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136 articles for “Metabolic Response”
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Gene Edited Livestock for Enhanced Feed Efficiency and Metabolic Adaptation Through Precision Genomic Interventions
Abstract: Advances in gene editing technologies have transformed the landscape of livestock production by enabling precise manipulation of genetic material associated with productivity, health, and environmental adaptability. Tools such as CRISPR Cas9 and emerging next generation editors allow targeted modifications that improve feed efficiency, growth performance, nutrient utilization, and stress tolerance in farm animals. This review highlights the genetic basis of feed efficiency and metabolic regulation, focusing on key genes and …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 2, 2026 · pp. 1–10 Read article
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Protein Metabolism in Plants during Abiotic Stress (Drought, Flood, Heat and Cold): An Overview
Abstract: Plants are frequently subjected to several abiotic environmental stresses under natural conditions causing profound impacts on agricultural yield and quality. Tolerance and acclimation of plants are always related with significant changes in protein, cellular localization, post transcription and post-translational modifications. Protein response pathways as well as pathways unique to a given stress condition shared by plants under different stressed environment are discussed. In a nutshell, this paper provide an overview …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 10, Issue 3, 2020 · pp. 21–45 Read article
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Ferrous bisglycinate (FBG) as a source of iron supplement
Abstract: Iron is a crucial element that holds significance in various essential biological functions. These include the synthesis of heme, which constitutes the core component of hemoglobin, the protein responsible for transporting oxygen in the bloodstream. Additionally, iron is involved in the production of myoglobin, energy metabolism, neurotransmitter synthesis, collagen formation, and the functioning of the immune system. There are mainly two reasons for iron imbalance: Iron deficiency and Iron overload. …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 13, Issue 1, 2023 · pp. 32–41 Read article
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The Mycobiome Frontier – Pre & Post 2020 Status: Integrating Fungal Bioactive Compounds, Probiotics, and Antimicrobial Peptides in Modern Therapeutics and Biotechnology.
Abstract: The fungal kingdom represents an indispensable resource in modern therapeutics and biotechnology, offering a diverse array of bioactive compounds, probiotics, and antimicrobial peptides (AMPs). Functional fungal polysaccharides (FFPs), such as beta-glucans, chitin, and mannans, are centrally involved in modulating the human gut microbiota, providing novel therapeutic avenues for chronic conditions including diabetes, neurodegenerative disorders, and cancer. These compounds act as prebiotics, nourishing beneficial bacteria and enhancing metabolic parameters such as …
Published in International Journal of Fungi · Vol. 3, Issue 1, 2026 · pp. 1–11 Read article
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Smart and Circular Lakshadweep: Innovating Solid Waste Management for Sustainable Tourism Development
Abstract: Urban growth necessitates effective resource management, especially for resource-constrained island communities. This study focuses on the Lakshadweep Islands, examining the shift towards a circular economy through the perspective of solid waste management, with an emphasis on enhancing tourism and circular economy principles. The circular economy aims to eliminate waste and continually use resources by creating closed-loop systems where products, materials, and resources are reused, repaired, refurbished, and recycled. This study …
Published in Journal of Geotechnical Engineering · Vol. 11, Issue 2, 2024 · pp. 32–37 Read article
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Review on Histological and Functional Effect of Alcohol on Liver and Kidney
Abstract: Alcohol consumption represents the third largest risk factor for disease burden in most countries of the world. The purpose of this review is to give a comprehensive report of the existing data on the potential adverse effects of alcohol on liver and kidney toxicity. We used 82 different published materials for the compilation of this review article. The Google search engine was used for accessing published materials from databases like …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 7, Issue 2, 2018 · pp. 49–62 Read article
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Trichoderma: beneficial fungus for sustainable agriculture
Abstract: As environmentally beneficial substitutes for chemical pesticides, Trichoderma species are being utilized in agriculture more and more. Disease suppression, increased plant growth, and increased tolerance to environmental stress are just a few advantages they provide. These fungi are used in a wide range of cropping systems and formulations around the world. Their use is growing worldwide, particularly in Asia and Europe. In contemporary crop management, items derived from Trichoderma are …
Published in International Journal of Fungi · Vol. 2, Issue 2, 2025 · pp. 25–29 Read article
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Alcohol, Circadian Glymphatic Dysfunction, and Neurodegenerative Protein Accumulation: An Emerging Concern in the Indian Context
