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109 articles for “Mediation Effect”
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Ocular Films as a Drug Delivery System Against Fungal Infections: Current Insights and Future Directions
Abstract: Fungal infections of the eye, including keratitis, endophthalmitis, and blepharitis, represent a challenging class of ocular diseases due to their potential for vision loss and the limited efficacy of existing treatments. These infections are caused by a range of pathogenic fungi, such as Aspergillus, Candida, and Fusarium species, and often require long-term therapeutic intervention. Conventional topical antifungal therapies, such as eye drops and ointments, suffer from poor ocular bioavailability due …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 101–109 Read article
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Nutrition Induced Gut Microbiota Modulation in Food Animals: Implications for Viral Susceptibility, Shedding and Transmission Dynamics for Sustainable Development
Abstract: The gut microbiota has emerged as a central mediator linking host nutrition, immune competence, and vulnerability to viral pathogens in food animals. Diet is a primary driver of microbial community structure and function, influencing metabolite production, intestinal barrier integrity, and systemic antiviral immunity. Accumulating evidence indicates that nutrition induced modulation of the gut microbiota can substantially alter viral susceptibility, replication, and shedding patterns, with downstream effects on transmission dynamics within …
Published in International Journal of Virus Studies · Vol. 3, Issue 1, 2026 · pp. 46–56 Read article
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Nanoparticle Chemistry: The Synthesis, Properties and Applications of Polymer and Macromolecule-Based Nanoparticles and Their Composites
Abstract: Nanoparticles have arisen as a transformative branch of materials in chemistry, owing to their unique physicochemical and biological properties that vary from their bulk materials. Various synthesis techniques, including physical (e.g., laser ablation), chemical (e.g., sol-gel, co-precipitation) and biological (e.g., microbial or plant-mediated) approaches, offer control over particle size, shape and surface characteristics. These methods influence the optical, electronic, catalytic and mechanical properties of nanoparticles. Nanoparticles can exhibit high surface …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1236–1247 Read article
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Recombinant Lactobacillus helveticus PJ4-Down Regulates TLR4 Mediated Inflammatory Responses in Sucrose Induced Diabetic Rats: A Novel Therapeutic Approach
Abstract: High sucrose diet (HSD) is known to induce type 2 diabetes. Recombinant Lactobacillus helveticus PJ4 was constructed to express the InuJ gene under the xylose promoter resulting in the secretion of inulosucrase enzyme in gastrointestinal tract which polymerizes the fructose moiety of sucrose to inulin type fructans. L. helveticus (pSLP-InuJ-Vhb) transformant (LHI) was intragastrically administered to rats fed with HSD diet. The composition of fecal microbiota and short-chain fatty acids …
Published in Research and Reviews : A Journal of Immunology · Vol. 7, Issue 2, 2017 · pp. 44–65 Read article
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Pharmacodynamics and Drug–Receptor Interactions: Integrating PK/PD Modeling with Modern Drug Development
Abstract: Understanding drug action requires an integrated perspective of pharmacodynamics and pharmacokinetics, which together determine therapeutic efficacy and safety. This review provides a comprehensive overview of the mechanisms underlying drug action, with particular emphasis on drug–receptor interactions and their role in modulating physiological responses. Drugs exert their effects primarily through interactions with specific biological targets, including receptors, enzymes, ion channels, and transporters, resulting in a spectrum of desired and adverse outcomes. …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 · pp. 33–47 Read article
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Hematopoietic stem progenitor cells reduce the proliferation of Tregs via regulation of IL-12/STAT4 signaling during chronic stress
Abstract: Abstract. Physical or psychological chronic stress mediates the impaired immune response by inducing the proliferation of regulatory T cells (Tregs). Our recent studies showed that hematopoietic stem progenitor cells (HSPCs) significantly modulated the immune system. HSPCs prevented stress-induced lymphocyte apoptosis, exerting a protective effect in chronic stress-induced immune responses. Thus, whether HSPCs could prevent the proliferation of Tregs in conditions of chronic stress was assessed in the present study. Injection …
Published in Research and Reviews : A Journal of Immunology · Vol. 12, Issue 3, 2022 · pp. 1–10 Read article
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Frequency and Effect of CCR5 Alleles on HIV-1 Disease Progression among Untreated Seropositive Individuals Visiting Gondar University Teaching Hospital
