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175 articles for “Lead compound.”
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An Efficient Synthesis of Some Novel Benzo Coumarin Derivatives Under Solvent Conditions from 2-acetyl-benzo[f]chromen-3-one
Abstract: The synthesis of the target compounds began with the preparation of 2-[3-dimethylamino[acryloyl-3H-benzo[f]chromen-3-one. This intermediate was obtained through the reaction of 2-acetylbenzo[f]coumarin-3-one with N,N-dimethylformamide dimethyl acetal [DMFDMA[ under reflux conditions in xylene. The enaminone thus formed was subsequently reacted with 6-aminothiouracil in acetic acid, leading to the formation of 2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one. This compound served as a pivotal intermediate for the synthesis of a series of pyridotriazolopyrimidinones. These derivatives were synthesized by reacting …
Published in International Journal of Cheminformatics · Vol. 2, Issue 2, 2024 · pp. 33–46 Read article
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Environmental Pollutants and Biodiversity Loss: Analyzing the Role of Persistent Organic Pollutants in Ecosystem Decline
Abstract: Persistent Organic Pollutants (POPs) significantly impact biodiversity, with various factors influencing their effects on species and ecosystems. Species in poor body condition, like carnivores and predators, are more vulnerable to POPs due to weakened immune systems and reduced detoxification abilities. Dietary habits also affect the accumulation of POPs, as chemicals biomagnify up the food chain. Carnivores accumulate higher concentrations, leading to reproductive failures, hormonal imbalances, and death, while herbivores face …
Published in International Journal of Toxins and Toxics · Vol. 2, Issue 1, 2025 · pp. 9–20 Read article
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Polymer Chemistry and Composite Materials in Biomedical Applications
Abstract: The integration of polymer chemistry and composite materials has revolutionized biomedical applications. Recent advancements in polymer synthesis, functionalization, and nanotechnology have further expanded their applications, leading to significant improvements in biocompatibility, biodegradability, and mechanical performance. These polymeric carriers protect bioactive compounds from enzymatic degradation, enable controlled drug release, and improve therapeutic efficacy. The integration of polymer chemistry with nanotechnology has enabled the development of highly efficient, targeted therapeutic systems that …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 413–419 Read article
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Secondary Metabolites in Drug Development: Tracing Their Historical and Therapeutic Impact
Abstract: Secondary metabolites, also known as natural products, exhibit a level of structural and chemical diversity unmatched by synthetic small molecule libraries. These compounds, which have evolved to possess drug-like properties, continue to be a primary source for new medications and drug leads. Their discovery has significantly impacted advancements in chemistry, biology, and medicine, influencing drug development and therapeutic strategies throughout history. Derived from primary metabolic pathways such as photosynthesis, glycolysis, …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 2, 2024 · pp. 51–55 Read article
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Management of Steroid Induced Diabetes with Unani Medicine: A Case Report
Abstract: Background: Glucocorticoids (GC), such as prednisolone, are commonly used for their anti-inflammatory and immunosuppressive properties. However, chronic GC use can lead to adverse effects, including diabetes. This case study evaluates the efficacy of Arq Afsanteen, an Unani compound drug, in managing GC-induced diabetes. A 50-year-old man with a family history of type 2 diabetes and a history of partial gastrectomy was diagnosed with sarcoid tuberculosis and began treatment with ATT …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 11, Issue 3, 2024 · pp. 49–53 Read article
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Study of Groundwater Quality of Rewa, M.P. India: A Review
Abstract: Water is equivalent to life. One cannot predict life without water. Water is very essential for sustaining life in this planet. Water is an important compound as it sustains life however if It is not suitable for drinking or contaminated it may lead to an end of life. Therefore, the need of an hour is to analyse the quality of water before using it for any domestic purposes. There are …
Published in Research and Reviews: A Journal of Health Professions · Vol. 10, Issue 2, 2020 · pp. 18–24 Read article
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Noise Sources, Exposure, health effects and Control in Iron & Steel Foundry
