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508 articles for “Anti – infective”
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Study of the Antimicrobial Potential of Consortiums of Hot Alcoholic Extract of Plants against Multidrug Resistant Bacteria Including One Vancomycin-Resistant Staphylococcus aureus (VRSA)
Abstract: Increasing antibiotic resistance exerts threatening implications in human health care. It subsequently increases the need to develop an alternative strategy to counter the growing concern against the superbug infection in open wounds. In the present study, two combinations of herbal alcoholic extracts have been assessed for antimicrobial activity against the isolates collected from human burn wound sample and biopsies. Total of 42 strains have been isolated and screened for its …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 9, Issue 3, 2019 · pp. 18–25 Read article
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Evaluation of Antimicrobial Activity of Some Medicinal Plants against Most Prevalent Diabetic Wound Pathogens
Abstract: The present research work attempts to evaluate antimicrobial activity of 90% ethanolic extracts of three traditional medicinal plants viz. Terminalia bellirica, Terminalia chebula, Pyhllanthus emblica. Since ethanol is the best solvent for dissolving antimicrobial compound present as active phytoconstituents in plants, these plants were extracted with ethanol. Each extract was tested for its antimicrobial activity against three most prevalent pathogenic microorganism associated with diabetic wounds, viz. Staphylococcus aureus (MTCC3160), Pseudomonas …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 4, Issue 1, 2015 · pp. 13–20 Read article
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Microbiological Study of Respiratory Tract Infections in a South Indian Hospital
Abstract: This study was aimed to determine the common and clinically significant bacteria isolates in this environment. A retrospective study was conducted in the Rajiv Gandhi Institute of Medical Sciences for the period of 6 months. Case sheets & microbiological reports from general medicine department were included in the study and out patients in general medicine department and other departments were excluded from this study. Klebsiella sps. (15.8%) was more prevalent …
Published in Research and Reviews: A Journal of Health Professions · Vol. 5, Issue 2, 2015 · pp. 1–5 Read article
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Perceptions of Health Care Providers and the Community on the Management of Possible Serious Bacterial Infection (PSBI) in Young Infants where Referral is not Possible: A Qualitative Study
Abstract: Introduction: Every year, about 2.8 million children die in the first month of life, with 98% of these deaths occurring in developing countries. The current World Health Organization recommendation for management of infections in neonates and young infants (0–59 days old) is referral for hospital treatment with a 7 to 10 day course of a combination of two injectable antibiotics – Penicillin or Ampicillin plus Gentamicin. However, existing evidence demonstrates …
Published in Research and Reviews : A Journal of Immunology · Vol. 7, Issue 3, 2017 · pp. 23–27 Read article
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The Role of Polymers and Composites in the Development of a Dental X-ray Film Holder
Abstract: The advancement of dental devices has been significantly influenced by the development of polymer-based materials and composite structures. This paper explores the role of polymer chemistry in the design and manufacturing of a dental X-ray film holder, highlighting its impact on performance, safety, and sustainability. The use of biodegradable, durable, and patient-friendly polymer composites enhances the functionality and comfort of these dental tools, making them more cost-effective and efficient for …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 323–331 Read article
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Magnitude and Factors Associated with Tetanus Toxoid Vaccination among Female Youth in Mekelle City, Ethiopia: A Community Based Cross-Sectional Study
Abstract: Introduction: Tetanus can occur worldwide, and, in all age-groups, who acquire the infection through unhygienic conditions and in the youths, who have insufficient antitoxins due to no or sub-optimal immunization to protect themselves and their newborn babies. Objectives: To assess the magnitude and factors associated with tetanus toxoid immunization among female youths in Mekelle City, Tigray Regional state, Ethiopia. Method: Community based cross sectional study design was conducted. A total …
Published in Research and Reviews: A Journal of Health Professions · Vol. 9, Issue 3, 2019 · pp. 11–21 Read article
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Formulation Development and Evaluation of Opthalmic Ocusert Containing Timolol Maleate
