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634 articles for “B-Cell”
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Assessing the impact of lifestyle factors on autoimmune risk and survival outcomes: A Population-based Study
Abstract: This study investigated the interplay between lifestyle factors and genetic regulation in autoimmune diseases, focusing on the role of human T-cell metabolic and proliferative control through C-REL gene transcription. This study combined CRISPR-Cas9 manipulation of C-REL in human T-cells with a longitudinal cohort of 100 adults (autoimmune patients and controls), investigating metabolic and proliferation dynamics via flow cytometry and assays. It assessed lifestyle impacts through surveys and medical records, ensuring …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 15, Issue 2, 2025 Read article
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Synthetic and Natural Polymer Composites in Wound Healing and Drug Delivery
Abstract: Both man-made and natural polymer mixtures have become important materials in wound repair and medicine delivery because they can be used in many ways and work well with living things. The benefits of both man-made and natural polymers are combined in these composites. They have a wide range of mechanical, chemical, and biological qualities that make them useful for many medical uses. In wound healing, polymer mixtures help tissues grow …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 466–478 Read article
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An Overview of Fanconi Anemia: A Genetic Disorder
Abstract: Fanconi Anemia (FA) is a rare genetic disorder caused by DNA repair defects due to pathogenic variants in one of 21 genes. It is the primary cause of inherited bone marrow failure, marked by pancytopenia. Clinically, Fanconi Anemia (FA) is associated with congenital malformations in multiple systems, resulting in progressive bone marrow failure and heightened cancer risk, especially in the urogenital region and the head and neck. There are approximately …
Published in International Journal of Oncological Nursing and Practices · Vol. 2, Issue 2, 2024 · pp. 19–25 Read article
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Recent Developments in Polymer Concrete: Considerations for Materials, Performance, and Sustainability
Abstract: In modern infrastructure Growing need of durability and environmental has driven interest in polymer concrete (PC) as an alternative to conventional cement-based materials. This review critically evaluates recent developments in polymer concrete with emphasis on material innovations, performance characteristics, and sustainability aspects. Demonstration of Advanced polymer binders (e.g. epoxy, polyester and vinyl ester resins) shown significant improvements in mechanical strength, adhesion and chemical resistance. Investigation indicates that use of nanomaterials …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 910–920 Read article
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Pharmacological evaluation of Hepatoprotective activity of Indian medicinal plants Cordia Myxa and Canscora diffusa on wistar albino rats
Abstract: Two plants (Cordia myxa and Canscora diffusa), which were claimed to possess hepatoprotective activity, were selected. The Selected plants were authenticated by an expert botanist. In the current study, herbal extraction involving solvents of decreasing polarity (petroleum ether, ethyl acetate, and hydroalcoholic) was used to extract bioactive compounds from the plants of Cordia Myxa and Canscora diffusa in polyherbal preparations. A phytochemical evaluation was performed, including an acute toxicity study …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 1, 2025 · pp. 31–44 Read article
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ZnO Nanostructure Shape Effects in Photocatalysis of Methylene Blue
Abstract: Nowadays, dyes are used in the food industry, textile industry, paper industry, hair coloring, light-harvesting arrays, photoelectrochemical cells, etc. Most of the dyes are nonbiodegradable, toxic, carcinogenic, and consist of organic compounds. These dye wastages are discharged into water bodies and the environment causing serious hazards to the marine ecosystem as well as the humans extensively. To treat toxic dyes traditional methods such as adsorption, activated carbon, ultrafiltration, and reverse …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 722–727 Read article
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Development of Zinc Gluconate Vitamin C Effervescent Tablet for Immunity Improvement and Management of Corona Virus Disease (COVID-19)
Abstract: The global pandemic of coronavirus disease- 2019 (COVID-19) continues to pose a threat to people, societies, and economic and healthcare systems. COVID-19s progression and lethality are determine by the host immune system, as is the case with many other diseases. revolutionary idea that has been used to treat other diseases is the control of inflammatory response and cytokine production based on immunonutrition. Some COVID-19 clinical trials are now using zinc, …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 1, 2024 Read article
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Review on Sustained Released Matrix Tablet
Abstract: Pharmaceuticals often use sustained release dose forms to prolong the therapeutic agent’s presence in the bloodstream and maintain a consistent plasma profile. The matrix governs the drug’s release rate. Hydroxypropyl methyl cellulose, a release retardant, is a key excipient in formulations due to its ability to promote sustained release. Techniques that include wet granulation, direct compression, or the dispersion of solid particles within a porous matrix, integrating polymers, like polymethyl …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 60–69 Read article
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Viruses and Their Role in Periodontal Diseases: A Review
Abstract: Periodontal diseases are a group of inflammatory conditions that primarily affect the gums and other tissues surrounding the teeth. Traditionally, these conditions were thought to be driven largely by bacterial infections, with the bacteria triggering an immune response that leads to inflammation and tissue damage. However, recent research has revealed that viruses also play a significant role in the development and progression of periodontal diseases. Viruses, such as Human Cytomegalovirus, …
Published in Research and Reviews: A Journal of Dentistry · Vol. 15, Issue 3, 2024 · pp. 1–6 Read article
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Biodegradable Polymer Nanocarriers Composites for Biomedical Applications
Abstract: Smart polymeric nanocarriers, or SPNs, have evolved into a fascinating means of delivering medications especially to cancer cells. By improving the efficacy of chemotherapeutic treatments while lowering their negative effects, they have achieved a significant progress in exact medicine. Made to respond to certain elements in the tumours microenvironment, such as enzymes, temperature, pH, and redox conditions, these nanocarriers this reaction to triggers guarantees the release of the medicine at …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 293–305 Read article