Abstract: Foundries are one of the oldest industries and the most basic of all metallurgical processes, with two main procedures performed in a foundry: molding and metal casting. Workers are exposed to a wide range of hazardous compounds in the workplace due to the variety of materials and procedures performed in this industry, which can lead to chronic exposure to hazardous substances (physical and chemical). Noise is a major physical hazard …
Published in Journal of Industrial Safety Engineering · Vol. 8, Issue 2, 2021 · pp. 20–28 Read article
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In Silico Identification of Antimalarial Drug Targets and Screening of Potential Inhibitors in Plasmodium vivax
Abstract: AbstractMalaria is an infectious disease caused by the protozoan of the genus Plasmodium. It is a major problem in third-world countries, with hundreds of millions of infections and millions of fatalities annually. Plasmodium vivax is the most frequent and widely distributed cause of recurring (Benign tertian) malaria. Due to emergence of drug-resistance, one has to explore new dimensions in order to curb the menace. We propose a two-step strategy—first step …
Published in Research and Reviews : Journal of Computational Biology · Vol. 9, Issue 1, 2020 · pp. 52–75 Read article
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Protein Deficiency and Poisoning
Abstract: Proteins are the building blocks of enzymes, hormones and many other important compounds. So it is important to maintain its balance in the body. Excess or deficiency of protein may lead to certain diseases which are harmful for the human system. Diseases such as edema, fatty liver, increase in severity of infection, greater appetite, more risk for bone fracture, skin hair and nail problem, less muscle mass, nausea, headache, mood …
Published in Research and Reviews: A Journal of Medicine · Vol. 13, Issue 1, 2023 · pp. 9–14 Read article
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Design, Synthesis and Evaluation of Antitubercular Activity of Mannich Bases of Isoniazid-Containing Thiazolidin-4-one Rings
Abstract: Isoniazid (INH), the established antitubercular drug was selected as the lead for the design and development of antitubercular agents by many researchers. 4-thiazolidinones are well known heterocyclic compounds for their spectrum of biological activities such as antibacterial, antifungal [1], anticancer [2], antitubercular, anthelmintic, anti-inflammatory [3], analgesic [4], antithyroid, local anaesthetic, monoamine oxidase inhibition, anti-Toxoplasma gondii activity etc [5]. Modification of thiazolidinones via Mannich reaction to improve biological activity is also …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 7, Issue 1, 2016 · pp. 1–12 Read article
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Exploring Phytochemicals of Ficus religiosa against Corona Virus Protein using Molecular Modeling Techniques
Abstract: The current worst pandemic situation is brought about by novel Severe acute respiratory syndrome coronavirus 2 causing Covid-19 disease. The world fights against it with vaccines, self-sanitation techniques and drugs like ribavirin, beta-interferon and remdesivir which has not solved the problem to the desired extent. With technical and scientific developments in molecular biology field, though the genome and proteome of the organism is explored, potent drugs against it is still …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 8, Issue 2, 2023 · pp. 18–26 Read article
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Harnessing Ethylene and Brassinosteroids for Enhanced Agricultural Productivity and Food Quality
Abstract: This study provides a comprehensive review of the roles of ethylene and brassinosteroids, two vital hormonal regulators in plants, focusing on their impact on fruit ripening, stress responses, and overall plant growth. Ethylene, a gaseous plant hormone, is recognized as a key regulator in various physiological processes, particularly in the maturation of fruits. Its involvement in the ripening process has profound implications for agricultural practices, as it directly influences the …
Published in International Journal of Trends in Horticulture · Vol. 1, Issue 2, 2024 · pp. 29–32 Read article
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Photochemical Insights into Light: Responsive Heterocyclic Compounds
Abstract: eterocyclic compounds are significant in a wide range of chemical fields. They are crucial components of the structural makeup of bioactive substances. Such compounds can be conveniently transformed through photochemical processes. Chemical reagents are rarely utilized. It is possible for members of one compound family to change into members of another. There is discussion of three key categories of photochemical rearrangements involving heterocyclic compounds: Photochemical reactions involving hydrogen atom transfer …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 1, Issue 2, 2023 · pp. 01–07 Read article
