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83 articles for “drug loaded”
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Engineering of PEG-b-PCL/Pluronic F127 Polymeric Composite Micelles for Controlled Co-Delivery of Docetaxel and Curcumin in Prostate Cancer Therapy
Abstract: Polymeric composite nanocarriers made from amphiphilic block copolymers are popular for their customisable architecture, self-assembly behaviour, and drug release control. A PEG-b-PCL/Pluronic F127 micellar composite was developed and tested as a multifunctional nanocarrier for docetaxel and curcumin administration.The amphiphilic block copolymers Pluronic® F127 and PEG-b-PCL were employed to generate polymeric micelles using solvent evaporation-assisted self-assembly. The optimised polymer composite showed good colloidal stability and uniform size distribution with a zeta …
Published in Journal of Polymer & Composites · Vol. 14, Issue 5, 2026 Read article
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Evaluation of Pharmacopoeial and Quality Control Standards of Nelumbo nucifera Gaertn. Seeds
Abstract: ABSTRACTThe seeds of the plant Nelumbo nucifera Gaertn. (Fam: Nymphaeceae) are used against the ailments of poor digestion, enteritis, chronic diarrhea, insomnia and palpitation. In view of its medicinal importance, the present study was conducted to standardize the drug using pharmacognostical, physico-chemical and WHO methods. Microscopical studies show the presence of cotyledonary parenchyma cells filled with starch grains, palisade-like cells and non-lignified thick-walled sclerenchyma cells. TLC of chloroform and alcohol …
Published in Research & Reviews : Journal of Botany · Vol. 1, Issue 2, 2012 · pp. 1–8 Read article
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A Case Study & Report on Drug Related Adverse Effect Observed and Addressed during Optimal Therapy by Doctor of Pharmacy, in an Antiretroviral Therapy Ward of a Tertiary care teaching Hospital.
Abstract: In the present case study, a drug related adverse effect is observed and addressed during optimal therapy in Antiretroviral Therapy ward of Rajiv Gandhi Institute of Medical Sciences, Kadapa, Andhra Pradesh, India. As a part of Doctor of Pharmacy profession, Manasa Rekha has identified dose related adverse effect and have taken to the notice of Physician and monitored the dose of drug by using therapeutic drug monitoring parameters and have …
Published in Research and Reviews: A Journal of Medicine · Vol. 8, Issue 1, 2018 · pp. 1–5 Read article
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A Comparative Study on the Effectiveness of Therapeutic Ultrasound and Phonophoresis in the Management of Jumper’s Knee
Abstract: It is very essential to know the effectiveness of one modality over the other and this study is designed to compare the effectiveness of therapeutic ultrasound and phonophoresis using piroxicam gel on jumper’s knee. Rehabilitation of jumper’s knee and correction of any deficiency is strength abnormal loading pattern and dysfunction is must. The various rehabilitation of aims on relief of pain, reduction of abusive load. Improving musculotendious function and maintaining …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 2, Issue 1, 2013 · pp. 1–9 Read article
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Microsponges: A Novel Approach for Transdermal Delivery of Tolnaftate
Abstract: The present study was aimed at preparing tolnaftate-loaded microsponges and incorporating them into a topical formulation. Microsponge delivery system was chosen as it can increase the concentration of the drug on the superficial layer of the skin. Microsponges were prepared by quasi-emulsion technique. The studies like drug entrapment efficiency showed that the drug was completely entrapped within the pores of the microsponges. The microsponges were incorporated into the optimized carbopol …
Published in Trends in Drug Delivery · Vol. 2, Issue 2, 2015 · pp. 38–46 Read article
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Advancements in Solubility Enhancement Through Liquisolid Compact Technology: A Comprehensive Review
Abstract: The study examines Liquisolid Compact Technology as an innovative approach for improving the bioavailability and solubility of drugs that are poorly soluble in water. Liquisolid systems, comprising solid carriers and liquid drugs, offer advantages such as improved drug release and bioavailability, reduced manufacturing costs, and controlled drug delivery. The technique involves dissolving or suspending the drug in non-volatile solvents, adding carrier materials, super disintegrants, and coating materials, and then compressing …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 2, 2024 · pp. 25–34 Read article
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A Novel Liquid Crystal Drug Delivery for Transdermal Application
Abstract: The present study was aimed at the formulation of liquid crystals of acyclovir that will be incorporated into a transdermal patch. Liquid crystals serve as drug carrier and have a good penetration-enhancer property, due to the extensive similarity of these colloidal systems with the intercellular lipids in the stratum corneum. The liquid crystals were prepared using tween 80 as emulsifier, cetosteryl alcohol as emulsion stabilizer and double-distilled water. Liquid crystals …
