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118 articles for “gene regulation”
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Targeting PTPN22 in Arthritis: Molecular Docking and Pharmacokinetic Evaluation of Artemisia vestita Compounds
Abstract: Rheumatoid arthritis (RA) is a long-term autoimmune condition characterized by inflammation of the synovial membrane, commonly resulting in swelling, pain, stiffness, and overall fatigue. Protein tyrosine phosphatase non-receptor type 22 (PTPN22) has been identified as a risk factor linked to various autoimmune diseases, including RA. In the PTPN22 gene, two missense Single nucleotide polymorphisms (SNPs) are associated with autoimmune conditions. The R620W (C1858T, rs247660) variant in exon 14 has been …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 1, 2025 · pp. 20–31 Read article
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Driving Digital Transformation with Robotic Process Automation
Abstract: Compared to conventional administration methods, robotic process automation (RPA) has a number of advantages. Without a less intrusive mechanical hurdle, it allows for cost savings and resource liberation. Other benefits include more output, greater precision (and fewer errors), the potential to streamline regulatory compliance, quicker service (and hence higher customer satisfaction), and more uniformity. A description of business and digital transformation using procedure technology.The creation and use of computer-generated robots …
Published in International Journal of Advanced Robotics and Automation Technology · Vol. 1, Issue 1, 2023 · pp. 27–31 Read article
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Super-twisting Algorithm Based Sliding Mode Controlled Boost Converter
Abstract: This work provides analysis of boost converter with super-twisting algorithm under sliding mode operating in continuous conduction mode. The super-twisting algorithm reduces the chattering effect which is inherent in conventional sliding mode control. Generally, chattering increases heat losses, thereby decreasing the performance of the boost converter. The aforementioned control strategy minimizes the initial current peak and provides highly improved output voltage regulation irrespective of the input voltage perturbation and load …
Published in International Journal of Electro-Mechanics and Material Behaviour · Vol. 2, Issue 1, 2024 · pp. 38–48 Read article
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Advancing Gene Therapy: Next-Generation Viral Vector Engineering for Precision, Safety, and Scalability
Abstract: Gene therapy has emerged as a paradigm-shifting modality for the treatment of genetic disorders, malignancies, and rare diseases through the delivery of therapeutic nucleic acids aimed at correcting or modulating dysfunctional gene expression. Among the various delivery systems, viral vectors including adeno-associated viruses (AAVs), lentiviruses, adenoviruses, retroviruses, and herpes simplex viruses have proven indispensable owing to their high transduction efficiencies and adaptability. This review offers a comprehensive assessment of viral …
Published in International Journal of Virus Studies · Vol. 2, Issue 2, 2025 · pp. 37–55 Read article
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AI-News 4.0: Most Suitable LLM for UPSC Aspirants
Abstract: In recent years, the domain of interactive artificial intelligence (AI) has experienced a significant surge with large language models (LLMs) at the forefront of this evolution. AI systems, including those based on the GPT-3.5 framework, have been engineered to address various tasks such as responding to intricate inquiries, participating in conversations, and executing sophisticated natural language processing (NLP) operations. A prominent LLM, known for its adaptability, prompts an essential inquiry: …
Published in International Journal of Computer Science Languages · Vol. 2, Issue 2, 2024 · pp. 47–53 Read article
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Revitalizing São Cristóvão: Integrating Industry, Commerce, and Community for a Sustainable Urban Future
Abstract: This paper introduces a comprehensive framework for the sustainable regeneration of São Cristóvão, a historically industrial district in Rio de Janeiro, South America, which presently demonstrates significant urban deterioration, socio-economic instability, and increasing environmental hazards. Through an interdisciplinary methodology integrating spatial analysis, ethnographic profiling, environmental assessment, and stakeholder engagement, the study develops a phased master plan aimed at transforming the neighborhood into a resilient, inclusive, and economically diverse urban environment. …
Published in International Journal of Urban Design and Development · Vol. 4, Issue 1, 2026 · pp. 58–68 Read article
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ECZEMA {Atopic Dermatitis}
Abstract: Many of the persons around the world suffer from eczema which is also called atopic dermatitis. It is a kind of skin disorder that makes the skin dry, itchy, and sometimes even painful. There is no specific age group who got affected by this particular disease, no matter what age you are. But particularly it is seen that the children were mostly affected by eczema, as there is no cure …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 1, 2023 · pp. 53–66 Read article
