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143 articles for “method development and validation”
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Design and Development of a Triboelectric Sensor for a Generic Counting Application
Abstract: In today’s consumer-oriented market, researchers are increasingly focusing on harvesting energy from ambient and renewable sources to enable sustainable power generation and reduce dependency on conventional energy resources such as batteries and fossil-fuel-based electricity. The rapid growth of portable electronics, wireless sensor networks, and Internet of Things (IoT) devices has created a significant demand for low-power, long-life, and maintenance-free energy solutions. In many practical situations, frequent battery replacement is difficult, …
Published in Journal of Experimental & Applied Mechanics · Vol. 17, Issue 1, 2026 · pp. 38–48 Read article
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Machine Learning Assisted Timing Violation Prediction in Sub-7nm VLSI Physical Design
Abstract: The continuous scaling of semiconductor technology into the sub-7nm regime has introduced significant challenges in timing closure due to process variability, interconnect delay, power density, and manufacturing uncertainties. Conventional static timing analysis techniques often require extensive computational resources and iterative optimization cycles, resulting in increased design complexity and longer turnaround time. This research proposes a Machine Learning Assisted Timing Violation Prediction framework for sub-7nm VLSI physical design to improve early-stage …
Published in International Journal of VLSI Circuit Design & Technology · Vol. 4, Issue 1, 2026 Read article
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Evaluating an ai-supported experiential learning intervention: a quasi-experimental study of the joyful saturday model for student engagement and holistic development
Abstract: Student disengagement, declining academic motivation, and passive classroom participation remain major challenges in modern higher education systems. Traditional lecture-based teaching methods often fail to accommodate diverse learning styles and do not sufficiently promote active participation or collaborative learning. To address these challenges, the present study evaluates the effectiveness of Joyful Saturday, a structured experiential learning initiative designed to improve student engagement, motivation, and holistic development through interactive academic activities supported …
Published in International Journal of Behavioral Sciences · Vol. 3, Issue 1, 2026 · pp. 79–88 Read article
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Iota carrageenan, a Sustainable polymer transformed into a nanogel formulation, by using environment friendly method for antitumor action
Abstract: In the pharmaceutical field, the utilization of polymers, both in their natural form and through chemical modifications, holds immense importance. In this context, a novel and eco-friendly method for the synthesis of nano carrageenan-based polymers has been developed. The efficacy of carrageenan in this domain is attributed to its crosslinking and biological properties, which are largely influenced by its sulfate ion content. This study aims to formulate nanogels via a …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 881–889 Read article
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Thermal Performance Analysis and Optimization of Pin-Fin Heat Sink Using CFD, Taguchi Method, and Machine Learning
Abstract: Efficient thermal management is essential for improving the performance and reliability of modern engineering systems and electronic devices. This study presents the design, simulation, and optimization of a pin-fin heat sink using SolidWorks for three-dimensional modeling and ANSYS for thermal and computational fluid dynamics (CFD) analysis. Four different pin-fin geometries, namely square, pentagon, octagon, and circular fins, are considered to evaluate their thermal performance under varying operating conditions. Aluminum is …
Published in Trends in Mechanical Engineering & Technology · Vol. 16, Issue 2, 2026 Read article
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ML-Based Predictive Modeling of Mechanical Properties in 3D-Printed Polymer Composites for IoT Applications
Abstract: This study aims to develop an interpretable and high-accuracy machine learning framework for predicting the mechanical properties of 3D-printed fiber-reinforced polymer composites, with a focus on structure–property correlations relevant to polymer processing and functional performance. Composite specimens based on PLA and ABS matrices were fabricated using FDM with varying weight fractions (5–20 wt%) of carbon and glass fibers. Standardized mechanical testing (ASTM D638, D256, D790) was performed to evaluate tensile …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 61–78 Read article
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Advancements in Phishing Detection: Automated Systems in Real-World Scenarios
