Research & Reviews: A Journal of Drug Design & Discovery
Volume 1, Issue 1 (2014)
Published
Table of contents
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Drug Designing and Research: Ayurvedic Approach
Abstract: Ayurveda the ancient Indian medical wisdom has served society through its holistic approach of healing. Ancient Indian scientists Acharya Charaka, Acharya Sushruta, etc. has done in drug research and clinical research. This approach was not only aims to treat a person but to bring the original state. Acharya Charaka clarifies that a physician or researcher ought to look at least four whilst treatment the patient i.e. roga bala (therapeutic effect …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 1, Issue 1, 2014 · pp. 1–3 Read article
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Targeting Cancer through Angiogenesis Inhibition: Prospective of Azole Based Small Molecules
Abstract: Anticancer drug discovery is a major focus area in the pharmaceutical industry and obtaining targeted drug molecules for the malignant tissue is a major hurdle in this process. With the advancement in the knowledge of biological targets, cancer specific molecules such as monoclonal antibodies have been designed and produced in the recent past. However, the cost and effectiveness of these special products are the biggest challenges for cancer treatment. Small …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 1, Issue 1, 2014 · pp. 13–18 Read article
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Synthesis and Anti-Bacterial Activity Profile of Cyclized Diazonium Compounds
Abstract: Synthesis of cyclised diazonium compounds and their in vitro activity against various microorganisms is described. Several primary aromatic amines were diazotised and the resulting diazotised compounds were coupled with active methylene compounds to give hydrazono derivatives. These were cyclized with hydrazine hydrate, phenyl hydrazine, urea and o-phenylene diamine to give pyrazolin-5-one, substituted pyrazolin-5-ones, pyrimidin-di-ones and benzodiazepinone derivatives, respectively. Some hydrazine derivatives were also produced by reduction of diazo compounds with …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 1, Issue 1, 2014 · pp. 4–12 Read article