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64 articles for “release kinetics”
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Formulation and Evaluation of Curcumin Microspheres
Abstract: Purpose: To prepare and evaluate curcumin microspheres to improve the absorption and bioavailability of the drug. Methods: Curcumin microspheres were prepared by solvent evaporation method, by using hydroxylpropyl methylcellulose (HPMC), ethyl cellulose (EC), Eudragit S 100 polymer in varying ratios of 1:1, 1:2, 1:3 by using ethanol/dichloromethane as the solvent. The prepared microspheres were evaluated for percentage yield, flow properties, entrapment efficiency, drug content, drug loading, particle size analysis, drug …
Published in Trends in Drug Delivery · Vol. 6, Issue 3, 2019 · pp. 1–11 Read article
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Formulation Development of Otic In Situ Gel containing Lomefloxacin Hydrochloride
Abstract: The present study was aimed at formulation development of a sustained release otic in situ gel of lomefloxacin hydrochloride for the treatment of chronic suppurative otitis media. Poloxamer 407 was used as the thermoreversible gelling agent. Poloxamer concentration in the range of 15–20% w/v was tried. Poloxamer 407 at 16% w/v gave satisfactory in situ gel forming formulations as it gelled near physiological temperature. Poloxamer 407 with various viscosity enhancing …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 3, Issue 1, 2016 · pp. 20–29 Read article
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Controlled Drug Delivery of Furosemides Using Floating Tablet System
Abstract: The development of gastroretentive drug delivery systems (GRDDS) has gained interest, particularly for drugs like furosemide with narrow absorption windows in the upper gastrointestinal (GI) tract. Furosemide, a commonly used diuretic, faces challenges due to limited bioavailability and rapid elimination, requiring frequent dosing and affecting patient compliance. This review highlights the formulation and evaluation of floating furosemide tablets as an effective strategy to enhance therapeutic efficacy. Floating tablets allow prolonged …
Published in International Journal of Membranes · Vol. 2, Issue 1, 2025 · pp. 23–31 Read article
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Synthesis and Characterization of pH-Sensitive Poly (N-isopropylacrylamide-co-acrylic Acid) Hydrogels for Controlled Release of Doxorubicin
Abstract: pH-responsive polymeric hydrogels have attracted significant attention as intelligent biomaterials for site-specific and controlled drug delivery in cancer therapy due to their ability to respond to the acidic tumor microenvironment. In the present study, poly (N-isopropylacrylamide-co-acrylic acid) [P(NIPAM-co-AAc)] hydrogels were synthesized via free radical copolymerization and systematically characterized to evaluate their suitability for controlled delivery of doxorubicin, a widely used chemotherapeutic agent. The copolymer hydrogels were prepared using N-isopropylacrylamide and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 449–458 Read article
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Evaluation of the Effect of Sodium Lauryl Sulphate on Curcumin Microspheres
Abstract: Purpose: To evaluate the effect of the surfactant - sodium lauryl sulphate (SLS) on curcumin microspheres.Methods: Curcumin microspheres were prepared by solvent evaporation method by varying the ratios of the polymers like Eudragit S 100, ethyl cellulose (EC). Ethanol/dichloromethane blend was used as solvent in a ratio of 1:1 to prepare the drug-polymer dispersion and the surfactant SLS was used to prepare the aqueous phase. The prepared microspheres were evaluated …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 8, Issue 1, 2023 · pp. 1–11 Read article
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Kinetic Studies of Pristine and Nanonickel Catalyzed Ammonia Borane
Abstract: The high hydrogen content chemical hydride, Ammonia Borane (NH3BH3, AB) is considered in its pure and catalyzed form for decomposition kinetics. The thermodynamics and slow kinetics are the major issues in addition to potential damage the material likely to cause to the fuel cell. The ability of AB for faster dehydrogenation at lower temperatures with Nickel in its nanoform is explored. The release kinetics, activation energy is computed using Kissinger …
Published in Journal of Alternate Energy Sources & Technologies · Vol. 6, Issue 1, 2015 · pp. 7–13 Read article
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Carboxymethyl Cellulose-Based Spray-Dried Microspheres: Recent Advances and Applications in Targeted Drug Delivery Systems