Abstract: The aim of formulating timololmaleate occusert was to prolong the drug residence time after ocular administration to achieve the controlled release of drug. Timolol maleate is an antiviral agent and it is used in the treatment of viral infections like herpes simplex infections. Ocular inserts were prepared by solvent casting method. Drug reservoir and rate controlling membrane were prepared using different hydrophilic and hydrophobic polymers respectively with polyethylene glycol 400 …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 4, Issue 1, 2017 · pp. 8–12 Read article
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Formulation and Evaluation of Transungual Drug Delivery of Fluconazole Using Permeation Enhancers Screened by Hydration of Nail Plate
Abstract: The objective of the work was to formulate nail lacquer containing fluconazole an antifungual drug for the treatment of onychomycosis. Onychomycosis, a common fungal nail infection affects the people. Topical and ungual therapy is limited because of the poor permeation of the drug through nail plate. Film base was prepared using varying concentration of cellulose acetate and ethyl cellulose as polymers. The permeation enhancers were screened by nail plate hydration. …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 3, 2017 · pp. 32–45 Read article
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Unmasking Human Metapneumovirus: The Emerging Threat to Vulnerable Populations
Abstract: Human Metapneumovirus (HMPV) is a contagious respiratory virus that commonly spreads among individuals. It can cause serious infections, especially in high-risk groups like infants, older adults, and individuals with weakened immune systems.It is a major contributor to acute respiratory illnesses. Since its discovery in 2001, HMPV has been identified as a common cause of both upper and lower respiratory tract illnesses, with clinical presentations ranging from mild symptoms to severe …
Published in International Journal of Virus Studies · Vol. 2, Issue 1, 2025 · pp. 16–24 Read article
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Computational Identification of Antigenic Proteins and Epitopes in Hantavirus sp. for Drug Repurposing
Abstract: Hantavirus is an emerging virus that spreads from animals to humans and can cause serious illnesses like hantavirus pulmonary syndrome (HPS) and hemorrhagic fever with renal syndrome (HFRS). there are no FDA-approved treatments available for these diseases. This study explores in-silico drug repurposing as a strategy to identify potential therapeutic candidates. The physicochemical, secondary structure, antigenicity, and post-translational modification analysis of hantavirus proteins – specifically the glycoprotein precursor, N protein, …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 20–26 Read article
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Excoecaria agallocha Extract from Leaves Encounters Antifungal, Antibacterial, and Cytotoxic Activity – In Vitro Studies
Abstract: Mangroves contain a wide range of bioactive substances, certain of and these have been used as solutions for a variation of conditions for thousands of years. Excoecaria agallocha leaf application components have been extracted in the presence of organic solvents along with water-based with a Soxhlet apparatus and antibacterial research properties employing diffusion agar well assays towards nine different kinds of culture infectious agents, six clinical trials isolated compounds, as …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 2, 2025 · pp. 1–7 Read article
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A Cross-Sectional Study on Prevalence and Seasonal Trends of Malaria and Dengue and Their Co-infection in Patients with Acute Febrile Illness Attending a Tertiary Care Hospital in Jhalawar, Rajasthan
Abstract: Unknown etiologies behind acute febrile illnesses make treatment choices tough for clinicians resulting high mortality rates amongst the vulnerable populations. Vector borne diseases viz. malaria and dengue are the major stake holders responsible for AFI. Determination of their individual as well as concurrent prevalence is important for disease control. The present study aimed to determine the prevalence and seasonality of malaria and dengue and their co infection in acute undifferentiated …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 7, Issue 1, 2017 · pp. 9–14 Read article
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Antimicrobial Peptides and Bacteriophages as Next-Generation Alternatives to Conventional Antibiotics
Abstract: The growing threat of antibiotic-resistant bacteria has underscored the urgent need for innovative alternatives to conventional antibiotics. Antimicrobial peptides (AMPs) and bacteriophages are gaining recognition as next-generation therapeutics due to their distinct mechanisms of action and ability to target resistant pathogens effectively. AMPs, which can be natural or synthetic, disrupt microbial membranes and offer broad-spectrum antimicrobial activity with a reduced likelihood of resistance development. Bacteriophages, as bacteria-specific viruses, provide precise …
