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57 articles for “treatment-resistant”
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Infectious illnesses in areas of violence and among refugees
Abstract: Infectious illnesses are a huge and ongoing hazard in conflict zones and among refugee populations. This is because frail health systems, population relocation, and poor living conditions all come together to make transmission risks higher. Armed conflict undermines vital public health infrastructure, such as vaccination programs, disease surveillance, water and sanitation systems, and access to medical care, resulting in the resurgence and proliferation of avoidable and treatable illnesses. Refugee camps …
Published in International Journal of Tropical Medicines · Vol. 3, Issue 1, 2026 · pp. 36–40 Read article
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STRUCTURAL–EPIGENOMIC ATLAS: CNV/SV- DRIVEN PROGNOSTIC REFINEMENT ACROSS CANCERS
Abstract: Structural genomic alterations, including copy number variations (CNVs) and structural variants (SVs), play a central role in cancer initiation and progression. These alterations extend beyond gene dosage effects and interact dynamically with epigenomic mechanisms such as DNA methylation, histone modifications, and three-dimensional chromatin organization. Recent pan-cancer studies have demonstrated that CNV burden and SV signatures reflect key oncogenic processes including chromothripsis, homologous recombination deficiency, enhancer hijacking, and extrachromosomal DNA (ecDNA) …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 4, Issue 1, 2026 Read article
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The Mycobiome Frontier – Pre & Post 2020 Status: Integrating Fungal Bioactive Compounds, Probiotics, and Antimicrobial Peptides in Modern Therapeutics and Biotechnology.
Abstract: The fungal kingdom represents an indispensable resource in modern therapeutics and biotechnology, offering a diverse array of bioactive compounds, probiotics, and antimicrobial peptides (AMPs). Functional fungal polysaccharides (FFPs), such as beta-glucans, chitin, and mannans, are centrally involved in modulating the human gut microbiota, providing novel therapeutic avenues for chronic conditions including diabetes, neurodegenerative disorders, and cancer. These compounds act as prebiotics, nourishing beneficial bacteria and enhancing metabolic parameters such as …
Published in International Journal of Fungi · Vol. 3, Issue 1, 2026 · pp. 1–11 Read article
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Understanding Metabolic Syndrome and its Nutritional Management
Abstract: Metabolic syndrome (MetS) is a collection of risk factors, especially when at least three occur together, including abdominal obesity, dyslipidemia, low high-density lipoprotein cholesterol (HDL-c) levels, hypertension, and insulin resistance. MetS is linked to an increased risk of diabetes and cardiovascular diseases (CVDs) if treatment is not received.The causes of MetS include both genetic and acquired factors that contribute to issues such as insulin resistance, chronic low-grade inflammation, and obesity. …
Published in International Journal of Sustainability · Vol. 2, Issue 1, 2025 · pp. 26–37 Read article
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Advancements in Antiviral Therapeutics: Strategies and Challenges in the Development of Drugs and Vaccines for Viral Diseases
Abstract: Viral infections continue to pose a significant threat to global health, leading to high rates of illness, death, and economic burden. The constantly evolving nature of viruses, along with the rise of drug-resistant strains, underscores the need for continuous advancements in antiviral treatments. This review highlights the pivotal role of antiviral drugs and vaccines in mitigating the impact of viral infections, showcasing recent breakthroughs and exploring emerging technologies. Key advancements …
Published in International Journal of Virus Studies · Vol. 1, Issue 1, 2024 · pp. 32–36 Read article
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Nature’s Pharmacy: Plant-Based Antifungal Agents and Their Therapeutic Potential
Abstract: Antifungal resistance has increased dramatically over the last 10 years, causing serious problems for healthcare because of higher morbidity and death. The urgent need for new treatments is highlighted by the scarcity of effective antifungal medications, their toxicity, and the rise of resistant strains. Since many plants have bioactive secondary metabolites with strong antifungal qualities, including alkaloids, flavonoids, terpenoids, phenolics, and saponins, ethnobotanical sources offer a viable path. Plants with …
Published in International Journal of Tropical Medicines · Vol. 3, Issue 1, 2026 · pp. 1–7 Read article
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Anti-microbial Activity of Herbal Plant Extracts
