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67 articles for “Failure path.”
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Role of Epigenetic Mechanisms in Lung Fibrosis: Therapeutic Opportunities and Challenges
Abstract: Lung fibrosis poses a serious risk to one's health since it might result in respiratory failure due to an abnormal accumulation of fibrotic tissue in the lungs. Epigenetic mechanisms, such as histone changes, DNA methylation, and non-coding RNAs, closely control gene expression patterns and cellular processes associated with lung fibrosis. Anomalies in DNA methylation patterns connected to changes in gene expression profiles and disturbances in fibrotic signalling pathways are potential …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 13, Issue 2, 2024 · pp. 9–20 Read article
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Progressive Collapse Prevention Analysis of Multi-Storeyed Buildings by Using Pushover Analysis
Abstract: AbstractThis paper investigates an actual structure’s potential to break due to progressive collapse. This report looks into the progressive collapse resistance of high-rise RC structures. Progressive collapse of building constructions, primarily concentrates on concrete structures. Progressive collapse of a structure occurs when major structural load carrying members are removed suddenly. A progressive collapse is initiated as a consequence of local structural damages. It produces a chain reaction mechanism, into a …
Published in Journal of Structural Engineering and Management · Vol. 4, Issue 3, 2017 · pp. 17–23 Read article
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Next-Generation Biodegradable Polymer Composites: Enhancing Mechanical and Thermal Performance through Green Reinforcements
Abstract: Next-generation biodegradable polymer composites, combining compostable matrices such as polylactic acid (PLA), polyhydroxyalkanoates (PHAs) and starch-based polymers with green reinforcements (e.g., nanocellulose, lignin, agricultural residues and other bio-fillers), offer a pragmatic route to reconcile high performance with end-of-life sustainability. This paper examines recent advances in the design, processing and interfacial engineering of such composites to enhance mechanical stiffness, strength, toughness and thermal stability while preserving—or intentionally controlling—biodegradation pathways. Emphasis is …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1780–1794 Read article
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Smart Street Lighting Enabled by Wireless Sensor Networks: A Path to Energy Efficiency and Fault Monitoring
Abstract: The increasing demand for energy efficiency and smart city infrastructure has led to the adoption of innovative technologies such as wireless sensor networks (WSNs) in street lighting systems. This research explores the design and implementation of a smart street lighting system (SSLS) integrated with WSNs to enhance energy efficiency and enable real-time fault detection. The proposed system utilizes a network of wireless sensors to monitor ambient light levels, vehicular movement, …
Published in International Journal of Wireless Security and Networks · Vol. 3, Issue 1, 2025 · pp. 24–38 Read article
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An Insight to Diagnosis and Management of Druginduced Hepatotoxicity: An Overview
Abstract: (ADRs) Adverse Drug Reactions are constitute and mutual chief health problem. Throughout the last period liver toxicity has remained one of the most recurrent reasons for pharmacovigilance protection intelligences and the withdrawal from the marketplace of an accepted medicinal product. Liver is a main organ elaborate in the systemic deposition and decontamination of exogenous and endogenous ingredients. Liver disfunction challenges not only health care specialists but also the pharmaceutical manufacturing …
Published in Trends in Drug Delivery · Vol. 8, Issue 2, 2023 · pp. 39–54 Read article
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Assessment of Matrix Cracking and Fiber Breakage in Hybrid Composite Materials.
