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475 articles for “Pathways”
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Epigenetic Regulation and Plasticity in Human Diseases
Abstract: In normal human development as well as in the case of diseased development, epigenetic changes are involved. The role of plasticity is important and directed on the understanding feature of epithelial cell biology, and maybe a significant pathway for disease pathobiology and pathogenesis. During embryonic development, an epigenetic mechanism is important for the growth and development of genetically identical cells that are obtained from different outcomes. In this review study, …
Published in Research and Reviews : A Journal of Immunology · Vol. 11, Issue 1, 2021 · pp. 12–20 Read article
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Review on Histological and Functional Effect of Alcohol on Liver and Kidney
Abstract: Alcohol consumption represents the third largest risk factor for disease burden in most countries of the world. The purpose of this review is to give a comprehensive report of the existing data on the potential adverse effects of alcohol on liver and kidney toxicity. We used 82 different published materials for the compilation of this review article. The Google search engine was used for accessing published materials from databases like …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 7, Issue 2, 2018 · pp. 49–62 Read article
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Review on Optic Atrophy
Abstract: The illness known as otic atrophy damages the eye. It causes anterior ischemic optic neuropathy, also known as glaucoma, and strokes of the optic nerve. A change in vision, notably blurred vision, problems with peripheral (side) vision, problems with color vision, and a loss of vision sharpness, are indications of optic atrophy. The final stage of a disease process that affects the retinogeniculate section of the visual pathway is called …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 12, Issue 1, 2024 · pp. 31–36 Read article
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A Review Drug and Biochemical Pharmacology Discovery
Abstract: The development of new therapeutic approaches and our understanding of disease mechanisms have both benefited ground-breaking medications as they are advanced and show the value of contemporary technologies, methodologies, and genetics in drug discovery. The synthesis, design, and application of these molecules have become a focal point in drug discovery efforts. The present research paper provided a comprehensive study of the recent developments in the field of biochemical pharmacology and …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 12, Issue 3, 2024 · pp. 27–31 Read article
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The First Days and Months of the COVID-19 Pandemic
Abstract: The outbreak of a mysterious illness that started in Wuhan, China by the end of 2019, spread and sickened millions of people around the globe to the extent of being declared as a pandemic by the WHO. A novel coronavirus strain named SARS-CoV-2 by the ICTV, testing the capabilities of our modern world and suffocating health care systems, meanwhile gathering all of scientist's research and governmental powers to fight off …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 12, Issue 1, 2022 · pp. 7–13 Read article
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An innovative antibiotic "Abaucin": Instigated by Artificial Intelligence
Abstract: Nosocomial Gram-negative pathogen, Acinetobacter baumannii repeatedly demonstrates multidrug resistance. Discovering novel antibiotics against A. baumannii has proven thought-provoking through conventional screening tactics. Providentially, machine learning approaches allow for the speedy exploration of chemical space, snowballing the probability of determining new antibacterial molecules. In the following research era, a neural network is accomplished with growth reserve dataset and accomplished in silico predictions for structurally unconventional molecules with commotion in divergence to …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 13, Issue 3, 2023 · pp. 29–33 Read article
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Neglect Analysis Using Semantic Picture Priming Paradigm among Hindi Speaking Developmental Dyslexics
Abstract: Introduction: Developmental dyslexia is a condition that is characterized by difficulties that mainly affect the ability of a child to read, write, calculate and spell. Developmental dyslexics may have neglected due to subtle weakness in a string of cortical areas on the bilateral dorsal pathway of the brain. Aim of the study: To analyze the presence of neglect in semantic picture priming paradigm among Hindi developmental dyslexics and typically developing …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 9, Issue 2, 2019 · pp. 39–45 Read article
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Renin-Angiotensin System as a Therapeutic Target for Colorectal Cancer Liver Metastasis
