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120 articles for “pharmacological action”
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Pharmacological Modeling of New Form of Anti-tumorigenic Medicines in Chemotherapy
Abstract: The existing methods of chemotherapeutic treatment do not permit to calculate the precise dose of medicine and the time of its action on the tumor that leads to unpredictability of result, and, therefore, to the ineffectiveness of the use of treatment itself. Furthermore, the damage of normal cells on chemotherapy becomes the reason for a whole series of complications, connected with side-effects action of chemotherapy. The paper presents the pharmacological …
Published in Trends in Drug Delivery · Vol. 6, Issue 1, 2019 · pp. 31–36 Read article
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Scorpion Poison-A Clinical Review
Abstract: Scorpion Venom is a Tasteless. It is slightly acidic in nature. The initial drop is more or less colourless but the subsequent one are translucent in normal conditions. The striated muscles in the stinger allow regulation of the amount of venom ejected, which is usually 0.1-0.6 mg. The venom dries up into a powdery mass, which later forms elongated whitish crystals, which gets dissolved in water. Lethal dose of Mesobuthus …
Published in Research and Reviews: A Journal of Toxicology · Vol. 11, Issue 2, 2024 · pp. 10–21 Read article
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Network Pharmacological Studies in Biological Interactions of Thymoquinone
Abstract: Thymoquinone, a bioactive phytochemical compound belonging to the class of benzoquinones, is prominently present in the plant Nigella sativa. Despite its widespread use, the precise molecular mechanisms underlying its beneficial effects remain elusive. To address this gap, we employed network pharmacology to investigate the actions of Thymoquinone (TQ). Our methodology encompassed the utilization of diverse bioinformatic tools to scrutinize this molecule of interest comprehensively. Initially, we retrieved the chemical structure, …
Published in Research and Reviews : Journal of Crop science and Technology · Vol. 12, Issue 3, 2023 · pp. 18–25 Read article
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Phytochemical, Pharmacological and Toxicological Studies of Solanum americanum: A Systemic Review
Abstract: Solanum americanum, a plant widely used in folk medicine, has recently gained attention in the scientific community due to its diverse therapeutic potential. The bioactive compounds found in different plant parts, such as alkaloids, flavonoids, and tannins, have significant medicinal effects. These compounds exhibit several pharmacological properties, such as antimicrobial, anti-inflammatory, anticancer, and antioxidant effects. However, despite these medicinal benefits, some compounds show significant toxicity to the human body if …
Published in Research & Reviews : Journal of Herbal Science · Vol. 14, Issue 2, 2025 · pp. 52–62 Read article
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A General Review of Mucuna Pruriens W.S.R to its effect on Parkinson’s Disease.
Abstract: Mucuna Pruriens is a very famous drug prescribed in classical ayurvedic science in various disorder of Nervous System including Kampavata .In Clinical Practice ,Physician used Levadopa as a Dopamine replacement agent in controlling bradykinetic symptoms apparent in Parkinson disease so used successfully in treatment of Parkinson disease.Kapikacchu(Mucuna Pruriens) is having Balya, Brimhanaha, Vrishya, and Vatahara properties and is a natural source of L-dopa. So, keeping in views of the degenerative …
Published in Research & Reviews : Journal of Herbal Science · Vol. 13, Issue 1, 2024 · pp. 1–6 Read article
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Pharmacological Comparison of Turmeric and Non-Steroidal Anti-Inflammatory Drugs in Pain Relief
Abstract: Pain is one of the most frequently encountered clinical symptoms affecting millions globally and is typically treated pharmacologically with nonsteroidal anti-inflammatory drugs (NSAIDs). However, long-term use of NSAIDs is associated with adverse effects such as gastrointestinal, renal, and cardiovascular issues. In recent years, turmeric and its main active compound, curcumin, have received considerable attention for their reported anti-inflammatory, analgesic, and antioxidant properties as natural therapeutic options. This review seeks to …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 13, Issue 1, 2026 · pp. 19–28 Read article
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Anti-Cancer Drugs-Common Types in Libya Tamoxifen: Structure and Synthesis
