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478 articles for “ADME”
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Anaphylaxis: Pathophysiology, Risk Factors, and Clinical Management
Abstract: Anaphylaxis is a syndrome characterized by broncho-constriction, vasodilatation, and hypovolemia, potentially fatal exposure to known or unknown antigens. It can be an immune-mediated (IgE & non-IgE) disease. Immunoglobulin G (IgG), complement related (C3a/C5a), bradykinin, leukotrienes, prostaglandin E2, and ligands of certain G-protein coupled receptors (GPCR) can directly activate mast cells, basophils, eosinophils, neutrophils, endothelial cells and smooth muscles. Serum tryptase level during episodes of anaphylaxis, skin test, and basophil activation …
Published in Research and Reviews : A Journal of Immunology · Vol. 15, Issue 2, 2025 · pp. 1–11 Read article
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Thermosensitive and pH-Responsive Polymers for Smart Drug Delivery Systems
Abstract: Sensitive to temperature and pH, polymers are becoming a fascinating new class of material suitable for application in drug delivery systems. These polymers can be utilised in controlled release of medications as they change form depending on temperature and acidity. Thermosensitive polymers vary their formation and breakdown behaviour with temperature variations. They are therefore perfect for delivering pharmaceuticals to individuals as heat may be utilised to activate the medications at …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 479–491 Read article
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Microsphere and Nanoparticle Drug Delivery Systems: Role of Polymers in Pharmacology
Abstract: Microsphere and nanoscale drug delivery methods have changed the field of pharmacology by making treatment agents more bioavailable, more targeted, and easier to manage. These delivery systems, which are mostly made up of polymers, look like a good way to get around the problems that traditional drug formulations have, like not dissolving well, clearing quickly, and spreading in different places. Plastics are very important in the creation of these improved …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 420–432 Read article
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Advances in Biodegradable Polymer-based Drug Delivery Systems
Abstract: An intriguing new approach to manage medication release that may assist with issues like making the therapeutic impact last longer, reducing the danger of side effects, and persuading patients to follow through with their treatment programs is biodegradable polymer-based drug delivery systems (DDS). By developing systems that can break down within the body, biodegradable polymers have revolutionised the way medications are administered. They so have less negative effects and do …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 326–338 Read article
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Effect of Polymer Crosslinking on Drug Release Kinetics
Abstract: In order to improve treatment effectiveness and minimise adverse effects, polymer-based drug delivery systems are often used to produce regulated and sustained drug release. Polymer crosslinking, which alters the structural, mechanical, and degrading characteristics of the polymer matrix, is one of the key elements affecting drug release kinetics. The porosity, swelling behaviour, and rate of degradation of the polymer are all impacted by the crosslinking process, which may be accomplished …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 636–647 Read article
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Electrospun Nanofibers for Biomedical and Pharmacological Applications
Abstract: In biological and pharmaceutical sectors, nanofibers which have unique properties including a lot of surface area, tunable porosity, and high mechanical strength are very fascinating and may be made flexibly and effectively by electrospinning. More and more in biosensors, tissue engineering, drug delivery, wound healing, and medication delivery are these electrospun nanofibers being used. They may fundamentally alter the way healthcare is administered. Advanced medical applications benefit from fibres' ability …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 375–387 Read article
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Graphene-Polymer Nanocomposites for Drug Delivery Applications
Abstract: Graphene-polymer nanocomposites (GPNCs) have gained significant attention in drug delivery due to their exceptional physicochemical properties, including high surface area, mechanical strength, tunable functionality, and biocompatibility. These nanocomposites integrate graphene derivatives, such as graphene oxide (GO) and reduced graphene oxide (rGO), with biocompatible polymers to enhance drug loading efficiency, stability, and controlled release. Various natural (chitosan, alginate) and synthetic (PLGA, PEG, PCL) polymers are used to functionalize graphene, enabling targeted …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 362–374 Read article
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Pharmacokinetics and Stability of Polymer-Encapsulated Drugs
Abstract: Making drugs that are covered by plastics is a fresh and useful way to make medicines work better, last longer, and treat diseases better. Putting drugs inside polymer materials helps them breakdown better, stays in the body longer, and lowers the number of side effects they cause. This is necessary to slowly release the drug and help people stick to their treatment plan. Polymers are used to wrap drugs. This …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 349–361 Read article
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Comparison of Several Clinical Scoring Systems in Predicting the Outcome of Variceal Bleeding
Abstract: Background: Stratification of variceal bleeding patients into high-risk and low-risk group is very important to guide them through the suitable clinical pathway and to save the medical costs. We purposed to find out the best scoring system in the prediction of rebleeding and death after variceal bleeding by comparing four clinical scoring systems(clinical Rockall score, complete Rockall score, AIMS65 score, Child-Pugh score) which seemed to be applicable and simple. Method: …
Published in Research and Reviews: A Journal of Medicine · Vol. 15, Issue 2, 2025 Read article
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Library Development: Transition from Traditional to Artificial Data
Abstract: Presently, conventional libraries, although using information tools, are encountering difficulties in effectively managing books. Traditional libraries must embrace innovation and adapt to the AI society in this technological age. Internet-of-things (IoT) technologies have the capability to collect data in real-time. By implementing business process re-engineering, it is possible to improve and optimize certain procedures. Implementing an AI library management system that incorporates IoT and automates the fundamental operations of a …
Published in Journal of Advancements in Library Sciences · Vol. 12, Issue 1, 2025 · pp. 33–39 Read article
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Remote Monitoring Sensor Systems and Applications in Health Informatics: Fostering Shell Programming
