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67 articles for “protein”
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Molecular Docking studies of Benzodiazepine Derivatives With GABA(B) Receptor
Abstract: Benzodiazepines (BZDs) are pharmacologically significant compounds that act by binding to GABA A neurotransmitter receptors, subsequently augmenting GABA-induced chloride ion flux, consequently inducing neuronal hyperpolarization. Benzodiazepines are commonly used in the treatment of sleep disorders, anxiety, muscle spasms, seizure disorders, and some forms of depression. The primary inhibitory neurotransmitter, GABA, functions on two types of receptors: the ligand-gated GABA A/C receptors and the G protein-coupled GABA B receptors. These neurotransmitters …
Published in International Journal of Toxins and Toxics · Vol. 1, Issue 2, 2024 · pp. 1–14 Read article
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Development and Formulation of Chocolate-coated Seeds Bar
Abstract: Vitamins E, D, and B6 minerals like zinc and selenium and amino acids like glutamine all play a role in the body's immune system development. Edible seeds are a great source of protein, healthy fats, fiber, and important minerals like magnesium, potassium, calcium, iron, and zinc in addition to vitamins B1, B2, B3, and E. Examples of edible seeds include pumpkin, flax, sesame, sunflower, mustard, amaranth, oat, barley, black rice, …
Published in International Journal of Nutritions · Vol. 1, Issue 1, 2024 · pp. 1–12 Read article
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Real Time Characterization of BA.2.86 and Its Variant (JN.1) in Senegal Using Midnight Protocol
Abstract: During the week ending August 13th, 2023, the most prevalent variant of interest (VOI), uploaded to GISAID, was the BA.2.86 variant. This SARS-CoV-2 Omicron lineage was described as the first phylogenetically distinct from the currently circulating SARS-CoV-2 Omicron XBB lineages, including EG.5.1 and HK.3. Compared to the XBB and BA.2 lineages, the BA.2.86 possesses more than 30 mutations in the Spike (S) protein, suggesting a significant potential for immune evasion. …
Published in International Journal of Vaccines · Vol. 1, Issue 2, 2024 · pp. 16–21 Read article
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Total Lipids and Storage Quality of Oil Seeds and Nuts as Influenced by Yeast Fermentation
Abstract: Oilseeds and the products made from them have a role in a healthy balanced diet, even though they are energy dense and contain a high proportion of fat. Most oilseeds are made up of protein and oil. In general, fat is 18–45% by weight of oilseeds and protein is about 16–40%. Fluctuations in oil yields can cause significant fluctuations in their rates. The oils contain fat-soluble vitamins and unsaturated fats …
Published in International Journal of Fungi · Vol. 1, Issue 2, 2024 · pp. 29–35 Read article
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In-Silico Screening of Phytochemicals for Identification of Alternative Therapy for Thyroid Cancer
Abstract: Thyroid cancer remains a significant health concern globally, necessitating the exploration of novel therapeutic alternatives to improve treatment outcomes. This study targets COT kinase (Cancer Osaka Thyroid Kinase), a protein implicated in the progression of thyroid cancer, using molecular docking methods with various phytochemicals to identify potential therapeutic compounds. PyRx and Discovery Studio were employed to evaluate the interactions and binding affinities of a diverse set of natural compounds with …
Published in International Journal of Toxins and Toxics · Vol. 2, Issue 2, 2025 · pp. 31–55 Read article
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Nutrient-Mediated Activation of Cellular Signaling Pathways: Mechanistic Insights into Attenuation of Toxin Induced Inflammation in Food Animals
Abstract: Dietary and environmental toxins remain a persistent challenge in food animal production, where subclinical and clinical inflammation compromises health, productivity, and food safety. Toxin induced inflammation is driven by oxidative stress, mitochondrial dysfunction, and dysregulated immune signaling, resulting in impaired metabolic efficiency and increased disease susceptibility. Recent advances in nutritional science have revealed that nutrients act not only as substrates for growth but also as signaling molecules capable of modulating …
Published in International Journal of Toxins and Toxics · Vol. 3, Issue 1, 2026 · pp. 1–12 Read article
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Benefaction of Nutraceuticals for Human Health: Review
