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177 articles for “in-silico studies.”
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In-Silico Docking of Rubia cordifolia Phytocompounds as Potential MMP-2 Inhibitors for Varicose Vein Management
Abstract: Varicose veins are one of the most common disorders, affecting the vein structure and function of lower limbs, yet there has been no absolute cure found yet. One of the underlying causes for worsening of the condition is the proteolytic activity of MMPs which are a group of enzymes that affect the extracellular matrix (ECM) surrounding the affected veins. Phytocompounds of Rubia cordifolia (Manjishta) were docked against the MMP-2 protein …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 2, 2025 · pp. 31–42 Read article
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In-silico screening of phytochemicals for identification of an alternative therapy for thyroid cancer
Abstract: Thyroid cancer remains a significant health concern globally, necessitating the exploration of novel therapeutic alternatives to improve treatment outcomes. This study targets COT kinase (Cancer Osaka Thyroid Kinase), a protein implicated in the progression of thyroid cancer, using molecular docking methods with various phytochemicals to identify potential therapeutic compounds. PyRx and Discovery Studio were employed to evaluate the interactions and binding affinities of a diverse set of natural compounds with …
Published in International Journal of Toxins and Toxics · Vol. 2, Issue 2, 2025 · pp. 31–55 Read article
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Sequence analysis, DNA Methylation and Molecular therapy of Oral cancer caused by Human Papilloma Virus
Abstract: DNA methylations with oral cancer are been associated with high-risk Human Papillomavirus (HPV) and Epstein-Barr Virus (EBV) onco-proteins interactions may cooperate to increase disease severity. The work focused on human papillomavirus strain 16, a high-risk, sexually transmitted responsible for 95% of all cervical cancers and a large portion of oropharyngeal cancers. The prediction of genes from has shown seven genes from HPV16 strain. Based on gene identification studies, Human papilloma …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 4, Issue 2, 2026 · pp. 1–9 Read article
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In Silico Docking Analysis to Identify Therapeutic Benzoic Acid Derivatives for Acute Myeloid Leukaemia
Abstract: Background: The study is anchored to initiate subjugation against modern cancer therapy for Acute Myeloid Leukaemia (AML) which involves natural therapeutics as an alternative therapy that would degrade the prospect of adverse side effects along with anti-cancer properties. Objectives: Collate the various characteristics of Giltertinib with natural benzoic acid derivative phytochemicals for a disquisition regarding their similarities and differences in the context of providing adverse side effects. Methods: ADME toxicity …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 · pp. 50–63 Read article
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Exploring the Therapeutic Potential of Phytochemicals in Aloe Barbadensis Miller Through Molecular Docking for Ulcerative Colitis Management
Abstract: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by mucosal inflammation of the colon, often associated with immune dysregulation and oxidative stress. Natural compounds have gained significant attention as alternative therapeutic agents due to their efficacy and minimal side effects. Quercetin, a flavonoid abundantly found in Allium cepa (onion), has demonstrated potent anti-inflammatory and antioxidant properties. This study employs an in silico approach to evaluate the therapeutic potential …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 13, Issue 1, 2026 · pp. 06–12 Read article
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Comparative study of Drain current of Symmetric and Asymmetric DGMOSFET with simulation in Silvaco_TCAD Software
Abstract: For nano regime devices the double gate MOSFET is one of the most promising and attractive devices. The main idea of a Double Gate MOSFET is to control the Si channel very efficiently by choosing the Si channel width to be very small and by applying a gate contact to both sides of the channel. This concept helps to suppress short channel effects and leads to higher currents as compared …
Published in Journal of Semiconductor Devices and Circuits · Vol. 8, Issue 1, 2021 · pp. 1–13 Read article
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The Comprehensive Study of Gallium Nitride (GaN) Semiconductor Technology
Abstract: Silicon is an important material in the field of semiconductors because of its special qualities. It has good semiconductor properties, is affordable, and can be found easily. However, it is becoming clear that silicon-based devices are reaching their limits in terms of what they can do. As a result, the search of alternative materials has been initiated. Gallium Nitride (GaN) is one such material. GaN is a type of semiconductor …
