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55 articles for “Gastrointestinal tract”
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Pediatric and Geriatric Formulation Tailoring Dosage Form for Age-Specific Needs
Abstract: This comprehensive review addresses the critical challenges and advancements in the formulation of oral medications for pediatric and geriatric populations, who often face unique pharmacokinetic and pharmacodynamic differences. The World Health Organization highlights that nearly 50% of long-term medications are not adhered to, with significant implications for health outcomes. Pediatric patients, due to their developmental stages, and geriatric patients, due to age-related physiological changes, require tailored drug formulations to enhance …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 · pp. 89–103 Read article
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Microneedles: An Innovative Drug Delivery System
Abstract: Microneedles represent a groundbreaking innovation in drug delivery systems, offering a transformative alternative to conventional hypodermic needles and transdermal patches. This advanced technology combines the precision and efficacy of needle-based delivery with the convenience and pain-free nature of patches, creating a minimally invasive platform that addresses many limitations of traditional drug administration. Microneedles are designed to penetrate the stratum corneum – the skin’s outermost layer – without reaching pain-sensitive nerves …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 60–67 Read article
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Biodegradable Polymer Nano Composites for Enhanced Drug Bioavailability
Abstract: Polymer-based nanoparticles have emerged as a revolutionary approach in drug delivery systems, particularly in enhancing the bioavailability of poorly soluble and unstable drugs. These nanoparticles, composed of both natural and synthetic polymers, serve as effective vehicles for encapsulating a wide range of therapeutic agents. Their surface characteristics can also be modified to enable targeted drug delivery, increasing the concentration of drugs at the site of action while minimizing side effects. …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 433–443 Read article
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Management of Kosthasakhashrita Kamala W.S.R. to Hepatocellular Jaundice – A Case Study
Abstract: Kosthasakhāśrit Kamala is a well-recognized clinical entity in Ayurveda and is widely correlated with modern hepatocellular jaundice. The condition arises primarily due to the vitiation of Pitta dosha within the Kostha (gastrointestinal tract), which subsequently spreads to the Sakha (peripheral tissues). Classical texts describe hallmark features such as Haridra Netra (yellowish discoloration of the eyes), yellowish hue of twak and nakha, pitta varṇa of mutra and sakrit (yellow urine and …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 15, Issue 1, 2026 · pp. 1–8 Read article
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The Renaissance and Resilience of CB1 Reverse Agonists: From Central Liabilities to Peripheral Promise
Abstract: Building upon these foundational insights, current research has increasingly focused on refining the pharmacological profile of CB1 reverse agonists to maximize therapeutic benefit while minimizing central adverse effects. The adverse neuropsychiatric outcomes associated with first-generation agents such as Rimonabant including anxiety, depression, and suicidal ideation highlighted the critical role of central CB1 receptors in mood regulation. Consequently, drug development strategies have shifted toward peripherally restricted CB1 reverse agonists that exhibit …
Published in International Journal of Cheminformatics · Vol. 4, Issue 1, 2026 · pp. 30–35 Read article
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Polymer Composite-Assisted Crystal Engineering for Drug Synthesis and Property Control through Solid Solutions and Co-Crystals
Abstract: The long-standing problem of low aqueous solubility, which affects about 90% of all new drug molecules under development, requires an immediate need for alternative approaches apart from the usual practice of crystallization. Polymer-composite-assisted crystal engineering is a novel technique for overcoming the aforementioned problem. This involves the addition of accepted pharmaceutical polymers, such as HPMC, PVP, PEG, and Eudragit copolymers in a single process, which can promote nucleation, stabilize the …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 172–189 Read article
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Role of Impaired Digestion in Disease Pathogenesis: According to Unani System of Medicine
