Search
78 articles for “Safety Profile”
-
Microneedles: An Innovative Drug Delivery System
Abstract: Microneedles represent a groundbreaking innovation in drug delivery systems, offering a transformative alternative to conventional hypodermic needles and transdermal patches. This advanced technology combines the precision and efficacy of needle-based delivery with the convenience and pain-free nature of patches, creating a minimally invasive platform that addresses many limitations of traditional drug administration. Microneedles are designed to penetrate the stratum corneum – the skin’s outermost layer – without reaching pain-sensitive nerves …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 60–67 Read article
-
Comparison of Recovery Profile for Total Intravenous Anaesthesia (TIVA) Using Propofol And Remifentanil in Laparoscopic Surgeries
Abstract: Total Intravenous Anaesthesia (TIVA) has become an increasingly preferred technique in modern anaesthetic practice due to advantages such as reduced postoperative nausea and vomiting (PONV), improved hemodynamic stability, minimal environmental impact, and faster recovery compared to conventional inhalational anesthesia. Propofol in combination with remifentanil is widely used for TIVA because of its rapid onset and offset of action, which supports quick postoperative awakening and enhanced patient satisfaction. Target Controlled Infusion …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 16, Issue 1, 2026 · pp. 39–50 Read article
-
A brief survey on Alternative and Complementary Medicine with special reference to safety, toxins and toxicological concerns
Abstract: Alternative and Complementary Medicine (ACM) is a wide range of healthcare practices that may be used within or alongside conventional medicine, and many of these practices are rapidly becoming accepted and integrated into the modern healthcare system. In addition to traditional medicine systems (e.g. Ayurveda, Unani Medicine, Traditional Chinese Medicine, and Homeopathy), ACM includes practices that utilize natural remedies including herbal medicine, phytotherapy, naturopathy, acupuncture, yoga, and meditation. While these …
Published in International Journal of Toxins and Toxics · Vol. 3, Issue 1, 2026 · pp. 30–45 Read article
-
Applications of Nanotechnology in Crop Improvement: New Era of Agriculture
Abstract: It represents a transformative force in agriculture, promising to improve the productivity, yield, sustainability, and food security. This review paper focused on the certain advantages of nanoscience and nanotechnology in enhancing the agricultural productivity, disease management, and food safety. By manipulating different materials and objects at the nanoscale, researchers can develop advanced tools such as smart sensors and targeted delivery systems that improve nutrient absorption and combat plant pathogens. By …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 15, Issue 3, 2025 · pp. 46–54 Read article
-
TOXICOLOGY: Present-Day Difficulties for Investigating Safety Science and Target Safety Evaluation of Major Human Hepatocytes
Abstract: Preclinical toxicology has developed into a more thorough understanding of toxicity pathways from its descriptive beginnings. Technological developments have made it possible to forecast safety occurrences, mitigate adverse effects, and create safety biomarkers. Because they are able to self-renew and specialize into different types of human body cells, stem cells are currently being employed for in vitro toxicological applications. However, as compared to primary human hepatocytes, stem cell-derived HLCs perform …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 3, 2024 · pp. 31–40 Read article
-
Revolutionizing Drug Delivery: Recent Advances in Pharmaceutical Dosage Forms
Abstract: Recent advances in pharmaceutical dosage forms revolutionize drug delivery, prioritizing targeted therapy and patient well-being. Enhanced drug carriers address complex medical challenges, from high-grade gliomas to ocular drug delivery, maximizing therapeutic efficacy while minimizing adverse effects. Traditional dosage forms like tablets and capsules undergo meticulous formulation and manufacturing processes, integrating Quality by Design principles for consistent product quality. Liquid formulations encounter stability challenges, necessitating rigorous stability testing and pH monitoring. …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 13, Issue 1, 2024 · pp. 77–89 Read article
-
Reliability-Based Prediction of Bearing Capacity of Shallow Foundation Along Ajaokuta-Kaduna-Kano Pipeline Track
Abstract: This paper investigates the geotechnical properties and reliability-based bearing capacity predictions for shallow foundations along the proposed Ajaokuta-Kaduna-Kano (A-K-K) pipeline track in Nigeria. The variability of subsoil properties along this route poses significant challenges to ensuring foundation stability and safety, necessitating an in-depth study. A total of twenty boreholes were strategically drilled at key locations to a maximum depth of 30 meters, providing comprehensive subsurface profiles. Soil samples collected from …
