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130 articles for “structural biology”
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Exploring the Thyroid Gland Physiology in Relation to Thyroid Hormones: An Overview through the Lens of 3D Computational Biology
Abstract: The endocrine system plays a pivotal role in orchestrating and sustaining diverse physiological functions by manufacturing and releasing hormones, which function as vital chemical messengers within the body. Among the prominent endocrine glands, the thyroid gland holds a central position. Situated in the lower part of the neck, this gland adopts a butterfly-shaped structure. Its significance lies in the synthesis of three key hormones: thyroxine (T4), tri-iodothyronine (T3), and calcitonin.The …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 11, Issue 1, 2024 · pp. 46–54 Read article
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Novel 1,3,4-Thiadiazole Derivatives: Design, Synthesis, Characterization and Anticancer Evaluation – A Review
Abstract: Cancer remains one of the leading causes of mortality worldwide despite significant advances in diagnosis and treatment. The clinical usefulness of many anticancer drugs is often restricted by toxicity, poor selectivity, and the emergence of drug resistance. These limitations have encouraged the search for novel heterocyclic compounds with improved therapeutic efficacy and safety. Among these, the 1,3,4-thiadiazole scaffold has gained considerable attention because of its favorable physicochemical characteristics, metabolic stability, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 Read article
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Long Non-Coding RNAs: Key Regulators of Gene Expression in Development and Disease
Abstract: Long non-coding RNAs (lncRNAs) are RNA molecules that do not make proteins but are essential for controlling how genes are turned on or off in the body. These molecules help with various biological functions, such as guiding cell growth, shaping development, and influencing the progression of diseases. Recent advancements in genomics and transcriptomics have revealed the vast and complex roles of lncRNAs, with an increasing recognition of their involvement in …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 1, 2025 · pp. 11–15 Read article
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Degradation of Building Materials by Corrosive Pollutants
Abstract: Fiber reinforced polymers (FRP) is used for the corrosion suppression of reinforced concrete structures (RCS). One of the main issues with reinforced concrete constructions is corrosion. It interacts with acids, alkalis and salts to produce disintegration in building materials components. Pollutants and effluents speed up disbanding inside and outside reinforced structures. Bio-wastes come in contact of building materials to develop miro and macro-organism and these organisms release acid substances to …
Published in International Journal of Minerals · Vol. 2, Issue 1, 2025 · pp. 15–24 Read article
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Platelets A Tiny Cell Fragments
Abstract: Platelets are disc-shaped, anucleate cells that are approximately 2-3 μm in diameter. Their primary function is to control hemostasis, or blood clotting, but they also play important roles in angiogenesis (the formation of new blood vessels) and innate immunity (the body's first line of defence against infection). With a diameter of just 2-3 microns, platelets are tiny, disc-shaped cells that lack a nucleus. While their main responsibility is to ensure …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 2, 2024 · pp. 22–28 Read article
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Artificial Intelligence in Drug Repurposing: A Short Impact Assessment
Abstract: Artificial intelligence (AI) in pharmaceutical repurposing has become a game-changing tool that opens new avenues for the application of new drugs that have already been approved. Traditional drug discovery is a lengthy and expensive process, whereas AI can rapidly analyze vast datasets of biological, chemical, and clinical information to predict drug-disease interactions. AI-driven techniques, such as machine learning, natural language processing, and deep learning, enable the identification of potential repurposing …
Published in Trends in Drug Delivery · Vol. 11, Issue 3, 2024 · pp. 42–45 Read article
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Preparation, Spectral Characterization and Bio-Evaluation of Five and Seven Membered Ring Derivatives
Abstract: Many cyclic compounds are made of heterogeneous atoms that are good electron donors to be the basic nucleus in the basic structure of chemical drugs, so most drugs and vitamins take cyclic compounds as a basic material for the manufacture of drugs, and without a doubt these drugs are distinguished by their high ability to make many biologically active derivatives in the fields of biochemistry and clinical medicine. Universal studies …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 16, Issue 2, 2025 · pp. 96–109 Read article
