Search
163 articles for “Diagnostic Methods”
-
Angioedema-Diagnosis & Management
Abstract: Angioedema (AE) encompasses a diverse range of conditions categorized into three main groups: (1) angioedema mediated by histamine (AE-H); (2) angioedema mediated by bradykinin (AE-BK); and (3) angioedema with an unknown mechanism (AE-UNK). It can manifest on any part of the body, though commonly affected areas include the face, lips, mouth, throat, larynx, extremities, genital regions, and gastrointestinal tract. AE-H can occur by itself or in conjunction with chronic urticaria, …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 2, 2024 · pp. 9–21 Read article
-
Wiskott-Aldrich Syndrome: A Comprehensive Guide
Abstract: Wiskott-Aldrich Syndrome (WAS) is an uncommon genetic disorder inherited through the X chromosome, marked by a combination of immune system deficiencies, eczema, and low platelet counts. This syndrome primarily affects males, leading to significant morbidity and mortality due to recurrent infections, bleeding complications, and autoimmune diseases. Mutations in the WAS gene disrupt the production of the Wiskott-Aldrich Syndrome protein (WASp), crucial for the functioning of immune cells and platelet formation. …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 2, 2024 · pp. 39–46 Read article
-
Stiff Person Syndrome: Advances in Understanding, Diagnosis, and Treatment of a Rare Autoimmune Disorder
Abstract: Stiff Person Syndrome (SPS) is a rare and complex autoimmune neurological disorder characterized by progressive muscle stiffness, rigidity, and painful spasms. This chapter provides a comprehensive overview of SPS, exploring its pathophysiology, clinical presentation, diagnostic challenges, and current treatment approaches. We discuss the latest research findings, including the role of autoantibodies, genetic factors, and environmental triggers in the development of SPS. The chapter examines various diagnostic methods, emphasizing the importance …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 35–43 Read article
-
A Comprehensive Review on Monkeypox Infection
Abstract: Monkeypox represents a zoonotic viral affliction instigated by the monkeypox virus, which is classified within the Poxviridae family and is distinct from the virus that causes chickenpox. Initially recognized in 1958, this infection has recently attracted international scrutiny due to its escalating incidence beyond traditional endemic territories. This review delivers an exhaustive examination of monkeypox, encompassing its epidemiology, viral morphology, modes of transmission, pathogenesis, clinical presentations, and therapeutic interventions. The …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 1, 2025 · pp. 23–32 Read article
-
An Evaluative Comparison of CD123 and CD66c as Biomarkers to Detect Minimal Residual Disease in B-Cell Acute Lymphoblastic Leukemia
Abstract: Background: B-cell Acute Lymphoblastic Leukemia (B-ALL) often shows lineage heterogeneity with lymphoid cells expressing myeloid markers. Minimal Residual Disease (MRD) refers to the small number of cancer cells that may remain in a patient's body after treatment and that are undetectable by standard diagnostic methods. In diseases like B-cell Acute Lymphoblastic Leukemia (B-ALL), MRD is a critical prognostic indicator, as its presence can signal a higher risk of relapse. In …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 13, Issue 3, 2024 · pp. 7–12 Read article
-
Comparative Efficacy of Hybrid Capture 2 and Real-Time PCR in Detecting High-Risk HPV Genotypes for Cervical Cancer Screening
Abstract: Human papillomavirus (HPV) infection is a leading cause of cervical cancer, making early detection critical for effective prevention and treatment. Among the diagnostic methods available, Hybrid Capture 2 (HC2) and Real-Time Polymerase Chain Reaction (PCR) are widely used for detecting high-risk HPV genotypes, particularly HPV 16 and 18, which account for the majority of cervical cancer cases. This review aims to compare the efficacy of HC2 and Real-Time PCR in …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 2, 2024 · pp. 13–17 Read article
-
Risk Factors Associated with Subclinical Mastitis in Dairy Cows: Implications for Microbial Dynamics, Environmental Influences, and Management Factors
Abstract: Subclinical mastitis is a prevalent yet often overlooked condition in dairy cows, leading to reduced milk yield and quality. This study examines the microbial dynamics, environmental influences, and management factors contributing to subclinical mastitis in dairy herds. Microbial agents, including bacteria such as Staphylococcus aureus, Escherichia coli, and Streptococcus uberis, are key contributors, with their ability to persist and form biofilms complicating detection and treatment. Environmental factors, including bedding quality, …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 2, 2025 · pp. 45–61 Read article
