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62 articles for “Metabolites”
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A Review on Phytochemistry and Pharmacology of Macaranga peltata
Abstract: Macaranga peltata, categorized within the Euphorbiaceae family, represents a prevalent pioneer arboreal species across Southeast Asia, specifically in regions such as India and Sri Lanka. This review scrutinizes the phytochemical properties and pharmacological profiles of Macaranga peltata, underscoring both its historical medicinal applications and prospective therapeutic roles. The plant exhibits a rich composition of secondary metabolites, encompassing flavonoids, stilbenes, tannins, and terpenes, with the majority of these compounds being extracted …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 1, 2025 · pp. 50–59 Read article
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Host-Microbiota Crosstalk in the Rumen: Signaling Pathways for Nutrient Metabolism and Disease Resilience in Dairy Cows
Abstract: The rumen serves as a highly intricate microbial ecosystem, fundamentally responsible for the degradation of fibrous plant materials in ruminant. The intricate host-microbiota crosstalk within the rumen significantly influences nutrient metabolism, growth, and health outcomes in livestock. The interaction between the host and its microbial community, mediated through signaling pathways including the production of short-chain fatty acids (SCFAs), bile acids, and various metabolites, is crucial for enhancing nutrient absorption, fermentation …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 1, 2025 · pp. 29–41 Read article
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Advancing Asthma Management: The Synergy of Systems Biology, Artificial Intelligence, and Next-Generation Therapeutics
Abstract: Asthma is an inflammatory disorder of the respiratory tract that is chronic and heterogeneous in nature and has various effects on millions of people. Being a chronic inflammatory disease, asthma remains incurable and the major conventional treatments offer limited success due to the mask nature of its pathophysiology. Systems biology/(AI), and next-generation has greatly enhanced knowledge and the management of asthma. The approaches based on gene, transcript, protein, and metabolite …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 14, Issue 2, 2024 · pp. 1–12 Read article
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Study of the response of Fenugreek Seedlings (Trigonella foenum-graecum L.) to some Plant Growth Regulators and Their effect on the production of the active Compound (Trigonelline)
Abstract: The experiment was conducted during the 2022–2023 academic year in the laboratories of the Department of Biology, Faculty of Education for Girls, University of Kufa, to investigate the effects of varying concentrations of gibberellic acid (GA₃) — specifically 0, 2, and 3 ppm — and salicylic acid (SA) (0, 2.5, 5 ppm) as well as the interaction between them on the germination percentage and some growth traits of fenugreek seedlings …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 15, Issue 2, 2025 Read article
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Health Hazards of Benzene Exposure Among Petrol Pump Attendants in North Indian Cities
Abstract: Benzene exposure is an undisputed occupational risk, notably among petrol pump attendants who come in contact with fuel vapors. Chronic exposure to benzene is linked to several conditions, such as hematological disorders, respiratory issues, and increased cancer prevalence. This research aims to assess the health effects related to benzene exposure amongst petrol attendants in the northern cities of India. A cross sectional study was conducted at each petrol pump in …
Published in Research and Reviews : Journal of Crop science and Technology · Vol. 14, Issue 2, 2025 · pp. 36–43 Read article
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The Role of Gut Microbiota in the Health Effects of Fermented Dairy Products
Abstract: The human gut microbiota plays a crucial role in maintaining physiological health, influencing digestion, metabolism, immune function, and even mental well-being. Among dietary interventions aimed at modulating gut microbiota, fermented dairy products have emerged as particularly promising due to their rich content of live microorganisms, bioactive compounds, and nutrients. This review explores the intricate interactions between fermented dairy products and the gut microbiota, highlighting their potential health benefits and underlying …
Published in Research and Reviews : Journal of Dairy Science and Technology · Vol. 14, Issue 2, 2025 · pp. 5–10 Read article
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Review on Dioscorea alata and its Pharmacological application
