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177 articles for “in-silico studies.”
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In Silico Pharmacological Evaluation of Certain Commercially Available Terpenoids As Αlpha-Amylase Inhibitors for The Management of Diabetes Mellitus.
Abstract: The objective of this study was to investigate the α-amylase inhibitory activity of certain commercially available terpenoids using in silico docking studies. In this perspective, terpenoids like Abietane, Artemisinin, Carvone, Cucurbitane, Ferruginol, Lupeol, Nerolidol, Retinol, Sabinene, and Zingiberene were selected. Glibenclamide, a well-known antidiabetic drug was used as the standard. In silico docking studies were carried out using AutoDock 4.2, based on the Lamarckian genetic algorithm as the working principle. …
Published in Research and Reviews : Journal of Computational Biology Read article
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In Silico Pharmacological Evaluation of Certain Commercially Available Terpenoids As Αlpha-Amylase Inhibitors for The Management of Diabetes Mellitus
Abstract: The objective of this study was to investigate the α-amylase inhibitory activity of certain commercially available terpenoids using in silico docking studies. In this perspective, terpenoids like Abietane, Artemisinin, Carvone, Cucurbitane, Ferruginol, Lupeol, Nerolidol, Retinol, Sabinene, and Zingiberene were selected. Glibenclamide, a well-known antidiabetic drug was used as the standard. In silico docking studies were carried out using AutoDock 4.2, based on the Lamarckian genetic algorithm as the working principle. …
Published in Research and Reviews : Journal of Computational Biology · Vol. 10, Issue 2, 2021 · pp. 1–9 Read article
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Study of Ablation Characteristics Carbon Fiber Reinforced Plastic with Silicon Carbide Pores
Abstract: Significant thermal stress is placed on spacecraft during atmospheric re-entry, primarily due to aerodynamic heating. This intense heat can cause severe material damage threatening the spacecraft's structural integrity. To address this challenge, efforts are focused on improving the ablation resistence of spacecraft components. In this work, carbon fiber reinforced plastic (CFRP) composites containing silicon carbide (SiC) holes are explored as a potential solution for enhancing thermal protection system. Four different …
Published in Journal of Polymer & Composites · Vol. 13, Issue 2, 2025 · pp. 617–627 Read article
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Characterization of Aluminum Metal-Matrix Composite with SiC and B4C Reinforcement with Different Weight Percentage
Abstract: Metal Matrix Composites (MMCs) have been prepared by compo casting method. The effect of matrix material on the wettability/compatibility of refinement with matrix is studied. Silicon and boron ceramic particles were used as reinforcement in aluminum matrices. The study of density, micro-hardness and the tensile strength has been done in order to characterize the same. It is found that Al-SiC MMC shows an increase in density with increasing weight percentage …
Published in Journal of Experimental & Applied Mechanics · Vol. 6, Issue 1, 2015 · pp. 1–6 Read article
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In Silico Screening and Molecular Docking of Cynodon dactylon phytochemicals against COPD-Associated Proteins
Abstract: Chronic Obstructive Pulmonary Disease or COPD is a pulmonary disease that obstructs airways and alveoli accompanied by respiratory issues like emphysema and bronchitis. This disease is caused mainly by inflammatory responses of the body to foreign particles that enter the respiratory path including tobacco smoke, air pollutants and irritants. The hallmark of COPD is excessive inflammation caused by imbalance in protease anti-protease activity. Proteases like elastase breakdown the ECM of …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article
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Studies on Erosion Wear Behavior of Aluminum-3 Magnesium-10 Silicon Carbide Composite
Abstract: Aluminum-based metal matrix composites (MMCs) offer potential for advanced structural applications when high specific strength and modulus as well as good elevated temperature resistance along with light weight are important. In the present work, aluminum alloy-silicon carbide composite (Al-3Mg-10SiC) is developed using the stir-casting technique and is subjected to study the wear behavior. Solid particle erosion on Al-3Mg-10SiC was conducted. Implementation of design of experiments (through Taguchi and statistical techniques) …
Published in Journal of Materials & Metallurgical Engineering · Vol. 3, Issue 3, 2013 · pp. 39–50 Read article
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Tribological Study on SiC+Graphene Reinforced Al319 Composite andOptimization of Stir Casting Parameters
