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705 articles for “Acidic pH”
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Pharmacokinetics and Stability of Polymer-Encapsulated Drugs
Abstract: Making drugs that are covered by plastics is a fresh and useful way to make medicines work better, last longer, and treat diseases better. Putting drugs inside polymer materials helps them breakdown better, stays in the body longer, and lowers the number of side effects they cause. This is necessary to slowly release the drug and help people stick to their treatment plan. Polymers are used to wrap drugs. This …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 349–361 Read article
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Unraveling Ulcerogenesis: A Comprehensive Delve of Enteric & Nonenteric Ulcers
Abstract: Enteric ulcers present a multifaceted landscape encompassing both peptic and non-peptic varieties, demanding a thorough exploration of their manifestations, causes, and pathophysiology. At the forefront of understanding lie pivotal factors such as Helicobacter pylori infection, nonsteroidal anti-inflammatory drugs usage, lifestyle choices, and stress, each wielding significant influence over ulcer development and progression. The intricate interplay of these factors underscores the complexity of enteric ulcer etiology. Helicobacter pylori infection—a prevalent culprit—inflicts …
Published in Research and Reviews: A Journal of Medicine · Vol. 14, Issue 1, 2024 · pp. 25–40 Read article
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A Novel Approach of Protein Peptide Drug Delivery System
Abstract: Protein and peptides perform vital functions in body and are essential for life. They show various roles as therapeutic agents in treatment of cancer and diabetes. Various routes are available for the delivery of proteins and peptides such as oral route, transdermal route, pulmonary route, parenteral route, ocular route, nasal route, buccal route. However physicochemical properties of protein and peptides make them challenging for exogenous administration, especially in oral administration. …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 7, Issue 2, 2020 · pp. 44–59 Read article
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Comparative Analysis of Natural vs. Synthetic Antioxidant during Deep-Fat Frying of Potato Chips
Abstract: The aim of this study was the comparative analysis of natural antioxidant derived from rosemary extract, mixed tocopherol, alpha tocopherol, Ascorbyl Palmitate with synthetic antioxidant (TBHQ) during deep fat frying. Palm oil with tertiary butylhydroquinone (TBHQ), a synthetic antioxidant, and palm oil without any added antioxidant were used as positive controls. Thermo-oxidative transformations were measured according to various physical and chemical parameters. Total polar compounds (TPC), free fatty acids (FFA), …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 4, Issue 2, 2015 · pp. 1–12 Read article
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SUBSTITUTED TRI-PEPTIDE DERIVATIVES SYNTHESIS, CHARACTERIZATION
Abstract: By using amino acid residues the peptides can be synthesized using either solid phase peptide synthesis or solution phase peptide synthesis. In this research article we preferred solution phase peptide synthesis because the formed intermediate unnecessary products can be easily isolated and purified. On through literature survey we found that the solution phase synthesis of tripeptides employing HATU/HOBt as coupling agent by using microwave irradiation[720 watts] has been mentioning in …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 10, Issue 1, 2023 · pp. 52–63 Read article
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Characterization of Endofungus Aspergillus nomius EF8-RSM Isolated from Aloe vera Western Ghats of Karnataka India
Abstract: The objective of the present research investigation was to reveal the versatile nature of endophytic Aspergillus nomius EF8-RSM. The fungus was purified from Aloe vera, Western Ghats of Karnataka, India and sequence was submitted at NCBI under the accession number MN871698. The fungus successfully produced Indole acetic acid at the rate of 49.21±6.1 μg/ml and phosphate solubilization was confirmed with solubilization index (1.63). The fungus showed production of siderophore, ammonia …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 11, Issue 1, 2020 · pp. 22–30 Read article
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In-silico Approach of Few Selected Phytoconstituents on Newer Cancer Targets
Abstract: Background: Cancer’s high death rates are mainly due to, drug resistance and unmet medical demands. It necessitates novel anticancer medications. AI tools aid in efficient and faster drug discovery by analyzing data, modeling processes and optimizing pipeline stages. Aim: The aim of this present study is to evaluate phytoconstituents against novel and newer cancer targets. Methodology: The ligands Daidzein, Resveratrol and Genistein were targeted against the Glutamate dehydrogenase (PDB ID …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 3, 2024 · pp. 12–17 Read article