Published in Journal of Geotechnical Engineering · Vol. 12, Issue 1, 2025 · pp. 9–17 Read article
-
Comprehensive Introduction: Epoxy and Polyurethane Floor Coatings—A Critical Evaluation for Modern Industrial Applications
Abstract: Industrial flooring systems are essential for ensuring operational durability, safety, and longevity in demanding environments. Epoxy and polyurethane (PU) coatings represent two predominant technologies, each offering distinct mechanical, chemical, and aesthetic profiles tailored to specific performance requirements. Epoxy systems, formed through the crosslinking of bisphenol-A-based resins with amine hardeners, excel in high-strength, chemically aggressive settings due to their superior hardness, adhesion, and chemical inertness. In contrast, PU coatings, synthesized from …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 13, Issue 1, 2026 · pp. 14–23 Read article
-
IoT-Based Battery Health Monitoring for Electric Vehicles Using Machine Learning
Abstract: With increasing utilization of the Electric Vehicles (EV)s in global scale, battery health management becomes a critical factor which has great impact on vehicle performance, safety and longevity. Battery materials, such as NMC LFP lithium-ion batteries and lithium-ion batteries, degrade over time from charging behaviour, heat stress, discharging voltage profiles and environmental limits. Conventional BMS only offer threshold based health diagnostics and cannot perform accurate degradation prediction. This work presents …
Published in International Journal of Machine Systems and Manufacturing Technology · Vol. 4, Issue 1, 2026 Read article
-
Veeros: Stranger to Stranger Help Application
Abstract: This article aims to address the prevalent issue of individuals, particularly women, facing various unwanted problems and the reluctance to seek help from strangers or emergency helplines. The team’s proposed solution involves the creation of a platform that enables individuals to seek help without hesitation and receive assistance from nearby volunteers, thereby fostering a sense of community and support. The project’s problem statement emphasizes the serious challenges faced by women, …
Published in Journal of Open Source Developments · Vol. 11, Issue 2, 2024 · pp. 20–27 Read article
-
Technical Review Of Manufacturing Defects In Cold Forged M6 Nuts
Abstract: This review delves into the intricacies of M6 cold forged nuts, a pivotal component in many assemblies. These nuts are essential for maintaining structural integrity, yet their production can often lead to defects that compromise their performance. Key issues include material flaws, such as impurities and inconsistencies, dimensional inaccuracies that can affect fit and function, and surface roughness that can impact the nut's strength and durability. Material flaws can arise …
Published in Journal of Materials & Metallurgical Engineering · Vol. 14, Issue 1, 2024 · pp. 01–06 Read article
-
Analyzing the Effects of Soil-Structure Interaction and Geometric Configuration on Structure
Abstract: This study investigates how varying soil types impact the seismic performance of a 30-story building, simulated using ETABS software. The research focuses on key parameters such as soil type, different shapes of structure, base shear, and inter-story drifts under different soil conditions, ranging from soft clay to dense sand. By comparing fixed-base models with those incorporating soil-structure interaction (SSI), the analysis highlights significant differences influenced by soil type. The findings …
Published in Journal of Geotechnical Engineering · Vol. 11, Issue 2, 2024 · pp. 1–15 Read article
-
Quality Control and Assurance Practices in Modern Pharmaceutical Industry
Abstract: This brief overview outlines the global techniques for figuring out the prevalence of geotaxis impurities (residual solvents and various inorganic and organic impurities) in medications. It is now necessary to reveal a pharmaceutical product's purity and impurity profiles due to both national and international regulations. These elements are discussed, together with the kinds of impurities, their origins, their control, and regulatory issues, as well as the significance of pharmaceutical quality, …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 3, 2025 · pp. 07–13 Read article
-
Revolutionizing Vaccine Development:The Transformative Role of Bioinformatics in Designing Next-Generation Immunotherapies
