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76 articles for “computational biology”
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Symmetry Breaking in Mathematical Models: Bifurcation, Chaos, and Pattern Formation
Abstract: Symmetry breaking serves as a central organizing principle in the understanding of nonlinear systems across physics, biology, chemistry, and engineering. When a system transitions from a symmetric state to an asymmetric configuration, it often signals the onset of new structures, dynamic behaviors, or even chaotic regimes. This review explores symmetry breaking from the theoretical and mathematical perspectives of bifurcation theory, chaos theory, and pattern formation. We discuss how small parameter …
Published in Emerging Trends in Symmetry · Vol. 1, Issue 2, 2025 · pp. 25–30 Read article
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Thermally Adaptive Bio-Inspired VLSI Interconnect Model for Next-Generation Embedded Systems
Abstract: The increasing complexity of next-generation embedded systems has intensified the challenges associated with power dissipation, thermal instability, signal integrity, and interconnect reliability in Very Large- Scale Integration (VLSI) architectures. This research proposes a thermally adaptive bio-inspired VLSI interconnect model designed to enhance communication efficiency and thermal resilience in advanced embedded platforms. The proposed model integrates bio-inspired adaptive routing principles with dynamic thermal-aware interconnect management to optimize data transmission under varying …
Published in Journal of VLSI Design Tools and Technology · Vol. 16, Issue 2, 2026 Read article
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A Neuromorphic-Inspired, Low-Power VLSI Architecture for Edge AI in IoT Sensor Nodes
Abstract: As the proliferation of Internet of Things (IoT) devices continues to rise, there is an increasing demand for real-time, energy-efficient artificial intelligence (AI) processing directly at the network edge. Traditional edge AI accelerators, often based on deep learning models like convolutional neural networks (CNNs), struggle to meet the ultra-low-power requirements of battery-constrained IoT sensor nodes. In response to this challenge, this study introduces a neuromorphic-inspired, low-power very- large-scale integration (VLSI) …
Published in Journal of Microelectronics and Solid State Devices · Vol. 12, Issue 2, 2025 · pp. 41–47 Read article
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Exploring the Role of MAPK3 in Major Depressive Disorder: Molecular Docking, Dynamics, and Binding Free Energy Analysis of Natural Compounds as Alternatives to Conventional Drugs
Abstract: Major Depressive Disorder (MDD) is a prevalent neuropsychiatric disorder with limited treatment efficacy and significant side effects associated with conventional antidepressants. Recent studies have highlighted the role of mitogen-activated protein kinase 3 (MAPK3) in the mechanisms underlying MDD, positioning it as a potential target for the development of novel therapeutic drugs. In this study, we employed various computational approaches to explore natural compounds as viable alternatives to synthetic antidepressants. Researchers …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 2, 2025 · pp. 53–68 Read article
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Industry 4.0 and Smart Manufacturing: A Review
Abstract: This review looks at Industry 4.0 and smart manufacturing's idea, enabling technologies, implementation issues, and future prospects. Drawing on recent literature, the paper synthesizes key pillars such as the Industrial Internet of Things (IIoT), cyber-physical systems (CPS), artificial intelligence, digital twins, and additive manufacturing. It highlights integration requirements across supply chains, cyber security concerns, workforce implications, and standards activities that influence adoption. The literature survey focuses on empirical studies and …
Published in International Journal of Manufacturing and Production Engineering · Vol. 3, Issue 2, 2025 · pp. 14–17 Read article
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Quantum Mechanics: Revolutionizing Pharmaceutical Sciences
Abstract: Quantum physics and pharmacy have generally been regarded as distinct areas—one investigates the microlevel behavior of non-living matter while the other concentrates on intricate biological systems. Nevertheless, progress in life sciences has increasingly depended on molecular-level insights, whereas quantum physics has advanced beyond basic principles to impact real-world uses. This intersection provides new opportunities for, pharmacy. Quantum entanglement, which allows for instantaneous relationships between particles, can be utilized for secure …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 72–77 Read article
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Everlasting Life Achieved Through Technology in AI
Abstract: The concept of immortality Life is a philosophical idea that states life is limitless and does not stop with death, it exists infinitely. In our Sanskrit scriptures and Santana dharma teach us that there is a life of beginning and an end, which are referred to as birth and death but our souls do not perish, instead, they switch bodies. In this scenario, our memories have evaporated to protect our …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 4, Issue 1, 2026 Read article
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A Review on the Interconnection Between Drug Design and Controlled Drug Delivery Systems
Abstract: Drug discovery and delivery are two branches of science that have historically developed as independent areas of discovery – one focused on optimizing the properties of molecules for biological activity, and the other on controlling the rate, site, and duration for drug release. However, in contemporary pharmacy, these two areas have merged into a single integrated approach – where drug discovery and delivery strategies co-influence each other at each point …
Published in Emerging Trends in Personalized Medicines · Vol. 3, Issue 1, 2026 · pp. 47–52 Read article
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A study on Controlling Artificial Heart
