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412 articles for “PKA/CREB pathway”
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Sustainable Air Conditioning Technologies: Innovations and Future Prospects
Abstract: The increasing demand for air conditioning across the globe, especially in emerging economies, has placed a significant strain on energy resources and contributed to rising greenhouse gas emissions. Conventional air conditioning systems, which largely rely on vapor compression cycles and high-GWP (global warming potential) refrigerants, are energy-intensive and environmentally unsustainable. In response to these challenges, there has been a growing focus on developing sustainable air conditioning technologies that are energy-efficient, …
Published in Journal of Refrigeration, Air conditioning, Heating and ventilation · Vol. 12, Issue 2, 2025 · pp. 26–31 Read article
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Collaborative Care for Diabetic Retinopathy: Integrating Artificial Intelligence and Clinical Pharmacy Services - A Comprehensive Review
Abstract: Background: Diabetic retinopathy (DR) remains the leading cause of blindness among working-age adults globally, affecting approximately 103 million people worldwide. The integration of artificial intelligence (AI) technologies with clinical pharmacy services presents unprecedented opportunities to enhance screening, diagnosis, and management of DR through collaborative care models. Objective: This comprehensive review examines the current landscape of collaborative care approaches for diabetic retinopathy management, focusing on the integration of AI-powered diagnostic tools …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 3, 2025 · pp. 118–128 Read article
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Graphene-Derived Reinforced Polymer Composites for Self-Healing and Durability Enhancement in Concrete Structures
Abstract: This study presents a matrix-centric polymer-composite repair binder: an epoxy–polyamide network reinforced with graphene derivatives (GO/rGO, 0.1–1.0 wt%). The polymer drives function via segmental mobility that closes microcracks, while 2D-filler topology densifies the interphase, improves load transfer, and enforces tortuous moisture pathways. Adhesion was high: pull-off (ASTM D4541) reached 13.5 MPa at 2.0 mm displacement; slant-shear (ASTM C882) reached 12.1 MPa at 2.8 mm, with greater deformation capacity (zero stress …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 77–91 Read article
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Samelisant, an H3 Receptor Agonist as an Anti-Alzheimer Potential – A Pilot Study on Molecular Docking
Abstract: Neurodegenerative diseases have become more prevalent and about 55 million of the population are affected by dementia globally. One of the most important neurodegenerative diseases is Alzheimer’s disease which is known for its effect on memory and cognitive impairment. Alzheimer’s disease (AD) is an area of intense scientific investigation due to its high prevalence and the lack of a definitive cure. Amyloid precursor protein plays a central role in Alzheimer’s …
Published in International Journal of Brain Sciences · Vol. 3, Issue 1, 2026 · pp. 15–26 Read article
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Integrating Digital Twins, Smart Materials, and Human Machine Collaboration for Sustainable Smart Manufacturing: Smart CNC & Industry 4.0 Applications
Abstract: The rapid evolution of Industry 4.0 and the emerging transition toward Industry 5.0 have been catalyzed by the convergence of intelligent digital technologies such as digital twins, cyber–physical systems (CPS), artificial intelligence (AI), the Internet of Things (IoT), and human-in-the-loop (HITL) frameworks. These technologies have transformed traditional manufacturing into adaptive, data-centric ecosystems capable of real-time optimization and predictive decision-making. In recent years, the fusion of computer numerical control (CNC) machines, …
Published in International Journal of Manufacturing and Production Engineering · Vol. 3, Issue 2, 2025 · pp. 1–8 Read article
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Fabrication and Assessment of Tribological Performance of Nickel-Graphene-MXene Hybrid Nano-composites
Abstract: As industries such as aerospace, automotive, defence, and electronics demand materials with superior wear resistance, high strength, and thermal stability, traditional metals are reaching their performance limits. Hybrid nanocomposites offer a pathway to meet these stringent requirements. In this study, novel Nickel-Graphene-MXene hybrid nanocomposites were fabricated using a powder metallurgy route, incorporating varying weight percentages (up to 2 wt.%) of MXene and 1 wt.% graphene nanosheets into a nickel matrix …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 780–798 Read article
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Dynamics of Prime Gap Sets: An Algorithmic and Set-Theoretic Approach
Abstract: In this paper, we present a theorem and an efficient algorithm for computing all prime numbers up to a given integer X. Our theorem establishes a relationship between the primes up to X and those up to (X+1)2, providing a theoretical foundation for the algorithm. The proposed method improves upon the traditional Sieve of Eratosthenes by dynamically eliminating multiples of primes using only the remaining numbers in the set, thereby …
