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614 articles for “progress”
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In Silico Exploration of Podophyllum Hexandrum-Derived Phytocompounds as Potential Therapeutics Against Small Cell Lung Cancer (SCLC): A Molecular Docking Approach
Abstract: Small Cell Lung Cancer (SCLC) is a fast-growing and aggressive type of lung cancer that spreads quickly strongly associated with smoking. It is characterized by symptoms, such as persistent cough, breathing difficulties, or hoarseness, though it can sometimes be asymptomatic which makes early detection challenging. The tumor suppressor gene TP53 is critical in regulating the cell cycle and preventing uncontrolled cell division. Mutations in TP53 result in the loss of …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 1–11 Read article
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Chronic Kidney Disease: A Comprehensive Review
Abstract: Chronic Kidney Disease (CKD) is a progressive condition characterized by a long-term decline in kidney function, leading to a gradual deterioration of the kidneys' ability to filter waste and maintain fluid balance. It is diagnosed when the Glomerular Filtration Rate (GFR) falls below 60 ml/min/1.73 m² or when there is evidence of kidney damage (such as proteinuria) lasting for 3 months or more. The most common causes of CKD are …
Published in International Journal of Emergency and Trauma Nursing and Practices · Vol. 3, Issue 1, 2025 · pp. 37–42 Read article
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A Review on Applications of Artificial Intelligence (AI) in Parkinsons’s Disease Diagnosis and Treatment and Its Future Challenges
Abstract: Parkinson’s disease (PD) is a long-term, progressive neurodegenerative disorder that mainly occurs in people older than 60 years, affecting nearly 1% of this population. It is chiefly marked by the loss of dopaminergic neurons in the substantia nigra, a crucial brain region responsible for controlling motor functions. The resultant dopamine deficiency significantly disrupts motor control, manifesting in clinical symptoms such as tremors, bradykinesia, muscle rigidity, and postural instability. While PD …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 15, Issue 3, 2025 · pp. 1–15 Read article
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Effects of Hydrotherapy Programmes on Knee Osteoarthritis
Abstract: Osteoarthritis (OA) of the knee is a progressive degenerative disorder characterized by the breakdown of articular cartilage, joint margins, and surrounding structures. It is one of the most common musculoskeletal conditions affecting weight-bearing joints, leading to functional limitation, pain, stiffness, and reduced quality of life. Although OA is irreversible, early intervention and appropriate therapeutic strategies can slow its progression and help delay invasive procedures such as total joint replacement. Hydrotherapy …
Published in International Journal of Orthopedic Nursing and Practices · Vol. 3, Issue 2, 2025 · pp. 18–22 Read article
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Monitoring The Hydrocarbon Utilizing Bacteria in Crude Oil Remediation Using Bio-Stimulant of Mint Leaf (Mentha Piperita)
Abstract: Conceptual monitoring of hydrocarbon utilization bacteria on crude oil remediation using bio-stimulant of mint leaf (Mentha piperita) was investigated. The bio-stimulant nutrient was determined by considering the available nitrogen, phosphorus, potassium, and hydrocarbon utilizing bacteria presence in both room and sun-dried samples of the remediant used. The mint leaf (Mentha piperita) was processed to obtain the powder form (nano particle size) of the bio-stimulant and the microbes isolated and identified …
Published in Journal of Materials & Metallurgical Engineering · Vol. 16, Issue 1, 2026 · pp. 34–39 Read article
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Women Empowerment: The Essential Role of Education for Women in India
Abstract: Education has long been acknowledged as one of the most powerful instruments of social transformation, and in the Indian context, it holds unique significance for women’s empowerment. The empowerment of women is central to reducing gender inequality, dismantling patriarchal norms, and achieving inclusive growth. Women’s education does not merely provide literacy; it develops autonomy, fosters confidence, and equips women with the skills necessary for meaningful participation in social, political, and …
Published in International Journal of Trends in Humanities · Vol. 3, Issue 1, 2026 · pp. 20–24 Read article
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Development of Zinc Gluconate Vitamin C Effervescent Tablet for Immunity Improvement and Management of Corona Virus Disease (COVID-19)
Abstract: The global pandemic of coronavirus disease- 2019 (COVID-19) continues to pose a threat to people, societies, and economic and healthcare systems. COVID-19s progression and lethality are determine by the host immune system, as is the case with many other diseases. revolutionary idea that has been used to treat other diseases is the control of inflammatory response and cytokine production based on immunonutrition. Some COVID-19 clinical trials are now using zinc, …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 1, 2024 Read article
