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401 articles for “profiling”
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Thermo-Fluid Characterization of Corrugated U-Tube Shell-and-Tube Heat Exchanger with Polymer Composite Tube Wall: A Combined CFD and Experimental Investigation
Abstract: Shell-and-tube heat exchangers built with metallic tubes work well thermally, but corrosion problems, extra weight, and the inability to adjust the wall’s thermal properties through material choice remain genuine engineering headaches, particularly for corrosive or weight-critical applications. Over the past few years there has been a fair amount of interest in replacing metal tubes with polymer composite alternatives, since blending thermally conductive fillers — graphite nanoplatelets, boron nitride platelets and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 Read article
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Prime Editing and Base Editing in Human Hematopoietic Stem Cells Toward Scarless Correction of Monogenic Blood Disorders
Abstract: Monogenic hematological disorders – such as sickle cell disease (SCD), β-thalassemia, and X-linked chronic granulomatous disease (X-CGD) – affect >400, 000 newborns worldwide each year, with a considerable burden in low-resource settings . Although donor-derived allogeneic hematopoietic stem-cell transplantation (HSCT) is widely regarded as curative, its application is limited due to issues of donor availability and graft-versus-host disease (GVHD) and conditioning-related toxicity. DSB-based conventional CRISPR-Cas9 strategies are limited by inefficient …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 4, Issue 1, 2026 Read article
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IoT-Based Battery Health Monitoring for Electric Vehicles Using Machine Learning
Abstract: With increasing utilization of the Electric Vehicles (EV)s in global scale, battery health management becomes a critical factor which has great impact on vehicle performance, safety and longevity. Battery materials, such as NMC LFP lithium-ion batteries and lithium-ion batteries, degrade over time from charging behaviour, heat stress, discharging voltage profiles and environmental limits. Conventional BMS only offer threshold based health diagnostics and cannot perform accurate degradation prediction. This work presents …
Published in International Journal of Machine Systems and Manufacturing Technology · Vol. 4, Issue 1, 2026 Read article
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Pharmacokinetics of Levothyroxine and Factors Influencing Its Therapeutic Efficacy in Hypothyroidism: A Comprehensive Review
Abstract: Levothyroxine (LT4) remains the standard therapy for hypothyroidism due to its effectiveness in restoring normal thyroid hormone levels and improving physiological functions. However, its pharmacokinetic profile exhibits considerable variability, which may influence therapeutic outcomes in clinical practice. This review aims to comprehensively evaluate the pharmacokinetics of levothyroxine, including its absorption, distribution, metabolism, and elimination, along with factors affecting its therapeutic efficacy. A structured literature search was conducted using electronic databases, …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 Read article
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Diabetes Risk Prediction from Survey Data Using Machine Learning Algorithms
Abstract: Diabetes mellitus represents one of the most significant global health challenges, affecting millions worldwide and leading to severe complications if left undiagnosed or poorly managed. Early detection and risk assessment are crucial for preventing the progression of this chronic condition. This research presents a comprehensive machine learning approach for predicting diabetes risk using survey-based health parameters. The study implements and compares four prominent classification algorithms: Logistic Regression, K-Nearest Neighbors (KNN), …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 4, Issue 2, 2026 Read article
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High-Gain Microstrip Patch Antenna for Satellite and Radar Applications
Abstract: The growing demand for high-speed wireless communication, satellite connectivity, and advanced radar systems has increased the necessity for compact and high-performance antenna designs. This study presents the design and analysis of a high-gain microstrip patch antenna intended for satellite and radar applications operating in the microwave frequency range. The proposed antenna structure is developed using a low-loss dielectric substrate to enhance radiation efficiency, bandwidth, and gain characteristics while maintaining a …
Published in Journal of Microwave Engineering and Technologies · Vol. 13, Issue 2, 2026 Read article
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Enhancement of LVRT Capability in DFIG based Microgrids Using STATCOM
Abstract: The improvement of a grid-connected wind microgrid's Low Voltage Ride-Through (LVRT) capability using a Static Synchronous Compensator (STATCOM) is investigated in this research. The increasing penetration of wind energy into modern power systems necessitates advanced control strategies to maintain grid stability during voltage disturbances and fault conditions. In this study, a STATCOM is employed with an effectively tuned PI controller to provide enhanced dynamic response, voltage regulation, and reactive power …
