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412 articles for “Gene targeting”
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Clinical Study of Role of Rasayana as a Pre adjuvant and Post Treatment of Chemotherapy in the Management of Carcinoma
Abstract: Integrative oncology is a novel form of medical theory which views cancer not merely as an accumulation of genetically transformed immature cells, but sum total of feelings, images, actions evoked by cancer. Not only by those afflicted with the disease, but also by their loved ones. This has been very well understood by Ayurveda. The important tool to manage the adverse reaction is Rasayana. Rasayana through their nutrient value improves …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 11, Issue 1, 2022 · pp. 5–13 Read article
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Nano-Chemical Revolution in Vaccinology: A Study
Abstract: The development of traditional vaccines, reliant on attenuated pathogens or purified proteins, has historically been limited by slow development timelines, poor stability, and low immunogenicity requiring potent, often non-specific, adjuvants. This synthesis argues that the convergence of nano-material science and meticulous chemical engineering represents the next major paradigm shift in preventative medicine. Nano-materials, particularly Lipid Nanoparticles (LNPs) and various polymeric or inorganic scaffolds, have transitioned from theoretical constructs to essential …
Published in Research and Reviews : A Journal of Immunology · Vol. 16, Issue 1, 2026 Read article
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The Role of Pyruvate Dehydrogenase in Non-Alcoholic Fatty Liver Disease: Therapeutic Insights and Future Directions
Abstract: Non-alcoholic fatty liver disorders (NAFLD) are defined by the accumulation of excess fat in the liver that has no other cause, such as drinking alcohol. Pyruvate dehydrogenase has been established as an alternative treatment for this disorder. NAFLD pathogenesis is complex and includes oxidative stress inflammatory processes and mitochondrial dysfunction. Impaired liver fatty acid oxidation and glucose oxidation are significant individuals in developing NAFLD, and strategies to reverse these defects …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 44–51 Read article
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In Silico Pharmacological Evaluation of Certain Commercially Available Terpenoids As Αlpha-Amylase Inhibitors for The Management of Diabetes Mellitus.
Abstract: The objective of this study was to investigate the α-amylase inhibitory activity of certain commercially available terpenoids using in silico docking studies. In this perspective, terpenoids like Abietane, Artemisinin, Carvone, Cucurbitane, Ferruginol, Lupeol, Nerolidol, Retinol, Sabinene, and Zingiberene were selected. Glibenclamide, a well-known antidiabetic drug was used as the standard. In silico docking studies were carried out using AutoDock 4.2, based on the Lamarckian genetic algorithm as the working principle. …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 4, 2023 Read article
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Recent Development to Track Contraband using Muon
Abstract: The muon is one of nature’s fundamental particles discovered in 1937 by Carl Anderson. A muon is an elementary subatomic particle similar to electron, but with a mass approximately 207 times greater and, sometimes it is called as a “heavy electron”. Muons are generated naturally when cosmic rays collide with atoms in earth’s upper atmosphere and, then raining down all the times upon the surface of earth. Muons can be …
Published in International Journal of Universe · Vol. 2, Issue 1, 2026 · pp. 23–34 Read article
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In Silico Pharmacological Evaluation of Certain Commercially Available Terpenoids As Αlpha-Amylase Inhibitors for The Management of Diabetes Mellitus
Abstract: The objective of this study was to investigate the α-amylase inhibitory activity of certain commercially available terpenoids using in silico docking studies. In this perspective, terpenoids like Abietane, Artemisinin, Carvone, Cucurbitane, Ferruginol, Lupeol, Nerolidol, Retinol, Sabinene, and Zingiberene were selected. Glibenclamide, a well-known antidiabetic drug was used as the standard. In silico docking studies were carried out using AutoDock 4.2, based on the Lamarckian genetic algorithm as the working principle. …
Published in Research and Reviews : Journal of Computational Biology · Vol. 10, Issue 2, 2021 · pp. 1–9 Read article
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Detection of Listeria monocytogenes in Milk and Ice Cream by Polymerase Chain Reaction
