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109 articles for “Mediation Effect”
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Carbon Nano Tubes: New Techniques for Cancer Treatment
Abstract: Carbon Nano tubes (CNTs) have been recently introduced as a novel carrier system in the biomedical field and produce small and large therapeutic molecules. CNTs have attracted increasing attention for their versatile applications. Based on layers of CNTs, CNTs are generally divided into two categories: single-walled carbon Nano tubes (SWCNTs), multi-walled carbon Nano tubes (MWCNTs). It shows the unique properties and cylindrical shape structure. It shows a greater advantage in …
Published in Trends in Drug Delivery · Vol. 5, Issue 1, 2018 · pp. 28–39 Read article
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Oncolytic Viruses (OV) Mediated Targeted Therapy to Eradicate Chronic Myeloid Leukemia (CML): A Review
Abstract: With the recent advances in scientific scenarios globally, an innovative introduction of cancer vaccines and a much safer and more effective way to eradicate cancer has been evolved. The viruses that are not severely harmful to the humans and do not recognize the human as their natural host can be deployed as an oncolytic virus to eradicate the malignancy either by killing or lysing the oncogenic cells or indirectly stimulating …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 12, Issue 2, 2022 · pp. 27–36 Read article
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Monoclonal antibodies in targeted cancer therapy advances, resistance mechanisms, and next-gen formats (Bispesifics, ADCs)
Abstract: Breast cancer is one of the leading causes of cancer-related morbidity and death worldwide, which emphasizes the need for more effective and focused treatment strategies. antibody-mediated drug delivery techniques. Specifically, antibody–drug conjugates (ADCs) have emerged as a potential approach that combines the specificity of monoclonal antibodies with the potent cytotoxicity of anticancer drugs. By selectively targeting tumor-associated antigens, ADCs enhance drug accumulation within cancer cells while minimizing systemic toxicity associated …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 · pp. 62–79 Read article
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Resolving International Sports Disputes: An Exploration of Mediation and Conciliation
Abstract: The globalization of sports has led to an increase in cross-border disputes, necessitating effective and efficient dispute resolution mechanisms. Traditional litigation and arbitration methods often prove time-consuming, costly, and ineffective in preserving relationships. This research explores the role of Alternative Dispute Resolution (ADR) methods, specifically mediation and conciliation, in resolving international sports disputes. Through a comparative analysis of international sports organizations and dispute resolution mechanisms, this study examines the benefits …
Published in Recent Trends in Sports · Vol. 1, Issue 2, 2024 · pp. 14–27 Read article
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Role of Human Neutrophils in Inflammation and its Modulation by Ixora coccinea
Abstract: Neutrophils are one of the key cells that actively participate in the innate immune reactions. Sequences of event of pathogen elimination by neutrophils are initiated with the activation of resting neutrophils. Pathogen is then eliminated by oxygen-dependent killing mechanism or oxygen-independent killing mechanism. This process includes margination, diapedesis, chemotaxis, phagocytosis and degranulation of neutrophils. Although, these mechanisms of the neutrophils are targeted to eliminate the pathogens and protect the body, …
Published in Research and Reviews : A Journal of Immunology · Vol. 6, Issue 1, 2016 · pp. 32–48 Read article
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Designer Zinc Finger Nuclease: A Versatile Tool for Genome Editing in Animals
Abstract: In this review, is provided an update on the most popular approaches, including zinc finger nuclease (ZFN)-based gene editing by homologous recombination (HR), gene knockout, non-homologous end joining (NHEJ), and gene therapy in mouse. Zinc finger nucleases (ZFNs) are synthetic restriction enzymes evolved by fusing zinc finger that facilitate genome editing by creating a double-stranded break in DNA at a user-specified location. ZFNs are new tools that promise to radically …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 4, Issue 1, 2014 · pp. 24–30 Read article
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Effects of Intraperitoneal Administration of ATRA on the Testis of Elastase Induced Emphysematous Rats
Abstract: Emphysema is the pathological manifestation primarily associated with lungs. However, there are evidences of extra-pulmonary manifestations related to emphysema. The inflammation developed during emphysema triggers the release of several inflammatory mediators, which affects the proximal as well as distal organs. The present study was designed to determine the effect of inflammatory spillage on testicular tissue of male Sprague dawley rats; moreover, the main focus was to assess the potential role …
Published in Research and Reviews: A Journal of Toxicology · Vol. 6, Issue 3, 2016 · pp. 1–12 Read article
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An Interactive Animatronics for Design and Implementation with Analysis
Abstract: Animatronics is a technology that involves the use of robotic devices to create life-like movements and actions in mechanical figures. In recreational games, the animatronic should be recognized as human companions in order to establish effective interaction situations to improve the recognition and performance of as a mediator for relationship. This work covers the design and implementation of human recognition of an electric dragon using a depth camera (Carmine by …
Published in Journal of Communication Engineering & Systems · Vol. 13, Issue 3, 2023 · pp. 1–5 Read article
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Thrombotic thrombocytopenic purpura: A Narrative Review of Diagnosis and Treatment by drugs and novel agents.