Abstract: Nutraceuticals are a broad category of palatable natural chemicals that are thought to offer benefits beyond their nutritional content. These can include foods high in nutrients, foods with therapeutic properties, or certain ingredients found in some foods, like dietary fiber, hydrolyzed protein, garlic, ginger, omega-3, soybean, minerals, vitamins, fortified foods, enriched foods, and even recombinant goods. People are becoming more concerned about their health due to the long work hours …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 1, 2024 · pp. 1–12 Read article
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Pharmacophore mapping, 3D QSAR, docking, and ADME prediction studies of novel Benzothiazinone derivatives
Abstract: Background Tuberculosis is a major public health concern worldwide which is caused by Mycobacterium tuberculosis. DprE1 (Decaprenyl Phosphoryl Ribose 2’- Epimerase) is the most challenging target for development of novel anti- tubercular agents because it is a small protein and located into cytoplasmic membrane. So, novel anti-TB drugs did not bound effectively with it. DprE1 catalyzes the oxidation of the 2’ hydroxyl group of DPR (Decaprenyl Phosphoryl D- Ribose) …
Published in International Journal of Antibiotics · Vol. 1, Issue 1, 2024 · pp. 59–82 Read article
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Millet Bran: Unveiling Its Potential Health Benefits
Abstract: Millet bran, derived from various millet grains, has emerged as a potent nutritional source, rich in fiber, vitamins, minerals, antioxidants, and omega-3 and omega-6 fatty acids. Its rising popularity is driven by its gluten-free nature, nutrient density, and sustainability. This review aims to explore the potential health benefits of millet bran, focusing on its digestive health, blood sugar control, heart health, antioxidant properties, and fatty acid composition. The Millet brand …
Published in International Journal of Nutritions · Vol. 1, Issue 2, 2024 · pp. 11–19 Read article
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Alopecia Areata: Complex Roots and Potential Cures
Abstract: Autoimmunity is when the healthy organs of an individual’s body are attacked by its own immune system, leading to illness or functional abnormalities. The hair follicles (HFs) are wrongly destroyed by the immune system in a condition known as Alopecia Areata and results in chronic non-cicatricial hair loss discernible by spherical patches. It’s a severely worsening or relapsing malady that can be permanent during severe falling out of hair. In …
Published in International Journal of Vaccines · Vol. 1, Issue 1, 2024 · pp. 41–54 Read article
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Importance of inflammatory marker ratio and lipid profile ratio in Acute Ischemic Stroke
Abstract: Background: Acute Ischemic Stroke is a chronic inflammatory disease that is projected to be one of the leading causes of mortality affecting millions of people globally. It is essential to study the Platelet lymphocyte ratio (PLR), Neutrophil lymphocyte ratio (NLR) ratios and C reactive protein (CRP) in impacting the inflammatory status during stroke. It is also important that altered lipid metabolism could influence the inflammatory conditions associated with AIS. Hence …
Published in International Journal of Brain Sciences · Vol. 1, Issue 1, 2024 · pp. 19–31 Read article
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Insulin : Comprehensive review on its Crucial Role in Metabolism and Disease Management
Abstract: Insulin's pivotal function lies in meticulously regulating blood sugar levels, thus guaranteeing cells access to the necessary energy for optimal functionality. When there is a rise in blood sugar, after a meal, the releases insulin gets released from the pancreas to facilitate the uptake of glucose by cells. Insulin primarily acts on muscle, fat, and liver cells, promoting the uptake of glucose from the blood. Another way to store glucose …
Published in International Journal of Virus Studies · Vol. 1, Issue 1, 2024 · pp. 37–43 Read article
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Advancements in Drug Design Technology and Its Impact on COVID-19 Treatment
Abstract: The deadly coronavirus disease 19 (COVID-19) pandemic has recently spread, raising concerns about global health. The search for novel therapeutic compounds is made more necessary by the persistent problem of the absence of licensed medications or vaccinations. By saving money and time, computer-aided drug design has sped up the process of finding and developing new drugs. The structured-based and ligand-based drug discovery subcategories of computer-aided drug design (CADD) are the …
Published in International Journal of Virus Studies · Vol. 1, Issue 1, 2024 · pp. 1–15 Read article
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Adaptation Strategies for Climate- Resistance Aquaculture: Insight from farmed fish