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Catalytic Performance Improvement in Polymer Derived Nanostructures for Fuel Cell Applications
Abstract: The performance and operational lifetime of PEMFCs are closely linked to the catalytic activity and durability of cathode electrocatalysts. In this research, a polymer-derived cobalt–iron nitrogen-doped carbon (CoFe–N/C) nanostructured catalyst is developed to enhance the ORR performance for PEMFC applications. PAN and melamine serve as nitrogen-rich polymer precursors, while cobalt and iron salts generate highly dispersed metal–nitrogen active sites within a porous carbon matrix through thermal treatment at 900 °C. …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 968–979 Read article
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Influence of Polymeric Materials on Osseointegration and Stability of Dental Implants: An In-vivo Resonance Frequency Analysis
Abstract: Osseointegration, the successful integration of dental implants with surrounding bone tissue, is crucial for long-term implant stability. Resonance frequency analysis (RFA) provides a valuable tool for assessing implant stability. This in-vivo study investigates the potential role of polymeric materials used in dental implants, such as surface coatings or membranes, in influencing osseointegration and RFA-measured stability. By analysing the impact of these polymers on factors like cell adhesion, proliferation, and differentiation …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 1051–1057 Read article
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Exploring The Multitarget Pharmacological Mechanism of Diabex for T2dm by Combining Network Pharmacology and Molecular Docking Techniques
Abstract: Objective: Hyperglycemia brought on by an absolute or relative absence of insulin synthesis or action characterises a set of illnesses known as diabetes mellitus. Chronic hyperglycemia in diabetes mellitus has been linked to organ damage, heart, and blood vessels. The persistent metabolic condition Diabetes is a severe global issue with negative social, health, and economic effects. It is a type of metabolism disorder that interferes with food digestion in the …
Published in International Journal of Bioinformatics and Computational Biology Read article
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Polymer Applications in Energy Generation and Storage: A Forward Path
Abstract: In the rapidly evolving landscape of energy generation and storage, the role of polymers cannot be overstated. The work titled "Polymer Applications in Energy Generation and Storage: A Forward Path" aptly captures the essence of the burgeoning intersection between polymer science and sustainable energy solutions. They effectively outline the diverse applications of polymers, highlighting their significance in various energy technologies such as solar cells, and supercapacitors. One of the standout …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 14, Issue 2, 2024 · pp. 30–38 Read article
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Botanical Blockade: Phytochemical Targeting Of Nf-Κb in Cancer Therapy
Abstract: The control of inflammation, corpuscle survival, proliferation, and allowed response are all influenced by the acute archetypal agent NF-κB. Its abnormal activity is typically seen in a range of malignancies, where it aids in bump advancement, metastasis, and treatment waste. The function of NF-κB in scar analysis is discussed in this product, along with significant phytochemicals that seem to be interested in targeting this pathway, based on recent investigation. It …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 1, 2025 · pp. 13–21 Read article
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An Effective & Novel Approach as Gastro-retentive Drug Delivery Systems
Abstract: Researcher’s curiosity about gastro-retentive drug delivery system increased so high in recent years because of its excellent drug releasing properties to the target site. The delivery system's residence time in the stomach can be extended with the usage of gastro-retentive drug delivery system by using a number of natural and synthetic polymers such as guar gum, hydoxy propyl methyl cellulose which can be used to improve the bioavailability of a …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 47–54 Read article
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Impact of a Structured Educational Program on Awareness of the Human Papilloma Virus Vaccine for Cervical Cancer Prevention Among Women in a Chosen Rural Region of Rajkot
Abstract: The World Health Organization (WHO) advocates for the inclusion of the human papilloma virus (HPV) vaccine in standard immunization schedules worldwide, in addition to other preventive strategies. The launch of the prophylactic HPV vaccine has markedly improved primary prevention measures against cervical cancer and other diseases caused by HPV. Following their approval in 2006, both the quadrivalent and bivalent HPV vaccines have received authorization in over 100 countries. As of …
Published in International Journal of Oncological Nursing and Practices · Vol. 2, Issue 1, 2024 · pp. 18–22 Read article
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Recent Development Technique in Management of Cancer
Abstract: Cancer develops when a change in one's genetic makeup leads to the development of tumour cells. These clusters of malignant cells eventually develop into tumours. Tumours can shed cancerous cells, which can then travel through the lymphatic system or the circulatory system to other organs. In the medical field, this occurrence is referred to as metastasis. Cancer cells proliferate even when they have no instructions to do so. Despite the …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 1, 2024 · pp. 25–41 Read article
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Deciphering the Pathophysiology of Migraine: Understanding Trigeminovascular System Activity and the Importance of the Gut-Brain Axis
Abstract: Migraine, a prevalent and disabling neurological condition, manifests in distinct phases: premonitory, aura, headache, postdrome, and interictal. Being a primary contributor to adult disability, it presents a substantial economic challenge on a global scale. Even with extensive research spanning centuries, the complete grasp of its root causes continues to evade us. This intricate neurovascular disorder primarily involves local vasodilation of intracranial and extracerebral blood vessels, coupled with simultaneous stimulation of …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 1, 2024 · pp. 50–61 Read article
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Virulence Factors in pathogens :mechanisms of infection & disease progression
Abstract: Pathogens, like bacteria, viruses, fungi, and parasites, have evolved specialized tools – known as virulence factors – that help them infect hosts, escape the immune system, and cause disease. These factors play a key role in determining how severe an infection becomes, how quickly it spreads, and how the body responds. Some pathogens use adhesins to stick to host cells, while others produce toxins that damage tissues or disrupt normal …
Published in International Journal of Pathogens · Vol. 2, Issue 1, 2025 · pp. 6–11 Read article