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394 articles for “therapeutic drug”
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Pharmacokinetics of Levothyroxine and Factors Influencing Its Therapeutic Efficacy in Hypothyroidism: A Comprehensive Review
Abstract: Levothyroxine (LT4) remains the standard therapy for hypothyroidism due to its effectiveness in restoring normal thyroid hormone levels and improving physiological functions. However, its pharmacokinetic profile exhibits considerable variability, which may influence therapeutic outcomes in clinical practice. This review aims to comprehensively evaluate the pharmacokinetics of levothyroxine, including its absorption, distribution, metabolism, and elimination, along with factors affecting its therapeutic efficacy. A structured literature search was conducted using electronic databases, …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 2, 2026 · pp. 27–33 Read article
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Review On: Liquid Crystal Cream for Topical Drug Delivery
Abstract: A Liquid crystal creams represent a novel approach in skincare formulations, leveraging the unique properties of liquid crystal technology to improve skin hydration and barrier function. An overview of current developments in liquid crystal cream formulations is given in this article, with an emphasis on the benefits they offer for skincare and their composition and structure. Liquid crystal creams mimic the lipid bilayers of the skin, offering enhanced compatibility and …
Published in Trends in Drug Delivery · Vol. 11, Issue 1, 2024 · pp. 1–8 Read article
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Biological Membranes: Structure, Function, and Their Roles in Disease Pathophysiology
Abstract: Biological membranes are important structures that control cellular work, signal transmission, transport, and communication. Dysfunction of membranes has been considered in the development of many diseases, such as cancer, neurodegenerative diseases, and infections, with the distortion of lipid composition, protein activity, and cellular connections involved in the pathogenesis of the disease. The damage on membrane can be caused by oxidative stress, genetic mutation, and environmental influence to disrupt cellular homeostasis. …
Published in International Journal of Membranes · Vol. 3, Issue 1, 2026 · pp. 38–46 Read article
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Evaluation of Drug Utilization Patterns and Prescription Trends in Patients with Hypothyroidism and Hyperthyroidism in a Tertiary Care Hospital
Abstract: Background: Endocrine disorders affecting the thyroid gland represent some of the most frequently encountered conditions globally, necessitating prolonged therapeutic intervention and vigilant clinical surveillance. The evaluation of Drug utilization patterns (DUE) serves an essential function in examining prescriptive behaviours and promoting appropriate pharmaceutical management. Objective: To evaluate drug utilization patterns, prescribing trends, and rationality of therapy in patients with hypothyroidism and hyperthyroidism. Methods: A prospective, cross-sectional observational investigation was performed …
Published in Research and Reviews: A Journal of Medicine · Vol. 16, Issue 2, 2026 · pp. 1–5 Read article
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Polymer Chemistry-Driven Approaches for Improved Therapeutic Delivery
Abstract: Polymer chemistry has revolutionized pharmaceutical technology by enabling the development of advanced drug delivery systems with improved precision, stability, and therapeutic outcomes. This review explores the role of polymer design, synthesis, and functionalization in the development of responsive and targeted drug carriers. Emphasis is placed on various types of polymers—biodegradable, synthetic, natural, and stimuli-responsive—and their suitability for drug delivery platforms such as nanoparticles, micelles, hydrogels, dendrimers, and implants. The physicochemical …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 Read article
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Synthesis and Characterization of Polymer-Based Benzamide Derivatives with Potential Biomedical Applications
Abstract: The present study explores the synthesis and characterization of polymer-supported benzamide derivatives, focusing on their potential biomedical applications. The use of polymer-supported synthesis offers several advantages, including improved reaction efficiency, ease of purification, and reusability of the support material, making it an environmentally friendly and cost-effective approach. The synthesis involved a stepwise reaction sequence, with polymeric supports facilitating controlled functionalization and ensuring high product purity. These materials have been widely …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 Read article
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Pharmacogenomics in Anesthesia: Individualized Drug Responses