Abstract: As global climate change threatens food security, particularly regarding the vital protein source of fish, innovative strategies such as climate smart aquaculture emerge as critical solutions. This approach emphasizes the cultivation of climate-resilient fish species capable of thriving in changing environmental conditions. By integrating air-breathing species like the Pangasius catfish and the Giant Snakehead, aquaculture industries can bolster local economies while mitigating environmental risks. However, successful implementation requires careful consideration …
Published in International Journal of Marine Life · Vol. 1, Issue 1, 2024 · pp. 29–34 Read article
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Epidemiology and Mycological Analysis of Superficial Mycosis in a Northern Indian Tertiary Care Hospital
Abstract: Background: A fungal infection that affects the outer layer of the skin and its connective tissue, including hair and nails, is called superficial mycosis. These infections are typically caused by fungi, which thrive on keratin, the proteinthat makes up the nails, hair, and skin. A common disease that can affect people of any age, gender, or race is superficial mycosis. Usually, it appears as a streaky red rash that can …
Published in International Journal of Fungi · Vol. 1, Issue 1, 2024 · pp. 1–12 Read article
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“Evaluation of superoxide Dismutase (SOD) enzyme level and some indicators in people exposed to smoke”
Abstract: The aim of this study is to assess the level of SOD enzyme and its impact in people who are exposed to smoking, in addition to measuring C-interactive protein, and finally measure a complete picture of blood samples taken from patients. The results of the current study showed there is a significant differences (p<0.05) in the activity of the SOD. The mean of SOD activity in patient was 127.9 U/ml …
Published in International Journal of Toxins and Toxics · Vol. 1, Issue 2, 2024 · pp. 52–55 Read article
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Preserving Saccharomyces cerevisiae Culture for Bee Health and Production
Abstract: Saccharomyces cerevisiae, a single-celled fungus also known as baker’s and brewer’s yeast, is extensively used in brewing, baking, and winemaking due to its robust genetics and utility as a model organism in scientific research. Its role extends beyond these applications into apiculture, where it is utilized to produce supplements and pollen replacements for honeybees. These yeast-based supplements are crucial, especially during times of pollen scarcity or colony stress, as they …
Published in International Journal of Insects · Vol. 1, Issue 2, 2024 · pp. 23–27 Read article
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Role of Genetics in Improving Fitness and Sports Performance
Abstract: Research indicates that variations in specific genes affects sports performance, comparing athletes with nonathletes. The genes that have been examined the most in relation to athletic performance are ACE and ACTN3. Strength and endurance have been associated with these genes, which also affect the type of fiber that makes up muscles. Sports performance factors primarily affected by genes are intrinsic motivation to exercise, power and endurance potential, training response to …
Published in Recent Trends in Sports · Vol. 1, Issue 2, 2024 · pp. 28–34 Read article
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Innovative Approaches in Bioinspired and Biomimetic Membrane Technologies: Bridging Nature and Engineering
Abstract: Bioinspired and biomimetic membranes represent a ground breaking advancement in membrane technology, offering innovative solutions to critical global challenges in water purification, chemical separation, and energy conversion. These membranes leverage the exceptional transport properties of biological systems, particularly through the incorporation of aquaporin proteins, which facilitate rapid and selective water transport. This review synthesises recent developments in aquaporin-based membranes, highlighting their remarkable efficiency in desalination processes, where they serve as …
Published in International Journal of Membranes · Vol. 1, Issue 2, 2024 · pp. 53–60 Read article
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FMR1 Key Biomarker in Fragile X Syndrome- A Comprehensive Review
Abstract: Fragile X Syndrome (FXS) is a complicated neurodevelopmental condition that causes intellectual disabilities, behavioural issues, and a variety of physical symptoms. Central to understanding FXS is the Fragile X Mental Retardation 1 (FMR1) gene, pivotal in the disorder's pathogenesis. This review examines FMR1 as a key biomarker in FXS, drawing on recent research insights. The FMR1 gene, situated on the X chromosome, encodes the fragile X mental retardation protein (FMRP), …
Published in International Journal of Brain Sciences · Vol. 1, Issue 2, 2024 · pp. 8–18 Read article