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419 articles for “Uses Pharmacological”
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Knowledge, Practice and Attitudes Towards Lifestyle Modifications Regarding Hypertension in Women
Abstract: Hypertension (HTN) is a major precipitating factor for cardiovascular diseases, kidney disease and stroke. Despite the intensive use of pharmacological agents, a rise in poorly controlled hypertensive cases has been observed due to the underutilization of therapeutic lifestyle changes (TLC) treatment approach. Objective of the study is to assess the knowledge, practice and attitudes of women towards lifestyle therapeutic modifications regarding hypertension among women in a third world country in …
Published in OmniScience: A Multi-disciplinary Journal · Vol. 12, Issue 2, 2022 · pp. 11–21 Read article
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Liquid Chromatography Mass Spectrometer (LC/MS) Profile Revealed Flavonoids with Antioxidant Potential in Butanol Fraction of Gymnema Sylvestre Leaf Extract
Abstract: Gymnema sylvestre (Asclepiadaceae) is widely used in the treatment of several diseases associated with oxidative stress. This study aimed to identify Flavonoids with antioxidant potentials in Butanol fraction of Gymnema sylvestre leaf extract. In vitro antioxidant activity was studied using DPPH and Ferric Reducing Antioxidant Power (FRAP). The results revealed higher radical scavenging activity of 86.53±0.86 in DPPH compared to the control Ascorbic acid with 84.71±0.61 and also similarly in …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 9, Issue 1, 2022 · pp. 26–39 Read article
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A Comprehensive review on phytomedicinal activity of chirchita (Achyranthes aspera): an Indian Rural Medicinal Plant
Abstract: Because it is used to treat many types of diseases. Native to India, Achyranthes aspera (Chirchita) has been used in rural medicine for generations.This review explores the phytomedicinal significance of Achyranthes aspera, focusing on its bioactive compounds and the pharmacological activities that support its use in treating various ailments. This plant is a useful tool in traditional and alternative medicine. Because it has anti-inflammatory properties Antioxidants Antibacterial, anticancer and liver …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 1, 2025 · pp. 74–85 Read article
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Integrating Network Pharmacology And Molecular Docking To Investigate The Possibility Of Rutin Against Gout
Abstract: Objective: Gout is an arthritic condition resulting from the deposition of monosodium urate crystals in and around the joints. Rutin, a bioflavanoid or a plant pigment that is mainly found in vegetables and fruits.It is widely known for its anti-inflammatory and antioxidant activity.Hence this research paper proposes the use of an integrated approach of network pharmacology and molecular docking to investigate the potential of Rutin as a treatment option for …
Published in Research and Reviews : Journal of Computational Biology · Vol. 11, Issue 03, 2022 · pp. 14–27 Read article
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The use of Genetics and Proteomics in the Finding of Therapeutic Targets
Abstract: Gene medicine is overcoming long-standing health issues that have confounded humanity. To fully comprehend and apply gene medicine, it is vital to grasp how it works at the molecular level. Currently, various technologies may be utilized to find pharmacological targets; the two most prominent are genomic and proteomic methods. In this paper, we go over how to use genomic and proteomic approaches to find pharmacological targets in depth. These materials …
Published in Research and Reviews : Journal of Computational Biology · Vol. 11, Issue 1, 2022 · pp. 9–12 Read article
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Solubility Enhancement of Paracetamol by Mixed Solvency Method
Abstract: The aim of this research work was to increase the solubility of poorly water soluble drugs by the mixed solvency method. This method is used for the proper pharmacological response. There are some techniques used for enhancing the solubility of poorly water soluble drugs. The recent trend possess that hydrotropic solution having high demand in industry because of some of its ideal features like easily available, having good recovery, does …
Published in Research and Reviews : Journal of Computational Biology · Vol. 8, Issue 2, 2019 · pp. 19–22 Read article
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Inhibition of PI3K/Akt/mTOR Signaling Pathway by Vitis Vinifera Phytocompounds: A Promising Strategy for Supressing Colorectal Cancer Growth and Metastasis
Abstract: Objectives: Colorectal cancer was not typically identified a few decades ago. Today, with almost 900 000 fatalities each year, it is the fourth most dangerous cancer in the world. Colorectal cancer is responsible for about 10% of all cancer diagnoses annually and cancer-related deaths worldwide. It is the second most common type of cancer in women and the third most common type in men. Incidence and death are roughly 25% …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 · pp. 64–75 Read article