Published in Research & Reviews: Discrete Mathematical Structures · Vol. 12, Issue 3, 2025 · pp. 20–25 Read article
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Host Invasion to Immune Evasion: Emerging Concepts in Pathogen Virulence Strategies
Abstract: Pathogens have evolved a wide repertoire of virulence strategies that allow them to invade host tissues, establish infection, and circumvent immune responses. From the initial steps of adhesion and colonization to complex molecular mimicry, antigenic variation, and immunomodulation, pathogens display remarkable adaptability. While traditional research has emphasized host cell entry and toxin production, emerging evidence highlights subtler and more dynamic strategies such as manipulation of host signaling pathways, subversion of …
Published in International Journal of Pathogens · Vol. 2, Issue 2, 2025 Read article
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Sustainable Membrane Technologies for Environmental and Industrial Applications: A Review
Abstract: Membrane-based technologies have become indispensable in addressing global environmental and industrial challenges, including water scarcity, pollution control, and energy efficiency. While conventional membranes provide high selectivity and process efficiency, their sustainability is limited by factors such as fouling, high energy consumption, and end-of-life waste management. Recent advances in material science, nanotechnology, and bio-inspired design have led to the emergence of sustainable membranes with improved durability, lower environmental footprint, and broader …
Published in International Journal of Membranes · Vol. 2, Issue 2, 2025 · pp. 7–12 Read article
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Reinforcement Learning for Adaptive Sensing with Shape Memory Polymer-Based IoT Nodes
Abstract: The rapid expansion of intelligent sensing in the Internet of Things (IoT) has revealed the pressing need for materials and algorithms capable of self-adaptation in volatile environments. Conventional polymer-based sensors and static control strategies often fail to capture nonlinear thermo-mechanical dynamics, leaving them unsuitable for unpredictable operating conditions. Although prior studies have improved polymer composites or introduced algorithmic optimization independently, few attempts have coupled the adaptability of smart materials with …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 370–391 Read article
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Integrated, Geospatial Risk Assessment of Air, Water, and Soil Pollution Impacts on Agricultural Sustainability using Advanced Digital Technologies
Abstract: The systemic threat posed by the convergence of air, water, and soil contaminants represents a critical challenge to global agricultural resilience and food security. Traditional, site-specific pollutant monitoring methods are insufficient for capturing the dynamic, diffuse, and often nonlinear nature of environmental risk pathways that permeate agrarian landscapes. This study presents a robust framework for comprehensive risk assessment utilizing a synergistic suite of modern tools designed for spatial, temporal, and …
Published in International Journal of Environmental Noise and Pollution Control · Vol. 3, Issue 2, 2025 · pp. 28–37 Read article
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Climate Change and Air Pollution Dynamics: Synergistic Effects and Mitigation Strategies
Abstract: Climate change and air pollution are deeply interlinked environmental problems that jointly exacerbate human health, ecosystem integrity, and economic well‑being. As global temperatures rise, shifts in meteorological conditions—such as increased heat, altered precipitation, and more frequent extreme weather events—modify pollutant generation, dispersion, chemical transformation, and removal processes. Meanwhile, many sources of air pollution are also sources of greenhouse gases (GHGs), giving rise to potential co‑benefits or trade‑offs when formulating mitigation …
Published in International Journal of Environmental Noise and Pollution Control · Vol. 3, Issue 2, 2025 · pp. 38–42 Read article
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Thermodynamic Optimization and Exergy-Based Performance Analysis of Hybrid Thermal Management Systems for Electric Vehicles
Abstract: The transition toward sustainable transportation has brought electric vehicles (EVs) to the forefront of modern engineering innovation. Despite their environmental benefits and improved energy efficiency, EVs face major thermal challenges that affect performance, safety, and durability. Efficient thermal management of batteries, power electronics, and electric drive systems is vital to ensure reliability under diverse operating conditions. This study presents a detailed thermodynamic optimization and exergy-based performance analysis of hybrid thermal …
Published in International Journal of Energy and Thermal Applications · Vol. 3, Issue 2, 2025 · pp. 19–23 Read article
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Novel Strategic Framework between Polymer Manufacturers and Waste Management Companies: A Mixed-Method Approach for Enhancing Circular Efficiency in Polymer Industries