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The Beneficial Effects of Short-term Therapy of Antidepressants on the Electrocardiograph Records in Patients Presented with Depression
Abstract: Normal 0 false false false EN-US X-NONE AR-SA Abstract:Drugs that are used in the psychiatric clinics or inpatients may interfere with the electrical activity of the heart and in certain circumstances may induce fatal cardiac arrhythmias. This study aimed to demonstrate the effects of short-term antidepressants compounds on the ECG records using the prolongation of QTc and JTc intervals as an indication of the harmful effects of antidepressants. A total …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 5, Issue 1, 2015 · pp. 19–23 Read article
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In Silico Tau Protein Kinase I Inhibitory Activity of Some Commercially Available Flavonoids
Abstract: Molecular docking is a frequently used tool in computer-aided structure-based rational drug design. Flavonoids are a group of natural products which exhibits various biological and pharmacological activities. The primary objective of this study was to investigate the tau protein kinase I inhibitory activity of flavonoids using in silico docking studies. Memantine, a known neuro-receptor antagonist is currently used in the treatment of Alzheimer’s disease (AD). In silico docking studies were …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 2, Issue 1, 2015 · pp. 6–12 Read article
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Review on: Elimination of Petroleum Hydrocarbons using Bacteriological Carpets
Abstract: In this review study, biodegradability of petrol hydrocarbon was premeditated on the petroleum sludge from the chemical industry using bacterial carpet. Bacterial carpet is consisting of biological fiber like jute fiber, coconut fiber. Accidentally, releasing of petroleum products are actual concern in the surroundings. Additionally, one of the main ecological difficulties at the present day is hydrocarbon pollution, which resulting from the activities associated with the chemical and allied industries. …
Published in Journal of Petroleum Engineering & Technology · Vol. 9, Issue 3, 2019 · pp. 21–27 Read article
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Health Hazards of Nanoparticles and Environmental Pollutants
Abstract: The exponential growth in the use of nanoparticles and the prevalence of environmental pollutants have raised significant concerns regarding their health hazards. Nanoparticles, owing to their unique physicochemical properties—such as small size, high surface areatovolume ratio, and chemical reactivity—can penetrate biological barriers, including the bloodbrain barrier, and interact at the cellular and molecular levels. This can lead to oxidative stress, inflammation, and cellular dysfunction, ultimately resulting in potential toxicity. Similarly, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 1, 2025 · pp. 1–9 Read article
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General Notion of Temperament
Abstract: and retort by their energy, then previous potentials become reduced. The concept of temperament is the column of Unani Medicine. This concept was firstly introduced by Hippocrates when he specified that “It is more important to know what category of person a disease has then to know that sort of disease a person has”. Galen reflected that one pair of qualities out of four possibilities was main leading to the …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · pp. 9–12 Read article
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General Notion of Temperament
Abstract: The term ‘Temperament’ is imitative from Latin word “Tempero” which means “to mix”. Mizaj is known as establishment of a new moderate quality, as a result of different characteristic of elements turn out and retort by their energy, then previous potentials become reduced. The concept of temperament is the column of Unani Medicine. This concept was firstly introduced by Hippocrates when he specified that “It is more important to know …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 9, Issue 1, 2022 · pp. 9–12 Read article
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An Evaluation of Photodynamic Therapy in Dentistry with a Focus on Surgical Applications
Abstract: Throughout the centuries, various forms of light therapy have found applications in medical settings. These include phototherapy for neonatal jaundice, psoralen molecules combined with ultraviolet A light (PUVA) in dermatology, and techniques like photodynamic therapy (PDT) and photodetection. In recent years, the emergence of antibiotic-resistant strains, such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis, has necessitated the exploration of alternative treatment options. Photodynamic antimicrobial chemotherapy (PACT) has arisen as …
Published in Research and Reviews : Journal of Surgery · Vol. 12, Issue 3, 2023 · pp. 1–9 Read article