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1344 articles for “Target”
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Targeting Vasopressin 2 Receptor (V2R) in Renal Cystogenesis by Exploring the Nephroprotective Potential of “Terminalia arjuna”
Abstract: Objectives: Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disorder, leading to the formation of multiple cysts in the kidneys. It is a major cause of end-stage renal disease (ESRD), which often requires dialysis or a kidney transplant for survival. This research focuses on identifying potential bioactive compounds derived from natural sources that show promise for drug development targeting the V2R gene. Methods: The naturally occurred …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 2, 2024 · pp. 14–24 Read article
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Botanical Blockade: Phytochemical Targeting Of Nf-Κb in Cancer Therapy
Abstract: The control of inflammation, corpuscle survival, proliferation, and allowed response are all influenced by the acute archetypal agent NF-κB. Its abnormal activity is typically seen in a range of malignancies, where it aids in bump advancement, metastasis, and treatment waste. The function of NF-κB in scar analysis is discussed in this product, along with significant phytochemicals that seem to be interested in targeting this pathway, based on recent investigation. It …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 1, 2025 · pp. 13–21 Read article
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Targeting Papain-Like Protease of Re-Emerging Coronaviruses
Abstract: Re-emerging Corona viruses (CoVs), including SARS-CoV (S-CoVs), and SARS-CoV-2 (S-CoV-2), continue to pose a global health threat due to their high mutation rates, zoonotic spillover potential, and capacity for immune evasion. The global pandemic of year 2019, caused by S-CoV-2, has highlighted the importance for robust antiviral strategies beyond vaccines and RNA polymerase or main protease inhibitors, which are susceptible to resistance. One promising therapeutic target is the S-CoV-2 papain-like …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 15, Issue 3, 2025 · pp. 46–62 Read article
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Molecular Docking-Based Analysis of Rauvolfia serpentina Alkaloids Targeting HPV E1 and L1 Proteins for Antiviral Therapeutic Potential
Abstract: Human papillomavirus (HPV) is a major cause of cervical cancer and other epithelial cancers. E1 and L1 proteins are crucial to the virus's lifespan. E1 is a viral helicase that is needed for HPV DNA replication, and L1 is the main structural capsid protein that builds the virion and infects target cells. Going after these proteins is a good way to stop viruses from spreading. In this case, Rauvolfia serpentina, …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 1, 2026 · pp. 100–113 Read article
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In Silico Identification of Antimalarial Drug Targets and Screening of Potential Inhibitors in Plasmodium vivax
Abstract: AbstractMalaria is an infectious disease caused by the protozoan of the genus Plasmodium. It is a major problem in third-world countries, with hundreds of millions of infections and millions of fatalities annually. Plasmodium vivax is the most frequent and widely distributed cause of recurring (Benign tertian) malaria. Due to emergence of drug-resistance, one has to explore new dimensions in order to curb the menace. We propose a two-step strategy—first step …
Published in Research and Reviews : Journal of Computational Biology · Vol. 9, Issue 1, 2020 · pp. 52–75 Read article
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Molecular Docking Analysis of Punica granatum Compounds as Potential Inhibitors for Colorectal Cancer-Associated Molecular Targets
Abstract: Objective: Cancer is one of the most common worldwide disease which threat the life of a person. Colorectal cancer is one of the common cause of death nowadays. As computation approach is now employed for new drug discovery, target protiens like CDK-2, matrix metalloproteinase 2 (MMP-2), cyclin A, poly (ADP- ribose) polymerase (PARP-1) and Cox2 were chosen to perform molecular docking against the derivatives of Punica granatum phtyochemicals and Food …
Published in Research and Reviews : Journal of Computational Biology · Vol. 11, Issue 03, 2022 · pp. 28–42 Read article
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Investigating Curcumin Phytocompounds as Prospective Parkinson's Disease Therapeutic Agents: A Computational Method that Targets LRRK2 Protein
Abstract: Objective: Parkinson’s Disease is the second stage predominant neurodegenerative illness. Primary aetiology is still unknown. One of the biggest battlegrounds in modern medicine is discovering the cause of Parkinson’s disease (PD), as well as the hunt for palliative treatments and, if feasible, a cure. The objective of this work is to identify the phytocompounds from curcumin (curcuma longa) for the treatment of PD. Curcumin, a well-researched phytochemical, has been suggested …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 3, 2023 · pp. 55–67 Read article