Abstract: Microspheres are spherical particles ranging from 1 to 1000 μm, made from natural or synthetic polymers and inorganic materials. Their structure allows precise drug delivery, improving targeted release and minimizing off-target effects. Natural polymers such as starch, chitosan, and alginate are favored for their biodegradability, adhesion, and compatibility, enhancing mucosal interaction and residence time. Microspheres are widely used in site-specific drug delivery, gene therapy, and vaccine administration, improving immunogenicity, extending …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 251–268 Read article
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A Novel Liquid Crystal Drug Delivery for Transdermal Application
Abstract: The present study was aimed at the formulation of liquid crystals of acyclovir that will be incorporated into a transdermal patch. Liquid crystals serve as drug carrier and have a good penetration-enhancer property, due to the extensive similarity of these colloidal systems with the intercellular lipids in the stratum corneum. The liquid crystals were prepared using tween 80 as emulsifier, cetosteryl alcohol as emulsion stabilizer and double-distilled water. Liquid crystals …
Published in Trends in Drug Delivery · Vol. 2, Issue 2, 2015 · pp. 28–37 Read article
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Polymer Chemistry in Sustained-Release Herbal Composites: Designing a Stable Euphorbia tithymaloides Topical System with Phospholipid and Polymer Matrices
Abstract: Polymer chemistry enables the stabilization and sustained release of herbal actives, critical for topical therapeutic applications. This study explores a novel process for preparing a stable, sustained-release topical composition of Euphorbia tithymaloides, leveraging polymer-based systems. Ethanolic extract (50 mg) of the plant, rich in unstable sugar moieties (e.g., D-ribose) and sterols (e.g., stigmasterol), is encapsulated within a phospholipid matrix of phosphatidylcholine (50–100 mg) and cholesterol (50–100 mg). This lipid-polymer complex, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 165–171 Read article
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Revolutionizing Gastro-retentive Drug Delivery: Exploring Innovative Formulation Strategies and Mechanisms in Floating in Situ Gel Raft Forming System
Abstract: An in-depth exploration of the transformative shift underway in gastro-retentive drug delivery, spotlighting the utilization of Floating Drug Delivery Systems (FDDS) and specifically honing in on the innovative formulation strategies and mechanisms inherent in Floating In Situ Gel Raft Forming Systems. FDDS present a promising avenue for revolutionizing drug delivery efficacy by capitalizing on buoyancy to float atop the gastric fluid surface, thereby extending gastric residence time and improving drug …
Published in Trends in Drug Delivery · Vol. 11, Issue 1, 2024 · pp. 9–21 Read article
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AI-integrated Responsive Polymer Composites for Controlled Drug Delivery
Abstract: In the current biomedical engineering, it has been established that the development of smart drug delivery systems has become a paramount of relevance especially in ensuring precise, controlled and targeted therapeutic effects. This paper proposes a responsive polymer composite architecture with built-in AI, which is used to deliver drugs in a controlled manner and involves the development of advanced material design and predictive modeling based on data. Biocompatible materials and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 Read article
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Polymer Chemistry-Driven Approaches for Improved Therapeutic Delivery
Abstract: Polymer chemistry has revolutionized pharmaceutical technology by enabling the development of advanced drug delivery systems with improved precision, stability, and therapeutic outcomes. This review explores the role of polymer design, synthesis, and functionalization in the development of responsive and targeted drug carriers. Emphasis is placed on various types of polymers—biodegradable, synthetic, natural, and stimuli-responsive—and their suitability for drug delivery platforms such as nanoparticles, micelles, hydrogels, dendrimers, and implants. The physicochemical …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 Read article
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Polymer-Based Film Coatings for Enhancing Drug Stability and Shelf-Life
Abstract: Pharmaceutical stability is a crucial factor in ensuring drug efficacy and safety throughout its shelf-life. Polymer-based film coatings have emerged as an effective strategy to enhance drug stability by protecting active pharmaceutical ingredients (APIs) from environmental stressors such as moisture, oxygen, temperature fluctuations, and light exposure. These coatings act as physical barriers that prevent degradation, improve mechanical integrity, and enable controlled drug release. Various types of polymers are employed for …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 558–570 Read article
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Influence of Polymeric Carriers on the pH-Modifying Properties of Intracanal Medicaments in Root Canal Treatment