Abstract: The relationship between digestion and disease occupies a central position in Greco-Arab (Unani) medicine, as emphasized by classical physicians such as Ibn Sina and Al-Razi. In Unani medicine, digestion (Haḍm) is not confined to the gastrointestinal tract alone but represents a comprehensive physiological and metabolic process involving four sequential stages: gastric digestion (Haḍm-e-Mi‘dī), hepatic digestion (Haḍm-e-Kabidī), vascular digestion (Haḍm-e-‘Urūqī), and tissue digestion (Haḍm-e-‘Uḍwī). These stages are governed by Quwwat-e-Hāḍima (digestive …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 13, Issue 2, 2026 Read article
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Enzymes used in Alcohol Fermentation
Abstract: Fermentation is the process that uses enzymes to cause chemical reactions in biomass feedstocks. In biochemistry, it is defined as the extraction of energy from carbohydrates in the absence of oxygen. The science of fermentation is known as zymology. Cellular respiration is the process in which a carbohydrate, like starch or sugar, is converted into an alcohol or an enzyme by an organism. Fermentation is a process in which yeast …
Published in Journal of Catalyst & Catalysis · Vol. 8, Issue 3, 2021 · pp. 15–21 Read article
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Oral Manifestation of Crohn's Disease: A Case Report and literature review Oral Manifestation of Crohn's Disease: A Case Report and literature review
Abstract: Crohn’s disease is a chronic granulomatous inflammatory disorder that can affect any part of the gastrointestinal tract from the mouth to the anus with the most common localization being the ileocecal region. This is a case of 17 years old young Sudanese boy presented to Khartoum Teaching Dental Hospital complaining of a swelling on the left side of his face And on the lower lip.Histopathological result show non-caseating giant cell …
Published in Research and Reviews: A Journal of Dentistry · Vol. 12, Issue 1, 2021 · pp. 23–27 Read article
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Recombinant Lactobacillus helveticus PJ4-Down Regulates TLR4 Mediated Inflammatory Responses in Sucrose Induced Diabetic Rats: A Novel Therapeutic Approach
Abstract: High sucrose diet (HSD) is known to induce type 2 diabetes. Recombinant Lactobacillus helveticus PJ4 was constructed to express the InuJ gene under the xylose promoter resulting in the secretion of inulosucrase enzyme in gastrointestinal tract which polymerizes the fructose moiety of sucrose to inulin type fructans. L. helveticus (pSLP-InuJ-Vhb) transformant (LHI) was intragastrically administered to rats fed with HSD diet. The composition of fecal microbiota and short-chain fatty acids …
Published in Research and Reviews : A Journal of Immunology · Vol. 7, Issue 2, 2017 · pp. 44–65 Read article
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Assessment of Mothers’ Knowledge Status and Impact of Clinical Pharmacist in Creating Awareness about Gastroenteritis Patient Education Programmes
Abstract: AbstractGastroenteritis results from the infection of the digestive or the gastrointestinal tract due to viruses or bacteria. It is characterised by the rapid onset of diarrhoea with or without vomiting which include nausea, fever, and abdominal pain. Diarrhoea usually causes frequent passage of unformed liquid stools. Aim and Objectives: To assess the mothers’ knowledge status and impact of clinical pharmacist in creating awareness about gastroenteritis and implementing patient education programmes. …
Published in Research and Reviews: A Journal of Medicine · Vol. 10, Issue 2, 2020 · pp. 6–13 Read article
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An Enhanced Fish Feed Supplemented with Probiotics and Spirulina Formulation for Commercial Production
Abstract: In recent years, the probiotics isolated from fish gut microbiota is used in aquaculture practices as there is a demand to improve the quality of life of fishes. The aim of the study is to isolate probiotic microbe from the gut of Etroplus suratensis and to evaluate the most suitable probiotic for feed formulation. Two bacterial isolates from the gastrointestinal tract (GI) of Etroplus suratensis was evaluated for probiotic properties. …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 10, Issue 2, 2020 · pp. 1–7 Read article
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Multiple Intestinal and Mesentrical Lymphangiomas in a 16-year-old Male: A Case Report
Abstract: Lymphangiomas are rare benign tumor of lymphatic vasculature. These usually occur in skin and soft tissues ofhead, neck and axillary region. Very rarely these affect gastrointestinal tract. Here, we present a case of lymphangiomatos is in a 16 year old male who was presented with acute abdomen. Exploratory laparo to my done and multi-lobulated mass in the intestinal wall and mesentry found. Segment of ileum, caecum and part of colon …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 5, Issue 3, 2016 · pp. 41–44 Read article
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Gallbladder Papillary Carcinoma, The Difficulty of Early Detection: A Case Report