Published in Journal of VLSI Design Tools and Technology · Vol. 13, Issue 2, 2023 · pp. 1–11 Read article
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Computational Identification of Antigenic Proteins and Epitopes in Hantavirus sp. for Drug Repurposing
Abstract: Hantavirus is an emerging virus that spreads from animals to humans and can cause serious illnesses like hantavirus pulmonary syndrome (HPS) and hemorrhagic fever with renal syndrome (HFRS). there are no FDA-approved treatments available for these diseases. This study explores in-silico drug repurposing as a strategy to identify potential therapeutic candidates. The physicochemical, secondary structure, antigenicity, and post-translational modification analysis of hantavirus proteins – specifically the glycoprotein precursor, N protein, …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 20–26 Read article
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Molecular Docking of Nigella Sativa Phytocompound as Inhibitors of Transcription Factors NF-KB Implicated in Rheumatoid Arthritis
Abstract: Objectives: Nigella sativa, a plant considered around the world as the most treasured nutrient-rich herb for centuries together in different civilizations, is exceptionally known for its high levels of antioxidant properties. Free radical intensification due to oxidative stress plays a key role in the pathogenesis of rheumatoid arthritis by activating the NF-KB protein that regulates the expression of the genes involved in inflammation. Methods: This study involves in-silico approach to …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 42–55 Read article
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In Silico Investigation of 2,3-Dihydrobenzofuranfrom Centella asiatica: A Possible Pioneer in the Management of Tetanus
Abstract: Objective: Tetanus toxin (TeNT) is a neuroprotein toxin, the most toxic known. They have three functional domains and are structurally similar. They possess an N-terminal catalytic section (light chain), an internal domain for heavy-chain translocation (HN domain), and a C-terminal receptor binding domain for the heavy chain (Hc domain or RBD). Tetanus, an acute nerve-affecting disease, is provoked by a toxin-producing bacterium called Clostridium tetani. This bacterium is environmental, Gram-positive, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 19–30 Read article
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The Rheological Effect of SiO2 Nanoparticles Additives for NBR/CR Blends
Abstract: The rheological alteration of NBR/CR after adding various nano-quantities of silicon oxide (0–50) wt.% was studied. The rheological properties that were tested are viscosity, scorch time, cure time and max torque. Oscillating disk rheometer was used for measuring the above properties. The experimental results have shown that the silicon oxide additives have a good effect on viscosity and max torque during vulcanization, but at the same time the scorch and …
Published in Journal of Catalyst & Catalysis · Vol. 4, Issue 3, 2017 · pp. 1–4 Read article
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Development and Characterization of Al2O3-SiC Graphite Reinforced Al7075 Hybrid Composite
Abstract: The aim of the present investigation is to carry out a study of mechanical properties of aluminium alloy (7075) reinforced with silicon carbide, aluminium oxide and graphite. This composite is produced by the vortex method. The constituents of the composite are mixed uniformly by stirring action. Due to rotation of a mechanical agitator, hence creating vertex by stirring of molten metal, then by adding ingredients, the product was produced. Then …
Published in Trends in Machine design · Vol. 6, Issue 2, 2019 · pp. 15–21 Read article
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Molecular Docking Study: Targeting mycobacterium leprae ML2640 Protein Using Active Compounds from Coscinium fenestratum
Abstract: Objectives: Leprosy is an infectious disease in skin, peripheral nerve and mucosa of upper airway. Around 70% of this infection is caused by Mycobacterium leprae, which was discovered during1873. Multi drug therapy is used for the treatment, still multiple drug resistance and reactions has been reported among patients. Hence, this work focused on identifying bioactive compounds from Coscinium fenestratum that can target mycobacterium leprae ML2640 protein by in-silico approach. Method: …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 2, 2023 · pp. 21–33 Read article
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AR Coatings in Solar Efficiency: A Study
