Search
1901 articles for “ADMET lab 2.0” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
Nothing matched all of your words, so these match any of them.
-
GLP-1 Receptor Agonists: A Dual Therapeutic Strategy for the Management of Type 2 Diabetes Mellitus and Obesity
Abstract: For the treatment of obesity and type 2 diabetes mellitus (T2DM), glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have become a revolutionary class of pharmaceutical drugs. These drugs were first created as glucose-lowering treatments, but they have now shown other advantages, such as notable weight loss, better cardiovascular results, and general metabolic control. The objective of this narrative review is to assess the pharmacological mechanisms, clinical efficacy, safety profile, and therapeutic …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 69–75 Read article
-
Assessment of Groundwater Quality in Rumuodara, Rivers State, Nigeria
Abstract: The assessment of groundwater quality from selected borehole in Rumuodara, Rivers State, Nigeria was evaluated. The results of the physicochemical parameters revealed that pH ranged from 6.57-6.60, temperature: 26.10-28.54oC, turbidity: 1.57-2.96NTU, conductivity: 41.24-68.44 μS/cm, salinity: 26.10-50.37mg/l, total dissolved solid: 18.9-63.14mg/l, total hardness: 38.21-48.30mg/l, alkalinity: 55.30-70.17mg/l, chloride: 28.40-75.14mg/l, sulphate: 21.50-30.60mg/l, nitrate: 1.50-3.04mg/l, phosphate: 59.24-65.40mg/l, calcium: 37.81-45.27mg/l, Iron: 0.133-0.190mg/l, sodium: 16.70- 21.13mg/l, copper: 0.22–0.50mg/l, total suspended solid: 2.94-3.60mg/l, Lead: < 0.01mg/l-2.27mg/l, zinc: …
Published in Research & Reviews : Journal of Ecology Read article
-
In Silico Molecular Docking of Indigofera tinctoria Phytocompounds to Target EGFR/ERK and FGFR/FGF Pathway Proteins Involved in Prostate Cancer
Abstract: Objective: Prostate cancer being the second major cause of cancer-related deaths in males, affects the small walnut-shaped gland below the bladder called the prostate gland. The epidermal growth factor protein (EGFR), cascade protein (ERK), and fibroblast growth factor proteins (FGFR and FGF) are involved in the different signaling pathways that lead to the formation of different products, that are responsible for the progression of cancer and thus can be considered …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 34–56 Read article
-
Molecular Docking and Pharmacokinetic Profiling of the Phytocompounds of Jatropha curcas as Antagonist for Salmonella typhi
Abstract: Background: Typhoid is an infection caused by the Gram-negative bacterium, Salmonella enterica serovar typhi. The study assessed the potential use of Jatropha curcas as a typhoid fever therapy alternative to traditional medications. The ability to uncover novel drug indications for currently available medications using in silico methods has increased thanks to the wealth of pharmacological and biological knowledge that is available. Objective: In this study, we assessed the potential inhibitory …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 1, 2023 · pp. 67–81 Read article
-
Effectiveness of a Planned Teaching Programme on Primigravid Mothers' Awareness of Specific Natural Pain Relief Techniques Used During Labor in Particular Bangalore Hospital
Abstract: Background: Pain is an exciting sensation and is caused by the stimulus during labor. Always Pain plays a major role in labor in empowering the women, whereby they triumph by giving delivery to the newborn. Objectives: Assess the knowledge level about selected natural pain relief methods. Methodology: A quantitative research approach and the design used in this study was a pre-experimental research design. Sixty primigravid mothers were selected for the …
Published in International Journal of Midwifery Nursing And Practices · Vol. 1, Issue 1, 2023 · pp. 9–16 Read article
-
Addressing Accountability and Fair Practices in Labor Contracting for Sustainable Harvesting in the Sugar Industry
Abstract: This study promotes the use of blockchain technology to solve issues with labor data management in the sugar business. Through decentralized blockchain storage, the proposed solution protects the security and openness of labor data, with an emphasis on preventing unethical activity by contractors holding numerous simultaneous contracts. Smart contracts make it easier for contractors to register and keep track of engagements, which helps the sugar industry enforce contractual compliance and …
Published in International Journal of Solid State Innovations & Research · Vol. 2, Issue 1, 2024 · pp. 1–7 Read article
-