Abstract: The artificial heart has moved from a visionary concept to a clinically viable organreplacement technology, yet its longterm success hinges on the sophistication of its control architecture. This paper presents a comprehensive investigation of closedloop control strategies that enable an artificial heart to mimic the dynamic, beattobeat adaptability of its biological counterpart. We first construct a highfidelity cardiovascular model that integrates ventricular elastance, systemic and pulmonary vascular compliance, and realtime …
Published in Journal of Control & Instrumentation · Vol. 17, Issue 1, 2026 · pp. 14–23 Read article
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Neuro-Symbolic Agentic AI for Autonomous Scientific Discovery: Integrating Deep Reinforcement Learning, Quantum Simulation, and XAI-Audited LLM Hypothesis Generation in Drug Target Identification
Abstract: The exponential growth of multi-omics data and the increasing complexity of disease-associated protein interactomes have rendered conventional drug target identification pipelines computationally and epistemologically inadequate. This paper presents the Neuro-Symbolic Agentic AI for Scientific Discovery (NS-AASD) framework, a unified architecture that cohesively integrates deep reinforcement learning (DRL) exploration strategies, variational quantum simulation (VQS) of protein conformational dynamics, and XAI-audited large language model (LLM) hypothesis generation within an autonomous scientific discovery …
Published in Research and Reviews : Journal of Computational Biology · Vol. 15, Issue 2, 2026 Read article
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Pharmacodynamics and Drug–Receptor Interactions: Integrating PK/PD Modeling with Modern Drug Development
Abstract: Understanding drug action requires an integrated perspective of pharmacodynamics and pharmacokinetics, which together determine therapeutic efficacy and safety. This review provides a comprehensive overview of the mechanisms underlying drug action, with particular emphasis on drug–receptor interactions and their role in modulating physiological responses. Drugs exert their effects primarily through interactions with specific biological targets, including receptors, enzymes, ion channels, and transporters, resulting in a spectrum of desired and adverse outcomes. …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article
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Modeling Dispersed Count Data: Evaluating the Conway–Maxwell–Poisson Regression with COVID-19 Mortality Data
Abstract: Count data are prevalent in diverse fields such as biology, healthcare, psychology, and marketing, characterized by non-negativity and inherent heteroskedasticity, often exhibiting overdispersion or underdispersion. Traditional Poisson regression, which assumes equal mean and variance, is inadequate for such dispersed data. To address this, various generalized linear models (GLMs) and their extensions, including negative binomial (NB) and Conway–Maxwell–Poisson (CMP) regressions, are utilized. This study evaluates the performance of CMP regression compared …
Published in Research & Reviews : Journal of Statistics · Vol. 13, Issue 3, 2024 · pp. 18–26 Read article
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Design and Analysis of Fluid Pressure in Microchannel for Healthcare Application
Abstract: The research article study explores an innovative approach for optimizing fluid pressure within microchannels using 2D integrated microcantilevers. These microcantilevers, strategically placed within the microchannel, serve as sensitive sensors to monitor fluid pressure variations. The computational simulations illustrate the effective approach to achieving improved pressure measurement for cell separation outcomes. The integrated microcantilever can determine the fluid pressure inside the microchannel, and also determine the pressure required for the cell …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 553–565 Read article
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Gold Nanoparticle Size, Biodistribution, and Toxicity: Insights from DualEnergy CT
Abstract: Dual-energy and spectral computed tomography (CT) have emerged as powerful platforms for noninvasive, quantitative mapping of nanoparticle biodistribution in vivo. By exploiting the energy-dependent attenuation profiles of high-atomic-number (high-Z) materials, these systems enable material decomposition and element-specific imaging, thereby distinguishing nanoparticle signals from those of soft tissues and conventional iodinated contrast agents. Photon-counting spectral CT further enhances this capability by binning individual photons into multiple energy channels, improving spatial resolution, …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 28, Issue 2, 2025 Read article
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From Differential Equations to Data Science: A Survey on Analytical Methods in Contemporary Problems
Abstract: The integration of differential equations and data science methods represents a dynamic and evolving approach to solving contemporary challenges across a wide range of disciplines, including engineering, physics, biology, economics, and finance. Differential equations have long served as fundamental tools for modeling continuous systems and processes, offering powerful insights into the behavior of natural and man-made phenomena. For example, they describe how heat diffuses through materials, how populations grow in …
Published in Recent Trends in Mathematics · Vol. 2, Issue 2, 2025 · pp. 1–6 Read article
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An Overview of New Coastal Research Vessel (N-CRV) Dry Dock and Construction
Abstract: A New Coastal Research Vessel (N-CRV) is a specialized ship designed for scientific research in fields like oceanography, geology, biology, and atmospheric studies, equipped with specific facilities and accommodations for sea missions. This paper discusses the coastal research ship dry-dock, construction, and design process, which involves three stages: concept, preliminary, and contract design. N-CRV must utilize scientific cruise, Exclusive Economic Zone (EEZ) survey, deployment, data collection, and seawater sample collection …
Published in Journal of Offshore Structure and Technology · Vol. 11, Issue 3, 2024 · pp. 1–11 Read article