Published in Trends in Electrical Engineering · Vol. 16, Issue 2, 2025 Read article
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Child Friendly Innovation: A New Era in Pediatrics Drug Delivery Systems
Abstract: Pediatric formulations are becoming more and more popular as a result of advancements in pharmaceutical delivery technology. For young patients, there isn't a safe and effective drug delivery system in place. Since children's pharmacokinetics and pathophysiologic profiles differ from those of adults, it is imperative to design and develop an innovative and appropriate delivery system to provide accurate and dependable medicine administration to pediatric patients. Discussions will be held under …
Published in Trends in Drug Delivery · Vol. 13, Issue 2, 2026 Read article
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An Empirical Analysis of Bluetooth Low Energy Reliability Challenges for Offline Messaging Applications
Abstract: In today's hyper-connected world, modern communication relies heavily on centralised internet infrastructure, making robust offline messaging solutions increasingly essential. A crucial vulnerability is revealed by network failures, natural disasters, and distant region deployments: communication breaks down when internet connectivity does. Due to its low power consumption and almost ubiquitous availability in contemporary smartphones, Bluetooth Low Energy (BLE) has become a promising candidate for offline, device-to-device communications. This study presents an …
Published in Journal of Mobile Computing, Communications & Mobile Networks · Vol. 13, Issue 2, 2026 Read article
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A Conceptual Framework for AI-Integrated Metabolomics in Predictive Health Systems for Resource-Constrained Environments
Abstract: The increasing prevalence of non-communicable diseases (NCDs) continues to place a significant strain on healthcare systems, particularly in low- and middle-income regions where access to early diagnostic infrastructure is limited. Conventional healthcare approaches remain largely reactive, often detecting diseases at advanced stages when treatment effectiveness is reduced. This challenge underscores the need for predictive, cost-effective, and data-driven healthcare solutions. This study presents a conceptual framework that integrates metabolomics with artificial …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 2, 2026 Read article
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Machine-Learning-Assisted Development of Polymer-Biochar Composite Adsorbents for the Removal of Heavy Metals from Gomti River Water
Abstract: Rapid urbanization, industrial discharge, and agricultural runoff pose a significant threat to freshwater sustainability and public health. Within these ecosystems, polymer pollutants—such as microplastics, nanoplastics, synthetic fibres, and additive residues—have emerged as persistent vectors capable of adsorbing and transporting toxic heavy metals. Because these polymeric contaminants dynamically interact with conventional aquatic parameters to alter pollutant mobility and ecological risk profiles, there is an urgent need to transition from passive environmental …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 72–95 Read article
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A Qualitative Comparative Study of Storytelling Through the Thematic Apperception Test Among Two Young Adults with a History of Substance Abuse in a Selected De-Addiction Centre in Delhi, India
Abstract: Introduction: Substance use can deeply affect an individual’s personality, relationships, and psychological functioning. The thematic apperception test (TAT), a projective psychological tool, helps uncover unconscious thoughts and emotions through storytelling. Objective: (i) To explore and compare the underlying personality dynamics of two young adult males with a history of substance use through TAT card analysis. Method: A qualitative comparative case study design was used. Ten standard TAT cards were presented …
Published in International Journal of Evidence Based Nursing And Practices · Vol. 4, Issue 1, 2026 · pp. 1–4 Read article
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Gastro Retentive Drug Target System: Its Needs, Advantages, Limitation and Approaches
Abstract: Background: Gastro retentive drug delivery systems (GRDDS) address limitations of oral therapy for drugs with poor solubility, instability at intestinal pH, or narrow absorption windows by prolonging gastric residence and increasing contact with the gastric mucosa. Objectives: To review GRDDS approaches—floating systems, mucoadhesive systems, and super porous hydrogels—with emphasis on formulation strategies and polymer–excipient selection to enhance gastric retention, modulate buoyancy/swelling/adhesion, and ultimately improve oral bioavailability and therapeutic outcomes for …
Published in Trends in Drug Delivery · Vol. 13, Issue 2, 2026 Read article
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Phytotherapeutic Potential of Melaleuca: An Integrative Review of Phytochemistry and Antimicrobial, Antifungal, Antioxidant, and Antiviral Mechanisms
