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109 articles for “Pathway analysis”
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A Surgical Exploration of the Mechanism and Regulation of the Respiratory System: A Conceptual Analysis
Abstract: The respiratory system plays a vital role in facilitating the movement of air in and out of the body, comprising a complex network of anatomical pathways. It is conventionally divided into two primary sections: the upper respiratory tract and the lower respiratory tract. Within the upper respiratory tract lie structures extending from the nasal passages down to the vocal cords, crucial for phonation. These vocal cords, composed of mucous membrane …
Published in Research and Reviews : Journal of Surgery · Vol. 13, Issue 1, 2024 · pp. 56–63 Read article
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A Comparative Techno-economic Analysis of Hydrogen Production Processes from Locally Available Resources in Nigeria
Abstract: In this work we report result of techno-economic analyses of three hydrogen production pathways - Steam Methane Reforming (SMR), SMR with Carbon Capture (SMR+CC) and Proton Exchange Membrane electrolysis (PEM) – using integrated process-cost simulation-estimation methodologies. Process modeling and simulation is performed with Aspen Hysys® and Aspen Plus® (V10). Cost modeling and estimation is based on full lifecycle cost of production using the Levelized Cost of Hydrogen (LCOH) approach. Feedstock …
Published in Journal of Alternate Energy Sources & Technologies · Vol. 15, Issue 1, 2024 · pp. 29–46 Read article
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OBD-II Big Data–Driven ML and AI-Based Virtual Sensing for Fuel Economy, Component Health, and Carbon Intelligence
Abstract: The rapid growth of connected vehicles has led to the large-scale availability of high-frequency On-Board Diagnostics II (OBD-II) data; however, much of this data remains underutilised, as existing studies and commercial systems typically address fuel economy, maintenance, or emissions in isolation or rely on additional physical sensors. Such fragmented and sensor-dependent approaches limit scalability and increase system cost, particularly in high-volume and resource-constrained vehicle markets. To address this gap, this …
Published in Journal of Automobile Engineering and Applications · Vol. 13, Issue 1, 2026 · pp. 39–50 Read article
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Synthesis, Production, and Mass Balance Analysis of Ten High-Volume Herbicides
Abstract: Herbicides play a crucial role in modern agriculture, enabling effective weed management and safeguarding crop yields amid rising global food demands and growing weed resistance, which can reduce productivity by up to 40%. This study provides a detailed examination of synthesis pathways, production methodologies, and mass balance dynamics for ten high-volume herbicides: Aclonifen, Ametryn, Amidosulfuron, Aminocyclopyrachlor, Aminopyralid, Atrazine, Azimsulfuron, Beflubutamid, Bensulfuron Methyl, and Bentazone, used to control broadleaf weeds, grasses, …
Published in Emerging Trends in Chemical Engineering · Vol. 12, Issue 3, 2025 · pp. 30–44 Read article
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Thermo–Electrical Performance Enhancement of a Lightweight Polymer–Metal Hybrid Electrostatic Precipitator Using Epoxy-Based Composite Housing for Industrial Particulate Control
Abstract: Airborne particulate emissions, particularly PM₁₀ and PM₂.₅ produced by industrial activities and combustion processes, they continue to pose a significant threat to both the environment and public health. Electrostatic precipitators (ESPs) are widely recognized for their ability to achieve high collection efficiencies; however, conventional metallic constructions often lead to increased system weight, higher fabrication costs, and long-term corrosion-related challenges. In this study, a lightweight hybrid material approach is proposed by …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 652–668 Read article
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Botanical Blockade: Phytochemical Targeting Of Nf-Κb in Cancer Therapy
Abstract: The control of inflammation, corpuscle survival, proliferation, and allowed response are all influenced by the acute archetypal agent NF-κB. Its abnormal activity is typically seen in a range of malignancies, where it aids in bump advancement, metastasis, and treatment waste. The function of NF-κB in scar analysis is discussed in this product, along with significant phytochemicals that seem to be interested in targeting this pathway, based on recent investigation. It …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 1, 2025 · pp. 13–21 Read article
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IoT-Enabled Polymer–Gel PCM Composites for Intelligent Thermal Management in Solar Facade Applications
Abstract: The present study investigates the development of a multifunctional polymer–gel phase change composite designed for solar façade applications with integrated real-time thermal monitoring capability. A crosslinked polyvinyl alcohol–borax matrix was employed as a three-dimensional polymer scaffold to encapsulate paraffin-based phase change material, ensuring leakage-free operation and structural integrity under repeated thermal cycling. Graphite nanoplatelets were incorporated as thermally conductive nano-fillers to enhance heat transfer through the polymer composite via percolation-driven …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 99–111 Read article