Abstract: Abstract:The natural history of HIV-1 infection varies considerably from one individual to another, with some individuals progressing to AIDS rapidly after primary infection, while others remain clinically asymptomatic with no evidence of immune dysfunction. Recent studies have shown that reasons for progression and non-progression are multi-factorial and may involve genetic, virological and immunological factors that influence HIV disease progression in various ways. Chemokine receptors act as important co-receptors mediating the …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 5, Issue 1, 2015 · pp. 8–13 Read article
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Molecular Pharmacokinetics and Structural Docking of Phenolic Acids for Targeting NF-κB Pathway Components in Inflammation and Fibrosis: A Computational Approach Toward Therapeutic Discovery
Abstract: Inflammation and Fibrosis are critical pathological processes associated with various chronic diseases, often mediated by the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway. This study investigates the therapeutic potential of phenolic acids as modulators of the NF-κB pathway, aiming to identify novel ligands that can effectively interact with key components of this signaling cascade. A comprehensive computational approach was employed, utilizing molecular docking, pharmacological screening, and post-docking …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 1, 2025 · pp. 14–31 Read article
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Comparative Analysis of AI-Enabled Conversational Agents and Recommendation Systems for Real-Time Customer Engagement in E-Retailing
Abstract: The rapid deployment of artificial intelligence (AI) in e-retailing has revolutionized the way companies interact with customers in real time. Conversational agents and recommendation engines are two of the most popular AI techniques used to influence customer engagement, while empirical knowledge on the relative effectiveness of these approaches is rare. To bridge this gap, the current research examines and compares the impact of AI-driven conversational agents to that of AI-oriented …
Published in E-Commerce for Future & Trends · Vol. 13, Issue 2, 2026 · pp. 15–32 Read article
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The Role of English Language in Communication: Multidisciplinary Perspectives
Abstract: The English language performs an essential role in communication, serving as the universal medium through which people exchange data, express feelings, and build relationships. This research explores the importance of language in communication, examining its role in human interactions, the dynamics of effective communication, and the socio-cultural impact of language. Communication is a skill that involves a systematic and continuous process of speaking, listening, and understanding. We are also taught …
Published in Emerging Trends in Languages · Vol. 3, Issue 1, 2026 · pp. 1–7 Read article
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Punjab’s Wetlands as Inland Analogues of Marine Ecosystems: Status, Stressors and CommunityLed Conservation.
Abstract: Aquatic and wetland ecosystems in Punjab, India, represent ecologically significant yet increasingly degraded socioecological systems embedded within an intensively managed agrarian landscape. Despite their recognised importance, existing studies largely treat these systems using conventional freshwater ecological frameworks, with limited integration of microbiologically mediated processes and broader ecosystem theories. A key research gap, therefore, lies in the lack of interdisciplinary approaches that can holistically interpret wetland structure, function, and governance across …
Published in International Journal of Marine Life · Vol. 3, Issue 1, 2026 · pp. 31–51 Read article
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Enhancing Rhizoremediation of Petroleum Hydrocarbon-Contaminated Soil Using Brachiaria ramosa: A Review of Plant Growth Promotion and Degradation Potential
Abstract: This paper examines rhizoremediation as a sustainable and environmentally acceptable remediation technique in response to the growing problem of petroleum hydrocarbon pollution in soils. Brachiaria ramosa, a tropical grass species that may be useful in contaminated settings, is the main emphasis. A critical analysis of the literature on plant growth-promoting rhizobacteria (PGPR), microbial consortia involved in hydrocarbon breakdown, and rhizosphere-mediated degradation is conducted. There is a thorough discussion of important …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 1, 2026 · pp. 24–41 Read article
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A Comprehensive Review on Monkeypox Infection
Abstract: Monkeypox represents a zoonotic viral affliction instigated by the monkeypox virus, which is classified within the Poxviridae family and is distinct from the virus that causes chickenpox. Initially recognized in 1958, this infection has recently attracted international scrutiny due to its escalating incidence beyond traditional endemic territories. This review delivers an exhaustive examination of monkeypox, encompassing its epidemiology, viral morphology, modes of transmission, pathogenesis, clinical presentations, and therapeutic interventions. The …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 1, 2025 · pp. 23–32 Read article