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The Art of Drug Design and Process Chemistry
Abstract: The creation of safe and efficient medications depends heavily on the art of drug design and process chemistry. This multidisciplinary discipline designs and optimizes drug candidates for therapeutic uses by fusing the concepts of biology, chemistry, and engineering. Researchers can develop compounds with pharmacological activity by using logical drug design techniques if they have a thorough understanding of the molecular targets implicated in disease pathways. By making it easier to …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 1, 2025 · pp. 1–10 Read article
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A Review on Different Species of Echinacea
Abstract: Echinacea is one of the plant species found in the North American tribes, which are commonly called as coneflowers. Echinacea species such as Echinacea angustifolia, Echinacea pallida, Echinacea purpurea, Echinacea serotina, etc. are used in the treatment of common cold, urinary tract infections, respiratory problems, etc. They also show anti-immunosupperssant activity, anti-viral activity, antifungal activity, anti-inflammatory activity, antioxidant activity, etc. This article mainly includes morphological features, chemical constituents, pharmacology, and …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 6, Issue 1, 2019 · pp. 1–6 Read article
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Prediction of Molecular Targets for Anthraquinone and Its Analogs for Treatment of Good Pasteur Syndrome
Abstract: Objective: In order to find prospective molecular targets for the treatment of Good Pasteur Syndrome (GPS), a rare autoimmune disease that affects the kidneys and other organs, computational methods and network pharmacology were applied in this work. The goal of the study is to identify particular human proteins that might interact with anthraquinone and its analogues as well as to uncover potential mechanisms of action by which these drugs might …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 3, 2023 · pp. 10–27 Read article
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Molecular Docking Evaluation of Cedrus deodara Secondary Metabolites as a Potent Anti-ovarian Cancer Agent
Abstract: Objective: According to the statistics for the year 2022 it was seen that cancer total cases is 14,61,427. After breast cancer, ovarian cancer is the second most frequent cancer among women. The estrogen receptor (PDB ID: 1X7E), progesterone receptor (PDB ID: 1A28), and Phosphoinositide 3-kinases (PDB ID: 4FJY) can be considered as target protein for ovarian cancer. The plant Cedrus deodara and its phytochemicals were chosen in this study to …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 77–93 Read article
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Dental Pulp Stem Cells Derived from Wisdom Teeth as Multitarget Biological Modulators of Alzheimer’s and Parkinson’s Disease: Mechanistic Insight and Translational Perspective
Abstract: Alzheimer’s disease and Parkinson’s disease are chronic, progressive neurodegenerative disorders with complex pathogenic pathways such as neuroinflammation, oxidative stress, mitochondrial dysfunction, synaptic degeneration, and reduced neurotrophic signalling. Despite the large amount of research, the pharmacological treatments in use offer only symptomatic relief and cannot significantly prevent or slow down disease progression sufficiently; new pathogenetic treatment strategies are necessary. In recent years, stem cell-based approaches have gained interest as potential therapeutic …
Published in Research and Reviews: A Journal of Dentistry · Vol. 17, Issue 2, 2026 · pp. 7–28 Read article
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Petroleum Ether, A Laboratory Solvent Induced Cannibalism, Piloerection and Straub Tail Reaction in Rodents
Abstract: Petroleum ether is one of the most commonly used solvent in extraction of herbals/biological substances. In pharmacognostical studies, petroleum ether is used as a solvent for extract of herbals which was used for further pharmacological investigation. In a few of their studies, the authors have observed petroleum ether-induced piloerection which may be related to the herbal extract or trace solvent effect. Complete removal of petroleum ether solvent in herbal extract …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 1, Issue 2, 2014 · pp. 6–10 Read article
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Α Review on a Potential Herb: Ixora coccinea Linn
Abstract: The plant Ixora coccinea (Rubiaceae) is a commonly available shrub throughout India. The plant has been documented of use not only in Ayurveda, but also in various folk system of medicine in India and Sri Lanka. The present article is an effort to collect information regarding its traditional use, phytochemical and pharmacological updates. The review reveals a wide variety of phytoconstituents that have been isolated, such as lupeol, ursolic acid, …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 2, Issue 1, 2015 · pp. 1–14 Read article
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A Review Study on Phytochemical and Pharmacological Aspects of Berberis asiatica Roxb. ex DC.
