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125 articles for “Signal”
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Deciphering the Roles of Estrogen Receptors and 27-Hydroxycholesterol in BC Progression
Abstract: Breast cancer (BC) ranks among the top causes of cancer-related deaths in women worldwide. Many risk factors of BC are linked to estrogen. Experiments of Beatson in 1896 show the role of steroid hormones as major determinant in BC. Action of steroid hormones is mediated by their receptors including Estrogen receptors (ERs). ERs are part of a subfamily of ligand-regulated transcription factors. Their primary role is to translate hormone signals …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 2, 2024 · pp. 18–26 Read article
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Mind-Machine Synergy: The Evolution and Future of Brain-Computer Interfaces
Abstract: Brain-Computer Interfaces (BCIs) represent a transformative technology that enables the direct communication between the human brain and external devices, bypassing the traditional output mechanisms, such as speech or physical movement. BCIs hold the potential to revolutionize fields, such as healthcare, neuroscience, and human-computer interaction by providing new ways to restore lost functions, enhance cognitive abilities, enable seamless communication, and create novel user experiences across various platforms and environments. This article …
Published in International Journal of Brain Sciences · Vol. 2, Issue 2, 2025 · pp. 19–31 Read article
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Light Waves and Data Highways: The Physics of Optical Communication Networks
Abstract: Optical communication has revolutionised modern telecommunication, allowing for the quick transfer of information by light signals. This technology uses optical fibres as the transmission medium and offers higher bandwidth, lower signal loss and faster data transfer than typical electrical communication systems. Optical communication has become a key enabler of internet services, mobile networks, satellite communication and data centers which are all driving the increasing demand for high speed and dependable …
Published in International Journal of Optical Innovations & Research · Vol. 4, Issue 1, 2026 · pp. 13–24 Read article
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Design and Creation of Four-wheel Non- interaction Navigation Machinery
Abstract: Here we are trying to improve the steering mechanism, by rotating all 4-wheels to reduce the radius of rotation. This is a Mechatronics based project where different sensors and actuators has to employed. Electronic controller unit is going to be act as the vital element of this project through which the complete steering system has to be controlled. This electronic controller receives analog signal from the user and convert it …
Published in International Journal of Machine Systems and Manufacturing Technology · Vol. 1, Issue 1, 2023 · pp. 35–44 Read article
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Optical properties of Carbon quantum dots for AI enhanced flexible bioelectronics and nanomedicine
Abstract: Carbon nanodots are the emerging nanomaterials of 20 th century. Carbon nanodots is the family of carbon based material with distinguished bio-physical properties. In this paper, the optical properties of carbon nanodots are presented. One of the developments Nanoscale physics and nanotechnology is the ability of converting optical signals into meaning full information. This innovation is accelerated and improved by incorporating nanoscale materials including carbon quantum dot, carbon nanotube, and …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 3, Issue 1, 2025 · pp. 19–30 Read article
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Molecular Pharmacokinetics and Structural Docking of Phenolic Acids for Targeting NF-κB Pathway Components in Inflammation and Fibrosis: A Computational Approach Toward Therapeutic Discovery
Abstract: Inflammation and Fibrosis are critical pathological processes associated with various chronic diseases, often mediated by the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway. This study investigates the therapeutic potential of phenolic acids as modulators of the NF-κB pathway, aiming to identify novel ligands that can effectively interact with key components of this signaling cascade. A comprehensive computational approach was employed, utilizing molecular docking, pharmacological screening, and post-docking …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 1, 2025 · pp. 14–31 Read article
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DFT Compatible Low Power EDAC Based on Clock Gating
Abstract: The in-situ EDAC architecture is normally hired in timing-error tolerant circuits in a try and decrease the conservative timing protect band due to procedure, voltage, and temperature (PVT) fluctuations. But with the addition of the latch-based totally data channel, extra detection, and propagation common sense, it makes the implementation of the layout for- testability (DFT) tough. We present a new low area test overhead DFT EDAC architecture with extreme reduction …