Abstract: Alcohol consumption has long been identified as a major public health issue, yet its deeper and more subtle effects on the human brain are only now coming into sharper focus. Traditional explanations often emphasize direct neuronal damage, but emerging research in neuroscience suggests a more intricate story. Recent findings indicate that alcohol not only harms brain cells but also disrupts the body’s internal biological clock—the circadian rhythm—which plays a critical …
Published in International Journal of Brain Sciences · Vol. 3, Issue 1, 2026 · pp. 1–4 Read article
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Cis-9, Trans-11 Conjugated Linoleic Acid in Milk: Natural Sources, Nutritional Advantages, and Potential Health Benefits
Abstract: Cis-9, trans-11 conjugated linoleic acid (CLA) is the most common type of CLA found in milk. It has gained a lot of attention because it may have several health benefits. This bioactive lipid is primarily derived from ruminal biohydrogenation of dietary linoleic acid and endogenous synthesis in the mammary gland via Δ9-desaturase activity. Various dietary and management strategies influence CLA concentrations in milk, including forage composition, lipid supplementation, and grazing …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 15, Issue 2, 2025 Read article
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Living with Glucose-6-Phosphate Dehydrogenase Deficiency
Abstract: Glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency) is an X-linked recessive hereditary disease characterized by abnormally low levels of glucose-6-phosphate dehydrogenase, a metabolic enzyme involved in the pentose phosphate pathway, especially important in red blood cell metabolism. G6PD deficiency is the most common human enzyme defect. Individuals with this disease may exhibit non-immune hemolytic anemia in response to a number of causes, most commonly infection or exposure to certain medications or fava …
Published in Journal of Nursing Science & Practice · Vol. 6, Issue 1, 2016 · pp. 23–30 Read article
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Structural Analyses of SoxY and SoxZ Proteins from Epsilonproteobacterium Sulfurimonas denitrificans: A Structural Bioinformatics Approach
Abstract: Abstract:Molecular level participation of epsilonproteobacteria for the global sulfur oxidation phenomena is an essential zone to be indulged with. Epsilonproteobacteria aids in the microbial sulfur metabolism both at and beneath the seafloor. For the recycling of the inorganic sulfur compounds, microbial redox reactions are one of the responsible and most important reactions to maintain the environmental sulfur balance. These reactions are carried out by phylogenetically diverse sets of microorganisms. The …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 5, Issue 1, 2015 · pp. 35–44 Read article
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Genetic Variability and Significance of STAT Gene in Dairy Animals
Abstract: Abstract Importance in the bovine signal transducer and activator of transcription (STAT) gene has increased due to involvement of STAT1 in the development of the mammary gland and regulating the transcription of genes involved in milk protein synthesis and fat metabolism in lactating dairy animals. Signal transducer and activator of transcription gene are a family of cytoplasmic proteins that are stimulated in response to a large number of growth factors, …
Published in Research and Reviews : Journal of Dairy Science and Technology · Vol. 5, Issue 3, 2016 · pp. 1–6 Read article
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Role of Inflammatory Markers and Lipid Abnormalities in Glycemic Dysregulation Among Type 2 Diabetics
Abstract: Background: Diabetes mellitus (DM) is a chronic metabolic disorder characterized by systemic inflammation and associated with various complications in multiple organs. Type 2 diabetes mellitus (T2DM) specifically involves insulin resistance, hyperglycemia, and inflammatory responses. This study investigates the levels of various inflammatory markers and their correlation with glycaemic control in T2DM patients.Objective: To evaluate the levels of inflammatory markers (including NLR, PLR, SII, SIRI, CRP, IL-6, TNF-α, TGF-β, MCP-1, IL-4, …
Published in Emerging Trends in Metabolites · Vol. 2, Issue 2, 2025 Read article
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The Role of Natural Products in Antiviral Drug Discovery: Insights into Mechanisms and Therapeutic Potential
Abstract: Drug discovery has always relied heavily on natural sources, especially when it comes to creating antiviral medications. This review explores the therapeutic potential of various natural products, including plant extracts, marine compounds, and microbial metabolites, in the fight against viral infections. We examine the mechanisms of action by which these natural compounds exert their antiviral effects, including direct inhibition of viral replication, modulation of host immune responses, and interference with …
Published in International Journal of Virus Studies · Vol. 1, Issue 2, 2024 · pp. 36–47 Read article
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Anticancer Activity of Calotropis procera by Molecular Docking Analysis
Abstract: Cyclin-dependent kinase 2 (CDK2) is a protein synthesized by Calotropis procera. It is known to be responsible for causing cancer in the human body. Studies have presented the significance of the phytochemicals to inhibit the CDK2 protein. Adsorption, distribution, metabolism, and excretion (Swiss ADME) and PubChem were the pharmacological tools which were used to check molecular weight, which should be less than 500D, acceptors less than 10, and donors less …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 01–07 Read article
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Postbiotics Unveiled: Mechanistic Insights and Therapeutic Implications in Obesity.
