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109 articles for “pharmacological properties”
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Barg-e-Tulsi (Ocimum sanctum Linn.) in Unani Medicine: Bridging Classical Therapeutics with Contemporary Pharmacological Evidence
Abstract: In the Unani System of Medicine (USM), Barg-e-Tulsi (Ocimum sanctum Linn.), commonly known as Tulsi or Holy Basil, is a highly valued medicinal herb that has been extensively used for centuries in the prevention and treatment of various ailments. It occupies an important place in traditional Unani therapeutics due to its broad spectrum of medicinal properties and its effectiveness in managing respiratory, gastrointestinal, neurological, and infectious disorders. Classical Unani scholars …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 13, Issue 2, 2026 Read article
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Comparative Study of Bioactive Phytochemicals from Hexane Extract of Two Amaranthaceae Leafy Vegetables by GC-MS Method
Abstract: Amaranthus tricolor Linn and Amaranthus viridis Linn, belonging to the Amaranthaceae family, are popularly consumed leafy vegetables in India and many other countries globally. The bioactive components of Hexane extract from these two plants have been analysed using gas chromatography-mass spectrometry (GC–MS) technique. According to analysis, both species contain a total of nineteen important chemicals. Of these, ten were found in A. tricolour L. and nine in A. viridis L. …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 7–17 Read article
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Synthesis, Characterization and Evaluation of Pyridine derivatives
Abstract: Schiff bases, a class of organic compounds, have garnered significant attention due to their diverse applications in various fields such as pharmaceuticals, materials science, and coordination chemistry. This study provides a comprehensive overview of the synthesis of Schiff bases amino pyridine derivatives and aromatic ketones along with their anti-microbial activity. Method: The synthesis of Schiff bases primarily involves the condensation reaction between a primary amine and a carbonyl compound (ketone) …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 2, 2024 · pp. 35–48 Read article
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From Clinic Formulation to Development of Acebrophylline
Abstract: Acebrophylline, a commonly utilized bronchodilator with anti-inflammatory properties, has become a key therapeutic option for managing respiratory conditions like asthma, chronic obstructive pulmonary disease (COPD), and chronic bronchitis. This review explores the journey of Acebrophylline from its clinic formulation to its development and commercialization, focusing on the key aspects of formulation strategies, pharmacological properties, and regulatory considerations. The drug’s dual mechanism of action, which involves both bronchodilation and anti-inflammatory effects, …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 1, 2025 · pp. 35–48 Read article
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Use of NMR and Other Spectroscopy Techniques in Heterocyclic Oxadiazole Derivatives Studies: A Review
Abstract: It was possible to create a number of novel symmetrical 2,5-dialkyl-1,3,4-oxadiazoles with substituents including carboxymethylamino, isopropyloxycarbonylmethylamino, and bromine at the terminal positions of the alkyl groups. The multistep process that was devised used hydrazine hydrate, phosphorus oxychloride, and commercially available acid chlorides that varied in alkyl chain length and terminal substituent.Diisopropyliminodiacetate was an easy way to substitute the intermediate bromine-containing 2,5-dialkyl-1,3,4-oxadiazoles. This was followed by hydrolysis in an aqueous methanol …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 2, Issue 1, 2024 · pp. 07–13 Read article
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Synthesis and Characterization of Polymer-Based Benzamide Derivatives with Potential Biomedical Applications
Abstract: The present study explores the synthesis and characterization of polymer-supported benzamide derivatives, focusing on their potential biomedical applications. The use of polymer-supported synthesis offers several advantages, including improved reaction efficiency, ease of purification, and reusability of the support material, making it an environmentally friendly and cost-effective approach. The synthesis involved a stepwise reaction sequence, with polymeric supports facilitating controlled functionalization and ensuring high product purity. These materials have been widely …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 Read article
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Inhibition of PI3K/Akt/mTOR Signaling Pathway by Vitis Vinifera Phytocompounds: A Promising Strategy for Supressing Colorectal Cancer Growth and Metastasis
Abstract: Objectives: Colorectal cancer was not typically identified a few decades ago. Today, with almost 900 000 fatalities each year, it is the fourth most dangerous cancer in the world. Colorectal cancer is responsible for about 10% of all cancer diagnoses annually and cancer-related deaths worldwide. It is the second most common type of cancer in women and the third most common type in men. Incidence and death are roughly 25% …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 · pp. 64–75 Read article
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The Therapeutic and Biotechnological Potential of : Pogostemon benghalenesis, A Comprehensive Review
Abstract: Pogostemon benghalensis is a fragrant perennial shrub belonging to the family Lamiaceae, widely distributed across tropical and subtropical regions of Asia. It has been extensively utilized in traditional and ethnomedicinal systems for the treatment of wounds, skin infections, fever, digestive disorders, inflammation, and respiratory ailments. The plant is also valued for its antiseptic, aphrodisiac, insect-repellent, and veterinary medicinal properties. Its leaves, roots, and essential oil are incorporated into herbal formulations, …
Published in Research & Reviews : Journal of Botany · Vol. 15, Issue 2, 2026 Read article
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A General Review of Mucuna Pruriens W.S.R to its effect on Parkinson’s Disease.