Published in International Journal of VLSI Circuit Design & Technology · Vol. 3, Issue 1, 2025 · pp. 41–53 Read article
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Chemiluminescence: Recent Developments and Photochemical Applications in Analytical Chemistry
Abstract: Chemiluminescence (CL) is the observable production of electromagnetic radiation from a chemical reaction, typically in the form of ultraviolet, visible, or infrared light. According to subjective yield, CL has either been directly emitted from electronically excited intermediate products, or it has been supported by another molecule to emit CL. Since the 1950s, CL has been supported as a valid analytical tool, with the descriptive issued scope being limited to content …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 2, Issue 1, 2024 · pp. 20–25 Read article
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Exploring the Role of MAPK3 in Major Depressive Disorder: Molecular Docking, Dynamics, and Binding Free Energy Analysis of Natural Compounds as Alternatives to Conventional Drugs
Abstract: Major Depressive Disorder (MDD) is a prevalent neuropsychiatric disorder with limited treatment efficacy and significant side effects associated with conventional antidepressants. Recent studies have highlighted the role of mitogen-activated protein kinase 3 (MAPK3) in the mechanisms underlying MDD, positioning it as a potential target for the development of novel therapeutic drugs. In this study, we employed various computational approaches to explore natural compounds as viable alternatives to synthetic antidepressants. Researchers …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 2, 2025 · pp. 53–68 Read article
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The Rise of Fractional Calculus: Novel Applications in Engineering and Biological Systems
Abstract: Fractional calculus (FC) is an advanced mathematical framework that generalizes the classical concepts of differentiation and integration to non-integer, or fractional, orders. This extension of traditional calculus allows for the modeling of complex dynamic systems that exhibit behavior not easily captured by integer-order differential equations. Over the last few decades, fractional calculus has seen a rapid rise in popularity, particularly in applied mathematics, engineering, and biological sciences, due to its …
Published in Recent Trends in Mathematics · Vol. 1, Issue 2, 2024 · pp. 7–11 Read article
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Flying Drone Using KK Flight Controller
Abstract: This paper presents the design, development, and testing of a quadcopter drone using the KK2.1.5 flight controller, with an emphasis on stability and educational value. The KK2.1.5 controller features are inbuilt LCD screen, inbuilt programming, enabling direct configuration and tuning without the need for a computer interface, which makes it highly suitable for beginners and students. The drone is built using a modular frame architecture, which allows for easy replacement …
Published in International Journal of Advanced Control and System Engineering · Vol. 3, Issue 2, 2025 · pp. 20–25 Read article
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Photoreceptor Dynamics: Light Sensing and Cellular Responses for Photochemistry
Abstract: Photoreceptor dynamics represent a fundamental aspect of photochemistry, encompassing the mechanisms by which biological systems detect and respond to light stimuli. Photoreceptors are specialized proteins that undergo structural and functional changes upon photon absorption, initiating a cascade of molecular events that translate light signals into cellular responses. These proteins are ubiquitous across life forms, including microbial rhodopsins, plant phytochromes, and animal opsins, each finely tuned to specific wavelengths and light …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 3, Issue 2, 2025 · pp. 28–32 Read article
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Synergistic Integration of MEMS and Spintronics for Precision Data Analytics in Cheminformatics
Abstract: The transformational potential of merging spintronics and Micro-Electromechanical Systems (MEMS) technologies in cheminformatics is investigated in this work. Recent advancements in MEMS, particularly through the use of microbeam sensors and accelerometers, enhance the precision of data collection and processing, especially in biomedical applications such as drug delivery systems and chemical sensing. The synchronization of oscillations in MEMS devices leads to improved reliability and data accuracy, enabling the development of sophisticated …
Published in International Journal of Cheminformatics · Vol. 2, Issue 1, 2024 · pp. 20–26 Read article
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Nutrition Induced Remodeling Dynamics of Cell Membranes: Implications for Performance, Health, and Welfare Issues in Food Animals
Abstract: Cell membranes represent dynamic structural and functional platforms that integrate nutritional signals with cellular metabolism, immune competence, and physiological adaptation in food animals. Beyond their classical role as selective barriers, membranes actively regulate nutrient transport, signal transduction, and bioenergetics through highly responsive lipid and protein networks. Dietary components, particularly fatty acids, vitamins, minerals, amino acids, and bioactive compounds, critically influence membrane composition, fluidity, and stability, thereby shaping cellular function and …
