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1680 articles for “BCS Class II/IV drugs”
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Role of Artificial Intelligence in Simulation and Therapeutics in Neurodegenerative Diseases
Abstract: Neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, etc., are a cause of significant mortality rates due to a lack of curative treatments and their complex nature. Traditional therapeutic methodologies have several disadvantages such as slow diagnosis and a lack of effective treatments. They mainly focused on the management of the disease rather than curing it. The integration of artificial intelligence in the simulation and therapeutics of neurodegenerative …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 16, Issue 1, 2026 · pp. 19–29 Read article
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Formulation and Evaluation of a Natural Excipients-Based Diclofenac Sodium Topical Ointment
Abstract: The present study reports the formulation and evaluation of a diclofenac sodium topical ointment incorporating natural excipients to improve skin compatibility and formulation sustainability. Conventional topical non-steroidal anti-inflammatory drug (NSAID) formulations frequently rely on synthetic excipients that may cause dermal irritation and pose environmental concerns. To address these limitations, a 1% w/w diclofenac sodium ointment was developed using aloe vera gel, glycerin, xanthan gum, peppermint oil, vitamin E, and isopropyl …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 2, 2026 Read article
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Environmental Impact Assessment of Ocean Energy Converters Using Quantum Machine Learning
Abstract: The accelerating deployment of ocean energy converters (OECs) across tidal, wave, osmotic, and thermal domains necessitates rigorous, data-intensive environmental impact assessment (EIA) frameworks capable of modelling multi-stressor marine ecosystems in real time. Classical machine learning approaches, while operationally mature, encounter scalability bottlenecks and feature correlation limitations when applied to the high-dimensional, non-linear datasets characteristic of offshore monitoring networks. This paper presents a comprehensive quantum machine learning (QML) framework for the …
Published in Journal of Energy, Environment & Carbon Credits · Vol. 16, Issue 1, 2026 · pp. 22–31 Read article
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A Technical Blueprint for AI-Driven Localization in 6G Mobile Networks
Abstract: The advent of sixth-generation (6G) wireless systems promises unprecedented spatial resolution, ultra-low-latency, and pervasive connectivity, turning mobile localization from a peripheral service into a core enabler of immersive extended reality (XR), autonomous logistics, and digital twins. Yet, the sheer scale of dense terahertz (THz) deployments, the stochastic nature of reconfigurable intelligent surfaces (RIS), and the dynamic interference landscape render traditional model-based positioning techniques inadequate. This work investigates how artificial intelligence …
Published in Journal of Mobile Computing, Communications & Mobile Networks · Vol. 13, Issue 1, 2026 · pp. 26–34 Read article
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From Baseline Survey to Management Plan: A Systematic Framework for Port-Specific Mitigation of Underwater Radiated Noise
Abstract: The growing recognition of underwater radiated noise (URN) as a significant marine pollutant necessitates the development of actionable management frameworks at the port level, where noise sources are concentrated, and impacts can be particularly acute. While international guidelines exist, a standardized methodology for ports to transition from assessment to implementation is lacking, particularly in regions with high biodiversity and developing maritime infrastructure. This paper presents and demonstrates a systematic, four-phase …
Published in Journal of Offshore Structure and Technology · Vol. 13, Issue 1, 2026 · pp. 22–30 Read article
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Comprehensive Evaluation of Quercetin from Bauhinia purpurea for Its Anti-Acne and Anti-Inflammatory Potential, Including Advances in Quercetin-Loaded Nanogel Formulation
Abstract: Acne vulgaris is among the most prevalent chronic inflammatory dermatoses in clinical dermatology, afflicting a substantial proportion of the global adolescent and adult population. Conventional pharmacotherapies — including topical retinoids, benzoyl peroxide, and systemic antibiotics — remain the therapeutic mainstay; however, their long-term utility is progressively undermined by adverse cutaneous reactions, systemic toxicity, and the rising prevalence of antibiotic-resistant Cutibacterium acnes strains. These limitations have intensified scientific interest in plant-derived …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 2, 2026 Read article
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Molecular Dynamics and Therapeutic Architectures of Cannabinoid Receptors: A Comprehensive Review