Abstract: Calcium hydroxide (CH) preparations and medicated gutta-percha are widely used intracanal medicaments in root canal treatment. These materials often incorporate polymeric carriers to deliver the CH payload and influence its therapeutic effect. This in-vitro study investigates the impact of different polymeric carriers on the pH-modifying properties of intracanal medicaments within the root canal system. The research focuses on two key aspects: (1) the ability of the polymers to control the …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 967–974 Read article
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Development of Biodegradable Poly (Lactic-Co-Glycolic Acid) (PLGA) Nanoparticles for Sustained Release of Insulin
Abstract: This research outlines the creation of biodegradable composite nanoparticles made from poly (lactic-co-glycolic acid) (PLGA) designed for the sustained release of insulin. The emphasis is on the interactions between the polymer and the drug at the interface, along with the dynamics of the release matrix. The in vitro release kinetics, surface morphology, encapsulation efficiency, particle size, and polydispersity of insulin-loaded PLGA nanoparticles were analyzed following their production via a double …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1690–1699 Read article
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Development of Polymersomes as Macromolecular Platforms for Nanomedicine
Abstract: The conventional method of drug delivery is plagued with instability, low targeting and low bioavailability. A solution to these shortcomings is the use of polymersomes, artificial vesicles that are produced through self-assembly of amphiphilic block copolymer, and they are suggested as universal nanoscale carriers. They have stiff, tunable membranes (thickness = 2–50 nm) due to accurate control of polymer chemistry, chain length, and hydrophilic mass fraction (f), which allows predictability …
Published in Journal of Polymer & Composites · Vol. 14, Issue 5, 2026 · pp. 71–89 Read article
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Review On: Liquid Crystal Cream for Topical Drug Delivery
Abstract: A Liquid crystal creams represent a novel approach in skincare formulations, leveraging the unique properties of liquid crystal technology to improve skin hydration and barrier function. An overview of current developments in liquid crystal cream formulations is given in this article, with an emphasis on the benefits they offer for skincare and their composition and structure. Liquid crystal creams mimic the lipid bilayers of the skin, offering enhanced compatibility and …
Published in Trends in Drug Delivery · Vol. 11, Issue 1, 2024 · pp. 1–8 Read article
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Enhancing Peptic Ulcer Therapy: Innovations in Mucoadhesive Drug Delivery
Abstract: Peptic ulcer disease is still a sincere gastrointestinal demand makes medication administration difficult because of the harsh and changing stomach environment. This paper investigates the potential of using mucoadhesive drug delivery devices to improve the accuracy and effectiveness of peptic ulcer therapies. Due to the inherent characteristics of mucoadhesive drug delivery systems, localized and sustained drug release is made possible by their extended contact and adherence to the gastrointestinal tract's …
Published in Trends in Drug Delivery · Vol. 11, Issue 1, 2024 · pp. 62–76 Read article
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Nano-Therapeutics in Diabetes Mellitus: Revolutionizing Diagnosis, Treatment, and Drug Delivery
Abstract: Diabetes mellitus is a chronic metabolic disorder in which blood glucose concentration remains high over an extended duration, resulting in significant lethal complications, including neuropathy, nephropathy and cardiovascular diseases. However, conventional diabetes management strategies, including insulin therapy and oral hypoglycemic agents, rarely exhibit poor bioavailability, high doses, off target delivery, etc. Nanotechnology has brought the rise of diabetes treatment revolution, by overcoming the challenges present in standard treatment, owing to …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 08–19 Read article
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Advances in Polymer Chemistry for Coronary Artery Disease
Abstract: Coronary artery disease (CAD) remains the leading cause of morbidity and mortality worldwide, driving ongoing innovation in therapeutic materials and device design. Polymer chemistry has emerged as a cornerstone in the development of advanced cardiovascular interventions, offering versatile platforms to improve the safety, efficacy, and functionality of implantable devices. This review explores recent advances in the synthesis and application of biodegradable and biostable polymers, focusing on their roles in drug-eluting …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 710–716 Read article