Abstract: The Microbial resistance to major antibiotics due to overuse of them and problem observed rapidly during treatment of infectious diseases having a big challenge in health sector. Recently many researchers have been finding the solutions for come out these problems. There are many photochemical have been available, they have potential antimicrobial property against microbial species which occurs resistance against antibiotics. The present study is therefore an attempt for review on …
Published in International Journal of Tropical Medicines · Vol. 1, Issue 2, 2024 · pp. 40–52 Read article
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Virulence Factors in pathogens :mechanisms of infection & disease progression
Abstract: Pathogens, like bacteria, viruses, fungi, and parasites, have evolved specialized tools – known as virulence factors – that help them infect hosts, escape the immune system, and cause disease. These factors play a key role in determining how severe an infection becomes, how quickly it spreads, and how the body responds. Some pathogens use adhesins to stick to host cells, while others produce toxins that damage tissues or disrupt normal …
Published in International Journal of Pathogens · Vol. 2, Issue 1, 2025 · pp. 6–11 Read article
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Study of the Antibacterial Activity of Artemisia Absinthium against E. coli bacteria Isolated from Urinary Tract Infections
Abstract: Twenty clinically diagnosed samples were collected using transport medium swabs from the operating room at Al-Amal Specialized Laboratory in Iraq between November 2025 and February 10, 2026. Antibiotic susceptibility testing was performed on the 20 Escherichia coli samples. The results showed a clear difference in the bacterial isolates' response to the tested antibiotics. Imipenem demonstrated the highest inhibition rate, reaching 24.55% (100%), compared to the other antibiotics used in the …
Published in Recent Trends in Infectious Diseases · Vol. 3, Issue 2, 2026 · pp. 17–25 Read article
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Gene Therapy 2.0: Harnessing Cutting-Edge Technologies for Precision Medicine
Abstract: Somatic gene therapy has become the standard form of gene therapy; this creates the Gene Therapy 2.0 era. This new and distinct time consists in the new-generation genome-editing tools and markers, more efficient systems for gene delivery, and personalized medicine approaches that raise the efficacy and safety of the treatment. Base and prime editing are two types of CRISPR-based gene editing tools have provided high precision and reduced off-target effects …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 2, 2025 Read article
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Microorganisms used in aquaculture
Abstract: Microorganisms play a vital role in the health and sustainability of aquaculture systems, contributing to water quality management, disease control, and the overall productivity of aquatic farms. Beneficial microorganisms, including bacteria, fungi, algae, and probiotics, are increasingly recognized for their positive impact on aquaculture operations. These microorganisms can enhance nutrient cycling, promote the breakdown of organic waste, and reduce the need for harmful chemicals, thus improving the environmental footprint of …
Published in International Journal of Marine Life · Vol. 2, Issue 2, 2025 Read article
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Antimicrobial Resistance and AI-Based Strategies for Rapid Pathogen Detection
Abstract: Antimicrobial resistance (AMR) has become a major global health threat, significantly reducing the effectiveness of antimicrobial therapies and increasing the burden of infectious diseases worldwide. The rapid emergence of multidrug-resistant pathogens has created an urgent need for faster, more accurate, and scalable diagnostic approaches to support timely treatment and effective infection control. Artificial intelligence (AI) has emerged as a promising technology capable of transforming pathogen detection and AMR surveillance through …
Published in Recent Trends in Infectious Diseases · Vol. 3, Issue 2, 2026 · pp. 26–36 Read article
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The Dual Crisis: Antibiotic Resistance and the Discovery Void – A Review of Novel Therapeutic Strategies and Non-Traditional Approaches
Abstract: The global rise of antimicrobial resistance (AMR) has emerged as one of the most critical public health challenges of the 21st century, threatening to undermine decades of therapeutic success and rendering conventional antibiotic regimens increasingly ineffective. Parallel to the escalating resistance rates is a profound “discovery void,” characterised by a steep decline in the development of new antibiotic classes since the late 20th century. Together, these two interconnected crises create …
Published in International Journal of Antibiotics · Vol. 3, Issue 1, 2026 · pp. 47–65 Read article
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Causes and Measures to Control Root Rot Fungus in Mulberry Ecosystem
