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747 articles for “Targets”
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Investigating mosquito innate immune defence mechanism towards malaria vaccine development
Abstract: Mosquito-borne diseases weigh heavily on public health across the globe. The mosquito’s innate immune system certainly decides whether malaria parasites survive inside the vector, and that sighted it as a logical place to discover new vaccine ideas. In this review, we examine how Anopheles mosquitoes defend themselves against Plasmodium parasites and how those defenses could be turned into tools for malaria control. We focus on three layers of immunity: antimicrobial …
Published in International Journal of Insects · Vol. 3, Issue 1, 2026 · pp. 50–54 Read article
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Pharmacodynamics and Drug–Receptor Interactions: Integrating PK/PD Modeling with Modern Drug Development
Abstract: Understanding drug action requires an integrated perspective of pharmacodynamics and pharmacokinetics, which together determine therapeutic efficacy and safety. This review provides a comprehensive overview of the mechanisms underlying drug action, with particular emphasis on drug–receptor interactions and their role in modulating physiological responses. Drugs exert their effects primarily through interactions with specific biological targets, including receptors, enzymes, ion channels, and transporters, resulting in a spectrum of desired and adverse outcomes. …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article
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Machine Learning-Based Quantification of Polymer Structure Property Relationships for Predictive Material Design
Abstract: Polymer structures exhibit complex, hierarchical arrangements that strongly influence macroscopic properties, yet consistent quantification remains challenging due to nonlinear interactions and limited unified modeling strategies. Existing approaches inadequately capture generalized structure–property mappings across diverse polymer systems. This research aims to establish a machine learning-based quantification model for polymer structure–property relationships to support predictive material design. A Polymer Structure Property Dataset of 5,000 polymer samples includes structural descriptors and experimentally measured …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 737–754 Read article
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Mass Spectrometry–Based Phosphoproteomic Markers to Predict Kinase Inhibitor Response in Solid Tumors
Abstract: Mass spectrometry-based phosphoproteomics has emerged as a powerful tool for predicting kinase inhibitor responses in solid tumors, offering direct functional insights into signaling pathways that surpass traditional genomic profiling by capturing dynamic kinase activities and adaptive resistance mechanisms. Technological breakthroughs, including data- independent acquisition (DIA), trapped ion mobility spectrometry (timsTOF), and efficient enrichment methods like TiO2 or IMAC, now enable comprehensive profiling of over 40,000 phosphorylation sites from limited clinical …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 4, Issue 2, 2026 Read article
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Advancements in Battery Storage Technology for Renewable Energy Systems: Improving Reliability and Efficiency of Sustainable Energy
Abstract: Advances in battery storage technology are critical to improved reliability and efficiency of renewable energy systems, underpinning a sustainable energy future. Innovations exist in many different kinds of battery technologies- being developed and tested, and the leading contenders include innovations such as lithium-ion and sodium-ion, and much newer entrants like the solid-state and lithium-sulfur batteries. These developments respond to growing needs for sustainable solutions towards better integration of intermittent renewable …
Published in Journal of Alternate Energy Sources & Technologies · Vol. 17, Issue 2, 2026 Read article
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Recombinant Proteins and Nested Gene Regulation: Nutrient Driven Immune Response and Disease Resistance in Livestock
Abstract: Livestock production systems are increasingly challenged by infectious diseases, metabolic disorders, and environmental stressors that reduce productivity and compromise animal health. Advances in molecular biology and animal nutrition now offer new opportunities to strengthen disease resistance through integrated strategies that combine recombinant protein technologies, gene regulatory mechanisms, and nutrient mediated immune modulation. This review examines how recombinant proteins and nested gene regulation interact to shape nutrient driven immune responses in …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 1, 2026 Read article
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pH-Triggered In-Situ Nasal Gel Systems for Migraine Therapy: A Review