Abstract: Pharmacogenomics is the study of how a person’s genes influence how they react to medications. Pharmacology, the study of medications, and genomics, the examination of genes and their functions, merge in this field to develop safe, effective drugs that can be prescribed based on an individual’s genetic makeup. Pharmacogenomics examines how an individual’s unique genetic makeup can influence their responses to certain drugs. In anesthesia, where individual responses to pain …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 1, 2025 · pp. 83–95 Read article
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AQUASOMES: A Vesicular, Self-assembled Ceramic Nanoparticulate Drug Carrier
Abstract: Nano-biopharmaceutics involves delivery of biopharmaceutical product through different biomaterials like multi-functional nanoparticles, quantum dots, aquasomes, super-paramagnetic iron oxide crystals, and liposomes dendrimers. Aquasomes are considered as one of the most recently developed delivery systems for bioactive molecules like peptides, proteins, hormones, antigens and genes to specific sites. Aquasomes have a spherical shape and a particle size of 60–300 nm. These are three layered self-assembled nano-particulate carrier system. This three-layered structure …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 12, Issue 3, 2025 · pp. 1–14 Read article
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An Effective & Novel Approach as Gastro-retentive Drug Delivery Systems
Abstract: Researcher’s curiosity about gastro-retentive drug delivery system increased so high in recent years because of its excellent drug releasing properties to the target site. The delivery system's residence time in the stomach can be extended with the usage of gastro-retentive drug delivery system by using a number of natural and synthetic polymers such as guar gum, hydoxy propyl methyl cellulose which can be used to improve the bioavailability of a …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 47–54 Read article
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A Systematic Review of the Herbal Medicinal Plants With Anti-Obesity Potential
Abstract: Obesity is a chronic, multifactorial metabolic condition characterized by abnormal fat accumulation. It is mainly driven by the intricate influence of genetic, environmental, hormonal, metabolic and lifestyle determinants. The burden of obesity has risen considerably over the past few years, making it one of the major health concerns in both developed and developing countries alike. The rapid increase globally in obesity prevalence is linked with numerous health complications such as …
Published in Research & Reviews : Journal of Herbal Science · Vol. 15, Issue 2, 2026 · pp. 31–38 Read article
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Strategies in the Delivery of Nonsteroidal Antiinflammatory Drugs
Abstract: Non-steroidal anti-inflammatory drugs [NSAIDs]. are widely used for the management of pain, inflammation, and fever. However, their effectiveness is often limited by gastrointestinal side effects such as ulceration and bleeding, as well as systemic complications including renal toxicity and cardiovascular risks. To address these challenges, various strategies have been developed to improve the delivery of NSAIDs, aiming to enhance their therapeutic efficacy while minimizing adverse effects. This abstract provides an …
Published in Trends in Drug Delivery · Vol. 11, Issue 1, 2024 · pp. 44–61 Read article
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Role of Artificial Intelligence in Simulation and Therapeutics in Neurodegenerative Diseases
Abstract: Neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, etc., are a cause of significant mortality rates due to a lack of curative treatments and their complex nature. Traditional therapeutic methodologies have several disadvantages such as slow diagnosis and a lack of effective treatments. They mainly focused on the management of the disease rather than curing it. The integration of artificial intelligence in the simulation and therapeutics of neurodegenerative …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 16, Issue 1, 2026 · pp. 19–29 Read article
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Exploring Oroxylum indicum Phytochemicals as VEGFR-2 Inhibitors: A Molecular Docking Approach for Cancer Management
Abstract: Cancer is still a major health problem around the world and is one of the top causes of death. A protein called VEGFR-2 (vascular endothelial growth factor receptor 2) is important because it helps blood vessels grow by supporting the survival, movement, and growth of certain cells. This process is essential for tumors to grow and spread to other parts of the body. This study focused on evaluating the binding …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 48–62 Read article
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Standardization and Quantitative Estimation of Chemical Constituents of Lipotab Unani Herbal Tablets