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Identification of Secondary Metabolites from Zingiber officinale as Inhibitors for Keap 1-Nrf2 small Molecules through Molecular Docking Techniques
Abstract: Objective: Therapeutic plants aid in treating cancer-based cell signaling pathways and preventing certain risk factors. Zingiber officinale has a variety of anti-inflammatory characteristics also contributing to enhanced immunity, reducing cancer risk and used to target the KEAP NRF2. When overexpressed in response to oxidative stress and DNA damage, elevates the risk of developing multiple cancers. NRF2 cellular sensors, which also control and coordinate their expression aid in defending healthy cells …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 2, 2023 · pp. 35–48 Read article
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Evaluating Delay Impacts: From Root Cause Analysis to Dispute Resolution
Abstract: Construction projects inherently involve complex coordination among multiple stakeholders, interdependent tasks, and unpredictable external challenges, which frequently cause schedule overruns and disputes. Traditional contractual mechanisms—such as extensions of time (EoT), liquidated damages, and force majeure clauses—serve to define responsibilities, allocate risk, and establish formal dispute pathways when delays arise. For example, EoT provisions protect contractors from penalties when delays are beyond their control, provided proper notice and evidence are submitted …
Published in Journal of Structural Engineering and Management · Vol. 12, Issue 3, 2025 · pp. 11–25 Read article
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A Research Study on Cognitive Health Benefits of Nicotine to the Human Body
Abstract: Background: Nicotine has been primarily known for its addictive properties and associated health risks, particularly in tobacco products. However, recent research has highlighted nicotine’s potential cognitive health benefits, especially in neurodegenerative diseases like Alzheimer’s and Parkinson’s. This study investigates smoking prevalence across mental health conditions, and cognitive impairments in various psychiatric disorders, and explores the possible cognitive health benefits of nicotine. Methods: Data on age and gender distribution, smoking prevalence, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 1, 2025 · pp. 16–23 Read article
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Dynamic Mechanical Analysis of Carbon Fiber Reinforced Polymer Composites
Abstract: This study investigates the thermal decomposition and mechanical properties of Fiber-Reinforced Polymer Composites (FRPCs) using Dynamic Mechanical Analysis (DMA). The research focuses on improving the recycling and recovery process of Carbon Fiber-Reinforced Polymers (CFRPs), addressing environmental concerns regarding their disposal. By analyzing the effects of different heating rates (5°C and 10°C per minute) and atmospheric conditions (nitrogen, oxygen, and a combination of both), the study identifies optimal parameters for maximizing …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 386–393 Read article
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Intergenerational Trauma and Cultural Resilience: Exploring the Impact of Family Norms on Mental Health Disclosure
Abstract: This comprehensive review examines how intergenerational trauma and cultural resilience influence individuals' choices to disclose or conceal their mental health challenges in family contexts. This paper utilizes 50 peer-reviewed studies out of 80 in total from various cultural contexts, this paper explores how family norms, especially in collectivist cultures, impact the disclosure of mental health issues. This review paper uses a thematic analysis strategy, systematically integrating qualitative, quantitative, and mixed-method …
Published in International Journal of Behavioral Sciences · Vol. 2, Issue 2, 2025 · pp. 53–58 Read article
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Molecular Pharmacokinetics and Structural Docking of Phenolic Acids for Targeting NF-κB Pathway Components in Inflammation and Fibrosis: A Computational Approach Toward Therapeutic Discovery
Abstract: Inflammation and Fibrosis are critical pathological processes associated with various chronic diseases, often mediated by the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway. This study investigates the therapeutic potential of phenolic acids as modulators of the NF-κB pathway, aiming to identify novel ligands that can effectively interact with key components of this signaling cascade. A comprehensive computational approach was employed, utilizing molecular docking, pharmacological screening, and post-docking …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 1, 2025 · pp. 14–31 Read article
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Deep Learning for Real-Time Monitoring and Defect Detection in Additive Manufactured Polymer Composites