Abstract: Hybrid composite materials, combining two or more distinct fiber or matrix constituents, have emerged as advanced structural solutions for aerospace, automotive, marine, and civil engineering applications. However, their complex microstructure makes them susceptible to multiple interacting damage mechanisms, particularly matrix cracking and fiber breakage. This study provides a comprehensive assessment of these damage modes, emphasizing their initiation, evolution, and combined effects on the mechanical integrity of hybrid composites. Matrix cracking …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 3, Issue 2, 2025 · pp. 1–5 Read article
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Predictive Maintenance Strategies for Safety-critical Mechanical Systems
Abstract: Ensuring the reliability and safety of industrial systems is essential, especially in high-risk sectors such as aerospace, manufacturing, and energy. Predictive maintenance (PdM) has become a crucial approach for minimizing operational failures and improving maintenance efficiency. This research introduces an advanced PdM framework that enhances industrial safety by integrating Internet of Things (IoT) technology, machine learning (ML), and big data analytics. By enabling real-time monitoring and predictive fault detection, this …
Published in Journal of Industrial Safety Engineering · Vol. 12, Issue 1, 2025 · pp. 12–17 Read article
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Deformation Behaviour of the Billet and Tooling Design on AA5083 through Equal Channel Angular Pressing With Effect of Back Pressure
Abstract: Equal channel angular pressing is an emerging method applied to subject materials to significant plastic strains while maintaining the original shape of the billet. Researchers have discovered that the level of strain attained through equal channel angular pressing is influenced by factors such as the angle of die, friction conditions, and the implementation of back pressure. These variables significantly impact the microstructure and the irregularity of strain within the billet …
Published in Journal of Polymer & Composites · Vol. 12, Issue 1, 2024 · pp. 287–303 Read article
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Numerical Simulation of Crack Growth in Dynamic Loading Conditions
Abstract: Because it is crucial for forecasting structural failures in engineering applications, crack formation in materials under dynamic loading circumstances has become a crucial study topic. In this work, finite element methods (FEM) are used to numerically simulate fracture propagation in dynamic stress situations. The impact of loading rates, material characteristics, and crack geometries on crack growth patterns are assessed in a thorough parametric research. The work uses sophisticated computational methods …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 2, Issue 2, 2024 · pp. 30–34 Read article
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Fissure-in-ano: A Review
Abstract: Fissure-in-ano is a common a troubling and painful proctologic problem with a tendency towards nonhealing and persistence. It affects a great majority of the population world over. Failure of fissures to heal has been attributed to persistent internal sphincter spasm. Medical manipulation should be a first-line treatment in anal fissure, but their limitations include side effects, poor compliance, and recurrence of the fissure. A cautious surgical approach is required to …
Published in Research and Reviews : Journal of Surgery · Vol. 9, Issue 3, 2020 · pp. 13–22 Read article
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Decompensated Liver Failure and Acute Renal Failure in a Patient with Chronic HBV,HCV, and HIV Infections
Abstract: This case study focuses on a 30-year-old male patient suffering from decompensated liver failure and acute renal failure, complicated by chronic hepatitis B (HBV), hepatitis C (HCV), and HIV/AIDS. Presenting with severe abdominal pain, nausea, and general weakness, the patient had a history of alcohol and intravenous drug use, leading to chronic liver disease and acute renal failure. Despite aggressive interventions, including intravenous antibiotics and fluid therapy, his condition worsened …
Published in International Journal of Pathogens · Vol. 2, Issue 1, 2025 · pp. 17–23 Read article
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Exploring the Intersection of Blockchain and Cybersecurity
Abstract: The digital landscape is an increasingly contested battleground, where the escalating sophistication of cyber threats consistently challenges the efficacy of traditional, centralized security architectures. Pervasive data breaches, identity theft, and vulnerabilities stemming from single points of failure underscore an urgent need for a paradigm shift in cybersecurity. This study posits that blockchain technology, with its foundational principles of decentralization, immutability, cryptographic security, and transparent distributed consensus, offers a transformative framework …
Published in Current Trends in Information Technology · Vol. 16, Issue 1, 2025 · pp. 32–42 Read article
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Power Supply Design Issues for Personnel Computers Application: A Review