Abstract: This research reviews the role of anticancer organic compounds, focusing on Tamoxifen as a Selective Estrogen Receptor Modulator (SERM) and briefly comparing it to Vincristine and Vinblastine (Vinca alkaloids). At first, the review includes: classification of cancer stages, revealing symptoms of each stage. Moreover, the review gives an overview of the general classification of most of the cancer drugs, types of cancer drugs used specially in Libya, their structural differences …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 1, 2026 · pp. 114–123 Read article
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Literature review on Kalarchi - Caesalpinia bonduc (L.) Roxb
Abstract: AbstractKalarchi is one of the Siddha drug traditionally being in use since ancient times to treat Poly Cystic Ovarian Syndrome (PCOS). The botanical name of Kalarchi is Caesalpinia bonduc (L.) Roxb is belonging to the family Caesalpiniaceae. It is a climber up to 15 m long, throughout India, near sea-coast, especially all over Bengal, Bombay and whole of Southern India. Poly Cystic Ovarian Syndrome is the highly prevalence disease among …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 7, Issue 1, 2020 · pp. 1–6 Read article
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A Review on Natural Radio-protective Agents
Abstract: AbstractRadioprotectors play crucial role in safeguarding biological system from various damages to DNA (Deoxyribonucleic acid), protein molecules, lipids by peroxidation as well as hematopoietic, gastrointestinal, reproductive and central nervous system exposed to radiation dose especially against radiation injury in cancer survival patients undergoing radiotherapy. As over 40% patients require this therapy, during the treatment where ionizing radiation is used to shrivel tumors and exterminate cancer cells by disrupting their DNA. …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 10, Issue 2, 2020 · pp. 20–31 Read article
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Ethnomedicinal, Pharmacological and Phytochemical Screening of Supari (Areca catechu Linn.): A Review
Abstract: Supari (Areca catechu Linn.) is a tall tree about 10–20 m long. It is used both locally and internally. Local application is beneficial in various acute inflammatory conditions in the form of gargle, vaginal douche or abzan, decoction, juice and oil. Internally it act as muqavvie-qalb (cardiotonic) and muqavvi-e-ama (intestinal tonic), sozish meda (gastric irritation), dries the excessive secretions of mouth, used in vomiting and nausea, strengthen the teeth and …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 8, Issue 1, 2018 · pp. 6–20 Read article
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Pharmacology of Herbal Drugs: Ayurvedic Approach
Abstract: Herbal drugs are gaining acceptance globally. The present approach of studying them is based on modern parameters. Most of these drugs are described in ancient Ayurvedic treatises and so Ayurvedic method of studying pharmacology is necessary. It is also necessary to study pharmacokinetics as per Ayurveda only. The study of the herbs is to be done in following steps. The first step is to study fivefold properties of herb, i.e., …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 1, Issue 2, 2014 · pp. 12–14 Read article
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A Review on Phytochemistry and Pharmacology of Macaranga peltata
Abstract: Macaranga peltata, categorized within the Euphorbiaceae family, represents a prevalent pioneer arboreal species across Southeast Asia, specifically in regions such as India and Sri Lanka. This review scrutinizes the phytochemical properties and pharmacological profiles of Macaranga peltata, underscoring both its historical medicinal applications and prospective therapeutic roles. The plant exhibits a rich composition of secondary metabolites, encompassing flavonoids, stilbenes, tannins, and terpenes, with the majority of these compounds being extracted …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 1, 2025 · pp. 50–59 Read article
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Exploring The Multitarget Pharmacological Mechanism of Diabex for T2dm by Combining Network Pharmacology and Molecular Docking Techniques
Abstract: Objective: Hyperglycemia brought on by an absolute or relative absence of insulin synthesis or action characterises a set of illnesses known as diabetes mellitus. Chronic hyperglycemia in diabetes mellitus has been linked to organ damage, heart, and blood vessels. The persistent metabolic condition Diabetes is a severe global issue with negative social, health, and economic effects. It is a type of metabolism disorder that interferes with food digestion in the …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 3, 2023 · pp. 62–73 Read article
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From Clinic Formulation to Development of Acebrophylline
