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76 articles for “Site specificity”
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Emerging Therapies in Respiratory Tract Infections: Current Advances and Future Perspectives
Abstract: The impact of respiratory tract infections (RTI) as a global public health problem continues to be high morbidity and mortality rates. The development of novel therapeutic approaches stemmed from the fact that conventional treatment strategies, antibiotics, antivirals, antifungals etc. have become increasingly ineffective because of rise of antimicrobial resistance (AMR). Next generation therapies, such as novel antimicrobial agents, host directed therapies and novel drug delivery systems have come on the …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 2, 2025 · pp. 17–25 Read article
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Carboxymethyl Cellulose-Based Spray-Dried Microspheres: Recent Advances and Applications in Targeted Drug Delivery Systems
Abstract: Microspheres are spherical particles ranging from 1 to 1000 μm, made from natural or synthetic polymers and inorganic materials. Their structure allows precise drug delivery, improving targeted release and minimizing off-target effects. Natural polymers such as starch, chitosan, and alginate are favored for their biodegradability, adhesion, and compatibility, enhancing mucosal interaction and residence time. Microspheres are widely used in site-specific drug delivery, gene therapy, and vaccine administration, improving immunogenicity, extending …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 251–268 Read article
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Physico-Chemical Soil Analysis: A Scientific Approach to Life on Land and Terrestrial Ecosystem Conservation for Supporting SDG 15 Goals
Abstract: Soil health and fertility evaluation are foundational elements in the sustainable management of ecosystems and the enhancement of agricultural productivity. Accurate assessment of soil properties, especially Carbon (C), Nitrogen (N), and Phosphorus (P), is critical for informed decision-making in agriculture and environmental conservation. However, traditional laboratory methods for analyzing these essential nutrients often involve significant resource allocation and time commitments, making them less practical for large-scale or time-sensitive applications. To …
Published in Journal of Geotechnical Engineering · Vol. 12, Issue 1, 2025 · pp. 25–23 Read article
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Integrated, Geospatial Risk Assessment of Air, Water, and Soil Pollution Impacts on Agricultural Sustainability using Advanced Digital Technologies
Abstract: The systemic threat posed by the convergence of air, water, and soil contaminants represents a critical challenge to global agricultural resilience and food security. Traditional, site-specific pollutant monitoring methods are insufficient for capturing the dynamic, diffuse, and often nonlinear nature of environmental risk pathways that permeate agrarian landscapes. This study presents a robust framework for comprehensive risk assessment utilizing a synergistic suite of modern tools designed for spatial, temporal, and …
Published in International Journal of Environmental Noise and Pollution Control · Vol. 3, Issue 2, 2025 · pp. 28–37 Read article
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Aerodynamic Effects of Wind on Multi-Story Structures: A Height- and Terrain-Based Analysis
Abstract: Wind loads are a critical consideration in the structural design of buildings, with direct implications for safety and serviceability. This study investigates the aerodynamic behavior of reinforced cement concrete (RCC) buildings under varying heights and terrain conditions, in accordance with IS: 875 (Part 3): 2015. 12 structural models representing 20 m, 35 m, and 50 m tall buildings were analyzed using extended three-dimensional analysis of building system (ETABS) across four …
Published in Journal of Offshore Structure and Technology · Vol. 12, Issue 3, 2025 · pp. 1–14 Read article
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Review on Formulation and Evaluation of Herbal Gel of Moringa oleifera and Aloe vera for management of acne
Abstract: Acne vulgaris is a prevalent chronic inflammatory disorder of the pilosebaceous units, characterized by excessive sebum production, follicular hyperkeratinization, bacterial colonization, and inflammation. Conventional therapies often result in side effects and the development of drug resistance, prompting the exploration of natural alternatives. This review highlights the potential of Moringa oleifera and Aloe vera in acne management via topical drug delivery systems (TDDS). Moringa oleifera is rich in bioactive compounds such …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 1, 2026 · pp. 10–16 Read article
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Nanotechnology In Herbal Medicine
Abstract: Herbal medicine has been widely used for centuries as a natural and holistic approach to health care. However, many herbal compounds face challenges such as low solubility, low bioavailability, instability, and the lack of targeted delivery, which affect their efficacy. The integration of nanotechnology into herbal medicine has emerged as a promising strategy to overcome these challenges and enhance the pharmacological potential of plant-derived compounds. Nanocarriers such as liposomes, solid …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 28, Issue 1, 2025 · pp. 50–69 Read article
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Synthesis and Characterization of pH-Sensitive Poly (N-isopropylacrylamide-co-acrylic Acid) Hydrogels for Controlled Release of Doxorubicin
Abstract: pH-responsive polymeric hydrogels have attracted significant attention as intelligent biomaterials for site-specific and controlled drug delivery in cancer therapy due to their ability to respond to the acidic tumor microenvironment. In the present study, poly (N-isopropylacrylamide-co-acrylic acid) [P(NIPAM-co-AAc)] hydrogels were synthesized via free radical copolymerization and systematically characterized to evaluate their suitability for controlled delivery of doxorubicin, a widely used chemotherapeutic agent. The copolymer hydrogels were prepared using N-isopropylacrylamide and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 449–458 Read article