Abstract: Expanding on these foundations, recent structural biology studies using cryo-electron microscopy have provided high-resolution insights into the conformational dynamics of CB₁ and CB₂ receptors. These findings have enabled a more precise understanding of ligand–receptor interactions, particularly how agonists, antagonists, and reverse agonists stabilize distinct receptor states. Such knowledge is critical for rational drug design, allowing researchers to selectively modulate downstream signaling pathways. For instance, CB₁ receptors primarily couple to Gi/o …
Published in International Journal of Cheminformatics · Vol. 4, Issue 1, 2026 · pp. 36–40 Read article
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Uttarabasti in Female Infertility: A Retrospective Analysis of Clinical Outcomes and Safety Profile
Abstract: Background: Uttarabasti (UB) is a specialized Panchakarma procedure involving intrauterine instillation of medicated Sneha, classically indicated in Yonivyapad and Vandhyatwa. It facilitates targeted local drug delivery, bypassing gastrointestinal metabolism and enabling direct therapeutic action at the uterine level. In Ayurvedic understanding, UB achieves Garbhashaya Shuddhi and Apana Vata Anulomana — the two primary pathological corrections considered essential in Vandhyatwa. Infertility affects an estimated 10–15% of couples globally, with a substantial …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 13, Issue 2, 2026 Read article
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Machine Learning Based Sentiment Analysis of Student Feedback in Higher Education
Abstract: Educational institutions routinely collect feedback from students to understand their perceptions of academic programs, infrastructure, and campus facilities, to improve the overall quality of the college environment. In current practice, feedback is often gathered using numerical or grade-based rating systems, which tend to oversimplify student opinions and may overlook important details related to their level of satisfaction. In contrast, open-ended textual feedback allows students to clearly express their views, concerns, …
Published in International Journal of Data Structure Studies · Vol. 4, Issue 1, 2026 · pp. 01–10 Read article
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Academic Performance and Its Associated Factors Among Pawe Health Science College Students in Benishangul-Gumuz Regional State, North-West Ethiopia
Abstract: Background: Academic performance can be defined as the degree to which a teacher, an institution, or a student meets short-term or long-term learning objectives. Continuous assessments and the student’s overall cumulative grade point average (CGPA) are typically used to measure academic achievement. Objectives: To assess academic performance and its associated factors among students, in the case of Pawi Health Science College, Benishangul-Gumuz Regional State, North-West Ethiopia, 2025. Methods: An institution-based …
Published in Journal of Nursing Science & Practice · Vol. 16, Issue 1, 2026 · pp. 24–35 Read article
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AI-Driven Pharmacogenomics and Precision Medicine: Future of Personalized Therapy
Abstract: Pharmacogenomics and artificial intelligence (AI) are emerging as important drivers of precision medicine, enabling healthcare systems to adopt individualized therapeutic approaches. Pharmacogenomics examines how genetic variations influence drug response, efficacy, metabolism, and toxicity, while AI provides advanced computational tools for analyzing complex genomic and clinical data. This review highlights the integration of AI-driven pharmacogenomics in personalized therapy and its potential to improve treatment outcomes. Machine learning, deep learning, natural language …
Published in Emerging Trends in Personalized Medicines · Vol. 3, Issue 2, 2026 · pp. 1–12 Read article
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Role of Impaired Digestion in Disease Pathogenesis: According to Unani System of Medicine
Abstract: The relationship between digestion and disease occupies a central position in Greco-Arab (Unani) medicine, as emphasized by classical physicians such as Ibn Sina and Al-Razi. In Unani medicine, digestion (Haḍm) is not confined to the gastrointestinal tract alone but represents a comprehensive physiological and metabolic process involving four sequential stages: gastric digestion (Haḍm-e-Mi‘dī), hepatic digestion (Haḍm-e-Kabidī), vascular digestion (Haḍm-e-‘Urūqī), and tissue digestion (Haḍm-e-‘Uḍwī). These stages are governed by Quwwat-e-Hāḍima (digestive …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 13, Issue 2, 2026 Read article
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Ashaya as Abode: Reconciling Ayurvedic Vata Theory with Intestinal Neurophysiology
Abstract: Background-Ashaya refers to a site or structure within the body where a substance resides. Ashaya refers to the internal sites or structures within the body where various substances reside Commonly, seven Ashayas are described in males, while in females there are eight, while Sharangadhara has described 9 Ashayas. Vatashaya denotes the specific site of Vata Dosha, which is considered the chief among the three Doshas due to its vital role …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 15, Issue 2, 2026 Read article