Published in International Journal of Membranes · Vol. 3, Issue 1, 2026 · pp. 25–37 Read article
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The Renaissance and Resilience of CB1 Reverse Agonists: From Central Liabilities to Peripheral Promise
Abstract: Building upon these foundational insights, current research has increasingly focused on refining the pharmacological profile of CB1 reverse agonists to maximize therapeutic benefit while minimizing central adverse effects. The adverse neuropsychiatric outcomes associated with first-generation agents such as Rimonabant including anxiety, depression, and suicidal ideation highlighted the critical role of central CB1 receptors in mood regulation. Consequently, drug development strategies have shifted toward peripherally restricted CB1 reverse agonists that exhibit …
Published in International Journal of Cheminformatics · Vol. 4, Issue 1, 2026 · pp. 30–35 Read article
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Photonic-Assisted Spintronic Solid-State Switching Model for High-Speed Memory Devices
Abstract: The rapid advancement of high-speed computing and data-centric applications has intensified the demand for energy-efficient and ultra-fast memory technologies. This paper proposes a Photonic-Assisted Spintronic Solid-State Switching Model for next-generation high-speed memory devices. The proposed framework integrates photonic excitation mechanisms with spintronic switching dynamics to enhance data transfer speed, minimize switching delay, and reduce power dissipation in solid-state memory architectures. By combining optical pulse-assisted spin polarization with magnetic tunnel junction-based …
Published in International Journal of Solid State Innovations & Research · Vol. 4, Issue 1, 2026 Read article
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Enhancing Smart Grid Resilience Through AI-Based Fault Classification
Abstract: Traditional power grids can be developed into smart grids, and they are comprised of the latest information and communication technologies (ICTs), which are based on establishing the relationship between the conventional electricity systems along with the usage of smart meters and distributed generation. This dynamic improves energy efficiency and the integration of renewables. Well, the dynamic and reversible power injection from Distributed Energy Resources (DERs) creates substantial operational problems. These …
Published in International Journal of Algorithms Design and Analysis Review · Vol. 4, Issue 1, 2026 · pp. 10–15 Read article
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Oceanmind Systems: AI-Driven Marine Life Intelligence for Climate Prediction and Ocean Ecosystem Stability
Abstract: Oceans regulate global climate systems, support biodiversity, and serve as critical carbon sinks, yet they remain under-monitored relative to their ecological importance. Traditional oceanographic methods rely heavily on satellite sensing, buoy networks, and periodic marine surveys, which often fail to capture real-time biological dynamics at micro-ecosystem levels. This paper introduces OceanMind Systems, an artificial intelligence (AI)-driven marine intelligence framework that integrates marine life behavior, oceanographic data, and computational modeling to …
Published in International Journal of Marine Life · Vol. 3, Issue 2, 2026 Read article
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In Silico Molecular Docking of Indigofera tinctoria Phytocompounds to Target EGFR/ERK and FGFR/FGF Pathway Proteins Involved in Prostate Cancer
Abstract: Objective: Prostate cancer being the second major cause of cancer-related deaths in males, affects the small walnut-shaped gland below the bladder called the prostate gland. The epidermal growth factor protein (EGFR), cascade protein (ERK), and fibroblast growth factor proteins (FGFR and FGF) are involved in the different signaling pathways that lead to the formation of different products, that are responsible for the progression of cancer and thus can be considered …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 34–56 Read article
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Identification of Secondary Metabolites from Zingiber officinale as Inhibitors for Keap 1-Nrf2 small Molecules through Molecular Docking Techniques
Abstract: Objective: Therapeutic plants aid in treating cancer-based cell signaling pathways and preventing certain risk factors. Zingiber officinale has a variety of anti-inflammatory characteristics also contributing to enhanced immunity, reducing cancer risk and used to target the KEAP NRF2. When overexpressed in response to oxidative stress and DNA damage, elevates the risk of developing multiple cancers. NRF2 cellular sensors, which also control and coordinate their expression aid in defending healthy cells …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 2, 2023 · pp. 35–48 Read article