Search
320 articles for “system biology”
-
Polymer Chemistry-Guided Development of Biomimetic Composite Scaffolds
Abstract: Polymer chemistry plays a fundamental role in advancing biomaterials for anatomical tissue engineering, particularly in the design of composite scaffolds that replicate the intrinsic characteristics of native tissues. The regeneration of damaged tissues, especially within anatomically complex structures such as bone, cartilage, and skin, necessitates biomaterials that closely emulate the hierarchical architecture and biological functions of native extracellular matrices (ECMs). The capacity to replicate both mechanical and biochemical cues of …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 7–13 Read article
-
A Comprehensive Review of Analytical Method – Development and Method Validation of Digoxin Tablets
Abstract: The main objective of this review is to give an outline of the method development and validation process of digoxin, and this review covers the different types of spectroscopic and chromatographic techniques, such as HPLC, UHPLC-Tandem mass spectroscopy, TLC, and LC-MS. A novel method for the determination of digoxin in biological samples has been developed and validated, focusing on improving sensitivity, specificity, and reproducibility. The method was validated in terms …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 47–58 Read article
-
Langhana- A boon to mankind: A Review
Abstract: In present scenario of hush and rush of life, we forget to take care of our health taking it for granted. Main factors contributing to lifestyle disorders include filthy food habits, physical inactivity, and disturbed biological clock. All of this leads to poor health, decreased immunity leading to easy susceptibility to different diseases. Ayurveda is an old age practice of healing. It not only aims at the treatment of disease …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 7, Issue 1, 2020 Read article
-
Crossroads of Ecology and Medicine: Evaluating Pollutant-Induced Risks to Biodiversity and Human Health
Abstract: Environmental pollution has emerged as a central challenge at the crossroads of ecology and human medicine. The rapid pace of industrialization, urbanization, and agricultural intensification has led to an unprecedented release of pollutants into the air, water, and soil—triggering cascading effects on ecosystems and human health. Pollutants such as particulate matter, heavy metals, pesticides, microplastics, endocrine-disrupting chemicals, and persistent organic pollutants not only degrade biodiversity but also exert multifaceted health …
Published in International Journal of Environmental Noise and Pollution Control · Vol. 3, Issue 1, 2025 · pp. 41–53 Read article
-
Tsetse Flies and African Trypanosomiasis: Biology, Epidemiology, and Integrated Vector Control.
Abstract: Tsetse flies (Glossina spp.) are hematophagous dipterans confined to sub-Saharan Africa and serve as cyclical vectors of human African trypanosomiasis (HAT) and African animal trypanosomiasis (AAT), with major implications for human health, livestock productivity, and rural development. An integrated understanding of tsetse biology, parasite transmission, climate, and land–use–driven distribution shifts, and the comparative performance of control tools—especially insecticides and sterile insect technique (SIT)—is essential for designing sustainable elimination strategies. HAT …
Published in International Journal of Insects · Vol. 3, Issue 1, 2026 · pp. 21–28 Read article
-
Systemic Lupus Erythematosus Revisited: A Milestones in Classification, Mechanistic Insights on Pathogenesis, Diagnosis, and Evolving Treatment Paradigms
Abstract: Systemic lupus erythematosus (SLE) is a prototypic, multi-systemic chronic inflammatory autoimmune disorder characterized by extreme clinical heterogeneity and the potential to involve virtually any organ or tissue. The condition is driven by a fundamental breakdown in immune tolerance, resulting in the overproduction of pathogenic autoantibodies and the formation of immune complexes that precipitate widespread inflammation and organ damage. This review aims to provide an exhaustive synthesis of recent developments in …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 3, 2026 Read article
-
A Review on Zinc Oxide Nanoparticles Based on Photocatalytic Activity
Abstract: The Zinc Oxide (ZnO) is a photocatalyst which is available for photoreaction system by using the metal oxide (MO) degradation present ultraviolet irradiation at high temperature. The removal rate of metal oxide (MO) was observed in zinc oxide has been reached up to 99.73, 99.29 and 99.70%. The composite ratio was increased from 2:1 to 4:1 after 30 minutes and continuously this ratio was also increased up to 5:1. Hence …