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Integrated Assessment of Soil Health Through Macronutrient Status and Physico-Chemical Properties in Selected Agricultural Blocks of Kangra District, Himachal Pradesh, India
Abstract: Soil health is a critical determinant of agricultural sustainability, particularly in ecologically sensitive Himalayan regions where intensive cultivation and heterogeneous landscapes influence nutrient dynamics. Balanced macronutrient availability, together with favourable physico-chemical properties, governs crop productivity, soil resilience, and long-term ecosystem functioning. Despite the agronomic importance of Kangra District (Himachal Pradesh), localized assessments integrating nutrient status with physico-chemical indicators across representative agricultural blocks remain limited. This study aimed to evaluate soil …
Published in Research & Reviews : Journal of Ecology · Vol. 15, Issue 1, 2026 · pp. 27–33 Read article
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Vaccines Through Time: Conventional Foundations and Next-Gen Innovations–Part 1
Abstract: Vaccination serves as a critical pillar of global public health, markedly decreasing infection rates and associated mortality. Traditional vaccine platforms such as live attenuated, inactivated, toxoid, and subunit vaccines have demonstrated effectiveness against pathogens like Mycobacterium tuberculosis and Plasmodium spp., yet they are constrained by antigenic variability, limited immune persistence, and complex production processes. Breakthroughs in synthetic biology, structural antigen design, and computational vaccinology have driven the development of advanced …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 16, Issue 1, 2026 · pp. 53–70 Read article
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A Multivariate Adaptive Regression Splines Based Study of Soil Parameters and Their Impact on Onion Yield in Bhavnagar District
Abstract: Bhavnagar district is one of the prominent onion-growing areas in the Saurashtra region of Gujarat, encompassing key talukas such as Mahuva, Talaja, Ghogha, Jesar, and Palitana. Onion cultivation in the district is carried out across three distinct seasons: rabi, kharif, and late kharif with harvesting periods extending from April to May for the rabi crop and from October to March for the kharif and late kharif crops. The productivity of …
Published in Research & Reviews : Journal of Agricultural Science and Technology · Vol. 15, Issue 1, 2026 · pp. 53–64 Read article
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Multi-Criteria Assessment of Renewable Energy Technologies for Solar Buildings Using Waspas Method
Abstract: This research comprehensively evaluates renewable energy alternatives for solar buildings using the WASPAS multi-criteria decision-making framework. The analysis covers six distinct energy technologies: geothermal heat pumps, wind turbines, biomass heating systems, micro-hydro installations, fuel cells and building-integrated energy efficiency systems. These options are assessed against four key criteria: energy efficiency, economic viability, environmental sustainability and technical feasibility. The WASPAS methodology combines both summative and multiplicative techniques to produce reliable rankings. …
Published in Journal of Alternate Energy Sources & Technologies · Vol. 17, Issue 2, 2026 Read article
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Enhancing the Bioavailability of Polyphenols: A Comprehensive Review
Abstract: The polyphenolic compounds are abundantly found in different plant parts including fruits, leaves, stem and seeds, and are known for possessing a wide range of biological activities. These include antioxidant, antimicrobial, anti-inflammatory, anticancer, antidiabetic, cardioprotective, and neuroprotective effects. Their functional relation with their structure highlights the significant therapeutic potential. As a result, the polyphenols are being further being exploited for applications in functional foods, pharmaceuticals, and targeted drug delivery. Despite …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 15, Issue 2, 2026 · pp. 37–51 Read article
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An Effective & Novel Approach as Gastro-retentive Drug Delivery Systems
Abstract: Researcher’s curiosity about gastro-retentive drug delivery system increased so high in recent years because of its excellent drug releasing properties to the target site. The delivery system's residence time in the stomach can be extended with the usage of gastro-retentive drug delivery system by using a number of natural and synthetic polymers such as guar gum, hydoxy propyl methyl cellulose which can be used to improve the bioavailability of a …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 47–54 Read article
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Development and Assessment of Levetiracetam Microspheres Utilizing Synthetic and Natural Polymers: A Biomedical Engineering Perspective
Abstract: In the present study, comparative study of Levetiracetam loaded microspheres using Ethyl cellulose as synthetic and Sodium alginate as natural polymers was done. Solvent evaporation and ionic gelation technique has been successfully employed to produce Levetiracetam loaded ethyl cellulose and sodium alginate microspheres with optimal drug encapsulation that sustained the drug release over a period of time. Based on the pre-formulation studies E1 to E4 and S1 to S4 batches …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 1, 2024 · pp. 1–18 Read article
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Evaluating the Effect of NPSB Fertilizers on Barely (Hordeum vulgare L.) Production and Productivity at Tocha Woreda, Southwest Ethiopia.
