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182 articles for “Formulation Optimization”
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Exploring Biomedical Innovations in the Formulation and Assessment of Medicated Hard Candy Lozenges Containing Metoclopramide Hydrochloride
Abstract: The objective of this study was to formulate and evaluate metoclopramide hydrochloride medicated lozenges for antiemetic action through buccal absorption by incorporating a polymer. All formulations were developed and assessed for in-vitro drug release, physical appearance, weight variation, thickness, hardness, moisture content, mouth-dissolving time, and drug content. The prepared lozenges exhibited uniformity in weight and thickness. The hardness of all formulations ranged between 7.3–15.50 kg/cm², falling within standard limits. The …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 2, 2024 · pp. 50–62 Read article
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Comparative Study on Oro Dispersible Tablets of Candesartan Cilexetil Formulated with Natural and Synthetic Disintegrants
Abstract: Candesartan cilexetil, a BCS class II drug with low aqueous solubility and poor bioavailability (15%), poses challenges for oral delivery. To address this limitation, the present study focuses on polymer-based inclusion complexation and composite formulation strategies to enhance solubility and dissolution behavior. The drug was incorporated into β-cyclodextrin (β-CD), a cyclic oligosaccharide polymer, by the kneading method in different drug-to-carrier ratios. Among these, the 1:1 molar ratio complex exhibited the …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 687–695 Read article
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Role of Pharmaceutical Software in Vaccine Development and Manufacturing Process Optimization
Abstract: Vaccine development and manufacturing have become increasingly complex due to the emergence of diverse vaccine platforms, stringent regulatory expectations, and global demand for safe and effective immunization. Across the vaccine lifecycle – from antigen design and preclinical evaluation to large‑scale manufacturing and post‑marketing surveillance – pharmaceutical software now plays a central role in handling data, optimizing processes, and ensuring regulatory compliance. Software tools support in silico antigen and epitope design, …
Published in International Journal of Vaccines · Vol. 3, Issue 1, 2026 · pp. 1–8 Read article
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Development and Assessment of Levetiracetam Microspheres Utilizing Synthetic and Natural Polymers: A Biomedical Engineering Perspective
Abstract: In the present study, comparative study of Levetiracetam loaded microspheres using Ethyl cellulose as synthetic and Sodium alginate as natural polymers was done. Solvent evaporation and ionic gelation technique has been successfully employed to produce Levetiracetam loaded ethyl cellulose and sodium alginate microspheres with optimal drug encapsulation that sustained the drug release over a period of time. Based on the pre-formulation studies E1 to E4 and S1 to S4 batches …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 1, 2024 · pp. 1–18 Read article
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Proposed System: Quantum Computing Processor Based on Linear Number Relation
Abstract: This paper details the design and implementation of a specialized quantum processor tailored for efficiently evaluating custom mathematical formulas. Optimized to perform a specific set of arithmetic and logical operations, this processor delivers a stable and high-performance computing platform. Unlike general-purpose quantum processors, which are designed for versatility across a wide range of algorithms, this dedicated processor aims to enhance performance and accuracy for a targeted set of tasks. The …
Published in Recent Trends in Parallel Computing · Vol. 11, Issue 3, 2024 · pp. 24–32 Read article
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Formulation and Evaluation of a Natural Excipients-Based Diclofenac Sodium Topical Ointment
Abstract: The present study reports the formulation and evaluation of a diclofenac sodium topical ointment incorporating natural excipients to improve skin compatibility and formulation sustainability. Conventional topical non-steroidal anti-inflammatory drug (NSAID) formulations frequently rely on synthetic excipients that may cause dermal irritation and pose environmental concerns. To address these limitations, a 1% w/w diclofenac sodium ointment was developed using aloe vera gel, glycerin, xanthan gum, peppermint oil, vitamin E, and isopropyl …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 2, 2026 Read article
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Accelerating Drug Discovery with AI: Transforming the Pharmaceutical Pipeline
