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1375 articles for “Pre-clinical”
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Pharmacoepigenomics of Replication Timing: How Anti- Cancer Drugs Reshape Chromatin Domains and Mutational Landscapes.
Abstract: DNA replication timing serves as a fundamental epigenetic feature that organizes genome function during the cell cycle (3), while anti-cancer drugs profoundly alter this process to disrupt tumor growth(4). These agents target chromatin architecture, shifting replication domains and reshaping mutational patterns critical for cancer evolution (1,5). DNA replication timing (RT) domains serve as dynamic epigenetic organizers, partitioning the genome into early- and late-replicating regions that correlate with chromatin states, gene …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 · pp. 41–50 Read article
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Adaptive Drift Correction in Polymer-Based Wearable Biosensors via Data-Driven Signal Modeling
Abstract: Polymer-based wearable biosensors have emerged as a promising technology for continuous health monitoring due to their mechanical flexibility, biocompatibility, and suitability for long-term physiological interfacing. However, prolonged exposure to biofluids, environmental variability, and mechanical deformation introduces signal drift, which significantly degrades measurement accuracy and limits clinical reliability. This paper presents a data-driven methodology for compensating signal drift in polymer-based wearable biosensors using adaptive signal processing and machine learning techniques. The …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 131–139 Read article
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Comparative Analysis of the Structural Integrity and Dimensional Stability of Additively Manufactured Biopolymers vs. Thermoformed PETG: A 1-Year Retrospective Study on Polymer Performance in Orthodontic Applications
Abstract: Objective: This study aimed to evaluate the long-term dimensional accuracy and structural performance of direct 3D-printed biopolymers compared to conventional vacuum-formed Polyethylene Terephthalate Glycol (PETG) composites. The investigation focused on how different polymer processing methods (additive manufacturing vs. thermoforming) influence material thinning and resistance to occlusal stress. Methods: A retrospective analysis was conducted on 60 cases (n = 60) of post-orthodontic maintenance. The sample was divided into two cohorts: Group …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 140–146 Read article
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Antioxidants in Dentistry: Clinical Significance and Controversies
Abstract: Antioxidants are extensively used in routine general clinical practice in the present era. Oxidative stress plays an important role in the etiology of various oral lesions. Increased incidence of oral cancer and potentially malignant disorders, where the oral environment is damaged by the production of free radicals warrants the need for research and evidence in the use of antioxidants in the field of dentistry. Keywords: Antioxidants, free radicals, oxidative stress
Published in Research and Reviews: A Journal of Dentistry · Vol. 4, Issue 3, 2013 · pp. 1–5 Read article
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Bone in Periodontal Health and Diseases: A Scoping Review
Abstract: Bone resorption is a basic physiologic process and central to the understanding of many key pathologies. Alveolar bone destruction is a hallmark of periodontal disease progression and its prevention is a key clinical challenge in treatment of periodontal disease. Bone loss is mediated by the host immune and inflammatory response to the microbial challenge. As individuals are not equally susceptible to the destructive effects of periodontal infections therefore, it is …
Published in Research and Reviews: A Journal of Dentistry · Vol. 12, Issue 1, 2021 · pp. 1–12 Read article
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Global Polio Eradication: Opportunities and Challenges
Abstract: Poliomyelitis (polio) is a disease of public health importance that occurs mainly in children. In a small percent of infected children, the virus invades central nervous system that could result in paralysis. Now, the global eradication of polio is considered to be in the final stage. By 2002, three World Health Organization (WHO) regions (the Americas, Western Pacific and European regions) had been certified as polio-free. Since the start of …
Published in Research and Reviews : A Journal of Immunology · Vol. 4, Issue 1, 2014 · pp. 8–12 Read article
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The HbA1C Values Used in Diagnosis of Diabetes in India: A Review