Abstract: Melaleuca alternifolia and other species of the Melaleuca genus stand out for the broad spectrum of pharmacological properties attributed to their bioactive compounds, such as monoterpenes, sesquiterpenes, flavonoids, and polyphenols. This study aimed to critically review and analyze scientific evidence produced between 2005 and 2025 regarding the antimicrobial, antifungal, antioxidant, and antiviral activities of Melaleuca, correlating its phytochemistry with molecular mechanisms of action. For this purpose, an integrative literature review …
Published in Research & Reviews : Journal of Herbal Science · Vol. 15, Issue 2, 2026 Read article
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Generative AI-Based Inverse Design of Sustainable Biodegradable Polymers with Target Mechanical and Thermal Properties
Abstract: The escalating global plastic pollution crisis has intensified the urgent need for sustainable biodegradable polymer alternatives that can match or exceed the performance of conventional petroleum-based plastics while minimizing environmental impact. However, traditional polymer discovery approaches are severely constrained by high experimental costs, protracted development cycles spanning years, and fundamental inability to simultaneously optimize multiple conflicting material properties such as mechanical strength, thermal stability, and degradation kinetics. This study presents …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 Read article
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Evaluation of the Formation, Concentration, and Mitigation of Heterocyclic Amines in Selected Nigerian Proteinaceous Delicacies
Abstract: This study characterised the kinetics and concentration profiles of six HCA congeners — 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), 2-Amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx), 2-Amino-3-methylimidazo[4,5-f]quinoline (IQ), 1-Methyl-9H-pyrido[3,4-b]indole (harman), and 9H-pyrido[3,4-b]indole (norharman) — in six Nigerian food preparations (grilling of popular delicacies — including suya, kilishi, asun, and smoked catfish (eja aro)) using validated liquid chromatography–tandem mass spectrometry (LC-MS/MS) under three cooking modalities (charcoal grilling, pan-frying, oven-roasting). The inhibitory potential of five natural marinade formulations — …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 15, Issue 2, 2026 · pp. 1–11 Read article
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A Physics-Informed Graph Neural Network Framework for Real- Time Thermal-Aware Fault Prediction and Adaptive Power Optimization in Heterogeneous System-on-Chip Architectures
Abstract: Heterogeneous System-on-Chip (SoC) architectures are increasingly adopted in edge computing, artificial intelligence, autonomous systems, and high-performance embedded platforms due to their superior computational efficiency and flexibility. However, increasing integration density and workload diversity introduce severe thermal hotspots, accelerated device degradation, and unexpected hardware faults that adversely affect system reliability and energy efficiency. This study proposes a Physics-Informed Graph Neural Network (PI-GNN) framework for real-time thermal- aware fault prediction and adaptive …
Published in Journal of VLSI Design Tools and Technology · Vol. 16, Issue 2, 2026 Read article
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Molecular Docking Analysis of Phytocompounds from Ficus hispida Aagainst Epidermal Growth Factor Receptor Kinase Domain
Abstract: The Epidermal Growth Factor Receptor (EGFR) kinase domain plays a key role in cancer, as it promotes tumour growth and helps cancer cells survive, making it an important focus for developing treatments. Through comprehensive computational analysis, this study investigates the anticancer potential of phytocompounds from Ficus hispida, a medicinal plant renowned for its diverse bioactive compounds, as novel EGFR inhibitors. Molecular docking techniques using Py Rx software were employed to …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 Read article
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Molecular Docking Analysis of Phytocompounds from Ficus hispida Against Epidermal Growth Factor Receptor Kinase Domain
Abstract: The Epidermal Growth Factor Receptor (EGFR) kinase domain plays a key role in cancer, as it promotes tumour growth and helps cancer cells survive, making it an important focus for developing treatments. Through comprehensive computational analysis, this study investigates the anticancer potential of phytocompounds from Ficus hispida, a medicinal plant renowned for its diverse bioactive compounds, as novel EGFR inhibitors. Molecular docking techniques using Py Rx software were employed to …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 48–62 Read article
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Acetaminophen: Current Understanding and Future Directions in Pharmacology
Abstract: In this review, acetaminophen is described as one of the most widely used analgesic and antipyretic medications worldwide due to its effectiveness and reduced gastrointestinal toxicity compared with traditional NSAIDs. Its precise mode of action is still unclear despite widespread therapeutic use. Acetaminophen has little peripheral anti-inflammatory effect and largely acts within the central nervous system, in contrast to NSAIDs, which mainly block peripheral cyclooxygenase (COX) enzymes and lower inflammation. …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 Read article