Abstract: The Unani poly-herbal drug Lipotab tablet is therapeutically used for cardiac health. There are no standard procedures available for evaluation of the constituents present in any herbal products. Standardization and quality control of indigenous medicines will not only increase the benefit of the drugs but also translate into higher profits for the industry. In the present study, the constituents of Lipotab tablet, i.e., turmeric (Curcumin) and garlic (thiosulphinate allicin) has …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 1, Issue 2, 2014 · pp. 23–31 Read article
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Molecular Dynamics and Therapeutic Architectures of Cannabinoid Receptors: A Comprehensive Review
Abstract: Expanding on these foundations, recent structural biology studies using cryo-electron microscopy have provided high-resolution insights into the conformational dynamics of CB₁ and CB₂ receptors. These findings have enabled a more precise understanding of ligand–receptor interactions, particularly how agonists, antagonists, and reverse agonists stabilize distinct receptor states. Such knowledge is critical for rational drug design, allowing researchers to selectively modulate downstream signaling pathways. For instance, CB₁ receptors primarily couple to Gi/o …
Published in International Journal of Cheminformatics · Vol. 4, Issue 1, 2026 · pp. 36–40 Read article
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Advances in Biological Systems Modeling for Predicting Drug Effects in Chronic Disease
Abstract: Biological systems modeling has emerged as a promising tool for understanding and predicting the effects of drugs in the treatment of chronic diseases. Chronic diseases, such as diabetes, cardiovascular diseases, and neurodegenerative disorders pose significant challenges to traditional drug development due to their complex, multifactorial nature. Systems biology approaches, which integrate computational modeling with experimental data, provide a holistic view of disease mechanisms and treatment responses. This review explores recent …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 1, 2025 · pp. 17–22 Read article
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Computational Examination of Curcumin Derivatives as Promising Inhibitors for BRCA1 and BRCA2 Proteins in Breast Cancer Treatment
Abstract: Objective: Breast cancer is a major problem for global health and one of the most popular and dangerous diseases. Data from the National Cancer Registry Program (NCRP) of the National Center for Disease Informatics and Research (NCDIR), an arm of the Indian Council of Medical Research (ICMR) in Bangalore, India, shows that an estimated 1,461,427 new cancer cases will occur… Conditions in India by 2022. Among these conditions, breast cancer …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 3, 2023 · pp. 68–87 Read article
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Emerging Therapies in Respiratory Tract Infections: Current Advances and Future Perspectives
Abstract: The impact of respiratory tract infections (RTI) as a global public health problem continues to be high morbidity and mortality rates. The development of novel therapeutic approaches stemmed from the fact that conventional treatment strategies, antibiotics, antivirals, antifungals etc. have become increasingly ineffective because of rise of antimicrobial resistance (AMR). Next generation therapies, such as novel antimicrobial agents, host directed therapies and novel drug delivery systems have come on the …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 2, 2025 · pp. 17–25 Read article
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COMPREHENSIVE APPROACHES TO UNDERSTANDING AND MANAGING ALZHEIMER’S DISEASE
Abstract: Alzheimer’s disease is an advanced neurodegenerative disorder described by intense memory loss. It strictly affects the patient’s quality life. The popularity of AD has been increasing in recent years. It is the most common form of mental disorder affecting more than 20 million people in the world. The Alzheimer’s disease is treated with cholinesterase inhibitors or NMDA-receptor (N-methyl D-aspartate) antagonists but here the question is about the therapeutic effect of …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 1, 2025 · pp. 1–9 Read article
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Nanotechnology: Recent Advances, Opportunities and Challenges
Abstract: Nanotechnology, the science of the minuscule, has catalysed a revolution across diverse fields, from pharmacy to veterinary science. This abstract encapsulates the dynamic interplay between nanotechnology and healthcare, unveiling its transformative impact on drug delivery, cosmeceuticals, veterinary medicine, dentistry, and biotechnology. In pharmacy, nanotechnology pioneers targeted drug delivery systems, amplifying therapeutic efficacy while mitigating adverse effects. Nano-cosmeceuticals redefine beauty standards, infusing skincare, haircare, lip care, and nail care products with …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 26, Issue 3, 2024 · pp. 44–64 Read article