Abstract: The goal of the abstract is to offer an automated method that uses login URLs to identify real-world scenarios. Phishing is a type of cyberattack that involves social engineering, when malefactors trick victims into providing their login credentials via a login form that sends the information to a hostile site. In this research, we offer a system that uses URL analysis to detect phishing websites by comparing machine learning and …
Published in Journal of Telecommunication, Switching Systems and Networks · Vol. 11, Issue 2, 2024 · pp. 12–17 Read article
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Finite Element Modelling of Contact Stresses in Helical Gear Systems
Abstract: Helical gears are widely used in modern power‐transmission systems because of their high load‐carrying capacity, smooth meshing action, and increased overlapping of gear teeth. However, the design of helical gear pairs is constrained by contact stresses generated at the mating tooth surfaces, which can lead to surface fatigue (pitting), micro-cracking, and ultimately gear failure. Traditional analytical methods, such as those of the American Gear Manufacturers Association (AGMA) or International Organization …
Published in Trends in Machine design · Vol. 12, Issue 3, 2025 · pp. 35–39 Read article
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Optimization of Process Parameters for AISI 304 Using Micro-EDM Drilling Process Through Response Surface Method
Abstract: The increasing demand for micro-parts in high-tech products, such as micro-electromechanical systems (MEMS) applications and micro-electronic devices, has driven significant advancements in micromachining technologies. Among the various micromachining processes, the fabrication of accurate microholes and pins is critical for the performance and reliability of miniature components. Micro-hole drilling plays a vital role by enabling the production of deep holes with excellent straightness, roundness, and surface quality. It is widely used …
Published in International Journal of Manufacturing and Production Engineering · Vol. 3, Issue 1, 2025 · pp. 37–47 Read article
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Pharmacophore mapping, 3D QSAR, docking, and ADME prediction studies of novel Benzothiazinone derivatives
Abstract: Background Tuberculosis is a major public health concern worldwide which is caused by Mycobacterium tuberculosis. DprE1 (Decaprenyl Phosphoryl Ribose 2’- Epimerase) is the most challenging target for development of novel anti- tubercular agents because it is a small protein and located into cytoplasmic membrane. So, novel anti-TB drugs did not bound effectively with it. DprE1 catalyzes the oxidation of the 2’ hydroxyl group of DPR (Decaprenyl Phosphoryl D- Ribose) …
Published in International Journal of Antibiotics · Vol. 1, Issue 1, 2024 · pp. 59–82 Read article
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Polymer-Coated Composite Granules of Clarithromycin: Design, Characterization, and Functional Evaluation for Taste Masking and Antibacterial Performance
Abstract: Background: Masking the unpleasant taste of clarithromycin is essential to improve patient adherence, especially among pediatric and elderly groups. However, enhancing palatability while maintaining its antibacterial effectiveness remains a significant formulation challenge. This study focused on developing polymer-coated clarithromycin granules (B1–B10) using novel non-sugar-based polymers and assessing their antibacterial activity against Staphylococcus aureus Methods: Clarithromycin granules were produced using a fluidized bed coating technique with non-saccharide polymers, specifically Eudragit E-100 …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 1042–1050 Read article
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Aerodynamic Optimization of UAV Wings Using Machine Learning
Abstract: Unmanned Aerial Vehicles (UAVs) are increasingly deployed across defense, transportation, agriculture, and environmental monitoring, demanding improved aerodynamic efficiency to enhance endurance, stability, and payload capacity. Traditional aerodynamic optimization approaches, relying on computational fluid dynamics (CFD) simulations and wind tunnel experiments, are often time-consuming and computationally expensive. This study proposes a machine learning (ML)-driven framework for the aerodynamic optimization of UAV wing geometries, aiming to significantly reduce design cycles while improving …
Published in International Journal on Drones · Vol. 2, Issue 1, 2026 · pp. 1–7 Read article
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Topology Optimization of Press Tools for Additive Manufacturing: Reducing Manufacturing Time
Abstract: This research paper presents a topology optimization study of a press tool consisting of a punch and a die, with the aim of optimizing the press tool topology to reduce material usage, and manufacturing time while maintaining necessary strength. The tools will be manufactured using additive manufacturing technology with Polylactic Acid (PLA) material. The Additive Manufacturing method can be used to make prototypes of press tools in the development stages. …
Published in Journal of Polymer & Composites · Vol. 11, Issue 8, 2023 · pp. 40–56 Read article
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Optimizing Parameters for Dry Sliding Wear Control in Stir-Cast AA7050/SiC Composites
