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1321 articles for “Method development”
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Computer-aided Drug Design Method for Anti-hepatitis C Drug Design
Abstract: Hepatitis C is a disease caused by the hepatitis C virus and can cause serious liver damage. There is currently no vaccine for this disease and the number of infections continues to increase worldwide. Currently used antiviral drugs are interferon alfa-2a and ribavirin, but about half of patients do not respond to therapy. Therefore, new drugs that protect against hepatitis C need to be investigated. Computational drug methods have been …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 2, 2024 · pp. 1–8 Read article
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Analytical Technique Optimization and ICH-Directed Verification of a Reverse Phase HPLC Approach for Quantification of Bupropion Hydrochloride
Abstract: This method was developed for retention time, peak resolution and baseline response using Bupropion Hydrochloride under optimized conditions as validation. The method resulted in two well separated, well defined peaks, a minor peak at 7.5 minutes 12 mV and a main peak at 11.52 minutes 150 mV. At the same time, the baseline has remained stable during the chromatographic run and the fluctuations of noise are very small (0.5 ± …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 · pp. 47–54 Read article
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Mechanical Testing Under Tensile-load
Abstract: Mechanical testing is a technique used to establish a material's mechanical qualities by examining its strength, toughness, hardness, and other characteristics. Specimens produced of various materials whose qualities need to be examined are used to verify this property. In which a static load is applied and a dynamic load is applied, and the test is completed. Understating loads in mechanical testing is the topic of this research article. Any manufacturing …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 3, Issue 1, 2025 · pp. 1–10 Read article
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Cheap and Effective Methods for Soil Stabilization in India: A Comprehensive Study
Abstract: Soil stabilization is a crucial aspect of infrastructure development, especially in regions like India, where diverse soil types present challenges to construction projects. This research paper delves into cost-effective methods for enhancing soil stability tailored specifically to the Indian context. Through a comprehensive study, various low-cost techniques are explored for their effectiveness in improving soil properties and mitigating construction risks. By analysing case studies and experimental data, this paper aims …
Published in Journal of Geotechnical Engineering · Vol. 11, Issue 1, 2024 · pp. 1–16 Read article
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Development and Validation of a Robust RP-HPLC Method for Rufinamide Quantification in Pharmaceutical Dosage Forms
Abstract: The creation and validation of a simple, precise, and targeted reverse phase high-performance liquid chromatographic (RP-HPLC) approach allowed for the quantification of rufinamide in pharmaceutical dosage forms. With a mobile phase of methanol and water (50:50, v/v), the technique used a gradient mode Symmetry Qualisil gold C18 column (4.6 x 150mm, 5 μm). For the detection method, a flow rate of 1 mL/min was employed at 220 nm. During a …
Published in Emerging Trends in Personalized Medicines · Vol. 1, Issue 1, 2024 · pp. 25–32 Read article
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Construction and Development of pSB111 Bar Plasmid Vector for Activation Tagging
Abstract: To get desired traits and to know the precise expression patterns of genes in the plant, Agrobacterium tumefaciens has been widely employed in the generation of transgenic plants using plasmid vectors. Many methods are come forward to establish the gene expression of unknown genes but in these techniques gene alteration isthe main drawback orsometimesit islethal to organisms also, to overcome these problems activator tag method developed to know the specific …
Published in Research & Reviews : Journal of Botany Read article
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Development of Sodium Alginate Beads of Telmisartan Using Emulsion Gelation Method: Formulation and In-Vitro Characterization
Abstract: Introduction: The antihypertensive medication Telmisartan (TEL) is a member of BCS class II, which is distinguished by limited oral rate and extent and water solubility. By localizing the medication release in the stomach, gastro-retentive floating bead devices may be able to address the issues related to partial absorption and the low solubility of TEL. The preparation of TEL floating alginate beads was the aim of this investigation. The current work …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 11, Issue 3, 2024 · pp. 13–21 Read article
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Interior Design for Disaster Resilience
Abstract: In the age of heightening environment actuated calamities and the thriving intricacy of metropolitan scenes, the basic to implant catastrophe flexibility inside plan resounds with remarkable criticalness. This examination paper embraces a general odyssey, diving into the complicated interchange between inside plan and catastrophe flexibility inside the constructed climate. Drawing upon a tremendous embroidery of insightful writing, exact investigations, and genuine models, the paper fastidiously disentangles the multi-layered methodologies, developments, …
Published in International Journal of Climate Conditions · Vol. 1, Issue 1, 2024 · pp. 01–15 Read article
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Intelligent Decision Support System for Production Planning and Control in an Automotive Assembly Line
Abstract: The automobile industry has realized the importance of Intelligent Decision Support Systems (IDSS) to improve production planning and control on assembly lines. In the context of automobile manufacturing, this review paper examines the most recent developments, methodology, and applications of IDSS. Key trends, obstacles, and possibilities are discovered through an in-depth examination of the literature. Examining real-world case studies and success stories, the integration of artificial intelligence (AI) and machine …
Published in International Journal of Industrial and Product Design Engineering · Vol. 1, Issue 1, 2023 · pp. 16–21 Read article
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A Sustainable and Green Prototyping Framework for Low-carbon and Resource-efficient Virtual Product Development
Abstract: The increasing emphasis on sustainable manufacturing has intensified the need for environmentally responsible design and development methodologies for polymer and polymer-composite materials, where material selection, processing routes, and waste generation play a critical role in overall environmental impact. This paper presents a Sustainable and Green Prototyping (SGP) framework that integrates Virtual Prototyping (VP), Life Cycle Assessment (LCA), and multi-objective optimization to systematically reduce carbon footprint, energy consumption, and material waste …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 459–471 Read article