Abstract: Acebrophylline, a commonly utilized bronchodilator with anti-inflammatory properties, has become a key therapeutic option for managing respiratory conditions like asthma, chronic obstructive pulmonary disease (COPD), and chronic bronchitis. This review explores the journey of Acebrophylline from its clinic formulation to its development and commercialization, focusing on the key aspects of formulation strategies, pharmacological properties, and regulatory considerations. The drug’s dual mechanism of action, which involves both bronchodilation and anti-inflammatory effects, …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 1, 2025 · pp. 35–48 Read article
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Activity of Cannabinoids in Type II Diabetes
Abstract: The present research is a theoretical study of the medicinal use of Cannabis (cannabinoids) compounds in Type II Diabetes based on literature citing animal models and available clinical evidence from human studies. The study emphasizes the positive physiological actions and benefits of cannabinoid compounds in Type II Diabetes. The pharmacological activities of cannabinoid compounds in Type II Diabetes have been studies only in limited human clinical trials that were often …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 7, Issue 2, 2017 · pp. 1–5 Read article
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Acetaminophen: Current Understanding and Future Directions in Pharmacology
Abstract: In this review, acetaminophen is described as one of the most widely used analgesic and antipyretic medications worldwide due to its effectiveness and reduced gastrointestinal toxicity compared with traditional NSAIDs. Its precise mode of action is still unclear despite widespread therapeutic use. Acetaminophen has little peripheral anti-inflammatory effect and largely acts within the central nervous system, in contrast to NSAIDs, which mainly block peripheral cyclooxygenase (COX) enzymes and lower inflammation. …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 Read article
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In Silico Molecular Docking of Indigofera tinctoria Phytocompounds to Target EGFR/ERK and FGFR/FGF Pathway Proteins Involved in Prostate Cancer
Abstract: Objective: Prostate cancer being the second major cause of cancer-related deaths in males, affects the small walnut-shaped gland below the bladder called the prostate gland. The epidermal growth factor protein (EGFR), cascade protein (ERK), and fibroblast growth factor proteins (FGFR and FGF) are involved in the different signaling pathways that lead to the formation of different products, that are responsible for the progression of cancer and thus can be considered …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 34–56 Read article
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Morphine: A Pharmacological Perspective on Its Cancer Pain Management
Abstract: Morphine continues to be a key treatment in managing cancer pain because of its strong pain-relieving effects and established clinical history. Despite the emergence of alternative opioids and pain management therapies, morphine continues to be widely prescribed, particularly in palliative care settings. However, its use has been accompanied by concerns regarding tolerance, dependence, and adverse effects, which complicate long-term administration. This review explores the pharmacological aspects of morphine in cancer …
Published in Trends in Drug Delivery · Vol. 12, Issue 1, 2025 · pp. 1–8 Read article
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Chompound contaning oxadiazole derivatives and their potential therapeutic uses.
Abstract: Derivatives of oxadiazole or furadi azole rings constitute a significant class of heterocyclic substances. Oxadiazole is a heterocyclic, five-membered ring with two carbons, one oxygen atom, two nitrogen atoms, and two double bonds. They are produced by substituting two nitrogen (-N =) atoms for two methylene groups (= CH) in furan. The furan ring's aromaticity was significantly decreased by substituting these groups, resulting in a conjugated diene character. There were …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 15, Issue 1, 2024 · pp. 68–74 Read article
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Psychoactive and Physiological Homogeneity of Cannabis: A Literature Review: Actions of the Medical Plant that Takes Care of Itself
Abstract: Naturally occurring plants like Cannabis and the biologically ubiquitous alkaloids (e.g., morphine, quinine, and atropine) are composed of mostly physiological and psychoactive compounds. Extracts of the Cannabis plant are not alkaloid substances nor are they not related chemically to alkaloids, having no component nitrogen in their structures. Three species of Cannabis (marijuana) are recognized in scientific classifications: Cannabis sativa, Cannabis indicus and Cannabis ruderalis. Cannabis sativa is the species that …
Published in Research and Reviews : A Journal of Immunology · Vol. 7, Issue 2, 2017 · pp. 1–4 Read article