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245 articles for “agent evaluation”
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Formulation, Evaluation, and Stability Studies of a Topical Clotrimazole and Zinc Oxide Suspension with Enhanced Skin Protective Properties
Abstract: Background: Clotrimazole is a well-known antifungal agent frequently used in the treatment of various superficial fungal infections, while Zinc Oxide is a widely accepted skin protectant with soothing, astringent, and antimicrobial properties. Combining these agents in a topical suspension offers a dual therapeutic approach, enhancing both antifungal efficacy and skin protection. Objective: The objective of this study was to formulate, evaluate, and conduct stability studies on topical suspensions containing Clotrimazole …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 3, 2025 · pp. 22–31 Read article
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Agentic AI: Architectures, Types, Capabilities, Mathematical Equations and Governance in the Era of Autonomous Intelligence
Abstract: Agentic Artificial Intelligence (Agentic AI) represents a major advancement in the evolution of intelligent systems by enabling autonomous planning, decision-making, and action execution. Unlike traditional AI models, which are primarily reactive and designed to respond to predefined inputs, Agentic AI systems possess capabilities such as memory, reasoning, goal-oriented planning, tool integration, and dynamic adaptation to changing environments. These characteristics allow them to perform complex, multi-step tasks with minimal human intervention, …
Published in Recent Trends in Mathematics · Vol. 3, Issue 2, 2026 · pp. 01–14 Read article
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Design And Evaluation Of Meloxicam Tablet For Colon Cancer
Abstract: Meloxicam, recognized as a preferential COX-2 inhibitor, has emerged as a promising chemopreventive agent for colorectal cancer. Leveraging its local and targeted action on the colon, Meloxicam proves to be a formidable component in the prevention of colorectal malignancies. This study aims to innovate by formulating and evaluating a targeted tablet delivery system for Meloxicam, emphasizing site-specific and instant drug release in the colon, thereby maximizing its therapeutic efficacy in …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 10, Issue 3, 2023 · pp. 1–7 Read article
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Regression Analysis of Topological Indices and Physicochemical Properties of Polymer-Based Anticancer Drugs
Abstract: The research analyzed the quantitative correlation between topological indices and the physicochemical properties of selected anticancer compounds using regression analysis. Various topological descriptors—such as the First Zagreb Index, Second Zagreb Index, and Forgotten Index were calculated and regressed against key molecular features, including polar surface area, melting point, and molar refractivity. The regression analysis revealed linear correlations between these topological indices and the properties of anticancer drugs, with particularly strong …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 255–267 Read article
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Evaluation of Rational Use of Antibiotics and Incidence of Surgical Site Infections in a Tertiary Care Hospital
Abstract: Context: Antimicrobial resistance is a major health issue nowadays. It can be reduced by framing, educating health care professionals, strictly following and reviewing the guidelines for antibiotics usage. Many hospitals are not following standard guidelines for antibiotics usage which has led to overuse of antibiotics which contributes for the emergence of resistant strains of microbes against antibiotics. Antibiotics are used pre-operatively to reduce the risk of surgical site infections. The …
Published in Research and Reviews : Journal of Surgery · Vol. 7, Issue 3, 2018 · pp. 4–8 Read article
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Formulation, Optimization and Evaluation of Flurbiprofen Liposomal Gel
Abstract: The present study deals with effect of various combinations of lecithin, cholesterol, chloroform-methanol and tween-80 on liposomes of flurbiprofen. Optimization of the flurbiprofen liposomes by Design Expert software was done. Vesicle size, drug content, SEM and entrapment efficiency were evaluated. Flurbiprofen gel with optimized liposome using Carbopol 934 as gelling agents, were formulated. pH, spreadability and drug content in the gel were evaluated. Results of skin irritation study showed that …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 2, 2017 · pp. 33–42 Read article
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Physicochemical Transitions and Polymerization Dynamics in Multi-Generational Dentin Adhesives: A Critical Review of the Resin-Dentin Composite Interface