Published in Research and Reviews : Journal of Computational Biology · Vol. 8, Issue 1, 2019 · pp. 13–25 Read article
-
Diet-Gene Interactions in Farm Animals: Molecular Dynamics, Gene Expressions, Signalling Pathways and Precision Nutrition for Sustainable Productivity
Abstract: Diet-gene interactions represent a central mechanism through which nutrition influences growth, health, and productivity in farm animals. Recent advances in molecular biology and genetics have revealed that nutrients act not only as metabolic substrates but also as signalling molecules capable of modulating gene expression, cellular pathways, and epigenetic regulation. This review synthesizes current knowledge on the molecular dynamics of nutrient utilization in farm animals, with emphasis on nutrigenomic responses, nutrient …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 4, Issue 1, 2026 Read article
-
Tinospora Cordifolia (Willd.) Hook.f. & Thomson: A Review on Herbal Formulations and Health Benefits
Abstract: India has a vast variety of medicinal plants utilised as natural medicines since prehistoric times. Herbal medicine was the main form of treatment earlier in the 20th century because neither antibiotics nor analgesics were readily available. Nowadays, natural plant products are becoming more significant in clinical research since they have no side effects and have greater pharmacological response than allopathic medications. Tinospora cordifolia (Giloy or Guduchi) is a climbing shrub …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 13, Issue 3, 2024 · pp. 14–19 Read article
-
Quorum Sensing and Biofilm Dynamics in Pathogens: An Evolving Frontier in Infectious Disease
Abstract: Bacterial and fungal pathogens rarely act as solitary invaders. Instead, they engage in sophisticated chemical communication known as quorum sensing (QS) to coordinate population-wide behaviours and construct structured, multicellular biofilm communities. These biofilms, composed of extracellular polymeric substances, not only facilitate microbial persistence on biotic and abiotic surfaces but also confer remarkable protection against host immune defenses and antimicrobial therapies. QS systems act as central regulators of biofilm dynamics, orchestrating …
Published in International Journal of Pathogens · Vol. 3, Issue 1, 2026 · pp. 18–23 Read article
-
Urinary Tract Infection (Tadiya-e-Majra-e-Baul) in Unani System of Medicine
Abstract: In classical Unani system of medicine Tadiya-E-Majra-e-Baul. (Urinary Tract Infection) comes under the heading of Hirqatul-baul (burning micturition) which is caused by obstruction in Urinary Tract due to stone, Jisme Gharib (foreign body) Ghaliz Ghost (Badgosh), Hamal (Pregnancy), and Characterized by frequency of micturition, urgency of micturition, burning micturition and anuria . It is an Unani Medicine of Shora Qalmi, Rewand Chini and Kababchini. Having safe and good result in …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 7, Issue 2, 2020 · pp. 34–39 Read article
-
Prevalence and Treatment Outcome of Burn Injury among Pediatric Patients Attending Pediatric Emergency OPD of Hawassa University Comprehensive Specialized Hospital, Hawassa, Southern Ethiopia
Abstract: Background: Burn injury is one of the most common and devastating forms of trauma and a major health problem of pediatric morbidity and mortality worldwide resulting in substantial physical, psychological and economic loss. Burn-related injuries are a significant burden in children, particularly in low and middle-income countries (LMICs), where more than 90% of burn-related pediatric deaths occur [1]. The aim of this study was to assess the prevalence and treatment …
Published in Research and Reviews : Journal of Computational Biology · Vol. 7, Issue 3, 2018 · pp. 8–15 Read article
-
Photochemically Assisted LC–MS Method Development and Validation for Stability-Indicating Determination of Glasdegib in Rat Plasma
Abstract: A simple, precise, and cost-effective LC–MS method was successfully developed for the determination of Glasdegib in rat plasma. The method optimization was carried out by systematically varying key chromatographic parameters, including flow rate, injection volume, analyte concentration, and mobile phase composition, to achieve optimal sensitivity and resolution. A C18 Hypersil BDS column (150 mm × 4.6 mm, 3.5 µm particle size) was used for chromatographic separation, offering effective peak shape …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 4, Issue 1, 2026 · pp. 11–20 Read article
-
Physiochemical and Microbiological Analysis of Drinking Water from Public Places of Bhimdatta Municipality