Abstract: In the global race toward renewable energy dominance, the focus often fixes upon the exotic materials within the photovoltaic cell: silicon type, junction structure, or emergent perovskites. Yet, the most immediate and profound efficiency gains are often secured by a layer so thin it is invisible, a film of optimized material applied directly to the glass interface: the Anti-Reflective (AR) coating. These coatings are not merely an expensive aesthetic choice; …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 12, Issue 3, 2025 · pp. 26–35 Read article
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Enhanced Thermal Stability and Thermophysical Properties of High Density Polyethylene Based Polymer Composite Synthesized Through Compression Moulding Route
Abstract: Polymer composite materials attract researchers as polymers can be filled with different fillers to get desired properties. Thermophysical properties of HDPE-silicon composite is reported in the present study. HDPE-Si composite was synthesized by hot compression and molding technique for different silicon volumetric ratio. Thermal conductivity as well as thermal diffusivity was found to be enhanced significantly on increasing the filler volumetric ratio. Thermal conductivity value for 20 volume % composite …
Published in Journal of Polymer & Composites · Vol. 11, Issue 5, 2023 · pp. 1–16 Read article
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E-glass Fiber Epoxy Composites: Role of Al2O3/SiC Fillers in Physical, Flammability and Mechanical Characteristics
Abstract: This study investigates the effects of varying weight percentages of Silicon Carbide and Alumina particles in epoxy-based composites, fabricated through compression molding, on their physical and mechanical properties. Comparing different studies on carbon fiber-reinforced polymer (CFRP) composites, as well as glass fiber-reinforced polymer (GFRP) composites, especially with the reinforcement of nanoparticles such as silicon carbide (SiC), alumina (Al2O3) and graphene. The investigations cover fabrication methods, like vacuum infusion and compression …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 238–250 Read article
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Investigation and Dependency Analysis of Silicon Film Thickness on Performance of Surrounding Gate MOSFET at Subthreshold Regime
Abstract: The characteristics of cylindrical gate all around MOSFET have been studied in terms of the dependence of various device performance metrics on silicon film thickness (Tsi). In this work, the effect of silicon film thickness on numerous performance metrics like threshold voltage (Vt), On current (Ion), subthreshold leakage current (Ioff), On-Off current ratio (Ion/Ioff) and DIBL of cylindrical GAA are comprehensively evaluated and analysed. It has been observed that cylindrical …
Published in Journal of VLSI Design Tools and Technology · Vol. 8, Issue 2, 2018 · pp. 49–54 Read article
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Fabrication and Mechanical Characterization of Hybrid Metal Matrix Composite Castings
Abstract: This work investigates and addresses the casting of a novel hybrid composite material with tungsten carbide and aluminum-silicate particles mixed at varying weight fraction rates. Production of hybrid composite has some advantages if it is processed by near net shape techniques. The simplest method for dealing with this hybrid composite is the turbulence produced by the vortex agitating technique. The vortex mixing method is used in this study to create …
Published in Journal of Experimental & Applied Mechanics · Vol. 15, Issue 3, 2024 · pp. 32–38 Read article
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Effect of Silicon Carbide Filler on Mechanical and Damping Behavior of Basalt/Stainless Steel Hybrid Laminated Composites
Abstract: This study consolidates three experimental investigations on hybrid laminated composites reinforced with basalt fibre, stainless steel (SS) wire mesh, and silicon carbide (SiC) filler using vacuum infusion moulding. Three laminates were fabricated with filler variations of 0%, 1.5%, and 3% by weight of matrix material, maintaining a stacking sequence of [0B/0W/45B/0W/0B/45W]s with a thickness of 4–5 mm. The first investigation focused on impact strength. Drop-weight impact testing revealed a steady …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 367–385 Read article
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A Review on Effect of Aluminium & Silicon Powder on Response Variables in Powder Mixed EDM
Abstract: In this paper, for machining different materials, the blending of aluminium and silicon powders into the dielectric liquid of electric discharge machining (EDM) has been studied. Different process parameters like peak current, powder focus, powder grain size, obligation factor, pulse on time, pulse off time, spout flushing and duty cycle has to be specific. The execution of procedure is done regarding response factors like tool wear rate (TWR)/electrode wear rate …
Published in Trends in Electrical Engineering · Vol. 8, Issue 3, 2018 · pp. 1–7 Read article