-
The Calcium Paradox – Calcium Dietary Intake and Supplementation in the Context of Calcium Oxalate Renal Calculus
Abstract: Renal Calculi, also known commonly as kidney stone is one of the most common manifestations of kidney function dysregulation causing discomfort and alterations to an individual’s life. Although kidney stones come in a variety of forms, calcium oxalate stones are the most prevalent kind. These Calcium Oxalate renal stones often arise from various issues like metabolic imbalances, dehydration and dietary imbalances. About 70–80% of kidney stones are calcium oxalate stones, …
Published in International Journal of Sustainability · Vol. 2, Issue 1, 2025 · pp. 17–25 Read article
-
Ovarian Cancer: Understanding Risk Factors, Diagnosis, and Advances in Treatment
Abstract: Ovarian cancer is a leading cause of cancer-related mortality among women worldwide, often diagnosed at advanced stages due to its subtle early symptoms. Ovarian cancer develops due to a combination of factors, including genetics, environmental influences, and hormonal changes. This article explores the pathophysiology of ovarian cancer, highlighting the genetic mutations, such as BRCA1 and BRCA2, that contribute to its development. It also discusses current diagnostic methods, including imaging techniques …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 2, 2025 Read article
-
Horizons in Neuralgia Care: Addressing Unmet Needs and Future Prospects
Abstract: Neuralgia refers to intense, sharp, and often chronic pain resulting from damage or irritation to nerves. It is typically characterized by sudden, shooting pain along the course of a nerve, significantly impairing daily functioning and impacting both physical and emotional well-being. Given its intensity and chronic nature, neuralgia presents a complex challenge in clinical management, emphasizing the importance of timely diagnosis and effective intervention to improve patient outcomes. This comprehensive …
Published in International Journal of Brain Sciences · Vol. 2, Issue 2, 2025 · pp. 1–8 Read article
-
Enhancing Glaucoma Diagnosis with Deep Learning: A Study Using ResNet-50 and DenseNet-121
Abstract: Glaucoma is a leading cause of irreversible blindness worldwide, mainly resulting from progressive optic nerve damage, often related to elevated intraocular pressure. Early detection is essential to prevent vision loss, but traditional diagnostic methods rely on specialized equipment and trained professionals, making large-scale screening difficult. This study uses a publicly available fundus imaging dataset to explore the effectiveness of deep learning models for glaucoma detection. These datasets provide medical images, …
Published in International Journal of Brain Sciences · Vol. 2, Issue 2, 2025 · pp. 9–18 Read article
-
Ayurveda as a Medium of Healing: A Critical Review of Classical Concepts and Modern Evidence
Abstract: Ayurveda, recognized as one of the world’s oldest holistic healing systems, has its origins in India over 5,000 years ago. Rooted in a philosophy that views health as a harmonious balance of body, mind, and spirit, Ayurveda offers a comprehensive and individualized approach to wellness. This traditional system of medicine is grounded in the concept of the Tridosha Vata, Pitta, and Kapha representing the fundamental bio-energetic forces governing physiological and …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 14, Issue 3, 2025 · pp. 40–44 Read article
-
A Systematic Review on Coronary Heart Disease: A Transient Ischemic Stroke
Abstract: Coronary Heart Disease (CHD) and Transient Ischemic Attack (TIA) are significant cardiovascular and cerebrovascular disorders that often share similar risk factors and underlying pathophysiological processes. CHD involves the narrowing or obstruction of the coronary arteries due to atherosclerosis, resulting in diminished blood flow to the heart. A transient ischemic attack (TIA), often called a "mini stroke," occurs when blood flow to the brain is briefly disrupted, usually due to a …
Published in Research and Reviews : Journal of Surgery · Vol. 14, Issue 3, 2025 Read article
-
Early Alzheimer's Disease Detection Using Deep Ensemble Learning and MRI Image Analysis