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Chlorophyll-Mimicking Ti₃C₂Tₓ MXene-Conjugated Polymer Nanocomposites: Nature-Inspired Exciton Funneling Architecture for Ultrahigh Photon-to-Electron Conversion in Organic Solar Cells
Abstract: Green plant photosynthetic machinery is one of the most efficient natural systems for harvesting solar energy and converting it into useable electronic charge. Specifically, chlorophyll molecules in the Light-Harvesting Complex II (LHC-II) achieve nearly unity quantum yield via a well-organized Förster Resonance Energy Transfer (FRET) mechanism that enables excitons to migrate towards reaction centers. This study presents a bio-inspired nanocomposite architecture using two-dimensional Ti₃C₂Tₓ MXene nanosheets functionalized with chlorophyll-mimicking porphyrin …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 114–130 Read article
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Unani Concepts of Brain Pathology: Humoral Mechanisms in Māddī Neurological Disorders
Abstract: Background The Unani System of Medicine (USM) considers the brain (Dimāgh) as the principal organ of Quwā Nafsāniyya (psychic faculties), responsible for sensation, cognition, memory, movement, and emotional regulation. According to Unani principles, health is maintained through equilibrium of Mizāj (temperament) and Akhlāṭ (humours), whereas disease develops when this balance is disturbed. Among neurological disorders, Sū’-i-Mizāj Māddī Dimāgh refers to pathological conditions of the brain associated with the accumulation of …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 15, Issue 2, 2026 Read article
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The Global and Regional Challenge of Pan-Antibiotic Resistance: A Review of Emerging Threats and Mechanisms
Abstract: Antimicrobial resistance (AMR) is one of the major and most intricate threats to the health of the 21st century as it is core to the undermined expertise of the common clinical practice and public health security worldwide. The problem is characterized by the extensive development of bacterial pathogens into extremely drug-resistant (XDR) and pan-drug-resistant (PDR) so- called superbugs faster than it can be done with therapeutics. It is a synthesis …
Published in International Journal of Antibiotics · Vol. 3, Issue 2, 2026 Read article
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Valorization of shrimp processing waste by green methodology and its application in Chitosan-PEG composite film
Abstract: Shrimp processing waste is mostly unidentified marine by product, presents considerable environmental pollution which also offers a rich but not fully exploited sources of biopolymers. The current work presents a sustainable method to convert shrimp processing waste into chitosan a biopolymer by green methodology. Isolation of chitin to chitosan from shrimp processing waste was carried through four green methodology steps i. Demineralization using citric acid ii. Deproteinization using papain iii. …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 Read article
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A Clinical Case Study of Kaphaja Visarpa W.S.R to Pemphigus Vulgaris
Abstract: Background: Visarpa is a classical Ayurvedic dermatological condition characterised by Swift spreading of lesions across the skin involving Twak, Lasika, Rakta, and Mamsa. Kaphaja Visarpa, a subtype dominated by Kapha dosha, presents with pallor-coloured oily lesions, itching, swelling, and mild pain. Case Summary: A 58-year-old female patient, a known case of Type 2 Diabetes Mellitus, presented with shiny, oedematous, pale skin lesions across the chest, abdomen, and back, accompanied by …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 15, Issue 2, 2026 Read article
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Analysis of the coffee market structure, conduct, and performance in the Gimbo District of the Kaffa Zone in Southwest Ethiopia
Abstract: Coffee is a vital export commodity for Ethiopia, contributing significantly to the country's GDP and rural livelihoods. In the Kaffa Zone, particularly in Gimbo District, coffee production serves as the primary source of income for smallholder farmers. Despite its economic importance, the coffee market in the study area faces several constraints, including low production capacity and inadequate market infrastructure. This study aimed to identify key actors in the coffee market …
Published in Research & Reviews : Journal of Agricultural Science and Technology · Vol. 15, Issue 2, 2026 · pp. 63–81 Read article
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ASSESSING OF FOREST STRUCTURE USING EARTH OBSERVATION DATA: ACASE STUDY IN MUNESSA FOREST, OROMIA REGION, ETHIOPIA
Abstract: Forest structure is essential for estimating forest-related carbon emissions, analyzing forest degradation, and quantifying the effectiveness of forest restoration initiatives. However, forest structure quantification is only limited to the specific area of interest without considering the whole forest coverage. Remote sensing data can easily deliver a large area to assess forest structure. Therefore, this study aims to assess forest structure of Munessa Natural Forest by integrating satellite based light detection …
Published in International Journal of Land Read article