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Industry 4.0 and Smart Manufacturing: A Review
Abstract: This review looks at Industry 4.0 and smart manufacturing's idea, enabling technologies, implementation issues, and future prospects. Drawing on recent literature, the paper synthesizes key pillars such as the Industrial Internet of Things (IIoT), cyber-physical systems (CPS), artificial intelligence, digital twins, and additive manufacturing. It highlights integration requirements across supply chains, cyber security concerns, workforce implications, and standards activities that influence adoption. The literature survey focuses on empirical studies and …
Published in International Journal of Manufacturing and Production Engineering · Vol. 3, Issue 2, 2025 · pp. 14–17 Read article
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Exploring Family Systems Therapy (FST) in Substance Dependence
Abstract: This paper intends to explore how family systems therapy (FST) can be utilized to address substance dependence issues. Substance abuse not only affects the individual but also impacts the extended family members' physical, emotional, and psychological health. The substance use disorder (SUD) not only has an impact on the individual, but also influences family members. This narrative review provides an examination of the connection between substance dependence and the family …
Published in Research and Reviews: A Journal of Medicine · Vol. 14, Issue 2, 2024 · pp. 9–26 Read article
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Genetic Variability and Statistical Methods: Key Insights for Computational Genetics Research
Abstract: Genetic variability, defined as the differences in DNA sequences among individuals, serves as the foundation of evolutionary biology and plays a pivotal role in species’ adaptability, resilience, and overall survival. Advances in genomic technologies, particularly high-throughput sequencing, have enabled unprecedented exploration of genetic diversity, fostering the growth of computational genetics. This interdisciplinary field combines statistical methods and computational tools to analyze genetic data, identify patterns, and link phenotypes to genotypes. …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 3, 2024 · pp. 19–23 Read article
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Application of Resource Allocation Similarity Based Link Prediction in Wireless Networks
Abstract: Link prediction in wireless networks plays a crucial role in predicting missing connections within multiplex networks. This study focuses on the utilization of similarity-based link prediction methods in wireless networks. These methods assume that the likelihood of linkage between nodes is determined by their similarity, based on shared features. Several similarity measures, such as Common Neighbors (CN), Preferential Attachment (PA), Adamic-Adar (AA), and Resource Allocation (RA) indices, are commonly employed …
Published in International Journal of Wireless Security and Networks · Vol. 1, Issue 2, 2023 · pp. 37–42 Read article
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Secondary Metabolites in Drug Development: Tracing Their Historical and Therapeutic Impact
Abstract: Secondary metabolites, also known as natural products, exhibit a level of structural and chemical diversity unmatched by synthetic small molecule libraries. These compounds, which have evolved to possess drug-like properties, continue to be a primary source for new medications and drug leads. Their discovery has significantly impacted advancements in chemistry, biology, and medicine, influencing drug development and therapeutic strategies throughout history. Derived from primary metabolic pathways such as photosynthesis, glycolysis, …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 2, 2024 · pp. 51–55 Read article
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Breeding Biology of Great Thick-Knee (Esacus recurvirostris) in Fresh Water Reservoir near Wankaner of Morbi District, Gujarat
Abstract: The Great Thick-knee (Esacus recurvirostris) is a captivating bird species that has garnered significant attention from researchers due to its unique breeding behaviors and adaptations. This large wader, characterized by its distinctive upturned bill and striking black and white facial pattern, is a local breeder in humid southern Asia. The breeding season of the Great Thick-knee typically commences in February and extends through July, with peak laying activity occurring in …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 15, Issue 1, 2025 · pp. 44–49 Read article
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Progression in multi-omics and immunological research on host-parasite interactions: Transcriptomics, proteomics, genomics, metabolomics, and immune responses
