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562 articles for “combined model”
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Pathways in Drug Discovery and Development: From Molecular Targets to Market Approval
Abstract: A complicated, multidisciplinary, and resource-intensive process, the discovery and development of new pharmacological drugs is essential to the advancement of contemporary medicine. Finding and optimising lead chemicals comes after a disease-relevant biological target has been identified and validated. Through preclinical research in animal models, these leads are thoroughly assessed for toxicity, pharmacokinetics, safety, and efficacy. Clinical trials, which are carried out in several stages to evaluate safety, efficacy, ideal dosage, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 1, 2026 · pp. 01–04 Read article
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Edge Computing Assisted Polymer Composite Biosensors for real time medical Analytics
Abstract: The fast development of healthcare technologies has generated the increased need of real-time, correct, and effective medical monitoring systems. Polymer composite biosensors have come out as a viable solution since they are flexible, biocompatible and highly sensitive in detecting physiological and biochemical signals. Nevertheless, traditional cloud-based data processing systems bring about latency, bandwidth issues, and privacy risks, and thus are not suitable to use in time-sensitive medical services. In order …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 Read article
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Image Processing and Deep CNN-based Automatic Liver Cancer Detection
Abstract: Liver cancer ranks among the leading causes of mortality for people worldwide. In the current situation, manually identifying the cancer tissue is a challenging and timeconsuming task. Treatment planning, response monitoring, tumor load assessment, and prediction are all made possible by the segmentation of liver lesions in CT scans. To address the current problem of liver cancer, the Hybridized Fully Convolutional Neural Network (HFCNN), which has been theoretically modeled, has …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 3, Issue 1, 2025 · pp. 39–41 Read article
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Drug-Induced Liver Injury: Hepatotoxicity and Treatment - A Literature Review
Abstract: Drug-induced liver injury (DILI) is a major clinical and regulatory challenge, posing risks to patient safety and drug development worldwide. As the primary organ responsible for xenobiotic metabolism, the liver is particularly susceptible to toxic injury from prescription drugs, over-the-counter medications, herbal products, and dietary supplements. Drug-induced liver injury (DILI) accounts for a substantial proportion of acute liver failure cases and remains a leading cause of post-marketing drug withdrawal. Its …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 1, 2026 · pp. 1–17 Read article
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Advanced Design and Prototyping with Fabrication, Architecture, And Material Design Techniques For 3D Printing Hybrid Polymer Composites
Abstract: Hybrid polymer composites are big steps forward in the field of 3D printing. They combine different materials to improve their engineering qualities, usefulness, and use potential. This essay looks at the advanced design and testing methods needed to use 3D printing to make and create mixed polymer materials. First, we look at material design methods, with a focus on choosing plastics and support materials that help the composite have the …
Published in Journal of Polymer & Composites · Vol. 12, Issue 4, 2024 · pp. 22–36 Read article
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Structure–Property-Guided Polymer–Metal Hybrid Design of a Wall Plastering Spray Assembly
Abstract: Wall plastering spray equipment requires a combination of low mass, dimensional stability, abrasion resistance, chemical compatibility with cementitious mortar, and comfortable operator interaction. The original assembly was primarily developed as a metallic mechanical system; however, a polymer-focused material architecture can reduce non-load-bearing mass while retaining a safe metallic pressure path. This study, therefore, presents a structure–property-guided polymer–metal hybrid design in which the pressure housing and nozzle insert remain metallic, whereas …
Published in Journal of Polymer & Composites · Vol. 14, Issue 5, 2026 · pp. 197–211 Read article
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Automated Evaluation of Descriptive Answers
Abstract: This paper offers a smarter system of automatic evaluation of descriptive responses in educational tests. The time-consuming aspect of testing with traditional manual marking, the subjectivity of that process, and the impossibility of scaling it makes it inapplicable, particularly to large academic environments. To resolve the issues, the proposed solution combines the methods of Natural Language Processing (NLP) and hybrid image-text processing on the responses of handwriting and typed answers. …
