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31 articles for “excretion”
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Pharmacokinetic and Pharmacodynamic Studies of Black Seed Derived Compound
Abstract: Black seed (Nigella sativa) has been celebrated for centuries for its remarkable therapeutic properties. Among its bioactive compounds, thymoquinone (TQ) has gained significant attention in pharmacological research due to its diverse health benefits. This review delves into the pharmacokinetic (PK) and pharmacodynamic (PD) properties of black seed compounds, with a particular emphasis on TQ, the most extensively studied component. The PK of TQ includes the parameters of absorption, distribution, metabolism, …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 15, Issue 1, 2025 · pp. 36–43 Read article
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Screening Phytocompounds of Tinospora cordifolia to Find Potential Drug Targets for Cystic Fibrosis
Abstract: This study aimed to evaluate the therapeutic potential of phytocompounds derived from Tinospora cordifolia in treating cystic fibrosis (CF), a genetic disorder caused by mutations in the CFTR gene that lead to severe respiratory and digestive complications. Phytocompounds were retrieved from the IMPPAT database and subjected to molecular docking simulations using PyRx to assess their binding affinity to the CFTR protein. The top-scoring compounds – sterol, magnoflorine, tembetarine, kaempferol, and …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 1, 2025 · pp. 16–24 Read article
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Repurposing Approved Immunomodulatory Drugs for Target Proteins in the Pancreas of European eel: A Molecular Docking Approach
Abstract: Leishmaniasis is a disease caused by tiny parasites called Leishmania, which spread to humans through the bite of an infected female sand fly. The disease manifests in three different forms, and the protein calcitonin promotes the disease’s spread. By reducing blood calcium levels, inhibiting osteoclast activity, increasing calcium excretion, and possibly playing a role in neurotransmitter modulation, calcitonin, a hormone released by vertebrates, promotes the progression of pathogenesis and lessens …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 12–19 Read article
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Phytoremediation of Aquaculture Wastewater: Duckweed (Lemna minor L.) as a Phytoremediator
Abstract: Aquaculture systems discharge huge quantities of waste into the aquatic ecosystem, in the form of excretory products and excess feed. These have grave implications on physicochemical and biological quality of the receiving environment. The study aimed to determine potential of duckweed (Lemna minor L.) for phytoremediation of aquaculture effluent. Hundred grams (100 g) of duckweed was grown in 10 L aquaculture effluent for 7-, 14-, 21-, and 28-day retention period …
Published in International Journal of Pollution: Prevention & Control · Vol. 3, Issue 1, 2025 · pp. 13–19 Read article
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Molecular Mechanisms of Drug Metabolism in Anesthesia: A Pharmacogenomic Perspective
Abstract: Pharmacogenomics studies how a person’s genetic profile affects their reaction to drugs, which is vital in anesthesia. Anesthetic pharmacology depends significantly on drug metabolism, which involves complex biochemical processes that manage the absorption, distribution, metabolism, and excretion (ADME) of anesthetic drugs. The cytochrome P450 (CYP) enzyme family plays a critical role in the metabolism of various anesthetic drugs, with genetic polymorphisms leading to inter-individual variability in drug responses. Specific CYP …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 90–95 Read article
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Investigating The Alkalizing Potential of Chandanasava For Restoring Acid-Base Homeostasis in Renal Tubular Acidosis: A Computational and In Silico Pharmacological Study
Abstract: Chandanasava, a traditional Ayurvedic formulation, is recognized for its potential alkalizing properties, which may help restore acid-base homeostasis in conditions such as renal tubular acidosis (RTA). This study aims to investigate the active components of Chandanasava and their interactions with key renal target proteins, Pendrin and Carbonic Anhydrase II, which are essential for maintaining acid-base balance. An in silico approach was utilized to explore the pharmacological potential of the phytochemicals …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 2, 2025 · pp. 28–52 Read article
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Pharmacology in Clinical and Therapeutic Settings
Abstract: Polypharmacy, which refers to the practice of taking many medications at the same time, is becoming more common among elderly populations as a result of the steadily increasing prevalence of chronic conditions. The clinical and therapeutic consequences of polypharmacy are investigated in this paper, with a particular emphasis placed on drug-drug interactions, altered pharmacokinetics, and patient safety. The physiological changes that occur with advancing age have a substantial impact on …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 3, 2025 · pp. 51–58 Read article
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Exploring the Therapeutic Potential of Phytochemicals in Aloe Barbadensis Miller Through Molecular Docking for Ulcerative Colitis Management
Abstract: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by mucosal inflammation of the colon, often associated with immune dysregulation and oxidative stress. Natural compounds have gained significant attention as alternative therapeutic agents due to their efficacy and minimal side effects. Quercetin, a flavonoid abundantly found in Allium cepa (onion), has demonstrated potent anti-inflammatory and antioxidant properties. This study employs an in silico approach to evaluate the therapeutic potential …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 13, Issue 1, 2026 · pp. 06–12 Read article
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Toxicokinetics of Herbicide Residues in Green Forages: Implications for Fertility, Health, and Welfare of Dairy Cows
Abstract: Herbicide residues in green roughages have emerged as a significant concern in dairy production due to their potential toxicokinetic interactions and detrimental effects on reproductive health. While herbicides are widely used to control weeds and enhance fodder yield, their persistence in forage poses a latent risk to dairy cattle fertility. This review explores the absorption, distribution, metabolism, and excretion of herbicide residues in dairy cows, emphasizing their bioaccumulation and systemic …
Published in Research and Reviews : Journal of Dairy Science and Technology · Vol. 14, Issue 3, 2025 · pp. 48–64 Read article
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Jaundice: Etiology, Clinical Manifestations, Diagnosis, Management, Nursing Care, and Prevention
Abstract: Jaundice is a significant clinical condition marked by a yellow discoloration of the skin, sclera, and mucous membranes resulting from increased bilirubin levels in the bloodstream. Rather than being a disease itself, jaundice represents an underlying disorder involving the liver, biliary system, or hematological processes. Hyperbilirubinemia develops when there is excessive bilirubin production, impaired hepatic uptake, defective conjugation, or obstruction in bile excretion. Jaundice remains a major global health concern …
Published in Research and Reviews: A Journal of Medicine · Vol. 16, Issue 1, 2026 · pp. 32–39 Read article
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Ashaya as Abode: Reconciling Ayurvedic Vata Theory with Intestinal Neurophysiology
Abstract: Background-Ashaya refers to a site or structure within the body where a substance resides. Ashaya refers to the internal sites or structures within the body where various substances reside Commonly, seven Ashayas are described in males, while in females there are eight, while Sharangadhara has described 9 Ashayas. Vatashaya denotes the specific site of Vata Dosha, which is considered the chief among the three Doshas due to its vital role …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 15, Issue 2, 2026 Read article