Published in Trends in Drug Delivery · Vol. 2, Issue 2, 2015 · pp. 28–37 Read article
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Hydrolysis-Driven Optimization of Hydroxypropyl Maize Starch for Improved Micro-Pellet Binding and Quick Solubility of Spirulina-Based Micro-Pellets
Abstract: Acid hydrolysis is a well-established approach for modifying the physicochemical properties of polysaccharides & macromolecules including hydroxypropyl Maize starch (HPMS). In this study, the effect of varying concentrations of hydrochloric acid on the partial hydrolytic degradation of HPMS (Lycoat RS-780) was investigated at 85°C for 4 h, yielding polymers of different molecular weights. The Acid-mediated degradation effects on polymer characteristics were systematically assessed using capillary viscometry and gel permeation chromatography …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 · pp. 41–61 Read article
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Formulation and Characterization of Mesoporous Nanoparticulate Drug Delivery Platform
Abstract: The aim of this study was to synthesize and characterize mesoporous silica nanoparticles, namely, SBA-15 (Santa Barbara Amorphous) and MCM-41 (Mobile Crystalline Material) as a drug delivery platform. These MSNs have been synthesized using triblock copolymer F 127, cetyl trimethyl ammonium bromide (CTAB) as a co-surfactant and tetraethyl orthosilicate (TEOS) as a silica precursor. The synthesized MSNs were characterized by scanning electron microscopy (SEM), powder X-ray diffraction (PXRD), particle size …
Published in Trends in Drug Delivery · Vol. 2, Issue 1, 2015 · pp. 21–27 Read article
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Phyto-Entrapped Carbon Dots as Emerging Nanomaterials for Anti-Cancer Activity
Abstract: Phytoconstituent-loaded carbon dots (C-dots) represent an innovative approach in targeted cancer therapy, combining the therapeutic power of plant-derived compounds with the advanced capabilities of nanotechnology. These ultra-small, biocompatible nanostructures offer excellent fluorescence, tunable surface chemistry, and low toxicity, making them ideal for drug delivery, bioimaging, and theranostic applications. Traditional phytochemicals often face challenges like poor solubility, low bioavailability, and high first-pass metabolism barriers that C-dots help overcome. C-dots synthesized through …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 51–63 Read article
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Nanotechnology in Surgical Drains: Reducing Infections and Promoting Healing Post-Surgery
Abstract: Surgical drains are widely used in postoperative care to evacuate accumulated fluids, minimize dead space, and reduce complications such as hematoma and seroma formation. Despite their clinical importance, conventional drains are frequently associated with retrograde bacterial migration, biofilm formation, and increased risk of surgical site infections (SSIs), which contribute significantly to postoperative morbidity and prolonged hospital stay. Recent advancements in nanotechnology have enabled the development of nano-functionalized surgical drains with …
Published in Research and Reviews : Journal of Surgery · Vol. 15, Issue 2, 2026 · pp. 54–67 Read article
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Radiopaque Polymer Composites for Improved Visualization of Interventional Devices
Abstract: Radiopaque polymer composites are increasingly important for improving the visualization of interventional medical devices under X-ray and fluoroscopic imaging while maintaining the flexibility, mechanical performance, and processability required for minimally invasive applications. This narrative review summarizes recent developments in radiopaque polymer composites, with emphasis on radiopaque filler selection, polymer–filler interactions, processing strategies, structure–property relationships, biocompatibility, and device applications. A focused literature search was conducted using PubMed, Scopus, Web of Science, …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 Read article
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Effective Antibiotics and ATP Loaded Delivery System in the Management of Diabetic Wounds
Abstract: The aim of present research work was to formulate and evaluate antibiotics and ATP-loaded delivery system (liposome) in the management of diabetic wounds. Wound is disturbance in the normal skin anatomy and their functions; tissue injury resulting in the “loss of continuity of epithelium with or without the loss of underlying connective tissue.” Wound bad is an ultimate situation for wound infection, while wound healing is a complex and dynamic …
Published in Research and Reviews : A Journal of Immunology · Vol. 3, Issue 2, 2013 · pp. 1–10 Read article
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Bionanocomposites in Green Synthesis of Bioplastics - The Composite Materials of Future & Their Role in Circular Bio-Economy