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Identification of Secondary Metabolites from Zingiber officinale as Inhibitors for Keap 1-Nrf2 small Molecules through Molecular Docking Techniques
Abstract: Objective: Therapeutic plants aid in treating cancer-based cell signaling pathways and preventing certain risk factors. Zingiber officinale has a variety of anti-inflammatory characteristics also contributing to enhanced immunity, reducing cancer risk and used to target the KEAP NRF2. When overexpressed in response to oxidative stress and DNA damage, elevates the risk of developing multiple cancers. NRF2 cellular sensors, which also control and coordinate their expression aid in defending healthy cells …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 2, 2023 · pp. 35–48 Read article
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Reusable Plastic Advantages, Challenges, and Impacts on Waste Management and Conservation Efforts
Abstract: The widespread utilization and ill-advised removal of single-use plastics have prompted critical natural contamination and asset consumption. Accordingly, society is progressively looking for supportable other options, with reusable plastic arising as a promising arrangement. This exploration paper intends to dig into the idea of reusable plastic, investigating its advantages, difficulties, and likely effect on squander the executives and preservation endeavors. Drawing on existing writing, contextual investigations, and mechanical progressions, the …
Published in International Journal of Pollution: Prevention & Control · Vol. 2, Issue 1, 2024 · pp. 14–22 Read article
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Efficacy of Combination Therapy with Osimertinib and Afatinib in epidermal growth factor receptor-mutant non-small-cell lung cancer Patients
Abstract: Treatment options for patients with non-small-cell lung cancer who have epidermal growth factor receptor mutations are constrained by the emergence of resistance to epidermal growth factor receptor tyrosine kinase inhibitors. Osimertinib or afatinib alone, when tested in a laboratory model, led to the formation of drug-resistant clones harboring epidermal growth factor receptor secondary mutations. However, combining these drugs prevented the emergence of such mutations. In a Phase II clinical trial, …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 1, 2024 · pp. 13–24 Read article
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Analyzing the Cognitive Proficiencies of Artificial Intelligence Within the Legal Paradigm: Prospects Within the Jurisdiction of India
Abstract: The swift progress of artificial intelligence (AI) has become a pivotal factor in various industries, notably affecting the legal sector. This study extensively investigates the substantial effects of AI on legal research and case analysis, mapping out the progression of AI technology within the legal domain. The exploration goes beyond mere acknowledgment of AI‘s presence, delving into a nuanced analysis of its potential advantages and the formidable challenges it poses …
Published in Journal of Artificial Intelligence Research & Advances · Vol. 11, Issue 1, 2024 · pp. 84–112 Read article
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Examining Connective Tissue Changes Across Various Grades of Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma: A Histochemical Polymeric Investigation
Abstract: Oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC) represent a spectrum of potentially malignant disorders posing significant challenges in diagnosis and management. The tumor microenvironment, particularly alterations in the connective tissue, plays a crucial role in the progression of these lesions. This histochemical investigation comprised with embedded polymers aimed to examine connective tissue changes across various grades of oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC). …
Published in Journal of Polymer & Composites · Vol. 12, Issue 3, 2024 · pp. 124–137 Read article
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A Novel Categorization System for Pressure Ulcers Reframed in the Context of Bioinformatics
Abstract: Pressure sores are a serious complication of multi morbidity and lack of mobility. Pressure injuries are commonly encountered in geriatric patients. Certain well-recognized risk factors, such as immobility and incontinence, may predispose to the development of pressure injury (PI); consequently, risk factor modification is an important aspect of prevention and treatment. One of the fundamental documentation details when describing a wound is the use of the appropriate staging system. Each …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 11, Issue 2, 2024 · pp. 1–5 Read article
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The Effect of Alcoholic, Aqueous and Crude Extracts of Lemon citrus Seeds on Staphylococcus and Klebsiella Bacteria