Abstract: Abstract The present study was undertaken to standardize PCR assay for detection of L. monocytogenes and Listeriolysin O from livestock foods and compare its efficacy with conventional cultural methods. A set of primer derived from iap gene and other set derived from hlyA gene were used for detection of L. monocytogenes and Listeriolysin O in the PCR assay. The PCR assay was initially standardized by optimizing the concentration of the …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 5, Issue 1, 2015 · pp. 24–35 Read article
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Recent Development Technique in Management of Cancer
Abstract: Cancer develops when a change in one's genetic makeup leads to the development of tumour cells. These clusters of malignant cells eventually develop into tumours. Tumours can shed cancerous cells, which can then travel through the lymphatic system or the circulatory system to other organs. In the medical field, this occurrence is referred to as metastasis. Cancer cells proliferate even when they have no instructions to do so. Despite the …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 1, 2024 · pp. 25–41 Read article
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Smart Horizons: Innovating Sustainability for Tomorrow’s World
Abstract: The idea of maintainable improvement has acquired a ton of consideration as of late and a few savvy developments and drives are taken which can upgrade its execution and can assist with facilitating our work and show progress to it as this large number of drives can work on our ecological circumstances. The critical need to address environmental change has ignited a worldwide push toward accomplishing net zero ozone depleting …
Published in Journal of Energy, Environment & Carbon Credits · Vol. 15, Issue 3, 2025 · pp. 48–53 Read article
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Research on Adversarial Disturbance Based on Meteorological Time Series Data
Abstract: When the deep learning model is used to predict time series data, it is easy to be adversarially attacked. The time series data is sensitive to the abnormal disturbance and has strict requirements on the disturbance amount. To solve these problems, we propose to generate adversarial time series by adding disturbance terms to the original time series, and design an adversarial attack algorithm based on the importance measure (AAIM in …
Published in Journal of Industrial Safety Engineering · Vol. 9, Issue 3, 2022 · pp. 1–19 Read article
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Design of an Automatic Device Controller Based on Temperature Sensing by Using Verilog HDL Targeting an FPGA
Abstract: To get a single controller that is capable to produce some control signal depending on sensing temperature is getting popularities for industrial and home applications. In this paper uses an LM34 Precision Fahrenheit Temperature Sensor IC and an ADC0820 8-Bit, high-speed, µP-compatible flash A/D converter IC in order to design and implement the mentioned controller onto a SPARTANTM-II Field Programmable Gate Array (FPGA) by using DigilentTM Pegasus SPARTAN-II FPGA Board, …
Published in Journal of Control & Instrumentation · Vol. 3, Issue 1-3, 2012 · pp. 6–16 Read article
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Role of Social Media in General Elections 2024 in India
Abstract: The role of social media in the 2024 general elections in India is poised to be a transformative force, significantly impacting political communication, voter engagement, and campaign strategies. With nearly one-third of the electorate having consistent access to social media, this election marks a critical juncture in Indian democracy, reflecting the rapid evolution of digital platforms as vital tools for political outreach and discourse. This shift follows a historical trajectory …
Published in Recent Trends in Social Studies · Vol. 2, Issue 2, 2025 · pp. 50–60 Read article
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Harnessing Polymer Chemistry for Pharmaceutical Technology
Abstract: Polymer chemistry has emerged as a cornerstone of modern pharmaceutical technology, offering unprecedented control over drug formulation, delivery, and therapeutic performance. This review highlights the pivotal role of polymers—both synthetic and natural—in revolutionizing drug delivery systems across various routes, including oral, parenteral, transdermal, ocular, nasal, and pulmonary administration. Special emphasis is placed on the structural and functional versatility of polymers, which allows for tailored drug release profiles, enhanced bioavailability, and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1–6 Read article
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Green Synthesis of Copper Nanoparticle for the Treatment of Neurodegenerative Disease