Unmasking Hallucinations in Large Language Models Using Analysis of the LLAMA 2 Model and RAG Intervention
Abstract: The study describes the creation of a chatbot for financial trading called "TradeBot" and how it uses Retrieval Augmented Generation (RAG) to overcome the problem of producing false or unverifiable information, sometimes known as hallucinations. RAG allows the chatbot to refer to an external data source in addition to its taught knowledge, which increases the accuracy of its responses. The NCFM (NSE's Certification in Financial Markets) book was integrated as …
Published in Journal of Artificial Intelligence Research & Advances · Vol. 12, Issue 1, 2025 · pp. 76–86 Read article
-
Investigation of Residual Stress, and corrosion behavior of AA6082/Al 2 O 3 /C/ Si 3 N 4 Composite Material
Abstract: The main objective of the current study was to create AA6082/ Al2O3/C/Si3N4 Composite Material by the use of stir casting. The properties of the AA6082/ Al2O3/C/ Si3N4 Composite Material shown a significant improvement, with a micro-hardness rise of 13.5% and a residual stress decrease of 60%. As the testing parameters were increased, the residual stress of the AA6082/ Al2O3/C/ Si3N4 Composite Material rapidly decreased from -65MPa to -15MPa. An electromagnetic …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 1104–1109 Read article
-
Impact of National Education Policy 2020 on Physical Education and Sports: A Comprehensive Review
Abstract: The Indian National Education Policy (NEP) 2020 is a historic project that aims to change the nation's educational system. The focus on improving sports and physical education in the classroom is one of its main elements. The importance of holistic education, where physical well-being is equally as significant as academic achievement, is acknowledged by this approach. NEP 2020 aims to make physical education a core part of the curriculum in …
Published in Recent Trends in Sports · Vol. 2, Issue 1, 2025 · pp. 14–18 Read article
-
FDA Drug Approvals 2024: A Comprehensive Review
Abstract: The year 2024 has been pivotal for the pharmaceutical industry, with the U.S. Food and Drug Administration (FDA) granting approval to a diverse array of new drugs. These approvals highlight significant strides in therapeutic innovation, targeting a spectrum of diseases from rare genetic disorders to prevalent chronic conditions. This article provides a detailed examination of the FDA-approved drugs of 2024, focusing on their therapeutic indications, mechanisms of action, and the …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 28–46 Read article
-
Bibliometric Analysis of TNAI’s The Nursing Journal of India, 2014-2023
Abstract: Since 1910, the Nursing Journal of India of TNAI has been playing a vital role in scattering of information and knowledge in various aspects of nursing and allied health care. This bibliometric (statistical) analysis is based on only 443 citing articles in English languages which are published in this Journal in 10 volumes (2014-2023). Out of total, 442 papers are under personal and one under corporate authorship. This study shows …
Published in Research & Reviews : Journal of Statistics · Vol. 13, Issue 2, 2024 · pp. 1–17 Read article
-
A Decade of Viral Evolution (2015–2025): Emergence, Mutations, and Implications for Global Health
Abstract: Over the past decade (2015-2025), viral evolution has profoundly reshaped the global health landscape, challenging healthcare systems, diagnostic tools, therapeutic strategies, and vaccine efficacy. This review comprehensively analyzes the evolutionary trajectories of major human and zoonotic viruses, with a focus on pandemic-prone, drug-resistant, and emerging pathogens. Viral evolution is driven by diverse molecular mechanisms including high mutation rates, recombination, reassortment, host immune pressure, and antiviral interventions, leading to genetic diversification, …
Published in International Journal of Vaccines · Vol. 2, Issue 2, 2025 · pp. 31–40 Read article
-
Emerging Programming Languages Shaping Technology in 2026
Abstract: As technology keeps changing quickly, it's more crucial than ever for developers, students, and tech fans to choose the correct programming language. This article talks about the best programming languages to learn in 2026, focusing on their most important features, how they can be used in the real world, and how much demand there will be for them in the job market in the future. Each language is looked at …
Published in Recent Trends in Programming languages · Vol. 13, Issue 1, 2026 Read article
-