Abstract: Vaccines have long been central to the prevention and control of infectious diseases, dramatically reducing morbidity and mortality worldwide. In the modern era, the integration of bioinformatics has revolutionized vaccine development by enabling rapid, precise, and cost-effective identification of potential vaccine targets. This seminar explores the multifaceted applications of bioinformatics in vaccinology, including antigen discovery, epitope prediction, structural modeling, molecular docking, and immunoinformatics-driven vaccine design. Special emphasis is placed on …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 12, Issue 3, 2025 · pp. 19–33 Read article
-
Phytotherapeutic Potential of Melaleuca: An Integrative Review of Phytochemistry and Antimicrobial, Antifungal, Antioxidant, and Antiviral Mechanisms
Abstract: Melaleuca alternifolia and other species of the Melaleuca genus stand out for the broad spectrum of pharmacological properties attributed to their bioactive compounds, such as monoterpenes, sesquiterpenes, flavonoids, and polyphenols. This study aimed to critically review and analyze scientific evidence produced between 2005 and 2025 regarding the antimicrobial, antifungal, antioxidant, and antiviral activities of Melaleuca, correlating its phytochemistry with molecular mechanisms of action. For this purpose, an integrative literature review …
Published in Research & Reviews : Journal of Herbal Science · Vol. 15, Issue 2, 2026 Read article
-
Structural Behavior of Flexible and Semi-Rigid Beam-Column Joint Connections by FEM
Abstract: This study investigates the structural behavior of flexible and semi-rigid beam-column joint connections in cold-formed steel (CFS) structures, focusing on the use of Finite Element Modeling (FEM) to simulate their performance under various loading conditions. Traditional analysis methods often oversimplify beam-column connections, treating them as either perfectly rigid or fully flexible, which does not accurately capture real-world joint behavior. In reality, many beam-column joints exhibit semi-rigid characteristics, where the stiffness …
Published in Journal of Structural Engineering and Management · Vol. 12, Issue 3, 2025 Read article
-
Review of Atorvastatin As A Potent Drug For Cardio-Vascular Disease(CVD)
Abstract: Cardiovascular disease (CVD), particularly atherosclerosis, remains the leading cause of death worldwide, significantly burdening public health, especially in Western societies. Metabolic syndrome and arrhythmic complications further exacerbate cardiovascular morbidity and mortality. Among restorative specialists, statins particularly atorvastatin have gotten to central in both the essential and auxiliary anticipation of coronary heart infection (CHD) due to their strong lipid-lowering properties and additional pleiotropic impacts. Atorvastatin, a selective HMG-CoA reductase inhibitor, not …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 3, 2025 · pp. 8–18 Read article
-
Medicinal Properties of Oxytenanthera abyssinica: A Narrative Review
Abstract: Oxytenanthera abyssinica, a plant local to the African landmass, has gotten a parcel of intrigued in later a long time for its conceivable restorative benefits; it has been utilized in conventional medication for decades since of its assumed mending capabilities. In spite of its long history, careful logical examination into its restorative potential is being attempted. This review paper explore into the multidimensional part of O. Abyssinica is in progressed …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 13, Issue 2, 2026 Read article
-
Enhancing Worker Comfort in High-Heat Environments: A Triangular Bladeless Cooling Fan Approach
Abstract: Workers in high-heat industrial environments frequently encounter thermal stress, fatigue, and dehydration, which significantly impact both productivity and safety. Existing cooling solutions such as pedestal fans, ceiling fans, and central air-cooling systems often fall short due to limited airflow reach, safety concerns from exposed blades, high energy consumption, and poor suitability for dynamic workshop layouts. To address these challenges, this study presents a novel triangular bladeless fan designed specifically for …
Published in Trends in Mechanical Engineering & Technology · Vol. 15, Issue 3, 2025 · pp. 25–31 Read article
-
Flexural Vibration of Non-Uniform Beam on Bi-Parametric Foundation Under Harmonic Moving Load with Non-Classical Boundary Conditions
Abstract: The dynamic response to harmonically varying moving loads of non-uniform elastic beam resting on bi-parametric foundation with non-classical boundary condition, time dependent in particular is examined in this paper. Here, the beam is considered non-uniform, with the moment of inertia and the distributed mass varying continuously along the span L as functions of the position 𝑥. In order to guarantee a more stable structure and a reduce risk of resonance, …
Published in International Journal of Mechanical Dynamics and Systems Analysis · Vol. 3, Issue 2, 2025 · pp. 28–42 Read article