Abstract: The pervasive use of petroleum-derived plastics has caused severe environmental pollution, accumulating in landfills and oceans while threatening human and animal health. This ecological crisis has accelerated an urgent transition toward biodegradable polymers within the circular bioeconomy. Bionanocomposites, comprising a biodegradable polymer matrix integrated with nanoscale fillers, successfully bridge the gap between high industrial performance and environmental responsibility. By incorporating advanced nanofillers such as cellulose nanocrystals, chitin nanofibers, layered silicates …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 16, Issue 2, 2026 Read article
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Current Prospective of NLCs in Parkinson’s Disease: An Outlook
Abstract: Parkinson's disease (PD) is 2nd most a neuro-degenerative disorder of the central nervous system affecting 7–10 million people of worldwide as the report of WHO 2014. It occurs due to the death of dopamine-generating cells in the substantia nigra, a region of the midbrain. It is characterized by tremor, rigidity, bradykinesia, dementia, depression and falls or emerges with the progression of the disease. Ropinirole Hydrochloride is a drug of choice …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 2, 2018 · pp. 18–29 Read article
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Nano-Therapeutics in Diabetes Mellitus: Revolutionizing Diagnosis, Treatment, and Drug Delivery
Abstract: Diabetes mellitus is a chronic metabolic disorder in which blood glucose concentration remains high over an extended duration, resulting in significant lethal complications, including neuropathy, nephropathy and cardiovascular diseases. However, conventional diabetes management strategies, including insulin therapy and oral hypoglycemic agents, rarely exhibit poor bioavailability, high doses, off target delivery, etc. Nanotechnology has brought the rise of diabetes treatment revolution, by overcoming the challenges present in standard treatment, owing to …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 08–19 Read article
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A Research Project on Identification and Reporting of Adverse Drug Reactions in General Medicine Ward of an ESI Hospital
Abstract: Aim: The study aims at identifying and reporting the adverse drug reactions (ADRs) in general medicine ward of an ESI hospital, Bangalore, Karnataka, India. Objective: Prescription study, analysis and prevention of medication-related problems (ADRs), identifying and minimizing medication-related problems, improving patient safety initiatives, improving the patient health-related outcomes, reducing work burden of physicians, and providing better therapy to large number of patients. Methodology: Study Design: It was a prospective and …
Published in Research and Reviews: A Journal of Toxicology · Vol. 8, Issue 3, 2018 · pp. 9–14 Read article
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Biopolymer-Based 3D Composite Scaffolds for Bone Tissue Engineering: Photothermal-Responsive Systems with Controlled Pt (IV) Prodrug Release
Abstract: Biopolymer-based composite scaffolds have attracted significant attention as multifunctional platforms at the intersection of polymer science, regenerative medicine, and cancer nanotherapy. In this study, a dual-functional scaffold was developed for simultaneous osteosarcoma treatment and bone regeneration using poly (L-lactic acid) (PLLA) reinforced with bioactive glass (BG) and integrated with a glutathione-responsive platinum (IV) prodrug system (PDA@Pt). To improve interfacial adhesion, photothermal conversion efficiency, and tumor-specific activation, the Pt (IV) prodrug …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 351–361 Read article
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Formulation and Evaluation of Transdermal Patch to Enhance Treatment of Alopecia
Abstract: The improvement of novel topical sedate conveyance frameworks has picked up noteworthy consideration due to their potential in upgrading the helpful viability and persistent compliance whereas minimizing systemic side impacts. This thinks about centers on the definition and assessment of transdermal patches planned to discharge allicin, the essential naturally dynamic compound determined from garlic (Allium sativum) extricate. Allicin is eminent for its wide range of pharmacological properties, counting antimicrobial, anti-inflammatory, …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 20–33 Read article
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A Research Study and Report on Clinical Pharmacy Services Provided by Doctor of Pharmacy during their Clerkship and Internship Postings to a Tertiary care teaching Hospital.
Abstract: Clinical pharmacy is defined as the area of pharmacy concerned with the science and practice of rational medication use. Aim: The study aims at implementing clinical pharmacy services by Doctor of Pharmacy during clerkship and internship postings to patients at different wards of Rajiv Gandhi Institute of Medical Sciences. Objective: Prescription study and analysis and preventing the medication related problems adverse drug reactions drug interactions, over dose), performing drug utilization …
Published in Research and Reviews: A Journal of Medicine · Vol. 8, Issue 1, 2018 · pp. 27–32 Read article