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307 articles for “gene regulation”
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New-Age E-voucher Utility: Redefining Peer-to-Peer Transactions in the Digital Economy
Abstract: This system introduces an innovative new-age e-voucher utility designed to facilitate peer-to-peer (P2P) intake through a person-pleasant cell platform. This revolutionary answer empowers people to create and list e-vouchers for numerous services, experiences, or bodily goods, circumventing conventional channels and fostering an extra direct financial machine. Operating on a decentralized architecture, the utility guarantees stable transactions through fee gateways and contains a recognition machine to set up acceptance as true …
Published in International Journal of Computer Science Languages · Vol. 2, Issue 2, 2024 · pp. 36–46 Read article
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Gene Therapy in Modern Medicine: Promises and Challenge in Treating Genetic Diseases
Abstract: Gene therapy is a medical approach that focuses on altering or adjusting an individual’s genes to treat or prevent illnesses. The aim is to repair faulty genes or insert new ones into the body to combat diseases. Gene therapy can involve directly introducing modified or new genes into a patient’s cells or altering the genes already present in the patient’s body. This approach shows potential for treating a range of …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 2, 2024 · pp. 27–32 Read article
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QSAR Modeling Techniques: A Comprehensive Review of Tools and Best Practices
Abstract: Quantitative Structure–Activity Relationship (QSAR) modeling has become an essential tool in drug discovery, toxicity assessment, and environmental chemistry. By correlating chemical structure with biological activity or toxicity, QSAR enables the prediction of compound behavior without extensive experimental testing. This approach not only saves time and resources but also supports ethical practices by reducing reliance on animal studies. The evolution of QSAR from basic linear models to advanced machine learning and …
Published in International Journal of Cheminformatics · Vol. 3, Issue 1, 2025 · pp. 56–63 Read article
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Telecommunications and New Technologies
Abstract: The rapid expansion of telecommunications is profoundly reshaping the global digital landscape, driven by the confluence of emerging technologies such as 5G, the Internet of Things (IoT), artificial intelligence (AI), blockchain, and edge computing. These new technologies are changing communication networks, making them more reliable and faster, and making it possible for data-heavy applications to work in many other fields. In order to ensure the safe and sustainable integration of …
Published in Journal of Telecommunication, Switching Systems and Networks · Vol. 13, Issue 1, 2026 · pp. 13–21 Read article
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Differential Gene Expression Analysis of Human Atrial Fibroblasts Reveals Dysregulation of RNA Metabolism and Translational Machinery in Atrial Fibrillation
Abstract: Atrial fibrillation (AF) is a complex cardiac arrhythmia characterized by extensive structural remodeling and the activation of atrial fibroblasts, which drive the progression of fibrosis. To identify the underlying transcriptomic alterations, we analyzed six human atrial fibroblast RNA-Seq datasets (three control and three AF) retrieved from the Sequence Read Archive. After performing rigorous quality control and adapter trimming, we aligned the reads to the GRCh38 human reference genome using a …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 4, Issue 2, 2026 · pp. 15–25 Read article
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A Comprehensive Study of various Multi-Area Hybrid Power Systems for Generation Control
Abstract: This paper is a detailed examination of multi-area hybrid power systems in the control of the generation taking into consideration the two area up to five area connected networks. As renewable energy sources are more and more integrated, and modern grids become more and more complex, the stability of the system itself and the frequency regulation have risen to a major issue. The study highlights the significance of Automatic Generation …
Published in International Journal of Electrical Power and Machine Systems · Vol. 3, Issue 2, 2025 · pp. 28–42 Read article
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Understanding the Impact of GMO on Hormones and Their Effect on Mood: A Review Paper
Abstract: The research evaluates how consuming genetically modified organisms affects endocrine functioning that can potentially lead to mood changes or disorders. This is a systematic review paper that analysed sixty publications before selecting thirty which were obtained from Sciencedirect, Frontiers, Springer, Oxfordacadamic, Cabidigitallibrary, Wileyonlinelibrary, Cambridgeuniversitypress, Scijournals, Mdpi, Metabolismjournal; while using Prisma Flow Diagram as the research tool; acknowledging that human hormonal health risks from GMO consumption remain largely unknown due to …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 14, Issue 3, 2025 Read article