Abstract: People on globe are under tremendous threat due to undesired changes in the physical, chemical and biological characteristics of air, water and soil. Due to increased human population, industrialization, use of fertilizers and man-made activity water is highly polluted with different harmful contaminants. Diseases caused by contaminated drinking water and poor hygiene practice are the leading cause of death among human population worldwide. In order to understand the quality of …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 11, Issue 1, 2021 · pp. 18–24 Read article
-
Voluntary Blood Donation, Future Willingness and Associated Factors Among Attendants of Obstetrics and Gynecology Patients in JIMA University Specialized Hospital, Oromia region, Ethiopia, 2015
Abstract: Background: Hemorrhage is the major cause of maternal death worldwide. This problem is more prevalent in developing countries including Ethiopia. Therefore, availability of adequate blood supply and timely transfusion has paramount importance in reducing maternal deaths. In this aspect, assessing practice, future willingness and associated factors towards voluntary blood donation among attendants can contribute in alleviating the scarcity of blood for transfusion.Objective: To assess voluntary blood donation, future willingness and …
Published in Research and Reviews : Journal of Computational Biology · Vol. 6, Issue 3, 2017 · pp. 1–8 Read article
-
A Systematic Review on Factors Contributing to Infertility
Abstract: Infertility is a multifactorial reproductive health condition affecting approximately 10–15% of couples worldwide and continues to represent a major clinical and social challenge. Despite substantial advances in assisted reproductive technologies, diagnostic methods, and therapeutic interventions, many couples still face difficulties in achieving pregnancy. The impact of infertility extends beyond physical health, often leading to emotional distress, social pressure, and financial burdens, especially in societies where parenthood is highly valued. Consequently, …
Published in International Journal of Tropical Medicines · Vol. 3, Issue 1, 2026 · pp. 31–35 Read article
-
Anthrax Toxin Time-Resolved Absorption and Resonance FT-IR and Raman Biospectroscopy and Density Functional Theory (DFT) Investigation of Vibronic-Mode Coupling Structure in Vibrational Spectra Analysis
Abstract: Anthrax toxin is a three-protein exotoxin that is secreted by the bacterium's virulent strains, the anthrax causative agent Bacillus anthracis. Harry Smith first found the toxin in 1954. Anthrax toxin consists of a protein called a protective antigen (PA) binding cell protein and two enzyme parts called an edema factor (EF) and a deadly factor (LF). These three protein components act together to impart their physiological effects. Assembled complexes containing …
Published in Research and Reviews : Journal of Computational Biology · Vol. 8, Issue 2, 2019 · pp. 23–51 Read article
-
CTCHFA: Discovery of Circulating Tumor Cells in Metastatic Breast Cancer and Nonmetastatic Cancer by using Novel Hybrid Hierarchical Clustering Algorithm in Firefly Distance
Abstract: AbstractBlood testing for circulating tumor cells (CTCs) has emerged as one of the highest fields in cancer research. CTC detection are an early gene marker of reaction to systemic therapy, whereas their molecular characterization has a strong field that can be translated to individualized targeted treatments and spare breast cancer (BC) patients from unnecessary and ineffective therapies. Genomic research regarding CTCs monitoring for BC is limited due to the lack …
Published in Journal of Computer Technology & Applications · Vol. 6, Issue 1, 2015 · pp. 9–18 Read article
-
SCIENTISTS REINVENT LOW ENERGY NUCLEAR REACTION (LENR)/COLD FUSION
Abstract: Two of the researchers of The University of Utah, USA in 1989 named Dr. Martin Fleishmann and Stanley Pons declared that they had discovered a sustained nuclear fusion reaction at room temperature during electrolysis experiment that could solve the problem of energy requirement on this planet. The cold fusion reaction, also called low energy nuclear reaction (LENR) takes place at room temperature, unlike conventional fusion reaction where temperature required is …
Published in Trends in Mechanical Engineering & Technology · Vol. 14, Issue 3, 2024 Read article
-
An Overview of New Coastal Research Vessel (N-CRV) Dry Dock and Construction
Abstract: A New Coastal Research Vessel (N-CRV) is a specialized ship designed for scientific research in fields like oceanography, geology, biology, and atmospheric studies, equipped with specific facilities and accommodations for sea missions. This paper discusses the coastal research ship dry-dock, construction, and design process, which involves three stages: concept, preliminary, and contract design. N-CRV must utilize scientific cruise, Exclusive Economic Zone (EEZ) survey, deployment, data collection, and seawater sample collection …
Published in Journal of Offshore Structure and Technology · Vol. 11, Issue 3, 2024 · pp. 1–11 Read article