Abstract: The aluminium 319 (Al319) is a commonly used material for fabricating automobile components. Due to continuous friction and vibration, those components are subjected to significant wear. Therefore, it is necessary to improve the wear characteristics of this Al319. Hence, in this study Silicon Carbide (SiC) and Graphene nanoparticles (GNPs) are reinforce to Al319 via electro-magnetic stir casting method to optimize wear characteristics without its affecting mechanical properties. Various proposition of …
Published in Journal of Polymer & Composites · Vol. 12, Issue 6, 2024 · pp. 105–123 Read article
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Iota carrageenan, a Sustainable polymer transformed into a nanogel formulation, by using environment friendly method for antitumor action
Abstract: In the pharmaceutical field, the utilization of polymers, both in their natural form and through chemical modifications, holds immense importance. In this context, a novel and eco-friendly method for the synthesis of nano carrageenan-based polymers has been developed. The efficacy of carrageenan in this domain is attributed to its crosslinking and biological properties, which are largely influenced by its sulfate ion content. This study aims to formulate nanogels via a …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 881–889 Read article
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A Combined Molecular Docking Analysis of The Phytochemicals of Ginkgo biloba against The Parkin Protein Target (Autoinhibited Parkin Catalytic Domain)
Abstract: This study's goal is to evaluate the specific therapeutic targets for Parkinson's disease (PDB ID: 4BM9) using molecular docking simulation and ADME analysis against bilobalide, quercetin, ginkgolide B, and protocatechuic acid (3,4-Dihydroxybenzoic acid). The Protein Data Base was used to extract theprotein's three-dimensional structure, and the PubChem database was used to retrieve the ligands. Using Auto-Dock Tools-1.5.7, a molecular docking simulation of the compounds was carried out. Since none of …
Published in Journal of Catalyst & Catalysis · Vol. 10, Issue 1, 2023 · pp. 1–9 Read article
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Drugs for Alzheimer’s Disease from Salix Alba Discovered Computationally Utilizing Virtual Screening and Docking against 1b41 Protein
Abstract: Objective : The of this research is to evaluate the feasibility of using molecular docking techniques to identify novel acetylcholinesterase, a key enzyme implicated in the pathogenesis of Alzheimer’s disease, a neurodegenerative disorder with a gradual but steady progression to death, due to the gradual accumulation of beta-plaques and neurofibrillary tangles, as well as a decline in acetylcholine levels. Due to its function in converting acetylcholine into acyl and choline …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 2, 2023 · pp. 07–19 Read article
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Study of the Influence of Thermal Tempering on the Bending Behavior of the Silico Soda Lime Glass Material
Abstract: In this contribution, we examine the mechanical behavior of tempered soda-lime-silica glass plates and show that improvements in performance can be achieved through the change of the structural and mechanical properties. Tests of thermal tempering by air jet have been performed on glass plates of different dimensions. Three-point bending tests have been conducted on nontempered and fully tempered float glass plates of four different sizes. A parametric study on the …
Published in Journal of Materials & Metallurgical Engineering · Vol. 2, Issue 1-3, 2012 · pp. 160–168 Read article
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Unveiling Nature’s Potential: In Silico Exploration and Identification of Herbal Remedies for Major Depressive Disorder Through Molecular Interaction Studies
Abstract: Major depressive disorder (MDD), a globally discussed mental health condition, has drawn significant attention because of its unique and intricate nature. This is marked by the enduring presence of negative emotions stemming from a lack of interest, diminished self-esteem, and excessive rumination. Despite the widespread availability of various antidepressant medications, their effectiveness is hindered by low response rates, prolonged treatment durations, and the prevalence of side effects, such as headaches, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 54–62 Read article
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Investigating the Effect of Spectral Variations on the Performance of Monocrystalline, Polycrystalline and Amorphous Silicon Solar Cells
Abstract: The study of spectral variations is very important in the characterization of silicon solar cells. The spectral variations of monocrystalline, polycrystalline and amorphous solar cells is studied through the spectral response with the help of spectral response evaluation meter, CEP-25HS-50SR. PVsyst 6.4.3 software is used to study the variation of air mass throughout the day and the year and to understand that how solar irradiance varies with the changing air …
Published in Journal of Alternate Energy Sources & Technologies · Vol. 7, Issue 3, 2016 · pp. 28–36 Read article
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Techniques of Atomic Structure Orbit Potential of The Frequency Characteristics of Silicon Element
