the reaction are determined. The plot of log{ks/k0} against the substituent constant (ï³ ) is plotted for para and meta substitution and the reaction constant (ï²) is calculated. The plot of ï„H against …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 7, Issue 2, 2016 · pp. 1–4 Read article
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Cytotoxic, Anthalmintic and Analgesic Activities of the Methanol Extract of Ricinus communis (Family: Euphorbiaceae)
Abstract: The aim of this study was to evaluate the phytochemical screening, cytotoxicity, anthelmintic activity and analgesic properties of the methanol extract (leaves) of Ricinus communis (Family: Euphorbiaceae). The methanol extract of the leaves showed mild cytotoxic activity with the LC50 value 6.456 µg/mL compared to vincristine sulfate (LC50 0.812 µg/mL) using brine shrimp lethality bioassay. The anthelmintic activity was performed by observing the time of paralysis and the time of …
Published in Research and Reviews: A Journal of Toxicology · Vol. 5, Issue 1, 2015 · pp. 27–35 Read article