Abstract: Classically, renin-angiotensin system (RAS), for a long time, has been perceived as the main regulator of cardiovascular homeostasis, due to its effect on blood vessels contraction or cardiac hypertrophy and is known to maintain blood pressure and body fluids. Hence, its pharmacological regulation is mainly associated with the management of hypertension. Currently, it was found that the RAS is involved in a broad range of physiological processes and diseases. RAS …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 7, Issue 2, 2018 · pp. 1–14 Read article
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Protective Role of Sulforaphane against Multiorgan Toxicity in Rats: An In-vivo and In-vitro Review Study
Abstract: Sulforaphane [1-isothiocyanate-(4R) -(methylsulfinyl) butane] is a natural dietary isothiocyanate produced by the enzymatic accomplishment of the myrosinase on glucopharanin, a 4-methylsulfinylbutyl glucosinolate contained in cruciferous vegetables such as broccoli, brussel sprouts, and cabbage. Exploring of this compound against various oxidative degenerative diseases such as hepatic, nephro and cardiac diseases is growing because of its anticarcinogenic and cytoprotective properties. In several invivo and invitro experimental paradigms proved SFN and its compounds …
Published in Research and Reviews: A Journal of Toxicology · Vol. 8, Issue 1, 2018 · pp. 1–8 Read article
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Parameters of “Safety” in the Food Additive Industry: A Review of Risks and Benefits
Abstract: “Safety is in the eye of the beholder.” What is deemed “safe” by one observer may seem dangerous or risky to others. To approach this apparent quandary and assure ongoing scientific input, most food additives should be tested on laboratory animals and subsequently monitored if approved for human or animal consumption (i.e., parallel to the pathway for the approval of drugs). The term “safety” in the study of the toxicology …
Published in Research and Reviews: A Journal of Toxicology · Vol. 5, Issue 2, 2015 · pp. 7–13 Read article
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Thymoquinone Induces Epigenetic Modulation in ROS Dependent Manner
Abstract: Traditional drugs have the ability to treat broad range of diseases by modulating the signaling pathwaysof inflammatory diseases and cancer. Epigenetic modulation is also one of the mechanisms already established as a process of action. Histone deacetylase (HDAC) inhibition leads to changes in gene expression promoting cell death. Thymoquinone (TQ), a bioactive compound from Nigella sativa seeds has shown to have an antineoplastic effect in many cancers. Here we have …
Published in Research and Reviews: A Journal of Toxicology · Vol. 7, Issue 1, 2017 · pp. 32–39 Read article
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Effects of Sub Chronic Dermal Exposure of Gasoline Blended with Varying Concentration of Benzene on Hepatic Mixed Function Oxidases in Rats
Abstract: Interaction of chemicals in a mixture, their biotransformation and adverse impact, if any, on environment and workroom atmosphere needs to be evaluated to identify the nature of potential toxic effects elicited by constituent chemical(s) in a mixture. The nature of chemical interaction(s) through which an individual chemical in a mixture undergoes metabolism and/or biotransformation in the target tissue could be helpful in evaluation of its toxic potential. Gasoline is a …
Published in Research and Reviews: A Journal of Toxicology · Vol. 3, Issue 1, 2013 · pp. 1–5 Read article
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Profiling of Essential, Potentially Essential and Non-essential elements in Onychomycosis affected nail samples using ICP-MS
Abstract: The Profiling of Essential, Potentially Essential, and Non- essential elements in Onychomycosis affected nail samples is done to understand the relationship between trace elements in the nail with Onychomycosis. The main objective of the study is to investigate the correlation between Onychomycosis and harmful heavy metal deposition in nail clippings based on the occupation, age, and sex of patients. About 14 Diseased and 5 normal human samples were used for …
Published in Research and Reviews: A Journal of Toxicology · Vol. 11, Issue 2, 2024 · pp. 46–55 Read article
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Myco-Engineering Systems: Harnessing Fungal Networks for Carbon Sequestration and Sustainable Ecosystem Restoration
Abstract: Fungal organisms play a foundational role in global ecosystem stability, particularly through their contributions to nutrient cycling, soil regeneration, and carbon sequestration. Recent scientific advances have highlighted the potential of fungal mycelial networks as natural bioengineered systems capable of supporting sustainable environmental restoration. This paper introduces the concept of Myco-Engineering Systems, an interdisciplinary framework that integrates fungal biology, environmental science, and artificial intelligence (AI) to enhance carbon capture and ecosystem …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 16, Issue 2, 2026 · pp. 11–22 Read article