Abstract: Early detection of Alzheimer's disease (AD) is crucial to slowing cognitive decline and enabling timely clinical interventions. Traditional diagnostic methods, including cognitive tests and single-model classifiers, have limited sensitivity during early stages of the disease. This paper presents a deep ensemble learning approach that integrates multiple convolutional neural networks (CNNs) for accurate Alzheimer's disease detection using structural Magnetic Resonance Imaging (MRI) data. The proposed framework utilizes ResNet50, VGG16, and DenseNet121 …
Published in Research and Reviews : Journal of Computational Biology · Vol. 15, Issue 1, 2026 Read article
-
Non-Small Cell Lung Cancer: Types, Pathogenesis, Diagnosis, and Novel Therapeutic Strategies
Abstract: Non-small cell lung cancer (NSCLC) is the most prevalent type of lung cancer, accounting for over 85% of all cases globally. It remains one of the primary causes of cancer-related death due to its rapid progression, few early symptoms, and late detection. The three main forms of non-small cell lung cancer (NSCLC) are adenocarcinoma, squamous cell carcinoma, and giant cell carcinoma; each has a unique histology, prognosis, and response to …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article
-
Fluid Dynamics of a Stressed Freshwater Lens: Integrated Flow Modeling and Pathways for Material-Centric Interventions in Khadir Island, Gujarat
Abstract: This study applies principles of fluid dynamics and porous media mechanics to analyze the behavior and sustainability of the freshwater lens in Khadir Island, an arid sedimentary island in Gujarat, India. We develop an integrated fluid flow model that couples surface hydrology with aquifer dynamics to quantify recharge fluxes, extraction stresses, and hydraulic responses. Using 11-year hydro-meteorological data (2011–2021) and sectoral demand projections, we characterize the island’s water budget through …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 12–29 Read article
-
Recent Update on Advanced Drug Delivery System
Abstract: Over the past decade, there has been a growing interest in the use of artificial intelligence (AI) technology for analysing and interpreting biological or genetic data, accelerating drug discovery, and identifying selective small-molecule modulators or rare molecules in addition to predicting their behaviour. The use of artificial neural networks (ANNs) for the rapid analysis of massive amounts of data, the development of novel hypotheses and treatment plans, the prediction of …
Published in International Journal of Advance in Molecular Engineering · Vol. 1, Issue 1, 2023 · pp. 22–30 Read article
-
Evaluating the Role of Platelet Indices, with a Focus on Immature Platelet Fraction (IPF), in Differentiating Hyper-Destructive and Hypo-Productive Thrombocytopenia: A Study from Ludhiana, Punjab, India
Abstract: Background: Thrombocytopenia, characterized by a reduction in platelet count, is commonly observed in clinical settings. Its etiology can be broadly classified into hyper-destructive thrombocytopenia, where platelets are destroyed at an accelerated rate, and hypo-productive thrombocytopenia, where platelet production is impaired. Differentiating between these two causes is essential for effective management. The Immature Platelet Fraction (IPF) has emerged as a promising non-invasive diagnostic tool to distinguish these causes. Objectives: The primary …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 2, 2025 Read article
-
Developing an Assessment Protocol in Ayurvedic Research for Hyperemesis Gravidarum with Special Reference to Garbhini Chardi
Abstract: Garbhini Chardi (nausea and vomiting in pregnancy) is described in Ayurvedic texts as one of the Vyakta Garbha Lakshanas – early physiological signs indicating pregnancy. However, when this symptom becomes excessive, persistent, or distressing, it may transition from a normal event to a pathological condition, requiring timely intervention to safeguard maternal and fetal health. In advanced stages, it leads to day-to-day incapacitation, weight loss, dehydration, and metabolic disturbances – clinically …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 15, Issue 1, 2026 · pp. 44–61 Read article
-
Sustainable Advances in Oral Pathology: The Impact of Artificial Intelligence
Abstract: Oral cavity cancers constitute about 4% of all malignant neoplasms. More than 9,900 new cases are reported from the developed countries yearly, and the 5-year mortality rate is higher than 39%. In Europe, the highest rates occur in Hungary, Croatia, and other Central and Eastern European countries; high levels are also seen in India, Pakistan, and Bangladesh. The management of endosseous pathologies presents considerable challenges because they often exhibit no …
Published in Research and Reviews: A Journal of Dentistry · Vol. 16, Issue 1, 2025 · pp. 24–27 Read article