Search
538 articles for “efficacy”
-
REVIEW OF PHARMACOEPIGENETICS: BRIDGING EPIGENETICS AND PERSONALIZED MEDICINE
Abstract: Pharmacoepigenetics is an emerging field that explores how alterations in gene expression, independent of DNA sequence changes, influence individual responses to drugs. Unlike pharmacogenetics, which focuses primarily on genetic variation, pharmacoepigenetics integrates genetic, environmental, and lifestyle factors to explain interindividual differences in drug efficacy, toxicity, and resistance. Key epigenetic mechanisms including DNA methylation, histone modifications, non-coding RNAs, and RNA methylation play critical roles in regulating drug metabolism and therapeutic outcomes. …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 Read article
-
Chemical Modifications of Polymer for Improved Anti-Microbial Action
Abstract: Infections caused by pathogenic microorganisms are a significant concern. Polymers, large molecules formed by chemically connecting monomers, have acquired significant interest due to their intrinsic properties. Polymers function as a matrix for the components that contain antibacterial agents. Developing polymers with antibacterial activity is a crucial research area that aims to alleviate the problem of microbe contamination. The antibacterial polymers typically exhibit prolonged effectiveness. Modification of polymers enhances their anti-microbial …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1919–1931 Read article
-
A Technical Survey on Nanotechnology in Nanorobots
Abstract: Nanotechnology, the manipulation of matter at the atomic and molecular scale, has given rise to a revolutionary frontier: nanorobots – microscopic machines capable of interacting with biological systems and environments with unprecedented precision. This study explores the design, functionality, and application of nanorobots in medicine, environmental remediation, and materials science. By integrating principles from materials engineering, biotechnology, and robotics, nanorobots are engineered to perform tasks such as targeted drug delivery, …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 16, Issue 1, 2026 · pp. 14–21 Read article
-
Stem Cell Therapy: Advancements, Applications, and Future Prospects in Regenerative Medicine
Abstract: Stem cell therapy has come up as a revolutionary technique in regenerative medicine living up to the promise in treating numerous diseases and injuries. The latest discoveries made in the field of stem cell research such as the introduction of gene editing technology like CRISPR and the creation of the 3D bioprinting process have increased the accuracy and efficacy of stem cell-based therapies. Examples include cardiac regeneration and repair of …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 4, Issue 1, 2026 Read article
-
The Mycobiome Frontier – Pre & Post 2020 Status: Integrating Fungal Bioactive Compounds, Probiotics, and Antimicrobial Peptides in Modern Therapeutics and Biotechnology.
Abstract: The fungal kingdom represents an indispensable resource in modern therapeutics and biotechnology, offering a diverse array of bioactive compounds, probiotics, and antimicrobial peptides (AMPs). Functional fungal polysaccharides (FFPs), such as beta-glucans, chitin, and mannans, are centrally involved in modulating the human gut microbiota, providing novel therapeutic avenues for chronic conditions including diabetes, neurodegenerative disorders, and cancer. These compounds act as prebiotics, nourishing beneficial bacteria and enhancing metabolic parameters such as …
Published in International Journal of Fungi · Vol. 3, Issue 1, 2026 · pp. 1–11 Read article
-
Preoperative Use of Midazolam vs Dexmedetomidine for Anxiolysis in Day-Care Surgery
Abstract: Surgical procedures trigger significant fear and anxiety that can adversely affect physiological responses and recovery outcomes. This prospective, randomized, double-blinded clinical trial compared the anxiolytic efficacy and safety of intravenous midazolam and dexmedetomidine in 60 patients undergoing day-care surgery. Primary outcomes included anxiety scores measured by STAI and sedation assessed by the OAAS scale at multiple perioperative time points. Secondary outcomes assessed in the study included detailed evaluation of hemodynamic …
Published in Research and Reviews: A Journal of Medicine · Vol. 16, Issue 1, 2026 · pp. 7–12 Read article
-
GLP-1 Receptor Agonists: A Dual Therapeutic Strategy for the Management of Type 2 Diabetes Mellitus and Obesity
Abstract: For the treatment of obesity and type 2 diabetes mellitus (T2DM), glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have become a revolutionary class of pharmaceutical drugs. These drugs were first created as glucose-lowering treatments, but they have now shown other advantages, such as notable weight loss, better cardiovascular results, and general metabolic control. The objective of this narrative review is to assess the pharmacological mechanisms, clinical efficacy, safety profile, and therapeutic …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 69–75 Read article