Published in International Journal of Antibiotics · Vol. 2, Issue 1, 2025 · pp. 9–27 Read article
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A Case Report on Ceftriaxone Induced Immediate Allergic Reaction
Abstract: The most common classes of drugs causing hypersensitivity reaction are antibiotics especially β-lactam antibiotic: cephalosporin’s and penicillin’s. Ceftriaxone, a third generation cephalosporin is used for variety of infections. This drug is associated with rare as well as mild side-effects such as urticaria, skin rash, diarrhea, vomiting, transient neutropenia, and hemolytic anaemia etc. We hereby try to present an adversary case report of a 19 years old male patient in which …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 10, Issue 2, 2020 · pp. 33–35 Read article
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BVM: A Promising Agent for Future HIV-1 Treatment
Abstract: Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} More than 20 individual and fixed-dose combinations of anti-HIV drugs are available for the treatment of human immunodeficiency virus (HIV) infection. However, owing to the development of …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 2, Issue 1, 2011 · pp. 11–21 Read article
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Investigating mosquito innate immune defence mechanism towards malaria vaccine development
Abstract: Mosquito-borne diseases weigh heavily on public health across the globe. The mosquito’s innate immune system certainly decides whether malaria parasites survive inside the vector, and that sighted it as a logical place to discover new vaccine ideas. In this review, we examine how Anopheles mosquitoes defend themselves against Plasmodium parasites and how those defenses could be turned into tools for malaria control. We focus on three layers of immunity: antimicrobial …
Published in International Journal of Insects · Vol. 3, Issue 1, 2026 · pp. 50–54 Read article
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Design and Evaluation Cefaclor Microspheres for Bioavailability Enhancement
Abstract: This study attempted to formulate microspheres for oral administration of Cefaclor by using different polymers like Hydroxypropyl methylcellulose (HPMC) K4M, (HPMC) K15M and Ethylcellulose (EC) which increases the gastric residence time and thereby the bioavailability. Solvent evaporation method was found to be the best due to its ease of fabrication without compromising the activity of the drug. Cefaclor is a second-generation cephalosporin antibiotic used to treat certain ear, lung, skin, …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 6, Issue 3, 2019 · pp. 39–48 Read article
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Therapeutic Potential of Cocculus hirsutus against COVID-19 Infection
Abstract: The complicated epidemiological situation of COVID-19 caused by continuous emergence of new variants with failure of eradication, monitoring and vaccination strategies opens the door to alternative solutions to save the current situation and prevent new disasters. One of the foremost promising alternatives is herbal products and botanicals. Herbal treatments are mainly dependent on the sign and symptoms of the patients. Cocculus Hirsutus is a rich source of phytochemical constituents which …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 12, Issue 1, 2022 · pp. 1–14 Read article
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A Comparative Study of the Antimicrobial Activity of Cinnamomum zeylanicum and Thymus vulgaris Essential Oils with Chlorhexidine on Salivary Streptococcus mutans and Candida albicans
Abstract: The antimicrobial effectiveness of essential oils has been broadly investigated in vitro against various pathogens. However, to our knowledge, there is a lack of reports on evaluating the antimicrobial activities of cinnamon essential oil (CEO) and thyme essential oil (TEO) versus chlorhexidine on oral Streptococcus mutans and Candida albicans. Here, we evaluated and compared the in vitro antimicrobial capabilities of CEO and TEO on oral S. mutans and C. albicans …
Published in Research and Reviews: A Journal of Dentistry · Vol. 10, Issue 1, 2019 · pp. 1–7 Read article
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Design of Novel Antiviral agents against Japanese Encephalitis virus NS3Helicase/NTPase Computational approach
Abstract: Pathogenic protozoa are commonly transmitted to food in developing countries, but food-borne outbreaks of infection are relatively rare in developed countries. The main protozoa of concern in developed countries are Toxoplasma, Cryptosporidium and Giardia, and these can be a problem in immune-compromised people. Other protozoa such as Entamoeba histolytica, Cyclosporacayetanensis and Sarcocystis can be a food-borne problem in non-industrialised countries. C. cayetanensis has emerged as a food-borne pathogen in foods …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 5, Issue 3, 2015 · pp. 29–35 Read article