Abstract: The revolutionary potential of artificial intelligence (AI) is examined in this essay the pharmaceutical industry, highlighting its application across the drug development lifecycle. Artificial Intelligence, specifically via deep learning models and machine learning (ML) such as GANs, RNNs, and transformers, enhances drug discovery, formulation, toxicity prediction, and clinical trials. It streamlines processes like identification of targets, virtual screening, modelling of structure-activity relationships, and medication repurposing. AI is also employed in …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 77–84 Read article
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Advancing Conductive Ink Formulations for DIW with Graphene and Hybrid Nanostructures
Abstract: The development of solvent-based conductive inks for direct ink writing (DIW) has gained significant attention as a pathway toward flexible, wearable, and scalable electronic devices. This review critically examines conductive fillers, binders, solvent systems, and hybrid ink strategies reported in recent literature. Graphene and carbon nanotubes (CNTs) remain the most studied fillers due to their high intrinsic conductivity and unique dimensionality, but challenges such as restacking, bundling, and high viscosity …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 12, Issue 3, 2025 · pp. 36–49 Read article
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Microsphere-Based Drug Delivery: A Critical Review of Innovations and Applications
Abstract: Microspheres have emerged as a revolutionary approach in pharmaceutical sciences, offering controlled and targeted drug delivery with improved bioavailability, stability, and patient compliance. These spherical carriers, ranging from nanometers to micrometers in size, can encapsulate both hydrophilic and hydrophobic drugs, enabling sustained and site-specific release. The development of microspheres has been significantly driven by the need to enhance drug efficacy while minimizing systemic side effects. This review provides a comprehensive …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 52–59 Read article
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Phase-Specific Nutrient Requirements in Broilers: Implications for Behavior, Gut Health, Performance, Meat Quality, Welfare, and Economics
Abstract: The broiler industry plays an inevitable role in global food security, requiring optimal formulation strategies tailored to each growth phase, starter, grower, and finisher for sustainable production. This review explores phase-specific nutrient requirements and their implications for broiler performance, meat quality, welfare, and economics. During the starter phase (1–10 days), nutrition focuses on immune development, gut health, and skeletal growth, with high protein and low energy needs. In the grower …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 15, Issue 1, 2025 · pp. 5–15 Read article
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Crystallographic Studies on The Stability of Pharmaceutical Compound
Abstract: Crystallographic studies provide detailed insights into the molecular structure and intermolecular interactions within a crystal lattice, which are key determinants of a compound's stability. By analyzing crystal structures, researchers can identify potential polymorphs, solvates, and hydrates that may impact the physical and chemical stability of the drug. This knowledge helps in optimizing formulation strategies, predicting shelf life, and ensuring consistent drug performance. Advanced techniques like X-ray diffraction and neutron diffraction …
Published in International Journal of Crystalline Materials · Vol. 1, Issue 1, 2024 · pp. 38–42 Read article
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Therapeutic Potential of Terminalia arjuna Bark in the Management of Hemorrhoids: A Comprehensive Review
Abstract: Background: Hemorrhoids appear frequently among anorectal disorders since they create vascular swelling together with pain symptoms, while leading to bleeding and mucosal tissue tending to slide out. Though effective therapy exists, traditional treatments produce various adverse effects and lead to recurrence and inconsistent patient following of medical recommendations over the long term. Plantbased therapeutic medicines have gained rising demand, which leads experts to investigate medicinal plants with established pharmacological effects. …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 2, 2025 · pp. 22–32 Read article
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Hybrid Epoxy Composites with Areca and Abaca Fibers: Effect of Nano-SiO₂ on Mechanical Properties
Abstract: This study explores the fabrication and mechanical evaluation of sustainable epoxy-based hybrid composites reinforced with Areca fiber (ARF), Abaca fiber (ABF), and nano-silica (SiO₂). The composites were made using a hand layup process, maked five variants (S1–S5) with ARF content ranging from 0–40 wt% and nano-silica content from 0–8 wt%, while maintaining ABF as the primary reinforcement. Mechanical performance was assessed through tensile strength (TS), flexural strength (FS), and impact …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 606–613 Read article
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Development and Characterization of a Solid Dispersion of an Anti-Diabetic Drug Using Pectin as a Natural Polymer