Abstract: Thrombotic thrombocytopenic purpura (TTP) is an infrequent but fatal disease, is primarily caused by autoantibodies against the von Willebrand factor (VWF) cleaving metalloprotease ADAMTS13. Overall, severe deficiency of plasma ADAMTS13 action (< 10 IU dL-1) with or without noticeable inhibitory autoantibodies counter to ADAMTS13 supports the diagnosis of TTP. The International Working Group for TTP released a consensus statement on the standardization of terminology in these disorders which we use …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 10, Issue 1, 2021 · pp. 40–55 Read article
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Probiotics in Food Science: Microbial Health Benefits and Future Trends
Abstract: Probiotics are mostly recommended as supplements by the doctors to administer nutritive and healthy benefits. Probiotic foods vary in different forms from yogurts to granola bars. It contains lactic acid bacteria and Bifidobacterium which makes the gastrointestinal tract healthy and whose mode of action involves epithelial barriers, and enhancement in the rate of adhesion to the intestinal mucosa. It helps to get rid from inflammatory diseases, acne, photo-aging, cancer and …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 9, Issue 3, 2020 · pp. 12–15 Read article
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Effect of Olive Leaves Extract on Inflammatory Cyclooxygenase (COX) Levels in High Fat Diet (HFD) Induced Diabetic Animals
Abstract: Development of diabetes and its complications are associated with persistent inflammatory activity. It has been suggested that cyclo-oxygenase (COX)-mediated pathway involved in this inflammatory process in diabetes. For example, thromboxane A2 (TXA2) and prostaglandin E2 (PGE2) released by platelets and monocytes due to the action of COX-1 and COX-2, respectively. They are important prostanoids involved in thrombosis and atherosclerosis development in diabetic condition, this also have been proved in our …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 1, Issue 1, 2011 · pp. 70–76 Read article
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Molecular Mechanism of Fluoride Induced Oxidative Stress and Its Possible Reversal by Chelation Therapy
Abstract: Fluorine (Fl) a member of the halogen family is the most electronegative and reactive of all the elements of the Periodic table. Chronic and acute exposures of fluoride leads to cardiovascular disease (hypertension and atherosclerosis), neurological disorders, gastrointestinal disturbances, liver disease, renal disease, reproductive effects, other health disorders and also affects the antioxidant system in the body. Furthermore, reactive oxygen species (ROS)-mediated oxidative damage is a common malady in fluoride …
Published in Research and Reviews: A Journal of Toxicology · Vol. 3, Issue 2, 2013 · pp. 7–34 Read article
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Recent Development in Safety Climate of Construction Industry
Abstract: Safety climate is of current interest to construction practitioners and researchers. The concept ofsafety climate has been actively explored in the field of industrial and organizational (I/O) psychology but is just gaining popularity in the construction industry. This paper purposes to review the literature of safety climate in a systematic manner and highlight future directions for safety research and development of safety practices in the construction industry. The value of …
Published in Journal of Industrial Safety Engineering · Vol. 5, Issue 2, 2018 · pp. 14–18 Read article
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Recent Development in Safety Climate of Construction Industry
Abstract: Safety climate is of current interest to construction practitioners and researchers. The concept ofsafety climate has been actively explored in the field of industrial and organizational (I/O) psychology but is just gaining popularity in the construction industry. This paper purposes to review the literature of safety climate in a systematic manner and highlight future directions for safety research and development of safety practices in the construction industry. The value of …
Published in Journal of Industrial Safety Engineering · Vol. 5, Issue 3, 2018 · pp. 19–23 Read article
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Psoriasis: Latest Trends in Treatment, Diagnosis and Management in Medical Science