Published in Emerging Trends in Languages · Vol. 3, Issue 2, 2026 · pp. 1–9 Read article
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Damage Evolution and Delamination Resistance in Polymer Matrix Functionally Graded Laminates
Abstract: Functionally graded laminates (FGLs) in polymer-matrix systems represent a promising pathway to enhance damage tolerance and delay delamination in advanced structural composites. In this study, we explore the mechanisms of damage initiation, propagation, and delamination resistance in polymer matrix functionally graded laminates (PM-FGLs) through a combined experimental–computational approach. Laminates with linear, exponential, and bio-inspired gradation profiles were fabricated using vacuum-assisted resin transfer molding (VARTM) and additive manufacturing techniques. Comprehensive mechanical …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 321–337 Read article
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Predicting Student Placement Readiness: A Machine Learning Approach Using Coding Activities and Multi-Dimensional Performance Indicators
Abstract: In the modern information-driven academic world, identifying student employability and placement preparedness has predicted. be made a part and parcel of academic planning and career. development. This study provides a machine learning-based. structure to evaluate and forecast student placement pre-paredness by combining various performance aspects-academic achieve- ment, coding activity, aptitude and behavioral engage-ment metrics. Multi-source was gathered and preprocessed in the study. student information, such as student records (CGPA, attendance), …
Published in International Journal of Education Sciences · Vol. 3, Issue 2, 2026 Read article
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Toxicological Optimization and Assessment of Buccal Films Containing Felodipine Co-crystals to Enhance Bioavailability
Abstract: The preformulation study of felodipine was carried out and it was found that the drug is poorly water soluble. The co-crystals were prepared using three different co-formers sorbitol, ascorbic acid and oxalic acid. The solublity enhancement was observed in combination with sorbitol compared to other co-formers used. The characterization of co crystals was performed like PXRD, FTIR, SEM Analysis. XRD results indicates the amorphous form of the drug. The co-crystals …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 2, 2024 · pp. 10–29 Read article
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Assessment of Matrix Cracking and Fiber Breakage in Hybrid Composite Materials.
Abstract: Hybrid composite materials, combining two or more distinct fiber or matrix constituents, have emerged as advanced structural solutions for aerospace, automotive, marine, and civil engineering applications. However, their complex microstructure makes them susceptible to multiple interacting damage mechanisms, particularly matrix cracking and fiber breakage. This study provides a comprehensive assessment of these damage modes, emphasizing their initiation, evolution, and combined effects on the mechanical integrity of hybrid composites. Matrix cracking …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 3, Issue 2, 2025 · pp. 1–5 Read article
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Fractal-Entropy Guided Adaptive Signal Reconstruction for Non-Stationary Biomedical and Communication Systems
Abstract: This paper presents a novel Fractal-Entropy Guided Adaptive Signal Reconstruction (FEG- ASR) framework designed for accurate processing of non-stationary signals in biomedical and communication systems. The proposed approach integrates fractal dimension analysis with entropy- based feature evaluation to capture the intrinsic complexity and irregularity of time-varying signals. By dynamically adapting reconstruction parameters based on fractal-entropy measures, the method effectively separates noise from meaningful signal components while preserving critical information. The …
Published in Current Trends in Signal Processing · Vol. 16, Issue 1, 2026 · pp. 22–33 Read article
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Interfacial Bonding Efficiency in Jute-Carbon Fiber Polyester Matrix Composites Evaluated Through Short-Beam Shear and Interlaminar Fracture Toughness Testing
Abstract: The natural Fiber–synthetic Fiber hybrid composites are jute–carbon Fiber hybrid in polyester matrix which could be used in semi-structural applications of automotive, construction and marine industry as an eco-friendly and cost-effective alternative of conventional carbon Fiber reinforced polymer. But the hydrophilic nature of jute Fibers and the relatively inert surface of carbon Fiber’s cause weak bonding at the interface of the polyester matrix, which causes premature delamination, poor interlaminar shear …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 68–80 Read article
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An IoT-Based Integrated Vehicle Safety System for Accident Detection and Driver Monitoring