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Growth of Cu2O on TCO by SILAR method acts as an alternative buffer electrode layer towards the development of organic solar cell
Abstract: In many types of optoelectronic devices, layer of PEDOT: PSS is sandwiched between the indium-tin oxide (ITO) electrode and the active layer. Buffer PEDOT: PSS provides a well- defined work function which is higher than that of ITO (4.2eV), it smooths the ITO surface and so avoids shorts, and it also protects the active layer from ingress of indium or oxygen, leading to longer device lifetimes. The role of PEDOT: …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 13, Issue 2, 2026 · pp. 18–25 Read article
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Security of Cloud Computing from a Blockchain Perspective
Abstract: Originally, the foundation of the Internet was trust. There are increased threats and problems after many information disclosures. We have employed even more modern Internet-based devices in recent years. Among the primary issues raised in literature, privacy, data protection, and trust require particular consideration. In this case, a new paradigm for information security has arisen, one that is built on transparency rather than the closed, cryptic methods used in present …
Published in Journal of Advanced Database Management & Systems · Vol. 11, Issue 1, 2024 · pp. 7–11 Read article
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Strategic Optimization of CNC Machining in Production Systems: A Managerial Review of Methods, Metrics, and Industry 4.0 Integration
Abstract: Computer numerical control (CNC) machining has significantly influenced modern production systems by enabling higher efficiency, quality, and sustainability. As industrial operations strive for leaner production and strategic competitiveness, optimization of machining parameters—including cutting speed, feed rate, depth of cut, and tool path strategies—has emerged as a cornerstone of production planning. This review evaluates the optimization methodologies developed from 2015 to 2025, spanning traditional mathematical models to artificial intelligence (AI)-driven metaheuristic …
Published in Journal of Production Research & Management · Vol. 15, Issue 2, 2025 · pp. 25–30 Read article
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Spectral Mapping and Tracking Error of MBOC signal and Wavelet based GNSS receiver
Abstract: This research paper delves into the historical evolution and contemporary state of the art in navigation technologies, emphasizing the paramount importance of reliable positioning systems. Tracing the journey from ancient primitive methods to the present-day Global Navigation Satellite Systems (GNSS), with a focus on the Global Positioning System (GPS), the paper explores the diverse instruments and methods developed by civilizations throughout history to determine location and navigate effectively. The main …
Published in Current Trends in Signal Processing · Vol. 16, Issue 1, 2026 Read article
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A Fuzzy Integrated Web-based Quality Function Deployment Application:A Conceptual Analysis
Abstract: The 'voice of customers' drives the Quality Function Deployment (QFD) process, which is a customer-focusedproduct development method. Making decisions is a critical component of the QFD process. Although QFD aids decision-making, its subjectivity results in ambiguity and uncertainty, resulting in less accurate and consistent findings. Fuzzy ideas must be incorporated to deal with the ambiguity and uncertainty inherent in the QFD process. This will result in better decision-making. Businesses can …
Published in Journal of Web Engineering & Technology Read article
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An Investigative Study on Secure Coding Practices with Shell Scripting
Abstract: This investigative research delves into secure coding practices within shell scripting, aiming to reduce prevalent security vulnerabilities and improve the overall security stance of shell scripts. It emphasizes three key areas: static analysis, dynamic analysis, and manual code review. Through static analysis, the code structure, usage of unsafe functions, and potential vulnerabilities are examined without executing the script. Dynamic analysis entails running the script in controlled settings to detect runtime …
Published in Journal of Advances in Shell Programming · Vol. 11, Issue 1, 2024 · pp. 16–23 Read article
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A Review on Additive Manufacturing Processes
Abstract: Additive manufacturing is a new and rapidly developing method in the business world. "Additive manufacturing process" refers to the process of creating products from layers of material. High speed printing or 3D printing is another name for this process. This manufacturing method uses no tools and can produce highly accurate products in less time. A rigid part can be formed and used in this way. Stereolithography (STL) files are created …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 13–24 Read article
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Assessing Urban Surface Runoff Management Using the SWAT Model, GIS, and the Rational Method: A Case Study of Karapakkam
Abstract: Urban surface runoff management encompasses strategies aimed at regulating rainwater flow, reducing urban flooding, enhancing groundwater recharge, and contributing to disaster risk mitigation for sustainable urban development. This study seeks to optimize surface runoff management in urban settings by using the soil and water assessment tool (SWAT) model integrated with geographic information systems (GIS) to minimize flood risks. The research focuses on the peak runoff in Karapakkam, a locality within …
Published in International Journal of Environmental Planning and Development Architecture · Vol. 4, Issue 1, 2026 · pp. 37–48 Read article
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Authentication of a Rapid RP-HPLC technique for Quantification of Remogliflozin and Metformin in Medicinal Formulations
Abstract: A new, precise, and stability-assessing advanced liquid chromatography (HPLC) technique for simultaneous quantification of Remogliflozin and Metformin in fixed dose pharmaceutical formulations was designed and verified. Optimization of the technique was carried out on flowing phase composed of ethanenitrile and buffer, under isocratic conditions, the resolution of peak being sharp with retention times of 3.24 min and 4.89 min for Remogliflozin and Metformin, respectively. Technology suitability was confirmed by the …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 70–77 Read article
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Designing a Model of Waste Management for Sustainable Rural Development (Case study: villages of Gilan Province)
Abstract: Paying attention to waste management is one of the most important tasks defined for urban and rural officials around the world. These days, every small and large city or every village and hamlet you visit is faced with a problem called waste and waste management. This is all the more important when we know that most of this waste comes from seasonal streams and rivers; On the other hand, the …
Published in Recent Trends in Social Studies · Vol. 1, Issue 2, 2024 · pp. 30–46 Read article