Abstract: A number of blended fertilizers (BFs) were formulated and introduced but site and crop specific rate was not identified. A research was conducted in Tocha woreda to evaluate the rate of NPSB fertilizer to improve barely yield during main cropping season of 2019 and 2020. The experiment consists of seven treatment such as control(0) , recommended NP (69kg N and 20kg P), NPSB: 18.9-37.7-6.95-0.1 (100kg NPSB), NPSB: 41.9-37.7-6.95-0.1(100kg NPSB + …
Published in Research & Reviews : Journal of Botany · Vol. 13, Issue 3, 2024 · pp. 39–45 Read article
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Exploring Potential Phytochemicals for Myasthenia Gravis Treatment: A Molecular Docking and ADME Analysis Approach
Abstract: Objective: Muscle feebleness and exhaustion derived from a disruption in neuromuscular transference are hallmarks of the crippling autoimmune disease myasthenia gravis (MG). The drawbacks of the current MG therapy options are frequently partial efficacy and adverse effects. To investigate the potential of phytochemicals in MG control, in this work we integrated molecular docking with ADME (absorption, distribution, metabolism, and excretion) analysis using a computer method. We identified molecules exhibiting favorable …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 1–13 Read article
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Adipofascial Flap Cover For Medial Maleolus Defect
Abstract: Soft tissue defects in the lower third of the leg, particularly over the medial malleolus, pose significant challenges due to poor vascularization and the limited availability of reliable local flaps. Over the past two decades, free tissue transfer has emerged as the preferred option for covering such defects. However, in certain cases, free flap transfer is not feasible due to patient-specific factors, cost constraints, or donor site morbidity. Traditional pedicled …
Published in Research and Reviews : Journal of Surgery · Vol. 14, Issue 1, 2025 · pp. 6–10 Read article
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Mass Spectrometry–Based Phosphoproteomic Markers to Predict Kinase Inhibitor Response in Solid Tumors
Abstract: Mass spectrometry-based phosphoproteomics has emerged as a powerful tool for predicting kinase inhibitor responses in solid tumors, offering direct functional insights into signaling pathways that surpass traditional genomic profiling by capturing dynamic kinase activities and adaptive resistance mechanisms. Technological breakthroughs, including data- independent acquisition (DIA), trapped ion mobility spectrometry (timsTOF), and efficient enrichment methods like TiO2 or IMAC, now enable comprehensive profiling of over 40,000 phosphorylation sites from limited clinical …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 4, Issue 2, 2026 Read article
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Evaluation of Patient-Specific Quality Assurance for RapidArc Treatment Delivery Using Dose Volume Histogram
Abstract: This study aims to evaluate the application of dose volume histogram (DVH) metrics within the patient-specific quality assurance (PSQA) protocol in various sites for RapidArc treatment delivery. Forty patients were included in this study, of which twenty each Head and Neck (H&N) and Pelvis Rapid Arc plans were evaluated. Octavius 4D 1500 detector array with vented parallel plate ion chambers was used for this study, which reconstruct the pre-treatment measured …
Published in Journal of Polymer & Composites · Vol. 11, Issue 7, 2023 · pp. 14–22 Read article