Abstract: Diabetes mellitus (DM) is a chronic metabolic disorder associated with retinopathy, nephropathy, cardiovascular disorder and other lethal complication of organ system. It has huge burden globally and expected to grow more in upcoming years; with alarming presence in epidemic proportions in countries like India and China. India currently faces challenges to handle the potential burden of DM which demands accurate and precise diagnosis by various clinical parameters. Since 2009, HbA1c …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 3, Issue 3, 2016 · pp. 15–19 Read article
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Cystitis in an Adult Buffalo—A Case Report
Abstract: An adult buffalo with history of fever, anorexia, and frequent urination with turbid urine for two days was presented to the hospital. Microscopic examination of urinary sediment revealed presence of pus cells, erythrocytes, bacteria and desquamated epithelial cells. Haematology revealed leukocytosis with neutrophilia. Concentrations of blood urea nitrogen and serum creatinine were higher than normal values. Ultrasonography examination revealed presence of mixed echogenic contents with hyperechogenic bladder wall. Based on …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 6, Issue 2, 2017 · pp. 21–22 Read article
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Evaluation of Antioxidant Activity of Coumarin Isolated from Eupatorium triplinerve
Abstract: Eupatorium triplinerve (Asteraceae) is a slender herb with narrow lanceolate leaves. Extract of the plant is used as antiseptic, and in the treatment of various ulcers and haemorrhages. Ayapana is a rich source of naturally occurring coumarin chemicals. Coumarins are chemical compounds found in many plants and which usually have a sweet scent—much like newly-mown hay. Coumarin has clinical value as the precursor for several anticoagulant drugs; most notably, one …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 1, Issue 1, 2014 · pp. 18–22 Read article
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Data to Diagnosis: A Systematic Review of AI/ML in Healthcare
Abstract: Artificial Intelligence (AI) and Machine Learning (ML) are fast revolutionizing the diagnosis of healthcare by augmenting accuracy, speed, and efficiency. AI/ML technologies facilitate earlier and more accurate disease identification with advanced algorithms for image processing, predictive modelling, and pattern recognition, frequently outperforming conventional diagnostic techniques. This review delves into the key contribution of AI/ML in contemporary healthcare, such as its use in clinical data analysis, imaging reports, and patient histories …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 3, Issue 2, 2025 Read article
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Antimicrobial Resistance and AI-Based Strategies for Rapid Pathogen Detection
Abstract: Antimicrobial resistance (AMR) has become a major global health threat, significantly reducing the effectiveness of antimicrobial therapies and increasing the burden of infectious diseases worldwide. The rapid emergence of multidrug-resistant pathogens has created an urgent need for faster, more accurate, and scalable diagnostic approaches to support timely treatment and effective infection control. Artificial intelligence (AI) has emerged as a promising technology capable of transforming pathogen detection and AMR surveillance through …
Published in Recent Trends in Infectious Diseases · Vol. 3, Issue 2, 2026 · pp. 26–36 Read article
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Significance of Randomized Clinical Trials
Abstract: The most exacting and reliable research tool for determining if there is a cause-and-effect relationship between an intervention and a result is the randomized controlled trial. When assessing the efficacy and safety of an intervention, a randomized controlled trial can produce high-quality evidence. Every randomized controlled trial (RCT) ought to have predetermined primary outcomes, be registered with a clinical trials database, and possess the necessary ethical permissions. The quality of …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 13, Issue 3, 2023 · pp. 12–16 Read article
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Study of Leucocyte Count, Serum Bilirubin and C-Reactive Protein Values in Preoperative Diagnosis of Acute Appendicitis
Abstract: Acute appendicitis is one of the most common surgical emergencies all over the world. In appendicular perforation, morbidity and mortality increases significantly. A prompt diagnosis and early surgery can only be done if clinical findings are supported by laboratory tests. To estimate preoperative serum leukocyte count, total bilirubin and C-reactive protein levels in patients with clinical diagnosis of acute appendicitis and compare them with histopathological diagnosis postoperatively. Cross sectional study …
Published in Research and Reviews : Journal of Surgery · Vol. 4, Issue 1, 2015 · pp. 20–26 Read article
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Isolation of Bacteria in Dogs with Recurrent Pyoderma in Andhra Pradesh