Abstract: Gallbladder carcinoma is the sixth most common malignant tumour of the gastrointestinal tract and the most frequent malignant neoplasm of the biliary tract. Papillary carcinomas are uncommon neoplasm’s, representing nearly 5–12% of all malignant gallbladder tumours. Evidence accumulated in the last 20 years indicates that papillary carcinomas of the gallbladder are associated with a better prognosis than conventional nonpapillary carcinomas.We report our experience with gallbladder papillary carcinoma incidentally diagnosed during …
Published in Research and Reviews : Journal of Surgery · Vol. 6, Issue 3, 2017 · pp. 12–16 Read article
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A Review of Toxicity, Genotoxicity and Teratogenicity of Formaldehyde
Abstract: Formaldehyde (FA) is important chemical found outdoor and indoor source, it is commonly used in the production of industrial, laboratories and household fule. Most FA exposure occurs by inhalation or by skin or eye contact. It is rapidly absorbed by lungs, gastrointestinal tract and skin. FA easily reacts with amino group in molecular compounds such as proteins and nucleic acid; these reactions caused alterations in tissues and leading to toxicity …
Published in Research and Reviews: A Journal of Toxicology · Vol. 10, Issue 3, 2020 · pp. 9–18 Read article
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Stomach Mimicry of A-Forte for Pharmacokinetic Insight
Abstract: Drug absorption from solid dosage forms after oral administration depends on the release of the drug substance from the drug product, the dissolution or solubilization of the drug under physiological conditions, and the permeability across the gastrointestinal tract. In vitro dissolution may be relevant to the prediction of in vivo performance. To evaluate the in vitro dissolution of A-forte, a siddha proprietary medicine and the influencing factors, a study of …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 2, Issue 2, 2015 · pp. 8–12 Read article
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Role of Impaired Digestion in Disease Pathogenesis: According to Unani System of Medicine
Abstract: The relationship between digestion and disease occupies a central position in Greco-Arab (Unani) medicine, as emphasized by classical physicians such as Ibn Sina and Al-Razi. In Unani medicine, digestion (Haḍm) is not confined to the gastrointestinal tract alone but represents a comprehensive physiological and metabolic process involving four sequential stages: gastric digestion (Haḍm-e-Mi‘dī), hepatic digestion (Haḍm-e-Kabidī), vascular digestion (Haḍm-e-‘Urūqī), and tissue digestion (Haḍm-e-‘Uḍwī). These stages are governed by Quwwat-e-Hāḍima (digestive …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 13, Issue 2, 2026 · pp. 30–36 Read article
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Drugs and Polymers Used for Colon Specific Drug Delivery System with Current Trends: A Systematic Review
Abstract: Due to greater flexibility in design of dosage form and high patient compatibility, oral route of administration is the most preferred route but the gastrointestinal tract has many types of other undefeatable barriers to drug delivery. In oral colon-specific drug delivery system, colon has a large amount of lymphoma tissue which facilitates direct absorption into the blood, negligible brush border membrane activity, and much less pancreatic enzymatic activity as compared …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 4, Issue 3, 2013 · pp. 1–8 Read article
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Immunomodulatory and Prebiotic Activities of White Oat β-glucans (Avena sativa L.) and the Potential for a Food-base Ecofriendly Therapy
Abstract: Intestinal health is an important sanitary factor for animals and humans and is closely related to the microbiota population of the gastrointestinal tract. Correlated to this fact is the diet that is consumed, which is fundamental for the development and proliferation of ‘beneficial’ bacteria. Modulation of the intestinal microbiota can be achieved by the prebiotic activity of some polysaccharides, which are fermented by these bacteria after being able to pass …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 10, Issue 3, 2021 · pp. 14–20 Read article
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Creating Awareness on Toxic Nature of Cadmium
Abstract: Every day, we come into touch with hundreds of harmful compounds, both natural and manmade. A dangerous heavy metal that is widely present in nature is Cadmium. There have been several reports of cadmium poisoning throughout the world. It is well known that all forms of cadmium are harmful to the environment and to living things. It is a widespread issue with world health that, in some situations, can lead …
Published in Research & Reviews : Journal of Ecology · Vol. 11, Issue 2, 2022 · pp. 28–31 Read article