Abstract: The study of ecologically friendly CuNP synthesis is a growing area with potential applications in biomedical research and environmental remediation, as well as sustainable nanotechnology. Generally, reducing, and stabilizing agents such as microbes, plant extracts, or other natural sources are used. The green synthesis methodology guarantees the production of nanoparticles with desired characteristics for biomedical applications while simultaneously mitigating the environmental effect that comes with conventional chemical processes. CuNPs possess …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 1, 2024 · pp. 13–24 Read article
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Introduction to Biological Networks and their Contributions to Systems Biology
Abstract: Biological networks provide a conceptual framework to represent and analyze the intricate interconnections among the numerous components that make up living systems. This review paper elucidates the foundational principles of networks and their diverse applications in systems biology, highlighting their crucial role in understanding the inherent complexity of biological processes. Utilizing graph theory, these networks represent entities like genes, proteins, and metabolites as nodes, with their interactions depicted as edges. …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 1, 2024 · pp. 53–70 Read article
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A REVIEW: P-GLYCOPROTEIN AND ITS ROLE IN CANCER
Abstract: Abstract The review is done on how P-glycoprotein recognizes various substrates and plays a key role in cancer. Chemotherapy is used for cancer treatment but multidrug resistance of cancerous cell is the major obstacle in therapy and also an important aspect which causes failure in the treatment by effluxion of a xenobiotic on the plasma membrane. In humans, P-glycoprotein is important transmembrane transporter. It is located on the apical surface …
Published in Trends in Drug Delivery · Vol. 7, Issue 2, 2020 · pp. 26–34 Read article
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TOXICOLOGY: Present-Day Difficulties for Investigating Safety Science and Target Safety Evaluation of Major Human Hepatocytes
Abstract: Preclinical toxicology has developed into a more thorough understanding of toxicity pathways from its descriptive beginnings. Technological developments have made it possible to forecast safety occurrences, mitigate adverse effects, and create safety biomarkers. Because they are able to self-renew and specialize into different types of human body cells, stem cells are currently being employed for in vitro toxicological applications. However, as compared to primary human hepatocytes, stem cell-derived HLCs perform …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 3, 2024 · pp. 31–40 Read article
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Partial Replacement of Sand with Waste PET in Concrete
Abstract: Plastic solid waste generation increases per annum with the present current consumption habit prevalent within the society nowadays. The improper disposal of plastic has been a serious concern to the environment because it isn't easily degradable. the difficulty of environmental pollution caused By Polyethelene Terephthalates (PET) has been extensively discussed and therefore the best solution proposed is recycling. Therefore, one among the potential means to the matter is to recycle …
Published in Journal of Structural Engineering and Management · Vol. 7, Issue 3, 2020 · pp. 24–28 Read article
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Quantitative Mass Balance Modelling for the Synthesis and Production of Ten High-Volume Insecticides
Abstract: This study presents a detailed quantitative mass balance analysis for the industrial synthesis and production of ten high-volume insecticides: acequinocyl, acetamiprid, acynonapyr, alpha-cypermethrin, benzpyrimoxan, bifenazate, bifenthrin, bistrifluron, broflanilide, and bromofos, focusing on material flows, process efficiencies, and environmental implications. These compounds, spanning diverse chemical classes like neonicotinoids, pyrethroids, and meta-diamides, are essential for crop protection but pose challenges due to resource-intensive syntheses and waste generation. For each insecticide, standardized manufacturing …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 16, Issue 3, 2025 · pp. 36–55 Read article
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Carbon Nano Tubes: New Techniques for Cancer Treatment
Abstract: Carbon Nano tubes (CNTs) have been recently introduced as a novel carrier system in the biomedical field and produce small and large therapeutic molecules. CNTs have attracted increasing attention for their versatile applications. Based on layers of CNTs, CNTs are generally divided into two categories: single-walled carbon Nano tubes (SWCNTs), multi-walled carbon Nano tubes (MWCNTs). It shows the unique properties and cylindrical shape structure. It shows a greater advantage in …
Published in Trends in Drug Delivery · Vol. 5, Issue 1, 2018 · pp. 28–39 Read article