Abstract: Mucuna Pruriens is a very famous drug prescribed in classical ayurvedic science in various disorder of Nervous System including Kampavata .In Clinical Practice ,Physician used Levadopa as a Dopamine replacement agent in controlling bradykinetic symptoms apparent in Parkinson disease so used successfully in treatment of Parkinson disease.Kapikacchu(Mucuna Pruriens) is having Balya, Brimhanaha, Vrishya, and Vatahara properties and is a natural source of L-dopa. So, keeping in views of the degenerative …
Published in Research & Reviews : Journal of Herbal Science · Vol. 13, Issue 1, 2024 · pp. 1–6 Read article
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Phytotherapeutic Potential of Melaleuca: An Integrative Review of Phytochemistry and Antimicrobial, Antifungal, Antioxidant, and Antiviral Mechanisms
Abstract: Melaleuca alternifolia and other species of the Melaleuca genus stand out for the broad spectrum of pharmacological properties attributed to their bioactive compounds, such as monoterpenes, sesquiterpenes, flavonoids, and polyphenols. This study aimed to critically review and analyze scientific evidence produced between 2005 and 2025 regarding the antimicrobial, antifungal, antioxidant, and antiviral activities of Melaleuca, correlating its phytochemistry with molecular mechanisms of action. For this purpose, an integrative literature review …
Published in Research & Reviews : Journal of Herbal Science · Vol. 15, Issue 2, 2026 Read article
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Network Pharmacology and Molecular Docking Approach to Reveal the Underlying Mechanisms of Isorhamnetin in the Treatment of Lymphangitis Carcinomatosis
Abstract: Objective: Lymphangitic carcinomatosis (LC) is a tumor that spreads through lung lymphatics and is most commonly seen secondary to adenocarcinoma. In the majority of cases, LC is a result of tumor cells spreading through the lymphatic system. However, approximately 20% of LC cases can be attributed to lymphangitis caused by tumors obstructing lymphatic drainage. This blockage commonly occurs near the lung hilum, where a centrally located mass can cause inflammation …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 1, 2023 · pp. 28–45 Read article
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Melanogenic Inhibitory Effects of Sesamum indicum Phytocompounds Towards CDK 2, c-KIT, and BRAF.