Abstract: The fascination of sensor systems has been promising for health informatics as their direct initiative for real-time information by observing its accuracy that was required at the time for data collection, monitoring and analysis to improve patient well-being and health system administering. By integrating these systems with wearable devices, biomedical sensors, and other IoT-enabled technologies, patients can experience continuous health tracking, early disease detection, and remote patient monitoring. For example, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 2, 2025 Read article
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Successful Treatment of Clinical Ketosis in Dairy Cattle
Abstract: Ketosis is a post-parturient metabolic disease encountered in high yielders due to imbalance in production and feeding leading to gluconeogenesis along with formation of abnormally high levels of ketone bodies. The disorder is particularly seen within the first few weeks after calving. It arises due to a negative energy balance when energy demands for milk production exceed dietary energy intake, leading to excessive mobilization of body fat reserves and resulting …
Published in Research and Reviews : Journal of Dairy Science and Technology · Vol. 14, Issue 2, 2025 · pp. 1–4 Read article
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Assessing the Socioeconomic Impacts of Land Tenure Systems Across Different Regions
Abstract: Land tenure systems are fundamental in shaping the socioeconomic structure and dynamics of communities across the globe. These systems, which define the legal and customary relationship between individuals, groups, and the land they own, use, or occupy, hold significant implications for economic development, social equity, and environmental sustainability. They determine how land resources are accessed, managed, and transferred, thereby influencing economic activities, wealth distribution, and community stability. This article provides …
Published in International Journal of Land · Vol. 2, Issue 1, 2025 · pp. 24–27 Read article
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Drone Safety Protocols Developing and Implementing Safety Procedures
Abstract: The increasing utilization of drones across various sectors, including agriculture, logistics, surveillance, and recreational activities, necessitates the establishment of robust safety protocols to mitigate risks associated with their operation. This study explores the development and implementation of comprehensive safety procedures for drone operations, focusing on both regulatory compliance and technological advancements. The study emphasizes how crucial it is to comprehend the legal frameworks set forth by aviation authorities, including the …
Published in International Journal on Drones · Vol. 1, Issue 1, 2025 · pp. 44–49 Read article
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Healthcare IT Innovations: Blockchain Technology for Healthcare Data Security and Privacy
Abstract: The healthcare sector has undergone a significant digital transformation, leading to the generation and sharing of vast quantities of sensitive medical data. While this digitization has improved patient care and outcomes, it has also introduced critical challenges related to data security and privacy. The increasing rate of data breaches in healthcare puts patient confidentiality at risk, mainly leading to identity theft, financial fraud, and loss of public trust in healthcare …
Published in International Journal of Information Security Engineering · Vol. 3, Issue 2, 2025 · pp. 01–12 Read article
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A Study on Mental Health, Psychological Support and Life Satisfaction For Tribal Community In Nilgiris-TN
Abstract: This research investigates the mental health challenges, psychological support systems, and overall life satisfaction among tribal communities in the Nilgiris district of Tamil Nadu. These indigenous groups, including the Todas, Kotas, Irulas, and Kurumbas, are undergoing significant social transitions due to modernization, environmental change, and cultural shifts: factors that increasingly influence their mental well-being. The primary objectives of this study are to assess the prevalence of mental health issues such …
Published in International Journal of Community Health Nursing And Practices · Vol. 3, Issue 2, 2025 · pp. 41–45 Read article
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The Relationship between Presentation of Online Self and Conscientiousness in Emerging Adults in India
Abstract: With the rise of social media use, understanding how individuals curate their online presence and experiment with different aspects of their digital identity is crucial in determining whether their online self is an extension of their offline identity or a distinct construct. This necessitates an examination of personality traits, particularly conscientiousness, to explore its role in online self-expression. Existing research suggests that individuals with high conscientiousness tend to maintain consistency …
Published in International Journal of Behavioral Sciences · Vol. 2, Issue 2, 2025 · pp. 38–45 Read article
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Impact of Training Program on Recent Innovations in Oncology Among Nursing Professionals
Abstract: Introduction: In recent years, there have been significant advancements and trends in the field of oncology treatment in India. This study aimed to evaluate impact of training program on knowledge regarding recent innovations in oncology among nursing professionals. After ethical approval, a pre-experimental, one group pretest- post-test design was used to conduct this research at anursing college of Punjab. Methods: The sample was selected using the total enumerative sampling technique. …
Published in International Journal of Oncological Nursing and Practices · Vol. 3, Issue 1, 2025 · pp. 9–14 Read article
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Evaluating Delay Impacts: From Root Cause Analysis to Dispute Resolution
Abstract: Construction projects inherently involve complex coordination among multiple stakeholders, interdependent tasks, and unpredictable external challenges, which frequently cause schedule overruns and disputes. Traditional contractual mechanisms—such as extensions of time (EoT), liquidated damages, and force majeure clauses—serve to define responsibilities, allocate risk, and establish formal dispute pathways when delays arise. For example, EoT provisions protect contractors from penalties when delays are beyond their control, provided proper notice and evidence are submitted …
Published in Journal of Structural Engineering and Management · Vol. 12, Issue 3, 2025 · pp. 11–25 Read article
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Investigating The Alkalizing Potential of Chandanasava For Restoring Acid-Base Homeostasis in Renal Tubular Acidosis: A Computational and In Silico Pharmacological Study
Abstract: Chandanasava, a traditional Ayurvedic formulation, is recognized for its potential alkalizing properties, which may help restore acid-base homeostasis in conditions such as renal tubular acidosis (RTA). This study aims to investigate the active components of Chandanasava and their interactions with key renal target proteins, Pendrin and Carbonic Anhydrase II, which are essential for maintaining acid-base balance. An in silico approach was utilized to explore the pharmacological potential of the phytochemicals …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 2, 2025 · pp. 28–52 Read article