Abstract: Using a pin-on-disc tribometer, this study examined the dry sliding wear behavior of AA7050/SiC composites. The production of this metal matrix composite was achieved through the stir-casting process, which involved an initial step of melting the AA7050 alloy, followed by the careful introduction of silicon carbide (SiC) particles, stirring to achieve uniform dispersion, and finally, casting the molten mixture. Wear rate (WR) was determined by three operational parameters: SiC reinforcement …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1624–1635 Read article
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Design and Analysis of Honeycomb Rear Door Map Pocket by Application of Finite Element Method
Abstract: In modern automobiles, the door trim plays a vital role in both functionality and occupant safety. It integrates various convenience features such as armrests, power window switches, and map pockets, while also contributing to crash energy absorption during side impacts. In such collisions, the occupant's body typically contacts the door trim, making its design and material selection critical for minimizing injury through controlled deformation and energy dissipation. This research focuses …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 940–951 Read article
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AI-Powered Drug Delivery: Revolutionizing Formulation Science
Abstract: Artificial Intelligence (AI) is emerging as a groundbreaking tool in revolutionizing Drug Delivery Systems (DDS), offering promising advancements in precision, efficiency, and personalized treatment strategies. The integration of AI technologies into pharmaceutical research and development is transforming how drugs are formulated, delivered, and monitored in real time. By leveraging machine learning algorithms and data analytics, researchers can design drug delivery models that are not only more effective but also tailored …
Published in Trends in Drug Delivery · Vol. 13, Issue 1, 2026 · pp. 48–61 Read article
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A Review of Drug Design Techniques Assisted by Computers to Combat Diabetes
Abstract: Diabetes mellitus is a global health concern characterized by chronic hyperglycemia and associated complications. The creation of innovative medicines with enhanced efficacy and safety profiles continues to be a top focus, notwithstanding improvements in treatment. A useful method in drug development, computer-aided drug design (CADD) makes it easier to identify possible therapeutic candidates and optimise lead molecules. An extensive synopsis of CADD tactics used in the fight against diabetes is …
Published in Emerging Trends in Personalized Medicines · Vol. 2, Issue 1, 2025 · pp. 1–10 Read article
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Investigating the Influence of Process Parameters on Photochemical Machining of Phosphor Bronze Alloy Microchannels
Abstract: Microchannels are widely employed in microfluidic devices, biomedical systems, and compact heat exchangers, where their functional efficiency depends strongly on surface finish, dimensional control, and edge quality. Traditional machining techniques often face limitations in producing such features with the required precision, prompting the use of advanced micromachining methods. In the present work, photochemical machining (PCM) has been applied to fabricate serpentine-shaped microchannels in phosphor bronze. The study systematically investigates the …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 837–846 Read article
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Metagenome-Informed Engineering of Monoclonal Antibodies: Mining Microbial Immunoglobulin-Like Domains for Ultra-Stable Therapeutics
Abstract: Metagenome-informed engineering represents an emerging strategy for improving the stability and functionality of monoclonal antibodies (mAbs) by leveraging the vast diversity of microbial immunoglobulin-like (Ig-like) domains (10,24). These domains, derived from uncultured bacteria and bacteriophages, exhibit exceptional thermostability, protease resistance, and structural resilience due to adaptation to extreme environments (29,30). This review highlights advances in metagenomic mining, structural characterization, and protein engineering that enable the integration of microbial Ig-like scaffolds …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 1, 2026 Read article
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Optimal Abrasive Jet Machining Parameters for Glass Fiber Reinforced Plastics
Abstract: Abrasive jet machining (AJM) is a best choice for processing of glass fiber reinforced plastics (GFRP). Inherent to the nonlinear behavior of performance characteristics during repeated experiments are inevitable variations, attributed to measurement errors and unknown influencing input variables. This study employs the Taguchi method with an orthogonal array to systematically identify optimal input variables through a limited number of experiments. The paper introduces a direct and reliable Taguchi-based multi-objective …
Published in Journal of Polymer & Composites · Vol. 11, Issue 8, 2023 · pp. 247–255 Read article