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Comprehensive Analysis of Advanced Methods, Materials and Technologies for Portable Water Purifier in Domestic and Industrial Applications
Abstract: Safe drinking water is still a major problem in developing countries, especially in areas with water scarcity, pollution or poor infrastructure. Portable water purifiers have come to the fore as solutions that are realistic to narrow this gap providing flexibility and accessibility in household and industrial environments as well. In this study, promising techniques, materials and technologies used in portable water treatment equipment design have been reviewed. We review important …
Published in Trends in Mechanical Engineering & Technology · Vol. 15, Issue 2, 2025 · pp. 8–19 Read article
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PEGASUS: A Privacy Killer—Some Unknown Facts
Abstract: In today’s time, world is full of various new and advanced technologies. With every new technology arriving, comes new challenges which cannot be ignored. Today, almost every industry has its root penetrated deep into the internet and its applications. Therefore, internet becomes a mediator or a common platform where organizations keep and exchange their data. With the increase in cybercrimes, providing cyber security is the need of the hour. One …
Published in Journal of Web Engineering & Technology · Vol. 9, Issue 3, 2022 · pp. 8–12 Read article
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In Silico Screening of Terminalia chebula Phytocompounds as Potential Inhibitors of NTCP and DDB1 in Hepatitis B Virus Infection
Abstract: Hepatitis B virus (HBV) infection is a major global health concern, and chronic carriers are at risk of developing cirrhosis, hepatocellular carcinoma (HCC), and even death. Existing treatments can effectively inhibit viral replication, but they achieve little eradication of the virus because of covalently closed circular DNA (cccDNA) retention. In this investigation, bioactive compounds of Terminalia chebula, a plant known for its hepatoprotective and antiviral properties in traditional medicine, were …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 1, 2026 · pp. 33–44 Read article
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Recent Advancement in Understanding the Aetiopathogenesis of Psoriasis: A Review
Abstract: Psoriasis is an immune-mediated inflammatory skin disease with periods of recurrence and remission. Various researches have globally explored the aetiopathogenesis of psoriasis but still it is not crystal clear. Abundant evidence suggest that dysregulation of immune cells in the skin, particularly keratinocytes, T cells, dendritic cells, natural killer cells, neutrophils, and macrophages play a vital role in the development of psoriasis. The combined effects of these cells explain most of …
Published in Research and Reviews : A Journal of Immunology · Vol. 7, Issue 2, 2017 · pp. 9–21 Read article
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A Review on Kaempferol Eye Drops for the Glaucoma Treatment
Abstract: One of the main causes of permanent blindness, glaucoma is defined by gradual damage to the optic nerve, mostly brought on by oxidative stress, neuroinflammation, and high intraocular pressure (IOP). The investigation of herbal alternatives is necessary since current synthetic therapies, such as beta-blockers and prostaglandin analogs, frequently result in ocular discomfort, systemic toxicity, and poor patient compliance. Clitoria ternatea contains kaempferol, a bioactive flavonoid that has shown anti-inflammatory, antioxidant, …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 110–121 Read article
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Superoxide Dismutase: An Emerging Target for Human Therapeutic
Abstract: Superoxide dismutases (SODs) represent a very essential antioxidant guard beside oxidative stress in the body. The enzyme does something as an excellent restorative mediator next to reactive oxygen species (ROSs)-mediated multiple sicknesses. The current review portrays the curative property of SOD in diverse physiological and pathological circumstances such as cancer, inflammatory diseases, gene mutation, cardio therapy, aging, neurodegenerative diseases, and diabetes. However, the enzyme has positive boundaries in experimental applications. …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 9, Issue 1, 2019 · pp. 165–172 Read article
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Preparation and Properties of Blends of Thermoplastic Polymer with Thermoplastic Starch
Abstract: Problems in making biodegradable plastics are incompatible between hydrophilic/polar and hydrophobic/non-polar ingredients. Ingredients like compatibilizers were added to improve the compatibility between the two ingredients. The purpose of this study was to determine the effect of thermoplastic potato starch (TPS) content and two compatibilizers (maleic anhydride, MA, and dibutyl maleate, DM) on melt flow behavior, mechanical features (tensile, bending, and Izod impact test), phase morphology, thermal behaviors (DSC, and TGA/DTG), …
Published in Journal of Catalyst & Catalysis · Vol. 9, Issue 1, 2022 · pp. 16–29 Read article