Abstract: The interaction occuring between hosts and parasites is a quick and multi step-complex biological process that tries to influence disease outcomes. In recent years, multi-omics approaches, such as transcriptomics, proteomics, genomics, metabolomics, and immunological studies, have gathered substantial eye in dissecting these interactions at a microscopic level. These techniques enable a vast understanding of the molecular structures involved in parasitic infections and host defense mechanisms. This article reviews the advancements …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 1, 2025 Read article
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Recombinant Proteins and Nested Gene Regulation: Nutrient Driven Immune Response and Disease Resistance in Livestock
Abstract: Livestock production systems are increasingly challenged by infectious diseases, metabolic disorders, and environmental stressors that reduce productivity and compromise animal health. Advances in molecular biology and animal nutrition now offer new opportunities to strengthen disease resistance through integrated strategies that combine recombinant protein technologies, gene regulatory mechanisms, and nutrient mediated immune modulation. This review examines how recombinant proteins and nested gene regulation interact to shape nutrient driven immune responses in …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 1, 2026 Read article
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Agro- residue Pretreatment Tools and Techniques: A Detailed review
Abstract: This review examines the significance of biomass pre-treatment in facilitating efficient biofuel production from lignocellulosic materials. Different methods of pre-treatment, such as acid, alkaline, liquid hot water, ionic liquids, organosolv, ozonolysis, wet oxidation, steam explosion, ammonia fiber explosion (AFEX), carbon dioxide explosion, and biological pretreatment, are examined in terms of their underlying principles, benefits, and drawbacks. Acid pretreatment effectively hydrolyzes hemicellulose but suffers from equipment corrosion and high operational costs, …
Published in Research & Reviews : Journal of Botany · Vol. 13, Issue 1, 2024 · pp. 22–31 Read article
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Innovative Synthesis Techniques and Comprehensive Mechanical Characterization of Biopolymer-Based Composites for Advanced Applications in Biochemistry and Materials Sciences
Abstract: Biopolymer-based composites have gotten a lot of attention lately because they could be used in biology and materials science in interesting ways. The main goal of this study is to come up with new ways to make composites and then fully characterize their material properties so that they can be used in more advanced ways. During the production step, a new method is used that combines green chemistry ideas with …
Published in Journal of Polymer & Composites · Vol. 12, Issue 4, 2024 · pp. 119–136 Read article
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AI-based Drug Discovery-Revolutionizing Pharmaceutical Research
Abstract: The traditional drug discovery process is often costly, time-consuming, and prone to high failure rates. The advent of Artificial Intelligence (AI) has revolutionized this field by significantly enhancing efficiency, reducing costs, and improving success rates. AI-driven approaches, including machine learning (ML), deep learning (DL), and natural language processing (NLP), have transformed key areas such as drug target identification, molecular screening, lead optimization, and clinical trial design. AI models can analyze …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 30–44 Read article
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Formation, Organic Investigation, Fluorescence Study of New Cyclic Derivatives of Thiophane-Triazole Compounds
Abstract: Azo compounds are used as intermediates in the preparation of many well-known and diverse organic derivatives. Cyclical or related azo derivatives, such as triazoles and thiophenes, possess useful applications in medicinal and pharmaceutical chemistry. Thiophene compounds and their derivatives have demonstrated a variety of biological activities, including antibacterial, antifungal, anti-tuberculosis, anti-inflammatory, analgesic, sedative, and hypnotic properties, immunosuppressive, and antihypertensive properties. Furthermore, thiophene derivatives can be used in the treatment of …
Published in Emerging Trends in Chemical Engineering · Vol. 12, Issue 3, 2025 · pp. 1–13 Read article
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A New Paradigm in the Intersection of Science and Consciousness through the Microvita Theory
Abstract: Microvita theory, first proposed by philosopher Prabhat Ranjan Sarkar, posits the existence of subtle energy-based entities called "Microvita" that act as the missing link between consciousness and matter. This paper explores Microvita as a novel conceptual framework that bridges the gap between particle physics, consciousness studies, and environmental sustainability. Unlike traditional scientific paradigms, which often exclude the non-material dimensions of reality, Microvita theory asserts that subtle energies and conscious forces …
Published in Journal of Alternate Energy Sources & Technologies · Vol. 16, Issue 2, 2025 · pp. 7–13 Read article