Abstract: Aim: The current study sought to improve the solubility and oral bioavailability of gliclazide by creating solid dispersions and oral dispersible tablets (ODTs) with enhanced physicochemical characteristics and maintained antidiabetic action. Methods: Preformulation studies were conducted to evaluate the physicochemical properties of gliclazide, including physical appearance, melting point, solubility, and partition coefficient. Solid dispersions were prepared using hydrophilic carriers-pectin and PVP K30, and subsequently characterized by Fourier Transform Infrared Spectroscopy …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 Read article
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A Research on Goat milk and Papaya Face Wash
Abstract: The increasing demand for natural and sustainable skincare products has driven interest in bio-based cosmetic formulations. This study focuses on the development and evaluation of a goat milk and papaya–based face wash aimed at providing gentle cleansing, moisturizing, and exfoliating properties through natural ingredients. Goat milk, rich in lactic acid, proteins, and essential fatty acids, contributes to hydration and mild exfoliation, while papaya (Carica papaya) extract, containing papain enzyme and …
Published in Recent Trends in Cosmetics · Vol. 3, Issue 1, 2026 · pp. 30–38 Read article
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Next-Generation Catalysts: Enhancing Efficiency and Selectivity in Chemical Reactions
Abstract: This study investigates the fundamental principles of coatings and their rejuvenation mechanisms, focusing on the development of advanced coatings that not only protect but also restore the performance of degraded surfaces. The article delves into the various types of coatings, including organic, inorganic, and hybrid formulations, emphasizing their distinct characteristics and applications. A significant portion of the study is dedicated to the mechanisms of rejuvenation, where we analyze how specific …
Published in Journal of Catalyst & Catalysis · Vol. 11, Issue 3, 2024 · pp. 24–28 Read article
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Innovative strategies in capsule formulation from concept to market
Abstract: Innovative strategies in capsule formulation have revolutionized drug delivery and nutraceutical development, offering advanced solutions from initial concept to market release. This report explores the transformative techniques at each stage of capsule formulation, detailing novel approaches in ingredient selection, encapsulation technology, and manufacturing processes. By leveraging advancements in artificial intelligence, encapsulation methods, such as liposomal and nanoparticle technologies, and materials science, formulators can optimize the bioavailability, stability, and targeted delivery …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 1, 2025 · pp. 1–8 Read article
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The Potential of Guava Leaf-Enriched Chocolate in Sugar-Free Anti-Diabetic Confectionery: A Review
Abstract: People of all age groups enjoy chocolate however, it is often linked to health issues like obesity, hypertension, diabetes, and cardiovascular diseases. This study aimed to develop a medicinal chocolate suitable for diabetic individuals by incorporating herbal ingredients. Specifically, guava leaves (Psidium guajava), known for their rich vitamin and antioxidant content and their ability to help regulate blood sugar, were used. The chocolate formulation included guava leaf powder, coffee, and …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 2, 2025 · pp. 55–63 Read article
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Comparison Study of Non-Alcoholic Sanitizer and Alcohol Based Sanitizer
Abstract: Hand sanitizer is the best choice to maintain the hand hygiene and stopping the spread of infectious diseases. The active ingredient in traditional hand sanitizers is usually alcohol, but worries about flammability, skin irritation, and possible abuse have prompted the creation and growing popularity of alcohol-free substitutes. The purpose of this review is to objectively assess the safety, effectiveness, and usefulness of alcohol-free hand sanitizers. To successfully eradicate germs, alcohol-free …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 1, 2025 · pp. 11–22 Read article
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Self-Healing Polymer Composites for Pharmaceutical Packaging Applications
Abstract: Pharmaceutical packaging plays a crucial role in ensuring the safety, stability, and effectiveness of pharmaceutical products. Conventional polymer-based packaging materials are prone to mechanical damage, microcracks, and environmental degradation, which can compromise drug integrity. Self-healing polymer composites (SHPCs) offer a promising solution by enabling autonomous or stimuli-responsive repair mechanisms that restore packaging integrity, enhance durability, and extend product shelf life. These materials function through intrinsic mechanisms, such as dynamic covalent …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 648–658 Read article