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Exploring the Botanical and Pharmacological Significance of Aristolochia rotunda Linn (Zarawand Mudahraj): Traditional Uses, Habitat, and Bioactive Potential
Abstract: The plant Aristolochia rotunada Linn (Zarawand Mudahraj) is a member of the Aristolochiaceae family. Its rhizomes are the most valuable portion utilised in the pharmaceutical industry, mostly because of their abundance in bioactive compounds. The medicinal plant Aristolochia rotunda Linn exhibits a spectrum of pharmacological activities essential for combating hyper-uricaemia-induced inflammation. Its anti-inflammatory effects are mediated by inhibiting TNF-α, IL-1β, IL-8, and NF-κB p65 protein expression, crucial in synovial tissue. …
Published in Research & Reviews : Journal of Herbal Science · Vol. 13, Issue 2, 2024 · pp. 33–39 Read article
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Evaluation of Antiulcer Activity of Allamanda cathartica Aqueous Leaf Extract in Experimental Rat Models
Abstract: A peptic ulcer is an open sore that forms on an epithelial surface of the stomach. To decrease the incidence of relapses, side effects, drug interactions of the existing drugs, and to increase the use of available phytochemicals, this present study was aimed to evaluate the antiulcer activity of Allamanda cathartica using pyloric ligation induced gastric ulcer model and Aspirin-induced gastric ulcer model. In pyloric ligation induced gastric ulceration model, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 7, Issue 1, 2020 · pp. 24–31 Read article
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Plant Bioactive Metabolites and Their Role in the Prevention and Control of Dental Diseases and Infections.
Abstract: The oral diseases, including dental caries and periodontitis, affect masses worldwide, and have historically been managed with synthetic antimicrobials that cause deleterious side effects, leading to mounting bacterial resistance. Consequently, contemporary dentistry is rapidly shifting toward phytomedicine using plant bioactive molecules, such as polyphenols, terpenes, anthraquinones (berberin, eugenol, curcumin, catechins, allicin, and azadirachtin. These compounds offer potent antimicrobial, anti-inflammatory, and tissue-regenerative properties that are crucial for preventing and curing dental …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 1, 2026 · pp. 47–66 Read article
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Extraction of Natural Dye from Red Rose Flowers
Abstract: In this research work, locally available red flowers of the red rose are selected for the extraction of anthocyanin. Ethanol solvent was used to extract anthocyanin from flowers. Different methods are used to obtain natural dyes from flowers. FTIR, pH, and UV tests were performed to characterize the extracted anthocyanin. The pH differential method was used to measure the total anthocyanin content in red rose flowers. The color of the …
Published in Research & Reviews : Journal of Herbal Science · Vol. 14, Issue 3, 2025 · pp. 14–23 Read article
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Jabuticaba Skin Flour AsA Functional Food Ingredient: Phenolic Profile, Antioxidant Potential and Functional Technological Properties
Abstract: Brazilian-native fruit, jabuticaba, is a member of the Myrtaceae family that is typically consumed naturally. The jabuticaba skin flour (JSF) is rich in phenolic compounds, the most active antioxidants present in plants, being able to stop oxidative damage and reduce the risk of oxidative stress linked to different degenerative diseases, thus become interesting to the consumer. Despite all this antioxidant potential, little is known about their characterization and about the …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 13, Issue 3, 2024 · pp. 01–08 Read article
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Antibacterial, Cytotoxicity Studies of Azukia mungo (L.) Masam and Correlation with in silico Docking Studies
Abstract: Introduction and Background: Azukia genus plants rich in proteinaceous anti-nutrients like tannins (especially condensed tannins) has been shown to have anti-bacterial activity against Staphylococcus aureus and antineoplastic activity against lung and liver cancer cells. Five types of procyanidins (condensed tannins) have already been isolated from Azukia mungo and structurally elucidated. But its activity against the Methicillin resistant Staphylococcus aureus (MRSA) has not yet been shown. Hence we focus our work …
Published in Research and Reviews: A Journal of Toxicology · Vol. 7, Issue 2, 2017 · pp. 21–31 Read article