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Integrating Biotechnology, Physiology, and Agroecological Practices for Sustainable Crop Production and Protection
Abstract: Global agriculture is currently confronting a wide range of complex challenges, including a rapidly growing population, climate change, increasing pest and disease pressures, soil degradation, water scarcity, and the urgent need for sustainable intensification of crop production. Addressing these issues requires integrated strategies that combine crop improvement (through modern breeding and biotechnology), precision agronomic practices related to soil, irrigation, and nutrition, as well as advancements in plant physiology, molecular biology, …
Published in International Journal of Trends in Horticulture · Vol. 2, Issue 2, 2025 · pp. 1–6 Read article
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Gene Editing in Dairy Cows: Advancing Milk Yield, Health, and Resilience for Sustainable Dairy Development
Abstract: Gene editing has emerged as a transformative tool in dairy science, offering unprecedented opportunities to enhance productivity, improve animal health, and bolster resilience against environmental challenges. This study explores the potential of gene editing technologies, including CRISPR-Cas9, in advancing milk yield, optimizing milk composition, and addressing genetic disorders in dairy cows. Specific applications include targeting genes associated with mastitis resistance, improving feed efficiency, and introducing heat tolerance traits to adapt …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 2, 2025 Read article
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The Power of Genetic Engineering in Revolutionizing Vaccines
Abstract: Genetic engineering techniques, including recombinant subunit, viral vector, and nucleic acid vaccines have transformed the landscape of vaccine development. These novel approaches offer precise antigen design, enhanced safety profiles, and rapid adaptability to emerging pathogens. Key advantages include improved efficacy through targeted immune responses, increased safety due to the absence of live pathogens, and the ability to modify vaccines to address new variants or diseases quickly. Notable success stories, such …
Published in International Journal of Vaccines · Vol. 2, Issue 1, 2025 · pp. 18–27 Read article
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Comparison of Models of Machine Learning and Hyperparameter optimization methods on various datasets
Abstract: The most likely phase in achieving powerful and robust machine learning models is probably the hyperparameters tuning step. The traditional exhaustive methods of search (Grid Search and others) ensure that the search space is covered, but are computationally very inexpensive; random search is less expensive and can still miss good regions; and lastly, the modern model-based and population-based methods (Bayesian Optimization, Tree-structured Parzen Estimator (TPE), Genetic Algorithms) are thought to …
Published in Recent Trends in Programming languages · Vol. 13, Issue 1, 2026 Read article
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Automatic Car Controller Based on Sign Board using Deep Learning and IOT
Abstract: The rapid growth of intelligent transportation systems has increased the demand for safer and more efficient driving solutions. Conventional vehicles often rely heavily on human intervention, which can lead to accidents due to negligence, fatigue, or poor visibility of traffic signs. This project proposes an automated car control system that utilizes deep learning and Internet of Things (IoT) technologies to recognize traffic signboards and respond accordingly. The primary objective is …
Published in Journal of Control & Instrumentation · Vol. 17, Issue 2, 2026 Read article
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The Renaissance and Resilience of CB1 Reverse Agonists: From Central Liabilities to Peripheral Promise
Abstract: Building upon these foundational insights, current research has increasingly focused on refining the pharmacological profile of CB1 reverse agonists to maximize therapeutic benefit while minimizing central adverse effects. The adverse neuropsychiatric outcomes associated with first-generation agents such as Rimonabant including anxiety, depression, and suicidal ideation highlighted the critical role of central CB1 receptors in mood regulation. Consequently, drug development strategies have shifted toward peripherally restricted CB1 reverse agonists that exhibit …
Published in International Journal of Cheminformatics · Vol. 4, Issue 1, 2026 · pp. 30–35 Read article
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Automation-Driven Composites: Pioneering the Next Generation of Lightweight and Sustainable Electric Vehicles