Abstract: This study explores the technological applications and material integration of semiconductor materials, with a focus on their electronic properties and practical implementations. The investigation primarily addresses four key objectives: analyzing the electronic band structure and density of states (DOS) of semiconductor materials, evaluating the band alignment in heterojunctions, and integrating these materials into practical technological applications. Using a simplified tight-binding model, we compute and plot the electronic band structure of …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 11, Issue 3, 2024 · pp. 16–32 Read article
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IN SILICO SCREENING AND EVALUATION OF SOME METABOLITES FROM MOMORDICA CHARANTIA IN THE TREATMENT OF PEPTIC ULCERS
Abstract: Peptic ulcers are also called as or duodenal ulcers or gastric ulcers that are open sores generally develop in the lining of the stomach due to food and climatic factors. H. pylori infections are potentially the most dangerous and are linked to several diseases like diabetes, cancer, cardiovascular diseases, etc. In the present study, in silico screening and evaluation of some metabolites from Momordica charantia like Momorcharin, Momordicin, Metformin, Pioglitazone, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 10, Issue 1, 2021 Read article
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Corrosion Characterization of Silicon Carbide and Fly Ash Particulates Dispersion Strengthened Aluminium 5083 Composites
Abstract: Corrosion behavior of aluminium metal matrix composites is a major study aimed at evaluating the potential of using the materials for aerospace components. Aluminium 5083 is a specific class of alloy which is known for its corrosion resistance in extreme environments and is used in aerospace components. However, the studies on effect of reinforcements such as silicon carbide and fly ash on corrosion behavior of aluminium 5083 alloy has not …
Published in Journal of Catalyst & Catalysis · Vol. 4, Issue 2, 2017 · pp. 9–21 Read article
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In Silico Screening and Evaluation of Some Metabolites from Momordica charantia in the Treatment of Peptic Ulcers
Abstract: Peptic ulcers are also called as or duodenal ulcers or gastric ulcers that are open sores generally develop in the lining of the stomach due to food and climatic factors. H. pylori infections are potentially the most dangerous and are linked to several diseases like diabetes, cancer, cardiovascular diseases, etc. In the present study, in silico screening and evaluation of some metabolites from Momordica charantia like Momorcharin, Momordicin, Metformin, Pioglitazone, …
Published in Research and Reviews : Journal of Computational Biology Read article
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Enhancing Mechanical and Thermal Properties of Glass Fiber-Reinforced Epoxy Composites with Silicon Carbide Additives
Abstract: This study explores the production and characterization of glass fiber-reinforced epoxy resin composites enhanced with silicon carbide (SiC) as a reinforcing filler. The primary objective is to evaluate the impact of SiC on the mechanical, thermal, and morphological properties of the composites. Four different samples with varying SiC weight fractions (0%, 5%, 10%, and 15%) were prepared, keeping the glass fiber content constant. The composites were fabricated using a combination …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 69–77 Read article
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Evaluating the therapeutic effects of Asystasia gangetica (Chinese violet) on the chronic respiratory condition- Asthma
Abstract: Asthma is a chronic condition affecting the respiratory system. Its symptoms affect the immune pathways via helper T-cells. The plant Asystasia gangetica is prevalent throughout tropical regions around the world. It has been used in some herbal remedies to relieve symptoms of asthma. This study used computational techniques to assess the effectiveness of several phytocompounds present in A. gangetica in relieving symptoms of Asthma. Three proteins associated with asthma, namely …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 1, 2025 · pp. 15–21 Read article
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Investigating the Mechanical Properties and Microstructure of AA 7074 Composites with Silicon Nitride Reinforcement
Abstract: This study investigates the mechanical and microstructural properties of AA 7074 aluminium alloy reinforced with 1%, 3%, and 5% by weight of silicon nitride (Si₃N₄), fabricated via the stir casting method, intended for structural aerospace applications. A thorough series of mechanical tests—comprising tensile, compression, hardness, impact, flexural, and wear tests—was performed to assess the influence of differing reinforcing content. The composite containing 5 wt% Si₃N₄ (SN5) demonstrated the most pronounced …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 268–281 Read article