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Bioanalytical Method Development and Validation for the Estimation of Levothyroxine in Human K₃EDTA Plasma by Using UPLC-MS/MS
Abstract: A rapid, sensitive, and highly selective UPLC-MS/MS method was developed and validated for the quantitative estimation of Levothyroxine in human plasma using Levothyroxine-D₃ as the internal standard (IS). Chromatographic separation was achieved on a Gemini NX-C18 column (50 × 3.0 mm, 3 µm) with a mobile phase consisting of acetonitrile and water (70:30, v/v) containing 0.015% formic acid at a flow rate of 0.5 mL/min. The total run time was …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 3, 2025 · pp. 32–46 Read article
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Study of pH Behaviour of Slurry on Surface Morphology of Copper Material with Single Pole Magnetic Abrasive Finishing Process
Abstract: The chemical oxidizers—sodium hydroxide, Marshall’s acid salt, and hydrogen peroxide—were effectively employed in the wet polishing of copper using the SPMAF experimental setup. The manuscript explores preparation of slurry used for polishing copper material using single pole magnetic abrasive finishing (SPMAF) framework. The slurry contains distilled water, 1200-grit aluminum oxide abrasives, sodium hydroxide (NaOH), potassium persulfate (K₂S₂O₈), and hydrogen peroxide (H₂O₂), combined in precise amount. Specifically, 100 ml of distilled …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1887–1896 Read article
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Effects of Germination on the Bioactive Compounds and the Flour Physicochemical Properties of Sorghum Grains
Abstract: Sorghum, being used as a staple food with many kinds of bioactive compounds, is one of the four types of used cereal around the world. Sorghum is also an important raw material for the food industry, such as a brewing material. Germination can lead to a change of bioactive compounds, and then change the biological activities and flour physicochemical properties of sorghum grains. This review aims to analyze and summarize …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 12, Issue 1, 2024 · pp. 15–25 Read article
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Proteins: Structure, Functions, Sources, Types, Advantages and Biological Importance
Abstract: Proteins are essential biological macromolecules composed of amino acids linked by peptide bonds and folded into specific three-dimensional structures. Their structural organization is closely associated with their biological functions, including structural support, catalysis, transport, regulation, defense, movement and storage. This review summarizes the basic features of proteins, including amino-acid composition, levels of structural organization, classification, major biological functions and important dietary sources. It also discusses the relationship between amino-acid sequence, …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 4, Issue 2, 2026 Read article
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Synthesis, Properties, Nanocomposites, and Electrochemical Applications of Polyaniline: A Review
Abstract: Polyaniline, also known as PANI, is a polymer in the that is becoming more significant for academics in the field of nanotechnology due to the potential uses it has in sensor technologies, optoelectronics, and photonics. PANI can be rapidly doped by a broad range of acids and dopants due to the ease with which it may be manufactured and its exceptional resilience in the natural environment. In this article, we …
Published in Journal of Polymer & Composites · Vol. 11, Issue 3, 2023 · pp. 13–20 Read article
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Evaluation Of Anti Obesity Activity Of Citrus Sinensis & Citrus Limon By High Fat Diet Induced Model Using Danio Rerio
Abstract: Obesity, defined by the World Health Organization (WHO) as an abnormal or excessive fat accumulation that may impair health, is becoming one of the greatest challenges to global health in this millennium, with more than 300 million men and nearly 450 million women obese globally in 2018. Obesity turns into serious problem globally. Zebrafish model can be used extensively for drug screening due to its low maintenance cost, comparatively short …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 1, 2024 · pp. 24–31 Read article
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Stimuli-Responsive Polymers for Drug Release in Targeted Therapy
Abstract: SRPs, or stimuli-responsive polymers, are becoming a good way to give specific drugs. They let medicines be released in a controlled way. Some of the things that can change these polymers are pH, temperature, light, magnetic fields, and the number of ions present. Some outside signs can make SRPs respond, which helps control how drugs are released. This cuts down on side effects and improves the effectiveness of focused treatments. …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 252–265 Read article