Abstract: Intranasal drug delivery has gained considerable attention as a non-invasive route for delivering drugs to both systemic circulation and the central nervous system, particularly for the treatment of migraine. Traditional nasal formulations such as sprays and drops often show poor therapeutic performance due to rapid mucociliary clearance and limited retention within the nasal cavity. To overcome these challenges, in-situ gel systems have been designed, which transform from a liquid to …
Published in Trends in Drug Delivery · Vol. 13, Issue 2, 2026 Read article
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AI and ML-Driven Immersive Technologies: A New Era in Education
Abstract: The very fast adoption of Artificial Intelligence (AI) and Machine Learning (ML) in education has transformed contemporary teaching and learning ecosystems driven by advances in immersive technologies and the growing engagement of global technology leaders with virtual environments. AI-powered educational platforms enable adaptive and personalized learning pathways by dynamically adjusting content, pace and instructional strategies to learners’ preferences, abilities and learning styles by improving engagement, retention and academic outcomes. Deep …
Published in International Journal of Education Sciences · Vol. 3, Issue 1, 2026 · pp. 116–123 Read article
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Design and Evaluation of Thermo-Responsive Poly(N-isopropylacrylamide)-Based Polymeric Nanoparticles for Temperature-Triggered Intratumoral Release of Doxorubicin in Solid Tumors
Abstract: Thermo-responsive polymeric systems have emerged as promising platforms for targeted intratumoral drug delivery in cancer therapy. This study aimed to develop and evaluate poly(N-isopropylacrylamide) (PNIPAM)-based polymeric nanoparticles as intelligent carriers for temperature-responsive delivery of doxorubicin (DOX) to solid tumors. Nanoparticles were synthesized via free radical polymerization using N-isopropylacrylamide as a thermoresponsive monomer and N,N′-methylenebisacrylamide as a crosslinker, forming a stable network with a tunable lower critical solution temperature (LCST).The optimized …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 159–168 Read article
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High-Gain Microstrip Patch Antenna for Satellite and Radar Applications
Abstract: The growing demand for high-speed wireless communication, satellite connectivity, and advanced radar systems has increased the necessity for compact and high-performance antenna designs. This study presents the design and analysis of a high-gain microstrip patch antenna intended for satellite and radar applications operating in the microwave frequency range. The proposed antenna structure is developed using a low-loss dielectric substrate to enhance radiation efficiency, bandwidth, and gain characteristics while maintaining a …
Published in Journal of Microwave Engineering and Technologies · Vol. 13, Issue 2, 2026 Read article
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Recent research trends in Bioethanol production – An Indian context
Abstract: Biofuels production is indeed a research hotspot. Prevention is better than cure. A paradigm shift from fossil based to bio-based fuels gives health, wealth and happiness. Among various biofuels, after biodiesel, bioethanol is next to and close to commercialization. The use of bioethanol is countries like Brazil and US is a success story. In India there is significant progress taking place in the transportation sector to use bioethanol as fuel …
Published in Journal of Energy, Environment & Carbon Credits · Vol. 16, Issue 2, 2026 Read article
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Awareness, Behavior, and Gaps: A Survey-Based Analysis of Personal Hygiene, Home Safety, and Road Safety Practices
Abstract: Personal hygiene and public safety remain two of the most critical yet behaviorally neglected pillars of community health in India. Despite decades of national health campaigns, a persistent gap continues to exist between what people know and what they actually do — particularly among urban youth. This cross-sectional, survey-based study examined awareness levels, behavioral practices, and compliance gaps across three interconnected domains: personal hygiene, home accident prevention, and road safety, …
Published in International Journal of Behavioral Sciences · Vol. 3, Issue 1, 2026 · pp. 65–72 Read article
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Polymeric Nanocomposite Aided Bioaugmentation for Marine Oil Spills – A Review
Abstract: Bioaugmentation is a promising, cost-effective bioremediation technique that enhances the degradation of marine pollutants by introducing hydrocarbon-degrading microorganisms. This review explores recent advancements in the use of bioaugmentation for petroleum biodegradation in marine environments, emphasizing the integration of microbial systems with polymeric and composite materials. Innovative methods, such as the immobilization of microbial cells within biodegradable polymeric matrices (e.g., alginate, chitosan, polyvinyl alcohol), have significantly improved microbial viability, metabolic efficiency, …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 1049–1061 Read article