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Nutritional Recovery Status and its Determinants of Targeted Supplementary Feeding Program among Pregnant and Lactating Women in Werie-Leke District, North Ethiopia, 2015
Abstract: In Ethiopia, around 1.5 million pregnant and lactating women (PLW) screened for acute malnutrition and those with moderate acute malnutrition (MAM) admitted to the targeted supplementary feeding program (TSFP). As the health system accepted, the TSFP is recognized as critical for the reduction of maternal morbidity and mortality in case of community emergency nutrition, but the recovery outcome was not measured yet. The study was undertaken to assess the nutritional …
Published in Research and Reviews: A Journal of Health Professions · Vol. 6, Issue 2, 2016 · pp. 21–30 Read article
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Target Tracking Mobile Sensor Network Using Mobile AdHoc Networks (MANET)
Abstract: Target trailing mobile device network could be a major challenge in mobile unintended networks due partly to the dynamically dynamic network topologies. For mobile device networks that square measure developed for police investigation applications, it's vital to use a quality management theme empower nodes to create higher choices concerning their positions specified strategic tasks like target trailing can like node movement to explain a distributed quality management theme for mobile …
Published in Journal of Mobile Computing, Communications & Mobile Networks · Vol. 5, Issue 3, 2018 · pp. 23–26 Read article
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In silico potential drug target identification against 4-aminobutyrate aminotransferase for Huntington diseases
Abstract: Huntington disease, HD is a progressive neurodegenerative disorder. Some excitatory chemicals released like glutamate which causes the cell damage and the neuron die due to over accumulation of the glutamate in Huntington diseases (HD), which is regulated by the GABA also known as gamma- amino butyric acid, it is a major inhibitory neurotransmitter of the nervous system. Here we are targeting the pyridoxal dependent enzyme which degrades the GABA neurotransmitter, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 4, Issue 3, 2017 · pp. 1–5 Read article
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Aurora Kinase: A Target for Cancer Therapy
Abstract: Aurora kinases are the enzymes that belong to the family of serine/threonine kinases. It consists of Aurora-A (AURK-A), Aurora-B (AURK-B) and Aurora-C (AURK-C), which are the essential kinases for cell division through mitosis regulation especially for the process of chromosomal segregation. Aurora kinases are involved in meiosis regulation along with the regulation of mitosis. Inhibition of Aurora kinase leads to neglected cell division. Various cancer studies generally deal with gene …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 9, Issue 3, 2019 · pp. 10–17 Read article
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Innovative 3D Printed Cell Scaffolds with Magnetized Nanocomposites for Targeted Cancer Therapy Drug Delivery
Abstract: In recent years, scaffolds have gained increasing attention in the field of tissue engineering, especially in cancer treatment. Nanocomposite scaffolds have emerged as promising candidates for delivering drugs to cancer cells. 3D printing technology has enabled the fabrication of customized scaffolds with precise pore size and complex geometries. This study explores the development of 3D printed scaffolds of nanostructured made of graphene oxide and Poly-Caprolactone (PCL) nanocomposites, which can be …
Published in Journal of Polymer & Composites · Vol. 11, Issue 3, 2023 · pp. 48–55 Read article
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Molecular Docking Study: Targeting mycobacterium leprae ML2640 Protein Using Active Compounds from Coscinium fenestratum
Abstract: Objectives: Leprosy is an infectious disease in skin, peripheral nerve and mucosa of upper airway. Around 70% of this infection is caused by Mycobacterium leprae, which was discovered during1873. Multi drug therapy is used for the treatment, still multiple drug resistance and reactions has been reported among patients. Hence, this work focused on identifying bioactive compounds from Coscinium fenestratum that can target mycobacterium leprae ML2640 protein by in-silico approach. Method: …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 2, 2023 · pp. 21–33 Read article
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Development and Fabrication of Biohydrogel for Targeted Delivery of Delafloxacin for Bacterial Skin Infections