-
LQR-Based Optimal Control of Inverted Pendulum System with State Estimation and Stability Analysis
Abstract: The inverted pendulum on a cart is a canonical benchmark problem in control systems engineering, capturing the essential challenges of stabilizing an inherently unstable, underactuated, and nonlinear plant. Classical Proportional-Integral-Derivative (PID) controllers, while widely employed in industrial practice, exhibit fundamental performance limitations when applied to such systems, primarily due to their inability to account for multivariable coupling, process noise, and the absence of a systematic optimization framework. This paper presents …
Published in International Journal of Advanced Control and System Engineering · Vol. 4, Issue 1, 2026 · pp. 31–43 Read article
-
Exploring the Intersection of AI Network Pharmacology and Ayurveda: Innovations in Traditional Medicine
Abstract: Integrative frameworks that integrate traditional medicine and modern computer research are increasingly important for advancing evidence-based, individualized healthcare. One interesting strategy is the combination of Ayurveda, network pharmacology, and artificial intelligence (AI). AI expands the capability by allowing for the quick analysis of biomedical big data, the identification of therapeutic trends, and the optimization of treatment plans. Ayurveda, with its long-standing emphasis on individualized care, holistic balance, and natural remedies, …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 14, Issue 3, 2025 · pp. 92–98 Read article
-
Optimization of Pesticide Requirement Calculations for IoT-Operated Hexacopter Delivery Systems
Abstract: The integration of Internet of Things (IoT) technology into precision agriculture has transformed pesticide application strategies, enabling resource-efficient and environmentally sustainable practices. This study presents a computational methodology for optimizing pesticide requirements in an IoT-operated hexacopter system, designed for dynamic, data-driven pesticide delivery. Leveraging a fusion of real-time telemetric data from onboard LiDAR, multispectral imaging sensors, and environmental monitoring modules, the system employs predictive analytics and edge computing to calculate …
Published in International Journal on Drones · Vol. 2, Issue 1, 2026 · pp. 08–14 Read article
-
Experimental Assessment and Statistical Argument of Al-Si/CSA/MoS2 Hybrid Composites for Mechanical and Tribological Characteristics
Abstract: To augment the mechanical and tribological properties of Al-Si matrix composites complement with molybdenum disulphide (MoS₂) and coconut shell ash (CSA), a mixed experimental and Face-Centered Composite (FCC)strategy was employed. A liquid metallurgical method called stir casting was used to create hybrid composites with 5–15 wt.% CSA and 1–3 wt.% MoS₂. A FCC experimental design with thirty runs was used to thoroughly evaluate the materials. This design allowed for the …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 792–802 Read article
-
An Analytical study of Government Scheme for Farmers in Gujarat: Impact, Implementation Challenges, and Policy Implications
Abstract: Gujarat’s economy is mostly dependent on agriculture, which increases food security, rural employment, and state revenue. Despite the state’s notable progress in irrigation infrastructure and agricultural commercialization, Gujarat farmers continue to face challenges, such as market volatility, water scarcity, unpredictable weather, and rising input costs. The governments of Gujarat and India have implemented several initiatives aimed at addressing these problems, including crop insurance, irrigation expansion, farm mechanization, income support, digital …
Published in International Journal of Rural and Regional Development · Vol. 4, Issue 1, 2026 · pp. 38–44 Read article
-
Effect of Unani Formulation in the Management of Non-Healing Ulcer – A Case Report
Abstract: Background and Aim: A non-healing ulcer (Qurooh-e-Aseerul-Indemal) of the foot is characterized by a persistent deterioration of the epidermal and dermal layers of the skin on the foot, continuing for more than six weeks without showing signs of recovery. Non-healing ulcers represent a significant global health challenge, markedly affecting patient well-being and imposing a considerable burden on their families. Global prevalence ranges between 1.9% to 13.1%, while in India, the …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 13, Issue 1, 2026 · pp. 7–12 Read article
-
Integrating Advanced Technologies for the Scientific Revalidation of Ayurvedic Principles
