Targeting Cancer through Angiogenesis Inhibition: Prospective of Azole Based Small Molecules

Pratap Chandra Acharya

Abstract

Anticancer drug discovery is a major focus area in the pharmaceutical industry and obtaining targeted drug molecules for the malignant tissue is a major hurdle in this process. With the advancement in the knowledge of biological targets, cancer specific molecules such as monoclonal antibodies have been designed and produced in the recent past. However, the cost and effectiveness of these special products are the biggest challenges for cancer treatment. Small molecules are considered as the best chemotherapeutic intervention to treat cancer at the present time. This article describes the possibility of azole based small molecules as inhibitor of tumor angiogenesis, which can be explored for anticancer drug discovery. Keywords: Angiogenesis, Anticancer Drugs, Monoclonal Antibodies, Azoles, Small Molecules, HUVEC Assay