Zeolite-Y Encapsulated Copper (II) and Cobalt (II) Species as Hybrid Nano-catalysts: Structural and Catalytic Aspects
Abstract: Special properties inherent to zeolites in facilitating the construction of novel upramolecular assemblies by encapsulation of guest molecules (metal complexes) into their large cages can be utilized to use these assembled materials as novel catalysts. These modified solids have the advantages of both behaving as the homogeneous and the heterogeneous catalytic system. In the present work, copper (II) and cobalt (II) complexes of 2-amino ethanoic acid (2-AEA) encapsulated in the …
Published in Journal of Catalyst & Catalysis Read article
-
Assessment of Hepatic Damage in Labeo rohita (Hamilton, 1822) Exposed to Azo dye C. I. Direct Green 6
Abstract: Textile industries are one of the major backbones of Indian economy. They are the major reason for contamination of water bodies and their toxicity to ecosystem is an alarming environmental issue. The present study was designed to evaluate the hepatotoxic effects of C.I. Direct Green 6 (DG 6), a commercially used textile azo dye on Labeo rohita fingerlings. For this, L. rohita fingerlings were exposed to three sublethal concentrations (2.5, …
Published in Research and Reviews : Journal of Veterinary Science and Technology Read article
-
Melanogenic Inhibitory Effects of Sesamum indicum Phytocompounds Towards CDK 2, c-KIT, and BRAF.
Abstract: Objective: Melanoma is thought to be the fifth most frequent cancer in the US population, despite cancer being the most common cause of death in the globe. BRAF, CDK2, and c-KIT proteins are regarded as potential therapeutic agents since mutations in these proteins are the primary cause of melanoma. For the investigation of their pharmacological properties and therapeutic activities against the target proteins, Sesamum indicum L. and its phytocompounds were …
Published in International Journal of Bioinformatics and Computational Biology Read article
-
Seasonal Variations of Air Quality Measures In Warri and Effurun, Delta State, Nigeria.
Abstract: Air quality in Urban Cities like Warri and Effurun has been deteriorating over time. The distribution levels of air pollutants in the Warri and Effurun environments may be related to both natural and man-made factors. In addition to evaluating the quality of rainwater with regard to pH, heavy metals (Fe, Pb, Cd, As, Hg, CU, Zn), and some anions (Cl-, NO3-, SO42-, CO32-), this project study aims to investigate, using …
Published in International Journal of Pollution: Prevention & Control · Vol. 2, Issue 1, 2024 · pp. 23–48 Read article
-
Comparative Study to Assess the Knowledge of Higher Secondary School Students Regarding Career Counselling in Selected Rural and Urban Schools of Kashmir
Abstract: Background: Career counseling assists individuals in choosing appropriate educational and occupational choices and making career options based on future employment demands and requirements. Career counseling comprises a wide variety of professional activities that assist people in overcoming career-related obstacles. Aim: The primary objective of the study was to evaluate the understanding of career counseling among students in chosen rural and urban high schools in Kashmir. Method: This study employed a …
Published in Research and Reviews: A Journal of Health Professions · Vol. 14, Issue 1, 2024 · pp. 11–18 Read article
-
Ayurveda Treatment of Type 2 Diabetes Mellitus WSR Kaphaja Prameha: A Case Study
Abstract: Type 2 diabetes mellitus is highly prevalent in society nowadays. This is result of deranged lifestyle and food habits of present era. It can be corelated with Prameha in Ayurveda, that is mentioned in all ancient texts of Ayurveda. In present case study, a 45 years old obese patient visited Kayachikitsa OPD with complains of lethargy, weakness, excess sleep, lack of sexual desire and calf pain. He was diagnosed to …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 11, Issue 3, 2024 · pp. 1–4 Read article
-
Targeting Vasopressin 2 Receptor (V2R) in Renal Cystogenesis by Exploring the Nephroprotective Potential of “Terminalia arjuna”
Abstract: Objectives: Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disorder, leading to the formation of multiple cysts in the kidneys. It is a major cause of end-stage renal disease (ESRD), which often requires dialysis or a kidney transplant for survival. This research focuses on identifying potential bioactive compounds derived from natural sources that show promise for drug development targeting the V2R gene. Methods: The naturally occurred …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 2, 2024 · pp. 14–24 Read article