Abstract: Background: Ayurveda, a 5,000-year-old holistic healthcare system, emphasizes the dynamic balance of body, mind, and spirit. Recent advancements in science and technology have accelerated its integration into global healthcare systems. Objective: This paper explores the contribution of modern tools and methodologies to the scientific validation and enhancement of Ayurvedic principles across education, clinical practice, and research. Methods: A comprehensive literature review was conducted using databases like PubMed, Google Scholar, and …
Published in Research and Reviews: A Journal of Medicine · Vol. 16, Issue 1, 2026 · pp. 1–6 Read article
-
Thermal and Electrical Performance of Aluminum-Reinforced GFRP Composites
Abstract: This work examines an economical approach to improve the thermal load protection of Glass Fiber Reinforced Polymer (GFRP) composites, commonly utilized in aircraft constructions, pressure containers, and electrical insulators. Notwithstanding their superior mechanical capabilities, GFRP composites are susceptible to elevated temperatures and electrical currents, frequently resulting in considerable structural deterioration. The study introduces an innovative method employing aluminum reinforcement to enhance the thermal conductivity and protection of GFRP composite laminates. …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 1062–1075 Read article
-
Nitrosamine Accumulation, Processing Variables, and Indigenous Plant Inhibitors in Nigerian Traditionally Processed Meats
Abstract: N-nitrosamines are classified as probable or possible human carcinogens by the International Agency for Research on Cancer. Carcinogenic N-nitrosamines — principally N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA) — are formed in abundance during the preparation of widely consumed Nigerian traditional processed meats including suya, kilishi, and balangu. This original investigation combined a six geopolitical zone of Nigerian market survey with laboratory-controlled model system experiments, effects of processing parameters on N-Nitrosamine formation …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 17, Issue 1, 2026 · pp. 61–72 Read article
-
Study of Contact Temperature During Polishing of Zinc Plate with Ultrasonic Vibration Using Single Pole Magnetic Abrasive Finishing
Abstract: The present work scrutinizes the impact of ultrasonic vibration on the contact temperature during polishing zinc plates with Single Pole Magnetic Abrasive Finishing (SPMAF). The efficacy and eminence of FMAB finishing are pointedly influenced by heat generation at the interaction point, as raised up temperatures can lead to the deprivation of abrasive elements or the bonding material inside the brush, which leads to the fading its overall effectiveness. The magnetic …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 1239–1247 Read article
-
Formulation and Evaluation of a Natural Excipients-Based Diclofenac Sodium Topical Ointment
Abstract: The present study reports the formulation and evaluation of a diclofenac sodium topical ointment incorporating natural excipients to improve skin compatibility and formulation sustainability. Conventional topical non-steroidal anti-inflammatory drug (NSAID) formulations frequently rely on synthetic excipients that may cause dermal irritation and pose environmental concerns. To address these limitations, a 1% w/w diclofenac sodium ointment was developed using aloe vera gel, glycerin, xanthan gum, peppermint oil, vitamin E, and isopropyl …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 2, 2026 Read article
-
Environmental Impact Assessment of Ocean Energy Converters Using Quantum Machine Learning
Abstract: The accelerating deployment of ocean energy converters (OECs) across tidal, wave, osmotic, and thermal domains necessitates rigorous, data-intensive environmental impact assessment (EIA) frameworks capable of modelling multi-stressor marine ecosystems in real time. Classical machine learning approaches, while operationally mature, encounter scalability bottlenecks and feature correlation limitations when applied to the high-dimensional, non-linear datasets characteristic of offshore monitoring networks. This paper presents a comprehensive quantum machine learning (QML) framework for the …
Published in Journal of Energy, Environment & Carbon Credits · Vol. 16, Issue 1, 2026 · pp. 22–31 Read article
-
Polymer-Coated Composite Granules of Clarithromycin: Design, Characterization, and Functional Evaluation for Taste Masking and Antibacterial Performance
Abstract: Background: Masking the unpleasant taste of clarithromycin is essential to improve patient adherence, especially among pediatric and elderly groups. However, enhancing palatability while maintaining its antibacterial effectiveness remains a significant formulation challenge. This study focused on developing polymer-coated clarithromycin granules (B1–B10) using novel non-sugar-based polymers and assessing their antibacterial activity against Staphylococcus aureus Methods: Clarithromycin granules were produced using a fluidized bed coating technique with non-saccharide polymers, specifically Eudragit E-100 …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 1042–1050 Read article