Abstract: The escalating challenge of bacterial resistance necessitates innovative drug delivery systems to enhance the efficacy of antibiotics. This study focuses on the development and optimization of a biohydrogel formulation for the targeted delivery of Delafloxacin, aiming to improve its therapeutic outcomes against resistant bacterial strains. Utilizing a 3² factorial design, biohydrogel formulations incorporating Poly(N-isopropylacrylamide) (PNIPAM) and Genipin were synthesized. The optimization process was guided by Design Expert software, focusing on …
Published in Research & Reviews: A Journal of Drug Design & Discovery Read article
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In Silico Molecular Docking Studies of Phytocompounds from Melissa officinalis Against MPXV Poxin Target
Abstract: Objectives: This study aimed to evaluate the inhibitory potential of phytocompounds of Melissa officinalis against the MPXV poxin protein target, a key virulence factor in monkeypox infection. Methods: Molecular docking performed using PyRx, a virtual screening software, was conducted to predict the binding affinities of the compounds to MPXV poxin. Prior to docking, the compounds were subjected to comprehensive analysis, including Lipinski's rule of five, evaluation of physicochemical properties, pharmacological …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 2, 2024 · pp. 25–38 Read article
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Drug Repurposing of Anticancer Agents JP-8g and REDX05358 Against the Target Protein Plectin 1a in Epidemolysis Bullosa Simplex with Muscular Dystrophy (EBS-MD)
Abstract: Epidermolysis Bullosa Simplex with Muscle Dystrophy is a genetic disease affecting the skin and muscles which can be seen at birth or start at adulthood due to the mutation in the protein Plectin 1a (PLEC gene) causing skin blisters and muscle weakness. This protein is seen in sarcolemma, Z disks in skeletal muscles, hemidesmosomes in skin and cardiac muscles giving stability to cytoskeleton, playing a crucial role in neuromuscular transmission …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 22–34 Read article
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Innovations in Targeted Drug Discovery for Personalized Medicine
Abstract: Personalized medicine is revolutionizing modern healthcare by custoizing treatment plans to match an individual’s genetic makeup, protein expression, and metabomlic characteristics. Also referred to as precision medicine, this approach seeks to improve therapeutic outcomes, reduce adverse effects, and make efficient use of healthcare resources. The incorporation of various omics technologies—including genomics, proteomics, transcriptomics, metabolomics, and epigenomics—has greatly advanced our ability to understand disease biology and molecular variations specific to each …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 3, 2025 · pp. 19–41 Read article
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Cell Membranes as Therapeutic Targets: Implications in Infectious and Metabolic Disorders
Abstract: This is a review of the crucial role played by cell membranes in health and disease with respect to their contribution to infectious and metabolic diseases. Dysfunction of membranes, such as membrane transporter changes and changes in lipid content, has been associated with a variety of diseases, including diabetes, cardiovascular disease, and cancer. The present therapeutic approaches are focused on attacking membrane constituents by disrupting the entry of pathogens or …
Published in International Journal of Membranes · Vol. 3, Issue 1, 2026 · pp. 47–53 Read article
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Identification of Specificity Determining Positions through Phylogenetic Studies and Molecular Modeling of ICP27 as a Drug Target of Herpes Simplex Virus-1
Abstract: An ever-growing effort to apply computational power to the combined chemical and biological space in order to streamline drug discovery, design, development and optimization can be achieved through computational approaches. Herpes simplex is an infection that is caused by a herpes simplex virus (HSV), and is one of the most common human infections transmissible to a body site. Infection with HSV can result in several diseases ranging from apparent infections …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 2, Issue 1, 2015 · pp. 32–43 Read article
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Targeting Cancer through Angiogenesis Inhibition: Prospective of Azole Based Small Molecules
Abstract: Anticancer drug discovery is a major focus area in the pharmaceutical industry and obtaining targeted drug molecules for the malignant tissue is a major hurdle in this process. With the advancement in the knowledge of biological targets, cancer specific molecules such as monoclonal antibodies have been designed and produced in the recent past. However, the cost and effectiveness of these special products are the biggest challenges for cancer treatment. Small …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 1, Issue 1, 2014 · pp. 13–18 Read article