Abstract: Adhesive dentistry has undergone a transformative refinement over the past three decades, transitioning from technique-sensitive, multi-step etch-and-rinse protocols to streamlined universal formulations. This narrative review critically synthesizes evidence from thirty peer-reviewed investigations to evaluate the evolution of dentin bonding agents from the fourth through the eighth generations. The analysis places particular emphasis on the physicochemical dynamics of the resin-dentin interface, including interfacial bond strength metrics, marginal integrity, and microleakage behavior. …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 209–228 Read article
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Synthesis, Characterization and Antibacterial Activity of Chalcone Derivatives
Abstract: Chalcone derivatives were produced by the Claisen-Schmidt condensation of aromatic aldehydes with methyl ketones. Chalone derivatives are valuable species as they belong to keto-ethylenic components. Chalcone is a one-of-a-kind template that is linked to a variety of biological processes. 2-hydroxy-2,5- dichloro acetophenon (1) were synthesized by Fries migration and condensed with aromatic aldehyde to produce the new chalcone derivatives (2a-e). The new 1-(2-hydroxy-3,5-dichlorophenyl)-aryl-prop2-ene-1-ones (2a-e) (chalcones) were characterized using FT-IR and …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 14, Issue 2, 2023 · pp. 42–46 Read article
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IN SILICO EVALUATION OF INHIBITORY POTENTIAL OF SOME COMMERCIALLY AVAILABLE FLAVONOIDS AGAINST BETA- SECRETASE IN THE MANAGEMENT OF ALZHIEMER’S DISEASE
Abstract: In a continuing effort to develop multitargeted compounds as potential treatment agents against Alzheimer's disease (AD), a certain commercially available flavonoids were evaluated against crystal structure of beta-secretase enzyme using in silico docking studies. In this perspective, flavonoids like apigenin, galangin, gallocatechol, genistein, luteolin, myricetin, and theaflavin were selected. AutoDock 4.2 software was used for the in-silico docking studies which possess the principle of Lamarckian genetic algorithm. In the docking …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 2, 2019 · pp. 30–35 Read article
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DURABILITY ASSESSMENT OF SELF COMPACTING, SELF CURING CONCRETE INCORPORATING CRUSHED ROCK POWDER AND MINERAL ADMIXTURES
Abstract: Curing plays a crucial role in achieving the desired strength, characteristics, and durability of concrete. Negligent curing practices can lead to adverse effects on hydration and mechanical properties of concrete. In recent times, self-curing concrete has gained significant attention due to its potential in reducing water loss through the use of self-curing agents. The Present Research study focus on investigation on durability characteristics of self-curing self-compacting concrete using crushed rock …
Published in Journal of Polymer & Composites · Vol. 11, Issue 10, 2023 · pp. 25–35 Read article
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Preparation and Characterization of Clay-Based Hybrid Membranes for Antibacterial Biodegradable Polymer Wound Dressings
Abstract: Recent developments in the field of polymer chemistry have resulted in many new forms of Hybrid polymer. This has further revolutionized the application of polymer chemistry in numerous fields. In this research, we manufactured clay-based hybrid membrane by adding clay to the biodegradable matrix of chitosan polymer. It is widely known that microbial and pathogenic organisms are responsible for wound hampering infections such as impetigo. They can spread in bodily …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 13–20 Read article
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Nanoparticles in Cutting-edge Healthcare: Current Use and Emerging Issues
Abstract: Nanoparticles are sub-micron-sized particles (less than 100 nm on average). Using these materials as contrast agents in imaging and as carriers for medication and gene transfer into malignancies has given them a prominent place in contemporary medicine. Nanoparticles allow for previously inconceivable levels of analysis and therapy. However, nanoparticles provide new societal and environmental challenges, especially regarding toxicity. In this overview, we discuss how nanoparticles have benefited contemporary medicine and …
Published in Journal of Polymer & Composites · Vol. 11, Issue 3, 2023 · pp. 105–118 Read article
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Formulation Development and Evaluation of Floating Tablets of Venlafaxine Hydrochloride
Abstract: The aim of the present study was to formulate and evaluate gastroretentive floating tablets of an antidepressant drug, Venlafaxine HCl. The matrix tablets of Venlafaxine hydrochloride were prepared by employing low viscosity grade hydrophilic polymer HPMC E15LV in combination with any one of the high viscosity grades of HPMC (K4M, K15M, and K100M) as swelling polymers. Sodium bicarbonate was employed as gas generating agent. The tablets were formulated using direct …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 6, Issue 1, 2015 · pp. 7–15 Read article
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Design and Evaluation of Promethazine Hydrochloride Rapimelts