Abstract: Berberis asiatica, belongs to family Berberidaceae, is commonly known as Asian barberry or Kilmora. The plant is widely distributed in Himalayas. Research evidences support its use in various traditional medicinal formulas. Properties like antimicrobial, antidiebetic, anticancerous etc. have been reported in this plant. This review aims to highlight a comprehensive account of phytochemical constituents and pharmacological activities along with traditional uses in a view of many recent findings and its …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 11, Issue 2, 2020 · pp. 8–15 Read article
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Phytoconstituents of Ticanto crista (L.) R. Clark & Gagnon (Caesalpiniaceae): A Review
Abstract: Ticanto crista (L.) R. Clark & Gagnon (= Caesalpinia crista L.), a member of the Leguminosae family, is a medicinally important plant traditionally used in various systems of medicine, including Ayurveda, for treating a wide range of ailments. It has attracted increasing scientific interest due to its rich phytochemical profile and therapeutic potential. This review serves as a comprehensive index of the chemical structures of common and medicinal compounds isolated …
Published in Research & Reviews : Journal of Botany · Vol. 14, Issue 3, 2025 · pp. 38–59 Read article
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Therapeutic Potential of Sheetraj (Plumbago Zeylanica Linn.)-A Potent Drug of Unani Medicine
Abstract: Plumbago zeylanica also known as Sheetraj or Chitraka belongs to the family Plumbaginaceae. It is one of the important medicinal plants which is used worldwide due to its therapeutic value. Therefore, this work carried out on Sheetraj has been, gathered, analyzed and reviewed using references from different sources like classical text and indexed journals. The aim of this review is to provide data or comprehensive information related to the chemical …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 13, Issue 2, 2022 · pp. 40–51 Read article
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Molecular Docking Analysis of Punica granatum Compounds as Potential Inhibitors for Colorectal Cancer-Associated Molecular Targets
Abstract: Objective: Cancer is one of the most common worldwide disease which threat the life of a person. Colorectal cancer is one of the common cause of death nowadays. As computation approach is now employed for new drug discovery, target protiens like CDK-2, matrix metalloproteinase 2 (MMP-2), cyclin A, poly (ADP- ribose) polymerase (PARP-1) and Cox2 were chosen to perform molecular docking against the derivatives of Punica granatum phtyochemicals and Food …
Published in Research and Reviews : Journal of Computational Biology · Vol. 11, Issue 03, 2022 · pp. 28–42 Read article
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Bitter Gourd (Momordica charantia): A Natural Gift in Support of the Research in Medicine and Biotechnology
Abstract: Bitter gourd (Momordica charantia) is acknowledged to be nature’s silent healer. It is a prospective herbal plant applied world widely in traditional systems of medicine (TSM) to modern medicine. It is medically very effective for various diseases such as diabetes, blood coagulation, cancer, menstrual stimulation and several diseases. Momordica fruit is frequently used in TSM, because it is very potent for cure, multidimensional function and reduces the consequences of diseases. …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 7, Issue 1, 2017 · pp. 1–13 Read article
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Review on Clinical Safety and Efficacy of Giant Calotropis in the 21st Century
Abstract: Calotropis gigantea, a highly valued plant in traditional Indian pharmacology, has emerged as a promising candidate for therapeutic innovation. This review delves into the clinical safety and efficacy of C. gigantea in the 21st century, examining its historical use, phytochemical composition, and pharmacological properties. While traditional medicine has long utilized C. gigantea for various ailments, modern research has sought to validate these claims through scientific investigation. This review critically analyzes …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 1, 2025 · pp. 26–34 Read article