Abstract: The study describes the perspectives of the industry stakeholders and qualitatively and quantitatively assesses the recycling efficiency, cost optimization, and environmental performance using a mixed-method approach. The framework features processes, as it were: onboard invention, coupling, and sustainable valorization of the intersection, thus solidly connecting the production side with the waste management. The primary function of the patterns of interaction between the plant waste-management system, the retrieval of polymer composites, …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1570–1609 Read article
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AI EdTech Synergy: From Chalkboards to Smartboards
Abstract: Beyond textbooks and classrooms, AI paints a future from adaptive tutors to immersive realities. AI is not just a tool sculpted by algorithms but an architect of a learning revolution where knowledge becomes truly boundless. The convergence of AI marks an era of revolution in learning, promising individualized learning pathways, optimized evaluative metrics, interactive virtual pedagogies, and enhanced accessibility. This convergence examines the emergent field of AI-powered educational innovation, shedding …
Published in Journal of Open Source Developments · Vol. 12, Issue 3, 2025 · pp. 18–25 Read article
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Evaluating Andrographis paniculata Phytochemicals as Potential Glioma Therapeutics via Molecular Docking Approach
Abstract: Evaluating Andrographis paniculata Phytochemicals as Potential Glioma Therapeutics via Molecular Docking ApproachGlioneuronal tumors and gliomas are grade I tumors classified by the World Health Organization (WHO). They typically grow slowly and primarily affect infants, children, and teenagers, but can also occur in adults. They mostly cause seizures caused by gangliomas. Most current treatments include surgery and radiotherapy. Since this disease affects children, the current treatments may cause complications. Andrographis paniculata …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 1, 2026 · pp. 82–93 Read article
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In-Silico Repurposing of Antipsychotic Drugs Against Novel Protein Targets in Multidrug-Resistant Mycobacterium tuberculosis
Abstract: Multidrug-resistant TB is a growing worldwide health concern, particularly in high-burden areas. Resistance to frontline drugs like isoniazid and rifampicin is caused by mutations in key Mycobacterium tuberculosis proteins. Given the difficulty of developing new antibiotics, medication repurposing offers a good alternative. The potential use of molecular docking to target resistance-associated TB proteins with FDA-approved antipsychotic drugs is investigated in this work. Three proteins were selected: InhA (PDB ID: 5W07), …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 1, 2026 · pp. 49–63 Read article
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Solar-Responsive Photo-Thermal Polymer Composites with Carbon Nanostructures for On-Demand Water Purification
Abstract: The development of solar-responsive polymer nanocomposites offers a sustainable pathway for water purification. In this work, polyvinyl alcohol (PVA) films reinforced with graphene nanoplatelets (GNPs) and multi-walled carbon nanotubes (MWCNTs) were fabricated and systematically investigated for their mechanical, thermal, viscoelastic, and thermal transport properties. Neat PVA displayed moderate tensile strength (~38 MPa) and high elongation (~165%), whereas 1.0 wt% nanofiller loading enhanced tensile strength to ~52 MPa and modulus to …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 199–209 Read article
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A Review on Lung Cancer Prediction Using Machine Learning
Abstract: Lung cancer continues to be a major contributor to cancer-related mortality across the globe. Timely diagnosis and reliable prediction models play a crucial role in enhancing treatment outcomes and survival rates for patients. The present study focuses on the utilization of machine learning (ML) methods for the prediction of lung cancer. Using datasets that incorporate clinical records, imaging modalities, and genetic profiles, the research assesses the predictive capabilities of multiple …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 3, 2025 · pp. 1–11 Read article
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Integrating Biotechnology, Physiology, and Agroecological Practices for Sustainable Crop Production and Protection
Abstract: Global agriculture is currently confronting a wide range of complex challenges, including a rapidly growing population, climate change, increasing pest and disease pressures, soil degradation, water scarcity, and the urgent need for sustainable intensification of crop production. Addressing these issues requires integrated strategies that combine crop improvement (through modern breeding and biotechnology), precision agronomic practices related to soil, irrigation, and nutrition, as well as advancements in plant physiology, molecular biology, …
Published in International Journal of Trends in Horticulture · Vol. 2, Issue 2, 2025 · pp. 1–6 Read article