Abstract: Electric vehicle (EV) market is undergoing a dynamic change due to the changes in regulations, increasing demands of consumers, and a swift development of material science. Composite materials were one of these innovations which have become the key facilitators of lightweight, efficient and safe EV designs, with immense strength to weight ratios, corrosion resistance, and design flexibility unmatched before. The paper will discuss the growing use of composite materials in …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 513–525 Read article
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An AAV Vector for Inducible Gene Expression Preferentially in Muscles
Abstract: Adeno associated viral (AAV) vectors has been used widely in gene therapy and efforts have been made to improve their utility by adding genetic elements that would enable targeting transgene expression to particular cells or tissues of interest and permitting on/off regulation of expression. In this study, we designed a recombinant AAV9 variant PHP.eB vector with muscle creatine kinase (Mck)-derived enhancers, a synthetic muscle-expression promoter, in combination with a third-generation …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 2, 2023 · pp. 46–61 Read article
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Yoga and Neural Health: Enhancing Brain Function Through Postural Alignment
Abstract: Correct posture significantly influences neural function and brain health by ensuring optimal alignment of the spine and nervous system. Poor posture disrupts neural communication, impairs blood flow, and affects cerebrospinal fluid (CSF) circulation, leading to adverse effects on cognitive performance, emotional regulation, and overall brain health. This study examines the physiological connection between posture and neural health, emphasizing its impact on cognitive function, mood, and neuroplasticity. Using a mixed-methods approach, …
Published in Recent Trends in Sports · Vol. 2, Issue 1, 2025 · pp. 24–28 Read article
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Prime Editing and Base Editing in Human Hematopoietic Stem Cells Toward Scarless Correction of Monogenic Blood Disorders
Abstract: Monogenic hematological disorders – such as sickle cell disease (SCD), β-thalassemia, and X-linked chronic granulomatous disease (X-CGD) – affect >400, 000 newborns worldwide each year, with a considerable burden in low-resource settings . Although donor-derived allogeneic hematopoietic stem-cell transplantation (HSCT) is widely regarded as curative, its application is limited due to issues of donor availability and graft-versus-host disease (GVHD) and conditioning-related toxicity. DSB-based conventional CRISPR-Cas9 strategies are limited by inefficient …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 4, Issue 1, 2026 Read article
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Integrative Network Biology Analysis of GSE6011 Uncovers Molecular Signatures in Duchenne Muscular Dystrophy
Abstract: Duchenne muscular dystrophy (DMD) is a rare, severe neuromuscular disorder demonstrated by progressive skeletal muscle deterioration and premature mortality. Despite advances in supportive care, no definitive cure exists, highlighting the need to explore novel molecular targets. The current study aimed to uncover key dysregulated genes and molecular pathways in DMD through a dataset-specific network biology approach. Publicly available microarray data (GSE6011) from DMD quadriceps muscle biopsies of 22 patients and …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 3, 2025 · pp. 36–48 Read article
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Microalgae Based Wastewater Treatment: A Sustainable Approach
Abstract: The global water crisis and strict environmental policies demand advanced wastewater treatment techniques that combine pollution control with resource recovery. Microalgae-based wastewater treatment has emerged as a sustainable biotechnological solution that aligns with circular economy principles by simultaneously eliminating contaminants and producing valuable biomass that can be converted into useful products. This review paper provides an in- depth assessment of the application of microalgae in treating municipal, industrial, and agricultural …
Published in International Journal of Sustainability · Vol. 3, Issue 2, 2026 · pp. 1–15 Read article
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DEVELOPMENT OF POLYMERSOMES AS MACROMOLECULAR PLATFORMS FOR NANOMEDICINE
Abstract: The conventional method of drug delivery is plagued with instability, low targeting and low bioavailability. A solution to these shortcomings is the use of polymer Somes, artificial vesicles that are produced through self-assembly of amphiphilic block copolymer, and they are suggested as universal nanoscale carriers. They have stiff, tunable membranes (thickness = 2-50 nm) due to accurate control of polymer chemistry, chain length, and hydrophilic mass fraction (f), which allows …
Published in Journal of Polymer & Composites · Vol. 14, Issue 5, 2026 Read article