Abstract: Objective: In the present study, efforts were taken to develop rapimelts of promethazine HCl—an antiemetic agent with an objective to achieve rapid disintegration, and further improve thebioavailability of drug.Methods:Rapimelts were prepared by direct compression methodusing superdisintegrants such as crospovidone (cp), croscarmellose sodium (ccs), sodiumstarch glycolate (ssg). The prepared formulations were evaluated for precompressionparameters such as bulk density, tapped density, Carr’s compressibility, Hausner ratio andangle of repose. The prepared batches of …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 10, Issue 1, 2019 · pp. 11–19 Read article
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Formulation and Evaluation of Face Scrub using Mango Seed as Natural Exfoliant
Abstract: In this study, face scrub as oil in water cream with different ratios of mango seed coats’ powder and stearic acid in 12 different batches has been formulated. Also, mango leaves extract has been used as an antioxidant. Particle size of abrasive agent used was within range of 400‑600 um. Prepared face scrub was evaluated by spreadability, total fatty material (TFM), extrudability and pH. Sample formulation scrub for stability testing …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 3, 2019 · pp. 12–17 Read article
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Formulation, Development and Evaluation of Oral Thin Film of Metoclopramide Hydrochloride
Abstract: Metoclopramide Hydrochloride, an anti-emetic drug is indicated for the patients with diabetic gastroparesis and Gastro Esophageal Reflux Disease (GERD). It is difficult for a patient to swallow a tablet during emesis. So, an attempt was made to develop a patient-friendly orally dissolving film using clove oil and menthol as flavoring agents, aspartame as sweetener, polyvinyl alcohol and glycerol as film forming agent and plasticizer respectively. Based on appearance and palatability …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 2, Issue 2, 2011 · pp. 22–27 Read article
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THE BURDEN OF EMPIRICAL THERAPY: ANALYZING THE PREDOMINANCE OF BROAD-SPECTRUM ANTIBIOTIC USAGE IN LOWER RESPIRATORY TRACT INFECTIONS
Abstract: Lower respiratory tract infections (LRTIs) remain one of the leading causes of morbidity and hospitalization worldwide, particularly among older adults, immunocompromised individuals, and patients with chronic respiratory disorders. These infections include conditions such as community-acquired pneumonia, hospital-acquired pneumonia, bronchitis, and acute infective exacerbations of chronic lung disease, all of which often require rapid clinical intervention. Because microbiological confirmation of the causative pathogen frequently takes 48–72 hours, clinicians generally initiate empirical …
Published in International Journal of Antibiotics · Vol. 3, Issue 2, 2026 Read article
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A Study on Improving CBR Value by using EPE foam in Addition to GGBS Slag for Subgrade Soil
Abstract: This paper identifies the use of industrial by-product Ground Granulated Blast Furnace Slag (GGBS) as a stabilizing agent in expansive soil with high swelling property causing severe damage to buildings built on it, and this study identifies the optimal percentage of GGBS for increasing the strength of clayey soil. Using GGBS slag to improve the CBR value of subgrade soil can have potential benefits. Ground Granulated Blast Furnace Slag (GGBS) …
Published in Journal of Geotechnical Engineering · Vol. 11, Issue 3, 2024 · pp. 1–23 Read article
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A Comparative Study of Neem Oil and Mahogany Oil as Corrosion Inhibitors for Mild Steel Exposed to Hydrochloric Acid
Abstract: Corrosion is essentially an oxidation process, wherein the oxidizing agent itself undergoes reduction due to the influence of corrosion agents like salt, air, or moisture. Metals and their alloys naturally tend to react spontaneously with their surroundings, leading to a detrimental impact on their mechanical and physical properties. This project aimed to evaluate the effectiveness of two different oils, namely neem oil and mahogany oil, as agents to prevent acid …
Published in Recent Trends in Fluid Mechanics · Vol. 10, Issue 2, 2023 · pp. 13–18 Read article
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Synthesis, Characterization of New Imidazolidin-4-One Containing Azo Compound Derived from Acetylacetone as Antibacterial and Antioxidant Agents
Abstract: In the present study, new derivatives of imidazolidine-4-one was prepared. Which involved reactions to diazonium salt of o-methoxy aniline with acetylacetone in the presence of sodium hydroxide, and isolating the azo compound as a brown precipitate. The azo diketone reacts efficiently with aromatic amine derivatives to produce Schiff bases as a light yellow and dark brown precipitates, and from this Schiff bases three derivatives of imidazolidine-4-one was prepared by reacting …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 17, Issue 1, 2026 · pp. 94–114 Read article