Abstract: Five isolates of staphylococcus bacteria identified by phytic were obtained and activated on solid saline mannitol medium, where the colonies appeared in a golden color. Three extracts of dry lemon seeds were prepared (raw, 1% aqueous extract, 1% alcoholic extract). It was celebrated that the aqueous quotation was added operative on bacterial progress than the alcoholic and rudimentary sources. Three isolates of Klebsiella bacteria identified by VITEK were also obtained, …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 14, Issue 3, 2024 · pp. 32–36 Read article
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Viruses and Their Role in Periodontal Diseases: A Review
Abstract: Periodontal diseases are a group of inflammatory conditions that primarily affect the gums and other tissues surrounding the teeth. Traditionally, these conditions were thought to be driven largely by bacterial infections, with the bacteria triggering an immune response that leads to inflammation and tissue damage. However, recent research has revealed that viruses also play a significant role in the development and progression of periodontal diseases. Viruses, such as Human Cytomegalovirus, …
Published in Research and Reviews: A Journal of Dentistry · Vol. 15, Issue 3, 2024 · pp. 1–6 Read article
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Evaluating Advancements and Identifying Research Gaps in Automotive Spare Parts Demand Forecasting
Abstract: The automotive industry, a key driver of global economic activity, relies heavily on the effective management of spare parts to ensure vehicle longevity and reliability. Accurate prediction of demand for these components is imperative to uphold ideal stock levels, minimize expenditures, and elevate customer contentment. This review of literature assesses recent progressions in demand prediction methodologies for automotive spare parts, with a specific emphasis on conventional statistical methods and contemporary …
Published in Journal of Computer Technology & Applications · Vol. 15, Issue 3, 2024 · pp. 47–58 Read article
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Host Interface of Cystic Fibrosis and P. aeruginosa
Abstract: A clash between microbial infection and host immunity can contribute to multiple diseases. Cystic fibrosis is one of those diseases. It’s an autoimmune disorder and hyperinflammatory disease, caused by pseudomonas aeruginosa, it’s the most predominant pathogen causing this disease. The progression of the lung infection cystic fibrosis is driven by host pathogen interface that focuses on the host and the bacterial factors. The disease has an interplay between the host, …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 14, Issue 3, 2024 · pp. 9–31 Read article
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Competitive Programming and Its Importance in the Present World
Abstract: Competitive programming has become a vital skill set for both computer science students and professionals, fostering problem-solving abilities, algorithmic thinking, and time management in a highly competitive environment. This paper provides a comprehensive overview of competitive programming, beginning with its core principles and progressing through advanced strategies used by participants to solve complex problems efficiently. In addition to explaining fundamental concepts, the paper explores key algorithms and data structures frequently …
Published in Recent Trends in Parallel Computing · Vol. 11, Issue 3, 2024 · pp. 39–50 Read article
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Stingless Honeybee’s Rare Sugar and PCSK 9 - LDLR Interaction, A New Hope for Hormone Dependent Breast Cancer Patients – An In-silico Study
Abstract: Hypercholesterolemia is a lipid disorder characterized by elevated levels of low-density lipoprotein (LDL), commonly known as "bad" cholesterol. This condition is a significant risk factor in the development and progression of hormone-dependent breast cancer, as well as in the emergence of resistance to hormonal therapy. One of the key regulators of cholesterol metabolism is the proprotein convertase subtilisin/kexin type-9 (PCSK9) protein, which facilitates the degradation of the LDL receptor (LDLR) …
Published in International Journal of Cheminformatics · Vol. 3, Issue 1, 2025 · pp. 1–6 Read article
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Analysis of White Matter, Gray Matter, and Cerebrospinal Fluid Alterations in Neurological Disorders: A Deep Learning Approach
Abstract: This paper investigates the role of white matter (WM), gray matter (GM), and cerebrospinal fluid (CSF) alterations in the pathophysiology of neurological disorders, including Alzheimer’s disease, Parkinson’s disease, schizophrenia, and epilepsy. By leveraging advanced deep learning methodologies, we aim to automate the segmentation and analysis of brain structures from MRI scans, enabling a more detailed and precise evaluation of their roles in disease progression. These techniques allow for the identification …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 14, Issue 3, 2024 · pp. 21–27 Read article