Abstract: Psoriasis is a common chronic inflammatory and autoimmune skin disease that primarily affects the skin. It affects about 2–4% of the world populations. It is clinically characterized by skin rashes, highly inflamed red scale itchy plaque. Abundant therapeutic agents are accessible for the treatment of psoriasis. Wide range of therapeutic mediators such as coal tar, topical corticosteroids, anthralin, retinoid, calcineurin inhibitors, methotrexate, cyclosporine are proven to be effective in treating …
Published in Research and Reviews : A Journal of Biotechnology · pp. 24–32 Read article
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Carbon Dioxide as a Fundamental Component in Sustainable Organic Synthesis
Abstract: A lot of people are interested in carbon dioxide (CO₂) as a cheap, plentiful, and safe source of carbon for making chemical processes more sustainable. Using it as a C1 building block in organic synthesis is a promising way to make products with added value while having less of an impact on the environment. This article examines current advancements in CO₂ fixation into organic compounds, emphasising the creation of effective …
Published in International Journal of Advance in Molecular Engineering · Vol. 3, Issue 2, 2025 · pp. 22–34 Read article
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Impact of Hypoxia on Cardiopulmonary Adaptation in Canines: A Comprehensive Review
Abstract: Hypoxia triggers a series of cardiopulmonary responses that play an important role in oxygen delivery and the continuation of physiological activity in mammals. Canines are also a useful translational model of study to examine these adaptive responses because of their anatomical, physiological, and cardiopulmonary differences with humans. This review summarizes the experimental data of acute, subacute and chronic hypoxia in dogs with particular focus on the variations in cardiac functioning, …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 15, Issue 1, 2026 · pp. 13–24 Read article
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In vitro/In vivo Study of Anti-inflammatory Effect of Cyperus rotundus on Diabetic Complications
Abstract: The reactive oxygen species (ROS) develop oxidative stress that contributes to the cause of human diseases. Radicals which enhance inflammation are nitric oxide, hydroxyl radical, hydrogen peroxide, and superoxide. Anion mediate and amplify the inflammation process, mediate vascular permeability and platelet aggregation leading to diabetic complications due to disruption of steady state of pro-oxidants and antioxidants. Cyperus rotundus plant extract was subjected to foraging radical activity with hemolysate sample to …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 9, Issue 1, 2019 · pp. 24–32 Read article
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Sustainable Waste Management Using AI and Robotics
Abstract: The fast increment in squander era around the world has driven to noteworthy natural and open wellbeing concerns. Conventional squander administration strategies, which depend intensely on manual labor and obsolete forms, are battling to keep up with the developing volume, driving to wasteful aspects and environmental harm. AI and Mechanical autonomy give inventive arrangements by improving effectiveness in squander collection, sorting, reusing, and transfer. AI-driven squander sorting frameworks optimize exactness, …
Published in International Journal of Advanced Robotics and Automation Technology · Vol. 3, Issue 2, 2025 · pp. 42–48 Read article
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Nutrition Induced Remodeling Dynamics of Cell Membranes: Implications for Performance, Health, and Welfare Issues in Food Animals
Abstract: Cell membranes represent dynamic structural and functional platforms that integrate nutritional signals with cellular metabolism, immune competence, and physiological adaptation in food animals. Beyond their classical role as selective barriers, membranes actively regulate nutrient transport, signal transduction, and bioenergetics through highly responsive lipid and protein networks. Dietary components, particularly fatty acids, vitamins, minerals, amino acids, and bioactive compounds, critically influence membrane composition, fluidity, and stability, thereby shaping cellular function and …
Published in International Journal of Membranes · Vol. 3, Issue 1, 2026 · pp. 25–37 Read article