Abstract: The present study was carried out on 46 dogs having a history of recurrent pyoderma. . Clinical samples were collected aseptically from the skin lesions of the affected dogs and subjected for cultural examination. Seventy one isolates were recovered from the 46 clinical samples. Isolation studies revealed the presence of Staphylococcus aureus 11 (23.9%), Staphylococcus intermedius 27 (58.6%) and Staphylococcus schleiferi 8 (17.3%). other bacteria like Streptococci 8(17.3%), Klebsiella 8 …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 4, Issue 3, 2014 · pp. 15–18 Read article
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An Overview of Anticoagulants in Treatment of Thrombosis and Related Disorders: A review
Abstract: With the increasing ageing of population, clinicians are encountering patients with atrial fibrillation and venous thromboembolism who require anticoagulant therapy to prevent stroke and systemic embolism. Due to its high prevalence and unfavorable results, the treatment of thromboembolic disease has become a clinically important area. Traditional anticoagulants such as heparin, low molecular weight heparin, and warfarin have been used to prevent and treat venous and arterial thrombosis. However, bleeding problems, …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 13, Issue 2, 2023 · pp. 1–8 Read article
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Efficacy of Educational Intervention on Knowledge Regarding High-Risk Pregnancy and Its Management in Terms of Knowledge Gain Among Antenatal Women
Abstract: Background: High-risk pregnancies are associated with increased maternal and fetal complications and require timely identification and proper management. Many antenatal women have limited knowledge regarding high-risk conditions and the necessary precautions. Structured teaching programs can significantly improve awareness and empower mothers to take proactive steps for safe pregnancy outcomes. Aim: To assess the effectiveness of a structured teaching program on knowledge regarding high-risk pregnancy and its management among antenatal women …
Published in Research and Reviews: A Journal of Health Professions · Vol. 16, Issue 1, 2026 · pp. 1–5 Read article
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A Short Review on Mucormycosis/Black fungus
Abstract: The present article provides an outline regarding the mucormycosis, an angio invasive infection and an opportunistic condition with fungal infection that mainly targets the people who are with weaker immunity unable to fight with environmental pathogens due to other health related problems and people who are on long term medication and the present paper has been covered with all the information regarding the Predisposing factors, suspected diseased conditions, Targeted organs/tissues …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 10, Issue 1, 2021 · pp. 12–15 Read article
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Multimodal Disease Detection Using Deep Learning
Abstract: Artificial Intelligence (AI) is playing an increasingly pivotal role in modern healthcare, particularly in improving the speed and accuracy of disease detection. With the evolution of Machine Learning (ML), Deep Learning (DL), and high-performance computing, AI-based solutions are now capable of processing extensive medical datasets, ranging from patient records to diagnostic images, with remarkable efficiency. These systems offer immense potential for early intervention, improved clinical decision-making, and alleviating pressure on …
Published in Journal of Computer Technology & Applications · Vol. 16, Issue 2, 2025 · pp. 129–139 Read article
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Pharmacovigilance And Drug-Induced Toxicities: A Clinical Perspective
Abstract: Pharmacovigilance, which aims to detect, assess, and prevent medication-induced toxicities and adverse drug reactions (ADRs), is a crucial part of healthcare. This study examines the several kinds of drug-induced toxicities, such as idiosyncratic, dose-dependent, and allergic reactions, and emphasizes the function of clinical pharmacists in the tracking and treatment of these illnesses. Pharmacovigilance systems are crucial because they can identify and handle drug-related safety issues that might not surface during …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 3, 2024 · pp. 17–30 Read article
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Management of Kosthasakhashrita Kamala W.S.R. to Hepatocellular Jaundice – A Case Study
Abstract: Kosthasakhāśrit Kamala is a well-recognized clinical entity in Ayurveda and is widely correlated with modern hepatocellular jaundice. The condition arises primarily due to the vitiation of Pitta dosha within the Kostha (gastrointestinal tract), which subsequently spreads to the Sakha (peripheral tissues). Classical texts describe hallmark features such as Haridra Netra (yellowish discoloration of the eyes), yellowish hue of twak and nakha, pitta varṇa of mutra and sakrit (yellow urine and …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 15, Issue 1, 2026 · pp. 1–8 Read article