Abstract: Additives Fiber-reinforced polymer composite ADDs have high utility in making lightweight structural components, but due to process-related defects (interlayer delamination and reinforcement stacking) the integrity of consolidation during extrusion-based deposition is frequently compromised. This paper has presented a physics-informed deep learning framework that is applicable to real-time measurements of reinforced thermoplastic composite fabrication. Multimodal sensing was provided with thermal gradient, optical morphology, and acoustics emission signals being used to assess …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 974–999 Read article
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Utilization of Treated Textile Dyeing Wastewater and GGBFS–Perlite Blends for Sustainable Cementitious Composite Development
Abstract: The increasing global demand for concrete critically intensifies the consumption of potable water, raising significant environmental concerns and depleting vital resources. Concurrently, the textile dyeing industry generates substantial volumes of wastewater, posing considerable disposal and pollution challenges. Our investigation explores a dual solution by utilizing treated textile dyeing wastewater as an alternative mixing water source, combined with ground granulated blast furnace slag (GGBFS) and perlite as supplementary cementitious materials (SCMs), …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 291–300 Read article
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Advanced Functional Nanocomposites: Graphene Oxide Integration into Polyvinyl Alcohol Matrix
Abstract: This research explores how incorporating graphene oxide (GO) into polyvinyl alcohol (PVA) can improve its mechanical and thermal characteristics, with the goal of creating multifunctional nanocomposites suitable for advanced technological applications. GO was introduced into the PVA matrix at 0.5, 1, and 2 wt% via a scalable solution casting method. The resulting nanocomposites were characterized mechanically, thermally, and spectroscopically. Tensile testing revealed a significant improvement in mechanical performance, with tensile …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 50–59 Read article
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Integrative Network Biology Analysis of GSE6011 Uncovers Molecular Signatures in Duchenne Muscular Dystrophy
Abstract: Duchenne muscular dystrophy (DMD) is a rare, severe neuromuscular disorder demonstrated by progressive skeletal muscle deterioration and premature mortality. Despite advances in supportive care, no definitive cure exists, highlighting the need to explore novel molecular targets. The current study aimed to uncover key dysregulated genes and molecular pathways in DMD through a dataset-specific network biology approach. Publicly available microarray data (GSE6011) from DMD quadriceps muscle biopsies of 22 patients and …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 3, 2025 · pp. 36–48 Read article
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Molecular Docking and Interaction of Anthocyanin Derivatives in Regulating Hippo-taz Pathway for Renal Injuries
Abstract: Introduction: The Hippo pathway plays a pivotal role in renal disease, with Yes-associated protein (YAP) exhibiting promise for combined treatments. The crucial evaluation of YAP-targeted drug safety and efficacy through preclinical studies is imperative. Additionally, α-SMA and SMAD3 emerge as potential therapeutic targets in renal fibrosis, driving ongoing research toward innovative interventions. Materials and Methods: In the systematic identification of therapeutic secondary metabolites, Anthocyanin derivatives were methodically retrieved from the …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 23–38 Read article
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Evaluating Andrographis paniculata Phytochemicals as Potential Glioma Therapeutics via Molecular Docking Approach
Abstract: Evaluating Andrographis paniculata Phytochemicals as Potential Glioma Therapeutics via Molecular Docking ApproachGlioneuronal tumors and gliomas are grade I tumors classified by the World Health Organization (WHO). They typically grow slowly and primarily affect infants, children, and teenagers, but can also occur in adults. They mostly cause seizures caused by gangliomas. Most current treatments include surgery and radiotherapy. Since this disease affects children, the current treatments may cause complications. Andrographis paniculata …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 1, 2026 · pp. 82–93 Read article
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Structural Integrity Analysis of Reinforced Concrete Frames Under Progressive Collapse Scenarios
Abstract: This study examines how a tall reinforced concrete (RC) frame may gradually collapse under several column removal situations, such as edge, end, center, zigzag, and two-column failures. The study assesses the structural reaction based on displacement, inter-story drift, and Demand–Capacity Ratio (DCR) using nonlinear static pushover analysis carried out in ETABS. According to the analysis, the frame's stability is seriously jeopardized when two nearby columns and end columns are removed, …
Published in Journal of Geotechnical Engineering · Vol. 12, Issue 3, 2025 · pp. 1–15 Read article