Abstract: A power supply should meet various requirements for proper functioning of a PC. Electromagnetic Interface (EMI) causes catastrophic failures resulting in malfunctioning of PC's. It is therefore essential to meet the Electromagnetic Compatibility (EMC) requirements in addition to other design considerations demanded in a high technology system. The computer is operating and transmitting the signal with low voltage, so it is sensitive to Electromagnetic interference of leakage. Since the PC …
Published in Journal of Power Electronics and Power Systems · Vol. 3, Issue 2, 2013 · pp. 37–40 Read article
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Genomic Medicine Revolutionizes Heart Care: A New Standard of Practice
Abstract: The integration of genomic and precision medicine into cardiovascular healthcare represents a transformative advancement in addressing the global burden of cardiovascular diseases (CVDs). Precision medicine leverages genomic, proteomic, and metabolomic data to provide personalized care, optimizing treatment outcomes while minimizing adverse effects. Over the past decade, extensive research has highlighted its potential to revolutionize the management of major CVDs, including myocardial infarction, hypertension, and heart failure, which significantly contribute to …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 2, 2025 · pp. 30–37 Read article
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Achieving Surgical Accuracy in Implant Dentistry Using a CAD/CAM Stent: A Case Report
Abstract: Surgical accuracy is of utmost importance in implant dentistry as one of the most common aetiology of implant failure is related to incorrect placement. The surgical aspect of implant placement is vital to the stability, support and retention of the prosthesis to be placed later. CAD/CAM in dentistry has established strong footing in the field of Oral Implantology. The fabrication of a stent to guide the implant drill using CAD/CAM …
Published in Research and Reviews: A Journal of Dentistry · Vol. 8, Issue 1, 2017 · pp. 1–4 Read article
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Managing Infertility with Panchakarma— A Case Study of Anovulation Associated with Endometriotic Cysts
Abstract: Infertility is defined as the failure to conceive after 12 months or more of regular unprotected sexual intercourse. In any community, about 5–15% of couples who are of reproductive age have suffer from infertility. A 29-years-old female patient of 29 yrs. old of primary infertility with Pitta Pradhana Vata Prakruti was diagnosed as Anovulation along with Grade- 4 Endometriosis. In Ayurveda, it can be correlated to Bandhya with Vataja yoni …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 12, Issue 2, 2023 · pp. 23–31 Read article
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Improvement in Mechanical Properties Using High Velocity Oxyfuel Coating (HVOF): A Review
Abstract: Surface modification plays a vital role in improving the service life of different machine parts used in number of industries. Due to daily routine operations at difficult environment conditions, most of machine components have failure in their operations. In these types of cases, only materials with superior wear resistance can be used or material surface can be modified by coating. High velocity oxyfuel coatings (HVOF) play a significant role in …
Published in Trends in Machine design · Vol. 12, Issue 2, 2025 · pp. 1–8 Read article
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Signal Transduction Pathways in Xenotransplantation: Insights and Implications
Abstract: In this article, we will discuss Xenotransplantation which is used for the transplantation of tissues or organs cells from one species to another species. It holds tremendous promise for addressing the clinical shortage of human organs for transplantation. In this review we provide a comprehensive analysis of the key signal transduction involved in xenotransplantation is paramount for overcoming these hurdles and advancing the field toward clinical application. Many studies on …
Published in Current Trends in Signal Processing · Vol. 13, Issue 3, 2023 · pp. 15–23 Read article
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Material-Level Degradation of Magnetorheological Fluids Under Long-Term Cyclic Shear
Abstract: The long-term functional stability of magnetorheological fluids (MRF) remains a key limitation for their reliable use in adaptive systems and continuously operated magnetorheological devices. In this study, the intrinsic evolution of rheological properties in a commercial MRF (MRC-C1L) is systematically examined under prolonged cyclic loading, with the aim of isolating material-level degradation mechanisms independent of device-related effects. The fluid was subjected to 120,000 low-strain oscillatory shear cycles under a constant …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 101–112 Read article
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Seismic-Resilient Structural Systems: Geotechnical Engineering
Abstract: Earthquakes represent one of the most destructive natural hazards, capable of causing severe structural damage, loss of life, and substantial economic disruption. Seismic waves propagating through the ground can induce excessive forces and deformations in buildings, often leading to partial or complete collapse. Statistical records indicate that thousands of earthquakes occur globally each year, including several major events that result in significant damage. Past earthquake disasters have repeatedly demonstrated that …
Published in Journal of Geotechnical Engineering · Vol. 13, Issue 1, 2026 · pp. 55–63 Read article