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Smart Material for Energy Harvesting and Energy Storage in Mechanical Systems
Abstract: The integration of smart materials into mechanical systems for energy harvesting and storage marks a transformative leap in sustainable energy technology. These materials, responsive to environmental cues, offer innovative solutions for capturing energy from mechanical sources. Leveraging properties like piezoelectricity and thermoelectricity, smart materials efficiently convert mechanical energy into electrical energy, enabling devices to generate power from human motion or industrial machinery. Moreover, they enhance energy storage capacity and efficiency …
Published in International Journal of Energy and Thermal Applications · Vol. 2, Issue 1, 2024 · pp. 41–48 Read article
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Exploring the Role of MAPK3 in Major Depressive Disorder: Molecular Docking, Dynamics, and Binding Free Energy Analysis of Natural Compounds as Alternatives to Conventional Drugs
Abstract: Major Depressive Disorder (MDD) is a prevalent neuropsychiatric disorder with limited treatment efficacy and significant side effects associated with conventional antidepressants. Recent studies have highlighted the role of mitogen-activated protein kinase 3 (MAPK3) in the mechanisms underlying MDD, positioning it as a potential target for the development of novel therapeutic drugs. In this study, we employed various computational approaches to explore natural compounds as viable alternatives to synthetic antidepressants. Researchers …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 2, 2025 · pp. 53–68 Read article
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Functional Biomolecules in Animal Nutrition: Biochemical Mechanisms and Their Impacts on Growth Performance and Health Outcomes
Abstract: Functional biomolecules have emerged as critical modulators of animal nutrition, extending beyond conventional nutrient supply to regulate biochemical and physiological processes that determine growth performance and health outcomes. This review synthesizes current knowledge on diverse classes of bioactive compounds, including amino acids, peptides, fatty acids, vitamins, minerals, phytochemicals, and microbial-derived metabolites, and their roles in livestock systems. Emphasis is placed on underlying biochemical mechanisms such as enzyme activation, nutrient signaling …
Published in International Journal of Nutritions · Vol. 3, Issue 2, 2026 Read article
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A study in Leveraging Deep Learning and IoT Arrays for Dynamic, Hyper-Local Atmospheric Intelligence
Abstract: The critical demand for high-resolution, actionable atmospheric data is challenged by the high cost and sparse coverage of traditional regulatory monitoring stations. This paper explores the synergistic paradigm shift enabled by integrating low-cost, dense Internet of Things (IoT) sensor arrays with advanced Artificial Intelligence (AI) methodologies, specifically Deep Learning (DL) models. We address the primary limitations of low-cost sensors—inherent bias, sensitivity to environmental drift (temperature/humidity), and calibration inconsistency—by utilizing AI …
Published in International Journal of Atmosphere · Vol. 2, Issue 2, 2025 · pp. 50–62 Read article
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Effect of Skin Barrier Damage on Absorption and Action of Cosmeceuticals
Abstract: The skin acts as a primary defensive barrier protecting the human body against environmental aggressors, microbial invasion, and chemical exposure. The integrity of the skin barrier, particularly the stratum corneum, plays a crucial role in regulating the permeation of substances applied topically. Cosmeceuticals, a hybrid category between cosmetics and pharmaceuticals, are designed to deliver biologically active ingredients into the skin to exert therapeutic or beneficial effects. However, the condition of …
Published in Recent Trends in Cosmetics · Vol. 3, Issue 2, 2026 · pp. 1–19 Read article
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Energy-Efficient Thermal Management: Advanced Cooling Techniques for Electronics, Automotive, and Aerospace Applications
Abstract: The growing demand for energy-efficient systems across diverse industrial sectors, including electronics, automotive, aerospace, and renewable energy, has elevated the importance of advanced thermal management techniques. Effective heat dissipation is critical not only for maintaining optimal operating conditions in electronic devices but also for enhancing the performance and reliability of broader energy and mechanical systems. Inadequate thermal management can compromise energy efficiency, reduce component lifespan, and increase environmental impact. This …
Published in International Journal of Energy and Thermal Applications · Vol. 3, Issue 1, 2025 · pp. 18–23 Read article
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Ramifications of Artificial Intelligence and Cyber Security