Abstract: Dioscorea alata, also known as water yam, is an important crop found worldwide. About 600 different species have been reported worldwide. Many nations, including South America, Africa, Australia, and the southern United States, cultivate D. alata. D. Alata is a member of the Discordance family and has been demonstrated to possess anti-inflammatory, anti-apoptotic, and antioxidant qualities. Dioscorea's metabolites include phenolic chemicals, which reduce sugars, flavonoids, glycosides, saponins, alkaloids, anthraquinones, proteins, …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 2, 2025 · pp. 80–86 Read article
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Application of Metabolomics in Pharmacognosy
Abstract: In the field of pharmacognosy, the identification, quality control, and bioactivity evaluation of medicinal plants and natural products have become significantly more effective thanks to the development of a strong tool known as metabolomics, which is the complete study of small-molecule metabolites in biological systems. Metabolomics offers more in-depth insights into phytochemical composition, plant metabolism, and the mechanisms that underlie medicinal benefits. It does this by enabling high-throughput analysis and …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 3, 2025 · pp. 01–07 Read article
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Trichoderma: beneficial fungus for sustainable agriculture
Abstract: As environmentally beneficial substitutes for chemical pesticides, Trichoderma species are being utilized in agriculture more and more. Disease suppression, increased plant growth, and increased tolerance to environmental stress are just a few advantages they provide. These fungi are used in a wide range of cropping systems and formulations around the world. Their use is growing worldwide, particularly in Asia and Europe. In contemporary crop management, items derived from Trichoderma are …
Published in International Journal of Fungi · Vol. 2, Issue 2, 2025 · pp. 25–29 Read article
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Phytoconstituents of Ticanto crista (L.) R. Clark & Gagnon (Caesalpiniaceae): A Review
Abstract: Ticanto crista (L.) R. Clark & Gagnon (= Caesalpinia crista L.), a member of the Leguminosae family, is a medicinally important plant traditionally used in various systems of medicine, including Ayurveda, for treating a wide range of ailments. It has attracted increasing scientific interest due to its rich phytochemical profile and therapeutic potential. This review serves as a comprehensive index of the chemical structures of common and medicinal compounds isolated …
Published in Research & Reviews : Journal of Botany · Vol. 14, Issue 3, 2025 · pp. 38–59 Read article
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Microbial Competition in the Rumen: Insights into Fermentation Kinetics, Host Health, and Environmental Sustainability
Abstract: Microbial competition within the rumen is a crucial determinant of fermentation efficiency, nutrient utilization, and overall host health in ruminant animals. The complex microbial community in the rumen comprises bacteria, protozoa, fungi, and archaea, all of which interact in intricate and often competitive ways to degrade feed and produce essential metabolites. This competition significantly influences fermentation kinetics, determining the rate and efficiency of carbohydrate, protein, and fat breakdown. Such microbial …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 3, 2025 · pp. 27–42 Read article
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Neuroinflammation Is Aggravated by the Aqueous Extract of Myrmecodia Platytyrea Tuber
Abstract: Myrmecodia platytyrea, commonly known as the ant plant, is a medicinal epiphyte traditionally used in Southeast Asia for its purported health benefits, including anti-inflammatory, antioxidant, antimicrobial, and anticancer activities. Its tuber contains abundant secondary metabolites, including flavonoids, tannins, phenolic compounds, and saponins. While these phytochemicals are generally associated with therapeutic effects, the biological activity of Myrmecodia extracts varies depending on the type of extract, dosage, and route of administration. In …
Published in International Journal of Brain Sciences · Vol. 3, Issue 1, 2026 · pp. 5–14 Read article
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The Parasitic Fingerprint: Tracing Infection to Host Illness
Abstract: Parasitic infections remain a major global health burden, causing significant morbidity and mortality, particularly in tropical and subtropical regions. A critical aspect of disease pathogenesis is the unique molecular and cellular imprint left by parasites in their hosts, termed the “parasitic fingerprint.” These fingerprints encompass parasite-derived proteins, nucleic acids, metabolites, extracellular vesicles, and host responses, including gene expression changes, cytokine profiles, and metabolic adaptations. Advances in multi-omics technologies, which integrate …
Published in Recent Trends in Infectious Diseases · Vol. 3, Issue 1, 2026 · pp. 29–50 Read article
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The Mycobiome Frontier – Pre & Post 2020 Status: Integrating Fungal Bioactive Compounds, Probiotics, and Antimicrobial Peptides in Modern Therapeutics and Biotechnology.