Abstract: Root rot is a severe plant disease caused by various soil-borne fungi, including Phytophthora sp., Pythium sp., Rhizoctonia sp., Fusarium sp., and Armillaria sp. These pathogens attack plant roots, leading to decay, stunted growth, wilting, yellowing leaves, and plant death. Root rot typically develops in waterlogged soils with poor drainage, as these conditions create an environment favorable for fungal growth. Factors such as warm temperatures, compacted soil, improper watering practices, …
Published in International Journal of Fungi · Vol. 1, Issue 2, 2024 · pp. 36–41 Read article
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Biological Synthesis of Silver Nanoparticles Using Hibiscus Sabdariffa Leaf Extract and It’s Antibacterial Sensitivity Assay
Abstract: In this study, AgNO3 was effectively used to synthesize silver nanoparticles. Hibiscus sabdariffa leaf extract was used to promptly and easily synthesize silver nanoparticles. An UV-Visible spectrophotometer showed absorbance peak in range of 300-600 nm. The procedure was found to be easy to follow, quick, least step and safe for the environment. It is non-toxic, and a viable substitute for traditional physical or chemical procedures. At room temperature, silver ions …
Published in International Journal of Tropical Medicines · Vol. 1, Issue 1, 2024 · pp. 08–13 Read article
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Molecular Docking of Saraca asoca (Ashoka) Phytocompounds for Ovarian Cancer Therapy
Abstract: Objective: One of the top five cancers that causes death in women is ovarian cancer, with increases awareness till date the rate of survival is unpredictable. Even though there are advance treatments introduced, chemotherapy is most suggested to the ovarian cancer patients but the rate of relapses increased and the tumors get resistant towards the drugs. This present study is to evaluate the interaction of phytocompounds from Saraca asoca an …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 27–35 Read article
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Impact of HIV on Global Health: A Comprehensive Review of Epidemiology and Interventions
Abstract: H.I.V remains a significant health issue of great concern to the world and with great impact to the individuals and communities on a global scale. This is a comprehensive literature review on the epidemiology of HIV, including both the world prevalence of HIV and the regional variations, especially in sub-Saharan Africa. It discusses the most important modes of transmission including sexual, blood, and vertical transmission and investigates the effectiveness of …
Published in International Journal of Virus Studies · Vol. 3, Issue 1, 2026 · pp. 39–45 Read article
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Microstructural Design and Functional Properties of Polycrystalline Materials
Abstract: Polycrystalline materials, composed of an aggregate of crystallites or grains, are foundational to modern engineering applications due to their versatile functional properties. The microstructural design—encompassing grain size, shape, orientation, phase distribution, and grain boundary characteristics—plays a pivotal role in determining mechanical, thermal, electrical, and magnetic behavior. This abstract explores the intricate relationship between microstructure and functionality, emphasizing how tailored processing techniques such as thermomechanical treatments, sintering, and additive manufacturing can …
Published in International Journal of Crystalline Materials · Vol. 2, Issue 2, 2025 · pp. 16–20 Read article
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Overview of Virulence Factor of Staphylococcus sp.
Abstract: Staphylococcus is a highly virulent genus of bacteria that can cause a range of infections in humans and animals. The production of toxins, enzymes, and biofilms contributes to its ability to establish infections and evade host defenses. Understanding the characteristics and virulence factors of Staphylococcus is crucial for the development of effective prevention strategies and treatment options. Staphylococcus aureus is a significant etiological agent of nosocomial infections on a global …
Published in International Journal of Toxins and Toxics · Vol. 1, Issue 1, 2024 · pp. 25–31 Read article
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Postbiotics Unveiled: Mechanistic Insights and Therapeutic Implications in Obesity.
Abstract: The burgeoning global obesity epidemic necessitates innovative therapeutic approaches, and postbiotics, bioactive compounds arising from microbial fermentation, have emerged as promising contenders in reshaping obesity management. This comprehensive review explores the multifaceted mechanisms by which postbiotics impact obesity, from modulating gut microbiota composition to influencing metabolic pathways and enhancing energy expenditure. The exploration of postbiotics is rooted in a deeper understanding of the gut–brain axis and bidirectional communication between gut …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 1, 2026 · pp. 11–28 Read article