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Electron Impact Single and Double Ionization Cross sections of Cr Ions and Atoms
Abstract: The theoretical calculations of electron impact single and double ionization cross section of Cr ion/atom have been estimated from threshold 32 eV to 1000 eV and 40eV to 6000 eV impact energies respectively. The modified Binary Encounter Approximations (BEA) has been used in the aforesaid calculation. These theoretical electron impact ionization cross sections of Chromium ion are of pivotal importance in the several studies. The Accurate expression of , cross …
Published in Research & Reviews : Journal of Physics · Vol. 15, Issue 2, 2026 · pp. 01–10 Read article
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The Impact of AI-Driven Real-Time Feedback Systems on Students’ Self-Regulated Learning and Academic Persistence in Secondary Schools, Nigeria
Abstract: Self-regulated learning (SRL) is essential for secondary school students to achieve academic success and lifelong learning competencies, particularly in contexts requiring greater learner autonomy. This expository article examines the potential of Artificial Intelligence (AI)-driven real-time feedback systems to support SRL processes—planning (forethought), monitoring (performance/control), and reflection—within Nigerian secondary education. Grounded in Zimmerman’s cyclical SRL model and Bandura’s Social Cognitive Theory, the paper conceptualises AI tools (e.g., intelligent tutoring systems, learning …
Published in Journal of Advancements in Library Sciences · Vol. 13, Issue 2, 2026 Read article
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Evaluation and Fabrication of 3D Printed Bioactive β-TCP/PCL Scaffolds for Bone Tissue Engineering
Abstract: Bone is one of the tissue types that is transplanted the most worldwide. Each year, there are over four million procedures that incorporate the use of bone grafts or substitutes to help heal bone deficiencies. These treatments are still limited greatly, and there is always a demand to help because of trauma, cancer, infection, and arthritis. Because of this, researchers are targeting improvement in developing bioactive three-dimensional (3D) scaffolds that …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 Read article
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Next-Generation mRNA Vaccines: Applications Beyond COVID-19
Abstract: Messenger RNA (mRNA) vaccine technology has become a paradigm shift in contemporary medicine and, with remarkable success in the COVID-19 pandemic, has opened the door to a new wave of vaccines development. In contrast to the traditional vaccine methods, mRNA vaccines are based on the synthetic genetic code that allows host cells to express target antigens, thus eliciting strong humoral and cellular immunity. The speed of development, efficacy, scalability of …
Published in International Journal of Vaccines · Vol. 3, Issue 2, 2026 · pp. 15–26 Read article
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Nanotechnology-Based Cosmeceuticals for Anti-Aging and Skin Regeneration
Abstract: Nanotechnology has transformed the cosmetic industry of the cosmeceuticals by allowing the production of sophisticated delivery systems that improve the stability, penetration, bioavailability, and therapeutic efficacy of active ingredients in cosmetics. The present review identifies the value of nanotechnology-based cosmeceuticals in anti-aging and skin regeneration, with special focus on the recent developments in nanocarrier technologies and their use in dermatology. Many nanocarriers have exhibited great potentials in enhancing delivery of …
Published in Recent Trends in Cosmetics · Vol. 3, Issue 2, 2026 · pp. 33–45 Read article
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ML Analysis of Factors Affecting Vaccination in Rural Children: A Machine Learning Approach
Abstract: Vaccination remains one of the most effective public health interventions for preventing childhood diseases, yet rural regions in India continue to experience uneven immunization coverage due to multiple socioeconomic and geographic barriers. This research applies machine learning techniques to identify and analyze the major determinants influencing childhood vaccination uptake in rural communities. The study utilizes survey-based demographic, socioeconomic, and healthcare-related parameters to build predictive models that classify children as vaccinated …
Published in International Journal of Vaccines · Vol. 3, Issue 2, 2026 Read article
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Prospects and Growth Opportunities of Female-Owned Rural Farm Businesses in Plateau State, Nigeria
Abstract: The potential and growth chances of female-owned rural agricultural companies in Nigeria's Plateau State were investigated in this study. The objectives were to assess the prospects and opportunities available to female-owned rural farm businesses and to determine their effect on business growth and development across the state. The study covered female farm business owners engaged in crop production, livestock farming, mixed farming, and agro- processing across all 17 Local Government …
Published in Journal of Energy, Environment & Carbon Credits · Vol. 16, Issue 2, 2026 Read article