Abstract: The fungal kingdom represents an indispensable resource in modern therapeutics and biotechnology, offering a diverse array of bioactive compounds, probiotics, and antimicrobial peptides (AMPs). Functional fungal polysaccharides (FFPs), such as beta-glucans, chitin, and mannans, are centrally involved in modulating the human gut microbiota, providing novel therapeutic avenues for chronic conditions including diabetes, neurodegenerative disorders, and cancer. These compounds act as prebiotics, nourishing beneficial bacteria and enhancing metabolic parameters such as …
Published in International Journal of Fungi · Vol. 3, Issue 1, 2026 · pp. 1–11 Read article
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Nature’s Pharmacy: Plant-Based Antifungal Agents and Their Therapeutic Potential
Abstract: Antifungal resistance has increased dramatically over the last 10 years, causing serious problems for healthcare because of higher morbidity and death. The urgent need for new treatments is highlighted by the scarcity of effective antifungal medications, their toxicity, and the rise of resistant strains. Since many plants have bioactive secondary metabolites with strong antifungal qualities, including alkaloids, flavonoids, terpenoids, phenolics, and saponins, ethnobotanical sources offer a viable path. Plants with …
Published in International Journal of Tropical Medicines · Vol. 3, Issue 1, 2026 · pp. 1–7 Read article
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Plant-Derived Antimicrobials as Next-Generation Solutions to Multidrug Resistance
Abstract: The steady rise of multidrug-resistant (MDR) pathogens is reshaping how clinicians, researchers, and policymakers think about infection control. When bacteria acquire the ability to survive exposure to three or more antibiotic classes at once—whether through efflux pumps, enzyme-mediated drug destruction, target modifications, or reduced membrane permeability—treatment options narrow dramatically, hospital stays lengthen, and mortality climbs. Conventional pharmaceutical pipelines have struggled to keep pace with this biological arms race, pushing the …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 Read article
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Nutrient–Xenobiotic Crosstalk in Dairy Cattle: Implications for Metabolism, Immunity, Health, and Productivity in Resilient Dairy Development
Abstract: Dairy cattle are routinely exposed to a wide range of xenobiotics, including mycotoxins, heavy metals, pesticides, residues from veterinary drugs, and plant secondary metabolites, through feed, water, and environmental sources. These xenobiotics, being foreign to biological systems, can interfere with the absorption, metabolism, and utilization of essential nutrients, while also compromising immune function, organ health, and overall physiological performance. Chronic or subclinical exposure can reduce feed efficiency, disrupt energy and …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 16, Issue 1, 2026 · pp. 37–46 Read article
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Extracellular Vesicle-Based Liquid Biopsies: Decoding the Tumor Microenvironment for Precision Oncology
Abstract: The tumor microenvironment (TME) plays a pivotal role in cancer initiation, progression, and therapeutic response. Decoding the TME is, therefore, essential for advancing precision oncology. Extracellular vesicles (EVs), including exosomes and microvesicles, are nanoscale lipid bilayer particles secreted by tumor and stromal cells. They transport a wide range of bioactive molecules, such as DNA, RNA, proteins, lipids, and metabolites, which reflect the dynamic state of the TME. Recent advances in …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 15, Issue 1, 2026 · pp. 43–62 Read article
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Comprehensive Evaluation of Quercetin from Bauhinia purpurea for Its Anti-Acne and Anti-Inflammatory Potential, Including Advances in Quercetin-Loaded Nanogel Formulation
Abstract: Acne vulgaris is among the most prevalent chronic inflammatory dermatoses in clinical dermatology, afflicting a substantial proportion of the global adolescent and adult population. Conventional pharmacotherapies — including topical retinoids, benzoyl peroxide, and systemic antibiotics — remain the therapeutic mainstay; however, their long-term utility is progressively undermined by adverse cutaneous reactions, systemic toxicity, and the rising prevalence of antibiotic-resistant Cutibacterium acnes strains. These limitations have intensified scientific interest in plant-derived …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 2, 2026 Read article
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Functional Biomolecules in Animal Nutrition: Biochemical Mechanisms and Their Impacts on Growth Performance and Health Outcomes
Abstract: Functional biomolecules have emerged as critical modulators of animal nutrition, extending beyond conventional nutrient supply to regulate biochemical and physiological processes that determine growth performance and health outcomes. This review synthesizes current knowledge on diverse classes of bioactive compounds, including amino acids, peptides, fatty acids, vitamins, minerals, phytochemicals, and microbial-derived metabolites, and their roles in livestock systems. Emphasis is placed on underlying biochemical mechanisms such as enzyme activation, nutrient signaling …
Published in International Journal of Nutritions · Vol. 3, Issue 2, 2026 Read article