Abstract: Driver fatigue, alcohol and slow response of emergency services are among a significant issue of road accidents. The paper will provide a real-life example of an IoT-based vehicle safety system, which will combine the accident detection, driver drowsiness and alcohol sensors with a cohesive system. The proposed system consists of use of accelerometer for sudden collision detection, infrared eye blink sensor for determining alertness of the driver and MQ-3 alcohol …
Published in International Journal of Electronics Automation · Vol. 4, Issue 2, 2026 Read article
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Influence of Epoxy-Based Thermally Conductive Polymer Composites on the Thermo-Hydraulic Performance of Finned Helical Coil Heat Exchangers Across Flow Regimes
Abstract: The use of polymer composites in heat exchanger applications has gained increasing attention due to their advantages in weight reduction, corrosion resistance, and design flexibility. However, their relatively low thermal conductivity compared to conventional metallic materials remains a key limitation for efficient heat transfer. In this study, the thermo-hydraulic performance of a finned helical coil heat exchanger is investigated with particular focus on epoxy-based polymer composites reinforced with thermally conductive …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 586–602 Read article
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Composition of Ideal Fluid Flows Around Cylinder Using Bilinear Transformation
Abstract: Advent of conformal mapping eases to model a flow in sought-after domain without trade- off between laws of fluid mechanics and the theory of complex valued-functions. The far-reaching properties manifested by conformal mapping discern and facilitate solution of large class of two-dimensional flow problems. Bilinear transformation is amidst the conformal mappings. The properties, mapping a circular boundary onto horizontal line and composition of bilinear transformations is again a bilinear transformation …
Published in Recent Trends in Fluid Mechanics · Vol. 10, Issue 1, 2023 · pp. 31–38 Read article
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Advanced Private Cloud Security and Privacy Preservation Through the Integration of Machine Learning and Cryptography
Abstract: In modern technological landscapes, private cloud security is of paramount concern due to the ever-increasing volume and complexity of cyber threats. This research work explores the integration of machine learning and cryptography to enhance security within private cloud environments. This study aims to mitigate vulnerabilities that may compromise data integrity, confidentiality, and availability in private cloud infrastructures by using machine learning algorithms and strong cryptography. By detecting anomalous cloud patterns …
Published in International Journal of Advanced Control and System Engineering · Vol. 2, Issue 1, 2024 · pp. 1–10 Read article
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Role of Beowulf Clusters in Next-Generation Military Applications: A Comprehensive Study
Abstract: Beowulf clusters, which utilize cost-effective commodity hardware combined with open-source software for parallel computing, have emerged as a viable and efficient solution for high-performance computing needs. This paper explores their growing relevance and practical applications in modern and future military technologies. Contemporary military operations increasingly rely on rapid data processing, real-time intelligence, high-fidelity simulations, and autonomous decision-making systems. Beowulf clusters offer scalable and adaptable computational power that supports these demands …
Published in Journal of Advances in Shell Programming · Vol. 12, Issue 2, 2025 · pp. 01–07 Read article
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Exploring Recent Advancements in Nanomedicine for Tumor Microenvironmental Tissue Engineering
Abstract: The combination of tissue engineering and nanomedicine is transforming cancer treatment by offering creative ways to get around problems with conventional therapies. Recent developments in nanomedicine are examined in this review, with an emphasis on how they might be used to comprehend and control the tumor microenvironment (TME), a dynamic and complex environment that has a major impact on the course of cancer and the effectiveness of treatment. Targeted interactions …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 122–136 Read article
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Enhancing Power Conversion Efficiency in Tandem Solar Cells with Temporal Dynamic Graph Neural Network
Abstract: In modern homes, people want good comfort and also less electricity bill, so managing heating load and cooling load become very important. Heating Load (HL) and Cooling Load (CL) depend on many things like wall material, window size, sunlight, ventilation, and weather. Because of this many factors, calculation and optimization of HL and CL is little difficult and many time normal formulas give wrong or not perfect results. So in …
Published in Journal of Semiconductor Devices and Circuits · Vol. 13, Issue 2, 2026 · pp. 12–19 Read article