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Phytotherapeutic Potential of Melaleuca: An Integrative Review of Phytochemistry and Antimicrobial, Antifungal, Antioxidant, and Antiviral Mechanisms
Abstract: Melaleuca alternifolia and other species of the Melaleuca genus stand out for the broad spectrum of pharmacological properties attributed to their bioactive compounds, such as monoterpenes, sesquiterpenes, flavonoids, and polyphenols. This study aimed to critically review and analyze scientific evidence produced between 2005 and 2025 regarding the antimicrobial, antifungal, antioxidant, and antiviral activities of Melaleuca, correlating its phytochemistry with molecular mechanisms of action. For this purpose, an integrative literature review …
Published in Research & Reviews : Journal of Herbal Science · Vol. 15, Issue 2, 2026 · pp. 16–30 Read article
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Thorium Nuclear Reactor: A Sustainable Future for Clean Energy-A Review Study
Abstract: Thorium-232, a naturally abundant and fertile element, is increasingly regarded as a viable alternative to uranium-235 as the basis of future nuclear fuel cycles. This review examines the physical and nuclear properties that make thorium attractive as a reactor fuel, the mechanics of the thorium- uranium-233 fuel cycle, and the principal reactor concepts developed to exploit it, including pressurized heavy water reactors, pressurized water reactors, fast breeder reactors, advanced heavy …
Published in Journal of Nuclear Engineering & Technology · Vol. 16, Issue 2, 2026 Read article
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Dental Pulp Stem Cells Derived from Wisdom Teeth as Multitarget Biological Modulators of Alzheimer’s and Parkinson’s Disease: Mechanistic Insight and Translational Perspective
Abstract: Alzheimer’s disease and Parkinson’s disease are chronic, progressive neurodegenerative disorders with complex pathogenic pathways such as neuroinflammation, oxidative stress, mitochondrial dysfunction, synaptic degeneration, and reduced neurotrophic signalling. Despite the large amount of research, the pharmacological treatments in use offer only symptomatic relief and cannot significantly prevent or slow down disease progression sufficiently; new pathogenetic treatment strategies are necessary. In recent years, stem cell-based approaches have gained interest as potential therapeutic …
Published in Research and Reviews: A Journal of Dentistry · Vol. 17, Issue 2, 2026 · pp. 7–28 Read article
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Luminescent Phenomena and Materials: Fundamentals, Developments, and Multidisciplinary Applications
Abstract: Luminescence, defined as the emission of light without significant heat generation, represents a fundamental phenomenon bridging physics, chemistry, materials science, and biotechnology. Over the centuries, the understanding of luminescence has evolved from simple observational curiosity to a sophisticated quantum-mechanical framework describing electronic transitions in atoms, molecules, and solids. This review provides a comprehensive overview of the historical development, fundamental mechanisms, classifications, and material systems associated with luminescence. It places particular …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 16, Issue 2, 2026 Read article
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Nanotechnology in Surgical Drains: Reducing Infections and Promoting Healing Post-Surgery
Abstract: Surgical drains are widely used in postoperative care to evacuate accumulated fluids, minimize dead space, and reduce complications such as hematoma and seroma formation. Despite their clinical importance, conventional drains are frequently associated with retrograde bacterial migration, biofilm formation, and increased risk of surgical site infections (SSIs), which contribute significantly to postoperative morbidity and prolonged hospital stay. Recent advancements in nanotechnology have enabled the development of nano-functionalized surgical drains with …
Published in Research and Reviews : Journal of Surgery · Vol. 15, Issue 2, 2026 · pp. 54–67 Read article
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Anticancer, Bioactive, & Therapeutic Applications of Cannabinoids
Abstract: Cannabinoids, a complex class of lipophilic compounds found in Cannabis sativa L., are attracting significant clinical interest for their multifaceted therapeutic potential, particularly within oncology. This review provides a comprehensive synthesis of contemporary knowledge detailing the distinct anti-cancer properties of phytocannabinoids (such as δ-tetrahydrocannabinol and cannabidiol), endogenous endocannabinoids, and synthetic analogues. Accumulating evidence from robust in vitro and in vivo oncological models demonstrates that these compounds aggressively suppress tumor progression …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 15, Issue 2, 2026 · pp. 17–30 Read article