Abstract: Objective: Melanoma is thought to be the fifth most frequent cancer in the US population, despite cancer being the most common cause of death in the globe. BRAF, CDK2, and c-KIT proteins are regarded as potential therapeutic agents since mutations in these proteins are the primary cause of melanoma. For the investigation of their pharmacological properties and therapeutic activities against the target proteins, Sesamum indicum L. and its phytocompounds were …
Published in International Journal of Bioinformatics and Computational Biology Read article
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Evaluation Of Anti Obesity Activity Of Citrus Sinensis & Citrus Limon By High Fat Diet Induced Model Using Danio Rerio
Abstract: Obesity, defined by the World Health Organization (WHO) as an abnormal or excessive fat accumulation that may impair health, is becoming one of the greatest challenges to global health in this millennium, with more than 300 million men and nearly 450 million women obese globally in 2018. Obesity turns into serious problem globally. Zebrafish model can be used extensively for drug screening due to its low maintenance cost, comparatively short …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 1, 2024 · pp. 24–31 Read article
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Using Multitarget Molecular Docking to Examine the Antiviral Potential of Clerodendrum Phlomidis against Measles
Abstract: Objective: Measles, a viral disease caused by a member of the Paramyxoviridae virus family, is highly contagious and characterized by a respiratory illness and a maculopapular rash on the skin. Children are the main victims of the illness. In the context of drug development, this study investigates the efficacy of phytocompounds derived from Clerodendrum phlomidis against the target protein of the measles virus. Methods: The 7SKS protein was retrieved from …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 2, 2023 · pp. 32–42 Read article
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InSilico Analysis and Homology Modeling of Tetrahydroprotoberberine Oxide involved in the Berberine Biosynthesis
Abstract: Objective: Berberine, a bioactive compound found in various plant species, exhibits diverse pharmacological properties with potential applications in pharmaceutical research. The biosynthesis of berberine involves several enzymatic steps, with (S)-tetrahydroprotoberberine oxidase playing a pivotal role. This study aimed to elucidate the structural and functional characteristics of (S)-tetrahydroprotoberberine oxidase to better understand its role in berberine biosynthesis and its potential biotechnological applications. Methods: Using bioinformatics tools and computational methods, the physicochemical …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 1, 2024 · pp. 7–26 Read article
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Aquatic Ecosystems: A Review on Prospecting of Anticancer Molecules from Fungi & Other Microbes
Abstract: Marine biota; namely, actinomycetes, bacteria, fungi, microalgae, green algae, oceanic weeds, mangroves, and other extremophiles constitute about 90% of the oceanic biomass. The organisms are taxonomically diverse, biologically productive/active, and biochemically unique. These unique biochemiques may act as a great source for the discovery of new bioactive molecules, including anticancer drugs. The marines produce medicinally potent biochemicals; namely, sulfated saccharides, polyphenols, and, sterols. Only a few of these alkaloids have …
Published in International Journal of Fungi · Vol. 1, Issue 2, 2024 · pp. 1–22 Read article
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To Investigate Hormonal Fluctuations in Male Rattus norvegicus after Treatment with 50% Methanolic Extract of Acacia arabica
Abstract: The use of medicinal plants in traditional and modern medicine has garnered significant interest for their therapeutic potential. Acacia arabica, commonly known as babul, is renowned for its bioactive compounds and diverse pharmacological properties. This study investigates the hormonal fluctuations induced by 50% methanolic extract of Acacia arabica in male Rattus norvegicus, aiming to explore its potential as a male contraceptive. Male contraception remains limited primarily to condoms and vasectomy, …
Published in Research & Reviews : Journal of Herbal Science · Vol. 13, Issue 3, 2024 · pp. 28–38 Read article
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In Silico Molecular Docking Studies of Phytocompounds from Melissa officinalis Against MPXV Poxin Target
Abstract: Objectives: This study aimed to evaluate the inhibitory potential of phytocompounds of Melissa officinalis against the MPXV poxin protein target, a key virulence factor in monkeypox infection. Methods: Molecular docking performed using PyRx, a virtual screening software, was conducted to predict the binding affinities of the compounds to MPXV poxin. Prior to docking, the compounds were subjected to comprehensive analysis, including Lipinski's rule of five, evaluation of physicochemical properties, pharmacological …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 2, 2024 · pp. 25–38 Read article
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Exploring the Potential of Allium sativum Phytocompounds as B-Cell Leukemia 2 Inhibitors in Acute Lymphoblastic Leukemia: Molecular Docking Study
Abstract: Objective: Acute lymphoblastic leukemia (ALL) is a lymphoid progenitor cell malignancy that could be treated with plant-based drugs, thus alleviating the off-target effects caused by conventional chemotherapy. Since ancient days, Allium sativum has been an integral part of traditional medicine and an excellent antimicrobial, antioxidant, and antiproliferative agent. Hence, this study aims to assess the anti-leukemic potential of A. sativum phytoconstituents as the B-cell leukemia 2 protein (Bcl-2) natural inhibitor …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 2, 2024 · pp. 53–80 Read article
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Review on Clinical Safety and Efficacy of Giant Calotropis in the 21st Century
Abstract: Calotropis gigantea, a highly valued plant in traditional Indian pharmacology, has emerged as a promising candidate for therapeutic innovation. This review delves into the clinical safety and efficacy of C. gigantea in the 21st century, examining its historical use, phytochemical composition, and pharmacological properties. While traditional medicine has long utilized C. gigantea for various ailments, modern research has sought to validate these claims through scientific investigation. This review critically analyzes …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 1, 2025 · pp. 26–34 Read article