Abstract: The burgeoning global obesity epidemic necessitates innovative therapeutic approaches, and postbiotics, bioactive compounds arising from microbial fermentation, have emerged as promising contenders in reshaping obesity management. This comprehensive review explores the multifaceted mechanisms by which postbiotics impact obesity, from modulating gut microbiota composition to influencing metabolic pathways and enhancing energy expenditure. The exploration of postbiotics is rooted in a deeper understanding of the gut–brain axis and bidirectional communication between gut …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 1, 2026 · pp. 11–28 Read article
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Study of Anti-Leishmanial Activities of Metabolites on Leishmania major: A Structure-Based Drug Designing Approach
Abstract: Cutaneous Leishmaniasis is one of the major problem all over the world and has no suitable treatment to treat this disease. However, the range of drugs is limited and increased use of these drugs lead to multiple drug resistance and has posed a major concern. Here the genome sequences of Leishmania major (responsible for cutaneous Leishmaniasis) is identified for having few drug targets that are unique to these parasites. GPI …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 4, Issue 3, 2017 · pp. 30–40 Read article
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Explainable Artificial Intelligence in Personalized Medicine: Emerging Clinical Perspectives
Abstract: The convergence of artificial intelligence (AI) and precision medicine has transformed contemporary healthcare by enabling data-driven clinical decision-making, individualized therapeutic interventions, and predictive diagnostics. However, despite remarkable advances in machine learning (ML) and deep learning (DL), the widespread adoption of AI in healthcare remains constrained by the “black-box” nature of many computational systems. Clinicians, regulatory agencies, and patients increasingly demand transparency, interpretability, and trustworthiness in AI-guided medical recommendations. Explainable Artificial …
Published in Emerging Trends in Personalized Medicines · Vol. 3, Issue 2, 2026 · pp. 13–29 Read article
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Engineering Fatty Acid Oxidation Pathway for the Production of Yeast-based Monomers
Abstract: Yeast-based monomers have a wider application in many fields and used for polymer production. Yeast system is used to improve the production of such valuable monomers by exploiting the metabolic pathways of interest. Alkane-utilizing yeasts mediate the fatty acid catabolism inside the peroxisomes primarily through beta (β) oxidation pathway, which breaks up the long chain fatty acids resulting in the synthesis of energy producing molecules. This allows the reduced inflow …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 3, Issue 1, 2013 · pp. 6–9 Read article
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Beyond the Alternative Proteins: How Does Fungal-Insect Bioconversion Reshape Nutrient Quality and Functional Value of Animal Feeds?
Abstract: The growing demand for sustainable animal production has intensified interest in fungi and insects as alternative sources of feed protein; however, their nutritional significance extends well beyond simple replacement of conventional protein ingredients. Fungal-insect bioconversion represents an emerging biological platform in which microorganisms and insects can transform low-value biomass into nutritionally and functionally distinct feed resources. This review examines how sequential or integrated fungal and insect bioconversion can reshape the …
Published in International Journal of Insects · Vol. 3, Issue 2, 2026 Read article