Abstract: Artificial intelligence (AI) has pros and cons for cyber security: AI can improve network security, anti-malware, and fraud detection. AI can simulate cyberattacks, automate responses, and analyse enormous databases. AI-powered phishing and deepfakes are cyber risks. AI can potentially be attacked and become a liability for corporations. AI has transformed cyber security, bringing both new opportunities and challenges. AI-powered tools discover abnormalities faster, automate threat responses, and improve threat detection …
Published in International Journal of Information Security Engineering · Vol. 3, Issue 1, 2025 · pp. 40–45 Read article
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Automatic Power Switching Mains for Various Sources
Abstract: This project's major objective is to autonomously choose from four possible power sources—mains, generator, inverter, and solar—to guarantee a load's continuous power delivery. This is crucial due to the rising demand for electricity and the frequent power disruptions affecting industries, hospitals, and households. Establishing an alternative power source is imperative to address this issue. In this project, four switches are utilized to simulate the failure of individual power sources. Pressing …
Published in International Journal of Electrical Machine Analysis and Design · Vol. 1, Issue 2, 2023 · pp. 24–30 Read article
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Flaxseed and Diabetes Management: A Comprehensive Review of Recent Studies and Potential Mechanisms
Abstract: Diabetes mellitus, a condition characterized by chronic hyperglycemia, has become a significant global health challenge, leading to substantial morbidity and mortality rates. Dietary techniques are crucial for the effective control of diabetes, including both pharmaceutical and non-pharmacological therapies. Flaxseed (Linum usitatissimum) is one of the functional foods that has attracted a lot of interest because of its abundance of bioactive components, including lignans, dietary fiber, and alpha-linolenic acid (ALA). The …
Published in International Journal of Nutritions · Vol. 2, Issue 1, 2025 · pp. 24–32 Read article
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AI-Driven Pharmacogenomics and Precision Medicine: Future of Personalized Therapy
Abstract: Pharmacogenomics and artificial intelligence (AI) are emerging as important drivers of precision medicine, enabling healthcare systems to adopt individualized therapeutic approaches. Pharmacogenomics examines how genetic variations influence drug response, efficacy, metabolism, and toxicity, while AI provides advanced computational tools for analyzing complex genomic and clinical data. This review highlights the integration of AI-driven pharmacogenomics in personalized therapy and its potential to improve treatment outcomes. Machine learning, deep learning, natural language …
Published in Emerging Trends in Personalized Medicines · Vol. 3, Issue 2, 2026 · pp. 1–12 Read article
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Exploring the Synergistic Effects of Heavy Metal contaminants on Aquatic Organisms
Abstract: Human activities have a profound effect on aquatic habitats by altering water and sediment quality, which in turn impacts resident organisms. These changes are primarily caused by pollutants from agricultural, industrial, and health-related sources. Industrial effluents, often containing hazardous heavy metals such as chromium, manganese, and lead, are a major source of environmental toxicity. The discharge of these pollutants makes water unsafe for drinking, irrigation, and industrial uses, necessitating effective …
Published in International Journal of Marine Life · Vol. 1, Issue 2, 2024 · pp. 17–20 Read article
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Energy Conservation Using Street Light Monitoring and Vehicle Vibrations for EV Charging
Abstract: In the contemporary era, the escalating demand for sustainable energy solutions has prompted the exploration of innovative technologies to address energy conservation challenges. This research introduces a novel approach to energy conservation by integrating street light monitoring and utilizing vehicle vibrations for Electric Vehicle (EV) charging. The proposed system leverages smart sensors and advanced communication technologies to monitor street lights and harness vehicle vibrations, thereby contributing to the optimization of …
Published in International Journal of Energy and Thermal Applications · Vol. 3, Issue 1, 2025 · pp. 1–11 Read article
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Pathogens in Nosocomial Infections: Epidemiology, Resistance, and Control Measures
Abstract: Nosocomial infections, also known as healthcare-associated infections (HAIs), are a serious global health issue, leading to higher patient morbidity, prolonged hospital stays, and increased medical costs. Various pathogens—such as bacteria, viruses, fungi, and parasites—are responsible for these infections, especially in healthcare environments where they easily spread. They can be transmitted through direct contact with infected patients, contaminated medical equipment, or even airborne particles.Patients with weakened immune systems, those requiring prolonged …
Published in International Journal of Pathogens · Vol. 2, Issue 1, 2025 · pp. 12–16 Read article